Athletes and other sportspersons that work out at regular speed make sure to have their pre-workout drink. They follow a complete and precise workout meal routine, and hence they ultimately get good results. Nitric oxide is one of the most effective boosters for energy.

Not only will it boost your energy levels, but it will also make sure that you perform your exercise in the best way. There was once when you woke up early in the morning following a nice and healthy jogging and a nutritious breakfast. Then, you worked for eight straight hours by balancing your social circle at the same time.

But all of it went away. The answer might lie in your lifestyle. Age is also why we fail to achieve the targets, but the most important factor is the life that you are living. Combining these reasons, you do not have enough energy to even get out of your bed for a glass of water by the end of the day.

Not eating enough before a workout or not having ample energy before a workout would cause you pre-workout problems.

In the same way, you also need to make sure that you have enough meals after the workout to recover the damage. These important factors that can affect your workout routine badly:. Your eating habits have a huge influence on you. It is right to say you are what you eat. If you have the habit of binging on food or having excessive portions at any time of day, or starving too much, you might face inadequate energy problems in your body.

There are also food that can help you manage your wellness such as vegan protein powder. Not giving your muscles recovery time will reduce their functioning capacity. Working out is also important, but you need to give your muscles enough time to recover the damage.

Without proper rest time, it will be hard to develop strength in the muscles , which will affect your energy level. It is never a wise choice to sacrifice your sleep for any of your workouts. Getting proper sleep is necessary for many of your integral body functions.

A proper sleep cycle can effectively regulate your body processes, so pay attention to it. A nutritious meal can help you much to achieve your fitness goals.

With pre workout energy powder , you can perform better and have a lower risk of muscle damage. Rather than eating something before the workout, try to have some drink or supplement that is better absorbed. The best pre-workout drink is the one that is packed with all the essential nutrients that you need for the proper functioning of the body.

Nitric oxide is undoubtedly the best choice for high performance in the workout as it relaxes the muscles and promotes a smooth blood flow.

While we all know the significance of macronutrients, one thing that often gets ignored is necessary supplements. So, we will dive into the positive aspects and effects of nitric oxide and its role in improving workout performance.

Nitric oxide is the product of the oxidation of nitrogen in the body. It has various vital roles in the body. It regulates various physiological processes in the human body. It works as a neurotransmitter in the body and is also a vasodilator by causing relaxation of the smooth muscles.

Vasodilators are important for the regulation of blood pressure. They widen the blood vessels and ensure that there is no obstruction in the blood flow.

The blood carries essential nutrients that need to be supplied to your body, which vasodilators do effectively. Decreased immune function : Nitric oxide has antimicrobial properties and plays a role in immune system regulation.

Low levels may contribute to a weakened immune system and increased susceptibility to infections. Heart disease risk : Low nitric oxide levels can lead to atherosclerosis, the buildup of plaque in the arteries, increasing the risk of heart disease, heart attacks, and strokes.

Migraines : Nitric oxide helps regulate blood flow in the brain, and low levels have been linked to the development of migraines and other types of headaches. For more everything you need to know about nitric oxide and the role it plays in the human body, check out our comprehensive information page here.

We've created a Nitric Oxide boosting supplement with a combination of ingredients required by our bodies to produce optimal amounts of nitric oxide.

Our supplement comes as an easy to mix, great tasting powder, offering a therapeutic dose in each scoop. Learn more about it here. Ron Goedeke MD, BSc Hons MBChB, FNZCAM.

Ron Goedeke, an expert in the domain of functional medicine, dedicates his practice to uncovering the root causes of health issues by focusing on nutrition and supplement-based healing and health optimisation strategies.

An esteemed founding member of the New Zealand College of Appearance Medicine, Dr. Goedeke's professional journey has always been aligned with cutting-edge health concepts. Having been actively involved with the American Academy of Anti-Aging Medicine since , he brings over two decades of knowledge and experience in the field of anti-aging medicine, making him an eminent figure in this evolving realm of healthcare.

Throughout his career, Dr. Goedeke has been steadfast in his commitment to leverage appropriate nutritional guidance and supplementation to encourage optimal health. This has allowed him to ascend as one of the most trusted authorities in the arena of nutritional medicine in New Zealand.

His expertise in the intricate relationship between diet, nutritional supplements, and overall health forms the backbone of his treatment approach, allowing patients to benefit from a balanced and sustainable pathway to improved wellbeing.

This study found that mice deficient in neuronal nitric oxide synthase NOS were more susceptible to cerebral ischemia brain damage caused by a lack of blood flow.

The researchers suggest that NOS plays a role in protecting the brain from damage during ischemia. This study found that nitric oxide NO synthesis inhibition suppressed fertility in female rats. The researchers suggest that NO plays a role in the regulation of ovulation and implantation.

This study found that nitric oxide NO is generated in the mouth by the action of nitric oxide synthase NOS on L-arginine. The researchers suggest that NO may play a role in the regulation of oral health. This textbook provides a comprehensive overview of the principles of epidemiology, including the study of the health impact of environmental factors.

This special issue of Environmental Health Perspectives provides a comprehensive overview of the research on the health effects of nitric oxide NO exposure. Disclaimer: The information provided is for educational purposes only and does not constitute medical advice.

Always seek the advice of your physician or qualified healthcare provider with any questions or concerns about your health. Never disregard or delay seeking medical advice because of something you have heard or read on this website. Last updated 28th of April Just added to your cart.

Continue Shopping. Close search. Home Nitric Oxide Low Nitric Oxide Symptoms: A Comprehensive Guide on Signs and Solutions for Nitric Oxide Deficiency. Low Nitric Oxide Symptoms: A Comprehensive Guide on Signs and Solutions for Nitric Oxide Deficiency by Ron Goedeke.

Understanding Nitric Oxide and Its Functions Nitric oxide is a gas that acts as a signaling molecule in the human body. Some key functions of nitric oxide include: Vasodilation : NO relaxes the smooth muscles in blood vessels, allowing them to widen and increase blood flow. Blood Pressure Regulation : By promoting vasodilation, NO helps regulate blood pressure and maintain proper circulation.

Immune Response : NO can act as a defense mechanism against pathogens, as it has antimicrobial and antiviral properties. Neurotransmission : Nitric oxide plays a role in the communication between nerve cells and the brain.

Cell Growth and Differentiation : NO influences cellular processes such as growth, differentiation, and apoptosis. What is Nitric Oxide Deficiency?

Symptoms of Low Nitric Oxide Levels The following signs may indicate low nitric oxide levels: Fatigue: Low NO levels can lead to reduced blood flow and oxygen supply, causing feelings of fatigue and tiredness.

This lack of energy may also negatively impact your motivation and productivity. Erectile Dysfunction : Nitric oxide is essential for blood vessel dilation and proper blood flow, which is crucial for achieving and maintaining erections in men.

Low NO levels may contribute to erectile dysfunction ED , affecting both physical and emotional well-being. High Blood Pressure : A deficiency in NO can cause blood vessels to constrict, leading to increased blood pressure.

Hypertension can have severe long-term effects on heart health and overall well-being. Decreased Exercise capacity : Reduced blood flow and oxygen supply to muscles can limit physical performance.

This decrease in exercise capacity may affect your ability to maintain a healthy and active lifestyle. Slow Wound Healing : Nitric oxide plays a crucial role in wound healing by promoting blood flow and immune function.

Low NO levels can slow down the healing process, increasing the risk of infection and complications. Cognitive Decline : NO deficiency can negatively impact brain function, leading to poor memory, concentration, and cognitive decline.

These issues may affect your work performance and quality of life. Weakened Immune System : Nitric oxide is vital for a properly functioning immune system, and a deficiency can make you more susceptible to infections. This increased vulnerability may lead to more frequent illnesses and a longer recovery time Negative Health Effects of Nitric Oxide Deficiency Low nitric oxide levels can have several negative impacts on overall health.

Some potential consequences include: Cardiovascular Disease : Reduced NO production can increase the risk of heart disease, stroke, and other cardiovascular complications. This is because insufficient NO can lead to constriction of blood vessels, plaque buildup, and inflammation.

Diabetes: Nitric oxide deficiency can impair insulin sensitivity, increasing the risk of type 2 diabetes. Furthermore, low NO levels may exacerbate complications associated with diabetes, such as impaired blood flow and nerve damage.

Neurodegenerative Disorders: NO plays a role in neurotransmission and brain function, and its deficiency can contribute to conditions like Alzheimer's and Parkinson's disease.

Maintaining healthy NO levels may help prevent or slow the progression of these debilitating disorders. Osteoporosis: Low NO levels can negatively affect bone health, increasing the risk of osteoporosis and fractures.

Nitric oxide is involved in bone remodeling, a process that maintains bone density and strength. How to Fix a Nitric Oxide Deficiency The best way to give each and every cell in the body sufficient oxygen and nutrients is to improve blood flow.

To address nitric oxide deficiency, you can implement the following strategies: Consume a nitrate-rich diet: Foods like beets, spinach, arugula, and celery can increase nitrate intake, which your body can convert into nitric oxide.

Incorporating these foods into your regular diet can help boost NO levels and improve overall health. Exercise regularly : Physical activity stimulates NO production, especially cardiovascular exercises like jogging, swimming, and cycling.

Engaging in regular exercise can not only enhance NO levels but also promote general health and well-being. Maintain a healthy weight : Obesity can negatively impact NO production, so maintaining a healthy weight is crucial for optimal NO levels.

Adopting a balanced diet and engaging in regular physical activity can help you achieve and maintain a healthy weight. Supplements : Consider taking supplements like L-arginine or L-citrulline , which are precursors to nitric oxide.

These supplements can help increase NO production, especially in individuals with deficiencies or those who have difficulty getting enough through diet alone. Manage stress: Chronic stress can reduce NO production, so it's essential to manage stress through relaxation techniques, meditation, or yoga.

Nevertheless, L-citrulline proved to be safe and well tolerated 6. Two other nitric-oxide-boosting supplements have been shown to treat erectile dysfunction , inclduing the amino acid L-arginine and French maritime pine bark extract.

In several older studies, a combination of L-arginine and French maritime pine bark extract significantly improved sexual function in people with ED 7 , 8 , 9. When taken together, L-arginine and French maritime pine bark extract also appear safe Nitric oxide plays an important role in erectile function.

Several supplements, including L-citrulline, L-arginine, and French maritime pine bark extract, have been shown to increase levels of nitric oxide in people with erectile dysfunction ED.

A form of L-citrulline called citrulline malate not only increases nitric oxide production, but also decreases muscle soreness. Muscle soreness is an uncomfortable experience that tends to occur after strenuous or unaccustomed exercise This soreness is referred to as delayed-onset muscle soreness and usually feels the strongest 24—72 hours after exercise In one study, 41 people were randomized to receive either 8 grams g of citrulline malate or a placebo 1 hour before performing as many repetitions as possible on a flat barbell bench press Citrulline malate increases nitric oxide production, which increases blood flow to active muscles.

In turn, citrulline malate is thought to increase nutrient delivery and clear waste products that are related to muscle fatigue, such as lactate and ammonia However, a later study on the effects of citrulline after leg exercises did not find citrulline malate helpful for the treatment of muscle soreness Another review of 13 studies showed that while citrulline could reduce muscle soreness 24 hours and 48 hours after exercise, it did not improve muscle soreness 72 hours after exercise Therefore, the ability of citrulline malate to decrease muscle soreness may depend on the dose, exercise, and timing.

However, more research on this is needed. Citrulline malate is a form of L-citrulline that may help alleviate muscle soreness by increasing nitric oxide. The dose and type of exercise may affect the ability of citrulline malate to decrease muscle soreness.

People with high blood pressure are thought to have an impaired ability to use nitric oxide in their bodies High blood pressure occurs when the force of your blood pushing against the walls of your arteries is consistently too high.

Over time, high blood pressure can lead to health issues such as heart disease and kidney disease 18 , It has been shown that a diet high in fruits and vegetables decreases blood pressure and therefore lowers the risk of disease This has led researchers to test the beneficial effects of certain compounds found in fruits and vegetables on blood pressure levels.

Nitrate is a compound found in beetroot and dark leafy greens like spinach and arugula When you consume nitrate, your body converts it to nitric oxide , which in turn causes blood vessels to relax and dilate, lowering blood pressure.

Several studies have shown dietary nitrate may help lower blood pressure by increasing the production of nitric oxide 22 , In fact, one review of 22 studies found that taking nitrate supplements significantly reduced systolic and diastolic blood pressure in older adults Flavonoids are compounds found in almost all fruits and vegetables, which have powerful antioxidant properties Some studies have found that increased intake of flavonoids could be linked to a reduced risk of high blood pressure 27 , Scientists believe flavonoids not only increase production of nitric oxide but also decrease its breakdown, promoting higher levels overall.

For instance, one review of 15 studies found that consumption of flavonoid-rich fruits had no significant effect on blood pressure levels in adults Vegetables and fruits contain several compounds, such as nitrate and flavonoids, that may help keep blood pressure under control by increasing nitric oxide levels.

Nitric oxide is involved in many cell processes, including the widening of the blood vessels, or vasodilation. Wider blood vessels help increase the delivery of nutrients and oxygen to working muscles during exercise, thus enhancing exercise performance.

These supplements often contain several ingredients that are said to increase nitric oxide, such as nitrate or the amino acids L-arginine and L-citrulline. In many analyses, nitrate has been shown to improve exercise performance in cyclists, runners, swimmers, and even kayakers 30 , 31 , On the other hand, L-arginine has not proven to be effective for improving exercise performance in many studies 33 , According to one older study, this may be because much of the L-arginine that is ingested is metabolized or broken down before it gets a chance to reach the bloodstream Supplements intended to increase nitric oxide are commonly promoted as performance enhancers.

While the performance-enhancing benefits of L-arginine are minimal, nitrate and L-citrulline may be worthwhile. Nitric oxide production may be reduced in people with type 2 diabetes This leads to poor blood vessel health, which can lead to conditions like high blood pressure, kidney disease, and heart disease over time.

Therefore, supplements that increase nitric oxide may have important implications for diabetes treatment and disease prevention.

One review of 10 studies found that supplementing with L-arginine could significantly reduce insulin levels in people without diabetes Another study in people looked at the effects of L-arginine on preventing or delaying the progression of type 2 diabetes While L-arginine did not prevent people from developing diabetes, it did increase insulin sensitivity and improve blood sugar control However, other research has found no effect of L-arginine on fasting blood sugar levels and blood sugar control in people with diabetes Therefore, until more research is available, it is premature to recommend taking L-arginine supplements to treat or manage diabetes.

People with diabetes have impaired nitric oxide production, which can lead to harmful health effects. L-arginine has been shown to reduce insulin levels and slow the progression of diabetes, but more research is needed before it can be recommended. Nitric oxide supplements are generally safe when taken in appropriate amounts 13 , According to some older research, L-arginine taken in doses above 10 g can cause stomach discomfort and diarrhea Beetroot juice supplements can also turn your urine and stool a dark red color.

This is a common but harmless side effect Nitric oxide supplements are generally considered safe. However, there are some side effects to be aware of, including potential stomach discomfort and diarrhea, as well as dark red stool and urine. Many supplements are claimed to increase nitric oxide in the body and provide impressive benefits for health and performance.

However, other supplements, such as French maritime pine bark extract, have also been shown to increase or maintain nitric oxide levels. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

VIEW ALL HISTORY. Increasing evidence shows that NO regulates the mammalian metabolism of energy substrates and that these effects of NO critically depend on its concentrations at the reaction site and the period of exposure.

High concentrations of NO in the micromolar range irreversibly inhibit complexes I, II, III, IV, and V in the mitochondrial respiratory chain, whereas physiological levels of NO in the nanomolar range reversibly reduce cytochomrome oxidase.

Thus, NO reduces oxygen consumption by isolated mitochondria to various extents. In intact cells, through cGMP and AMP-activated protein kinase signaling, physiological levels of NO acutely stimulate uptake and oxidation of glucose and fatty acids by skeletal muscle, heart, liver, and adipose tissue, while inhibiting the synthesis of glucose, glycogen and fat in the insulin-sensitive tissues, and enhancing lipolysis in white adipocytes.

Chronic effects of physiological levels of NO in vivo include stimulation of angiogenesis, blood flow, mitochondrial biogenesis, and brown adipocyte development. Modulation of NO-mediated pathways through dietary supplementation with L-arginine or its precursor L-citrulline may provide an effective, practical strategy to prevent and treat metabolic syndrome, including obesity, diabetes, and dyslipidemia in mammals, including humans.

Keywords: energy metabolism; mitochondria; nitric oxide; oxidation.