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Blood pressure and LDL lowering in elderly do not slow cognitive declineHypertension and cognitive decline -
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Department of Epidemiology and Biostatistics, George Washington University Milken Institute School of Public Health, Washington, DC, USA. Department of Epidemiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. You can also search for this author in PubMed Google Scholar.
Correspondence to Rebecca F. Walker and Power declare no conflicts of interest relevant to this manuscript. Gottesman reports personal fees from American Academy of Neurology, outside the submitted work, as an Associate Editor for the journal Neurology.
This article does not contain any studies with human or animal subjects performed by any of the authors. This article is part of the Topical Collection on Secondary Hypertension: Nervous System Mechanisms.
Reprints and permissions. Walker, K. Defining the Relationship Between Hypertension, Cognitive Decline, and Dementia: a Review. Curr Hypertens Rep 19 , 24 Download citation. Published : 16 March Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Hypertension is a highly prevalent condition which has been established as a risk factor for cardiovascular and cerebrovascular disease.
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Article CAS PubMed Google Scholar Glodzik L, Mosconi L, Tsui W, de Santi S, Zinkowski R, Pirraglia E, et al. Compared to persons without hypertension, white matter lesions grade 3 and higher were 2. Numerous randomized, double-blind, placebo-controlled trials have demonstrated that antihypertensive drug therapy reduces cardiovascular events including stroke and mortality in older persons Reduction of stroke will reduce the incidence of vascular dementia.
However, the data from randomized, controlled clinical trials for antihypertensive drug treatment preventing dementia are conflicting 6. The new guidelines for treatment of patients with hypertension will be strongly influenced by the results from the Systolic Blood Pressure Intervention Trial SPRINT 16 , SPRINT randomized 9, patients with a systolic blood pressure of — mmHg and an increased cardiovascular risk to a systolic blood pressure of less than mmHg or to less than mmHg.
Median follow-up was 3. The persons in this study aged 75 years and older are being followed at present to determine the effect of lowering the systolic blood pressure to less than mmHg versus less than mmHg on cognitive function. Randomized, controlled clinical trial data on the efficacy of antihypertensive drug treatment on prevention of dementia are conflicting 18 - The Systolic Hypertension in the Elderly Program randomized 4, persons aged 60 years and older with isolated systolic hypertension to antihypertensive drug therapy versus double-blind placebo Mean follow-up was 5 years.
Compared to placebo, antihypertensive drug therapy insignificantly reduced cognitive impairment The Systolic Hypertension in Europe SYST-EUR trial randomized 2, persons aged 60 years and older with isolated systolic hypertension to antihypertensive drug therapy versus double-blind placebo Median follow-up was 2.
The extended follow-up to 3. The Perindopril Protection Against Recurrent Stroke Study PROGRESS randomized 6, persons with a prior stroke or transient ischemic attack to perindopril or perindopril plus indapamide versus double-blind placebo At a mean follow-up of 3.
The Hypertension in the Very Elderly Trial randomized 3, persons aged 80 years and older with hypertension to treatment with antihypertensive drug therapy versus double-blind placebo The Heart Outcomes Prevention Evaluation HOPE Study randomized 9, patients aged 55 years and older with vascular disease or diabetes mellitus plus an additional risk factor to ramipril versus double-blind placebo
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