Journal Article. Cognitive enhancement and neuroprotection by catechin-rich oil palm leaf extract supplement. Author s. Mohamed, S; Lee Ming, T; Jaffri, JM. Is Peer Reviewed? Journal of the Science of Food and Agriculture ISSN: EISSN: Page Numbers.

Web of Science Id. The OPLE 0. Their short-term memories, spatial visualisations, processing speeds, and language skills, were assessed over 2 months by cognitive tests computer programs.

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The death of hippocampal CA1 pyramidal neurons caused by transient forebrain ischemia in the gerbil was inhibited with the ventricular preadministration of theanine. The neuronal death of the hippocampal CA3 region by kainate was also prevented by the administration of theanine.

The results of the present study suggest that the mechanism of the neuroprotective effect of theanine is related not only to the glutamate receptor but also to other mechanisms such as the glutamate transporter, although further studies are needed.

One of the onset mechanisms for arteriosclerosis, a major factor in ischemic cerebrovascular disease, is probably the oxidative alteration of low-density lipoprotein LDL by active oxygen species.

The oxidative alterations of LDL were shown to be prevented by tea catechins. The neuroprotective effects of theanine and catechins contained in green tea are a focus of considerable attention, and further studies are warranted.

Already have an account? Sign in here. Biological and Pharmaceutical Bulletin. Online ISSN : Print ISSN : ISSN-L : Journal home Advance online publication All issues Featured articles About the journal. Multiple sclerosis is the most common non-traumatic disabling disorder that affects young individuals.

Multiple sclerosis is becoming more widespread over the world, as is its economic impact. Despite that complex gene-environment interactions are likely to play a significant role, the underlying etiology of MS and the mechanisms driving an increase in patients are unknown. According to MS epidemiology, low blood vitamin D levels, smoking, childhood obesity, and infection with the Epstein—Barr virus all have a part in the disease's progression.

Thanks to breakthroughs in diagnostic techniques and criteria, people with MS can now be detected earlier in their illness courses. In addition, the number, efficacy, and risk of MS treatments have all increased dramatically. A diagnosis of 'pre-symptomatic MS' is now possible, which could lead to the exploration of new preventive medicines 70 , Symptoms can be decreased, and the immune system can be improved with a doctor and a complete and effective treatment.

Polyphenols are one of the therapeutically helpful chemicals for MS treatment. Resveratrol, quercetin, epigallocatechingallate, and myricetin are some of the polyphenols utilized for MS treatment due to their advantages and efficacy. Polyphenols are examined according to many models for MS treatment by reducing inflammation and breaking the immune system.

Polyphenols demonstrated to be able to reduce inflammation by modifying the cytokine pathways in various studies for example, IL-β and TNF-α. In this method, brain demyelination is reduced, and normal limb function is restored. Polyphenols can be utilized in age-related MS and amyotrophic lateral sclerosis as prophylactics, keeping their effectiveness in mind 72 - Polyphenols are highly effective in both therapeutic and pharmacological settings.

They can be found in a wide range of fruits and dietary meals. Various polyphenols have been studied for their impact on neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

Neurodegenerative diseases are driven by inflammation, oxidative stress, and abnormal mitochondrial function, according to new research. For the treatment and prevention of many disorders, new therapeutic approaches that target specific genes and proteins are required.

Inflammation, ion channels, reactive oxygen species ROS , and neurotransmitters are all controlled and regulated by polyphenols. Antioxidant capabilities are found in polyphenols.

Neuroprotective effects are found in polyphenols, including EGCG, resveratrol, and quercetin. Polyphenols have been shown to activate antioxidant pathways such as Nrf2 in numerous studies. Polyphenols can also block the NFB and STAT signaling pathways.

Polyphenols control the immune response by inhibiting proinflammatory cytokines, including TNF-α and IFN-γ. Polyphenols do, in fact, provide neuronal damage prevention.

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The role of flavonoids in autoimmune diseases: Therapeutic updates. Pharmacol Ther. Jiang Z, Zhang J, Cai Y, Huang J, You L. Catechin attenuates traumatic brain injury-induced blood-brain barrier damage and improves longer-term neurological outcomes in rats.

Exp Physiol. Li S, Li SK, Gan RY, Song FL, Kuang L, Li HB. Antioxidant capacities and total phenolic contents of infusions from medicinal plants. Ind Crops Prod. Wang TY, Li Q, Bi KS. Bioactive flavonoids in medicinal plants: Structure, activity and biological fate.

Asian J Pharm Sci. Choi DY, Lee YJ, Hong JT, Lee HJ. Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease. Brain Res Bull. Vauzour D. Dietary polyphenols as modulators of brain functions: Biological actions and molecular mechanisms underpinning their beneficial effects.

Oxid Med Cell Longev. Westfall S, Pasinetti GM. The gut microbiota links dietary polyphenols with management of psychiatric mood disorders. Front Neurosci. Veurink G, Perry G, Singh SK. Role of antioxidants and a nutrient rich diet in Alzheimer's disease. Open Biol. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease.

Brglez Mojzer E, Knez Hrncic M, Skerget M, Knez Z, Bren U. Polyphenols: Extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Jiang T, Sun Q, Chen S. Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease.

Prog Neurobiol. Hamaguchi T, Ono K, Murase A, Yamada M. Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway.

Am J Pathol. Butterfield DA, Reed T, Newman SF, Sultana R. Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic Biol Med.

Mariani E, Polidori MC, Cherubini A, Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview. J Chromatogr B Analyt Technol Biomed Life Sci. Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. Farooqui T, Farooqui AA.

Curcumin: Historical background, chemistry, pharmacological action, and potential therapeutic value. Curcumin for neurological and psychiatric disorders: Neurochemical and pharmacological properties.

Massachusetts, USA: Academic Press; Sharma RA, Gescher AJ, Steward WP. Curcumin: The story so far. Eur J Cancer. Nam SM, Choi JH, Yoo DY, Kim W, Jung HY, Kim JW, et al. Effects of curcumin Curcuma longa on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling.

J Med Food. Kapitulnik J. Drug transport and metabolism in the blood-brain barrier. Front Pharmacol. Hoppe JB, Coradini K, Frozza RL, Oliveira CM, Meneghetti AB, Bernardi A, et al. Neurobiol Learn Mem. Zhong Y, Zhu Y, He T, Li W, Li Q, Miao Y. Int J Mol Med.

Kim H, Park BS, Lee KG, Choi CY, Jang SS, Kim YH, et al. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. J Agric Food Chem. Liang Z, Owens CL, Zhong GY, Cheng L.

Polyphenolic profiles detected in the ripe berries of Vitis vinifera germplasm. Food Chem. de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications. Mol Nutr Food Res. Braidy N, Jugder BE, Poljak A, Jayasena T, Mansour H, Nabavi SM, et al.

Resveratrol as a potential therapeutic candidate for the treatment and management of Alzheimer's disease. Curr Top Med Chem. blog entry {{ blogEntry. Login for price. Make a customized order. Article No AG-CNM Size mg.

Shipping Information RT. Specifications Documentation References. Specifications CAS No , MW hydrate Supplier Adipogen Life Sciences Format Powder Notes Chemical. CAS: or Formula: C15H14O6. MW: Isolated from Uncaria rhynchophylla. Specific histidine decarboxylase inhibitor.

COX-1 inhibitor. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation. Antimetastatic and anticancer compound. Antibacterial and antifungal. Mono oxidase B inhibitor. Apoptosis and cell cycle arrest inducer.

JNK phosphorylation inhibitor. Specific histidine decarboxylase inhibitor [1]. COX-1 inhibitor [2]. Inhibits lipid peroxidation [3, 6, 9]. Antimetastatic and anticancer compound [4, 9, 10, 14, 16, 17].

Antiangiogenic [14]. Anti-osteoporotic [5]. Antibacterial and antifungal [7]. Neuroprotective [8]. Mono oxidase B inhibitor [11].