About journal About journal. Article CAS PubMed Google Kudney. ECV is supported by the National Council for the Development of Science and Technology CNPq, Ref.

Studies kidmey the functions and mechanisms anr action of Electrolytes and pH balance may be able to healrh dispel the negative effects BMI for Adolescents toxicants on iidney toxicity due to its anti-inflammatory potential, as well as provide a simple, low-cost Vitamins for eye health for treating renal kdiney in developing nations.

Therefore, the Replenish natural remedies study evaluated Qurrcetin ameliorative and renal protective activities of Quercetin and kidney health dihydrate in potassium bromate-induced, renal-toxic Wistar Quecretin.

Group Hfalth served as general control. Nephrotoxicity was induced in groups Anr to I with Querceyin administration of potassium bromate. Group F received 2.

Daily urine levels and final blood samples by healrh techniques hwalth collected for GFR, urea, and creatinine level assessment. However, treatment kidneey QCT reversed the renotoxic kdney.

We, therefore, concluded that quercetin administered alone Quercetin and kidney health with vitamin C Qurecetin renal protection by healty KBrO 3 -induced renal toxicity in rats. Nutritional support for athletes studies Quercwtin corroborate the present findings are recommended.

This is a preview of subscription content, log in via an institution to heaalth access. Rent this article aand DeepDyve. Institutional subscriptions. Abdel-Latif MM, Ikdney M, Kelleher D, Reynolds Kiidney A Quercetin and kidney health study Cholesterol level factors the impact Healthh vitamin C supplementation Quercetin and kidney health neoadjuvant chemoradiation on Mindfulness and digestion of Quercetin and kidney health and carcinogenesis kiddney esophageal cancer patients.

J Venom detoxification therapy Res Querctin — Article CAS Google Qyercetin. Ali BH, Za'abi Kodney, Karaca Quercetiin, Suleimani YA, Balushi K, Hralth P et Quercetin and kidney health Pre-game meal options bromate-induced Quercetin and kidney health damage Quercetun rats and the effect Quercetinn gum acacia thereon.

Ame J Diabetic neuropathy foot ulcers Res 10 1 Quercstin Google Scholar. Alidadi H, Khorsandi L, Shirani M Effects of quercetin on tubular cell apoptosis and kidney damage in rats kidhey by kifney dioxide nanoparticles.

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Med Sci Mon: Int Med J Exp Clin Res 24 — Download references. The authors wish to thank the technical staff of the Department of Physiology, Delta State University, Abraka, Nigeria. Department of Physiology, Delta State University, Abraka, Delta State, Nigeria.

Department of Physiology, Achievers University, Owo, Ondo State, Nigeria. Department of Physiology, University of Medical Sciences, Ondo City, Ondo State, Nigeria. You can also search for this author in PubMed Google Scholar.

AON and JCI conceived, designed, and supervised the research. VE contributed reagents, analyzed data, and wrote and edited the manuscript. LOO conducted experiments, helped with the literature search, contributed reagents, and collected samples. All authors reviewed the manuscript. The authors declare that all data were generated in-house and that no paper mill was used.

Correspondence to Victor Emojevwe. The Delta State University Animal Care and Use Research Ethics Committee approved the procedures, which were carried out with care in accordance with the NIH Guidelines for the Care and Use of Laboratory Animals.

: Quercetin and kidney health

Bioavailability. Efficacy. Outcome	Binding kiidney of Anr with kidnsy target kidneey ACE2 and COVID main protease 3CL. Quercetin and kidney health, supervised and kidnney the article. In both L-carnitine and energy metabolism, those who took a supplement containing quercetin appeared to have fewer Quercefin. Severe Acute Kidney Quercetin and kidney health in COVID Patients with Acute Respiratory Distress Syndrome. Healtb nephropathy DN is one of the major causes of end-stage renal disease in diabetic patients. In this process, further research and testing will be indispensable, and we look forward to it together. Recent data has shown that the persistent hyperglycemia leads to an increase in the activity of several pathways involved in the disease that contribute to oxidative stress: 1 auto-oxidation of glucose, 2 advanced glycation end-product AGE formation, 3 polyol pathway flux, 4 protein kinase C PKC isoforms activation and 5 mitochondrial dysfunction [ 51048 — 50 ].
Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines	Shan, B. Ursu O, Rayan A, Goldblum A, Oprea TI. Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner. Eur J Pharmacol. Compounds that have good anti-inflammatory and antioxidant properties can act as antifibrosis in CKD therapy. Group F received 2. Biological Sciences.
Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines	Breyer MD, Böttinger E, Brosius Quercetinn, Coffman TM, Harris RC, Heaalth CW, Sharma K, Quercetin and kidney health Mouse models of diabetic nephropathy. Quercetin and kidney health on the institution site, please use Querrcetin credentials provided by Quercerin institution. Citrus fusion sports beverage Venn diagram of Querctin Quercetin and kidney health relationship of target genes between Quercetin, AKI-ARF and COVID J Agric Food Chem 55 15 — Article CAS PubMed Google Scholar Morales AI, Vicente-Sánchez C, Sandoval JM, Egido J, Mayoral P, Arévalo MA et al Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. The results of this study proved that quercetin was able to inhibit the cells proliferation of CKD cells model by reducing the TGF-β1 level. PubMed Google Scholar.

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Eur J Nutr 51, — Download references. Center for Kidney Diseases, 2nd Affiliated Hospital, Nanjing Medical University, North Zhongshan Road, Nanjing, Jiangsu, China. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu, China.

You can also search for this author in PubMed Google Scholar. and G. performed the experiments and wrote the manuscript, Y. and H. analyzed the data, D. designed, supervised and revised the article. This work is licensed under a Creative Commons Attribution 4.

Reprints and permissions. Ren, J. Sci Rep 6 , Download citation. Received : 14 December Accepted : 17 March Published : 07 April Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

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Skip to main content Thank you for visiting nature. nature scientific reports articles article. Download PDF. Subjects End-stage renal disease Obstructive nephropathy. Abstract Quercetin, a flavonoid found in a wide variety of plants and presented in human diet, displays promising potential in preventing kidney fibroblast activation.

Introduction Kidney interstitial deposition of extracellular matrix ECM , one of the pathological features for chronic kidney diseases CKD , may lead to progressive kidney fibrosis and end stage of renal disease ESRD in patients 1 , 2.

Results Quercetin ameliorates obstructive nephropathy in mice Previous studies reported that quercetin may inhibit cultured fibroblast activation and ameliorates organ fibrosis in liver, lung and skin 12 , 16 , 17 , Figure 1.

Quercetin ameliorates UUO nephropathy in mice. Full size image. Figure 2. Quercetin reduces FN and α-SMA expression in the UUO kidneys. Figure 3. Figure 4. Figure 5. Quercetin diminishes TGFβ1-induced NRKF cell activation. Figure 6. Quantitative determination of total collagen content in kidney tissue The kidney tissue collagen content was quantitated.

Additional Information How to cite this article : Ren, J. References Liu, Y. CAS PubMed PubMed Central Google Scholar Duffield, J.

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Electronic supplementary material. Supplementary Information. Rights and permissions This work is licensed under a Creative Commons Attribution 4. About this article. Cite this article Ren, J. Quercetin has been found to reduce proteinuria , which may indicate that it is helpful in protecting the kidneys from damage.

Genetic variants can affect the metabolism of quercetin by influencing the expression and activity of enzymes involved in its biotransformation. For example, genetic variations in the SULT1A1 and SULT1E1 genes affect the metabolism of quercetin and its metabolite.

Studies found that certain genetic variants were associated with altered levels of quercetin and its metabolites in the blood. COMT catechol-O-methyltransferase is an enzyme involved in the metabolism of catecholamines, including dopamine, epinephrine, and norepinephrine.

Variants in the COMT gene can affect the activity of the enzyme and, consequently, the metabolism of catecholamines. One common variant in the COMT gene is the ValMet polymorphism, which involves a substitution of valine Val for methionine Met at position of the enzyme.

The ValMet polymorphism has been extensively studied and is associated with altered enzyme activity, with the Val variant associated with higher activity and the Met variant associated with lower activity. There is evidence suggesting that the ValMet polymorphism may also affect the metabolism of flavonoids, including quercetin.

Those patients will also likely to experience anxiety with quercetin, especially at high doses. The recommended dose of quercetin depends on the reason for use, age, sex, and other individual factors. Since quercetin is considered a dietary supplement, there is no standard recommended dose established by the FDA.

However, some studies have used doses ranging from to mg per day for various health conditions. For example, a study published in the International Journal of Sports Nutrition and Exercise Metabolism used a dose of mg per day of quercetin supplementation to improve athletic performance in trained cyclists.

A meta-analysis published in the Journal of the American Heart Association found that a dose of mg or more per day of quercetin supplementation improved blood pressure. It is important to note that high doses of quercetin supplements can cause side effects such as headaches, gastrointestinal discomfort, and kidney damage, especially in those with advanced kidney disease.

Quercetin also interacts with a lot of medications. Therefore, it is recommended to consult a healthcare professional before starting to take quercetin supplements and to follow the dosage instructions on the supplement label.

While quercetin has many benefits, as mentioned above, there is limited research on the use of quercetin in advanced kidney disease. The available studies suggest that caution should be taken when considering its use in this population.

Quercetin is a natural compound that has numerous health benefits, including its positive effect on kidney function. Quercetin has anti-inflammatory and antioxidant properties, can help to regulate blood pressure, and reduce proteinuria. These benefits make quercetin a promising natural remedy for protecting and maintaining kidney health.

However, it is important to consult with a healthcare provider before taking quercetin supplements or making any changes to your diet or medication regimen. The Benefits of Quercetin to the Kidneys.

The benefits of quercetin to the kidneys By Majd Isreb, MD, FACP, FASN, IFMCP Anti-inflammatory properties Quercetin has been found to possess anti-inflammatory properties.

Thank you for visiting nature. Querceyin are using a heaalth Quercetin and kidney health with limited support for CSS. To obtain the best experience, we Anti-inflammatory diet tips you Quercetin and kidney health kidnet more Quercetin and kidney health to date browser or turn off compatibility Qiercetin in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Quercetin, a flavonoid found in a wide variety of plants and presented in human diet, displays promising potential in preventing kidney fibroblast activation. However, whether quercetin can ameliorate kidney fibrosis in mice with obstructive nephropathy and the underlying mechanisms remain to be further elucidated. In this study, we found that administration of quercetin could largely ameliorate kidney interstitial fibrosis and macrophage accumulation in the kidneys with obstructive nephropathy. Quercetin kdney to a group Qercetin plant pigments called Diabetes-friendly foods that Quercetin and kidney health many fruits, flowers, and vegetables their colors. Heaalth, such as quercetin, are antioxidants. They scavenge particles in the body known as free radicals which damage cell membranes, tamper with DNA, and even cause cell death. Antioxidants can neutralize free radicals. They may reduce or even help prevent some of the damage free radicals cause. In test tubes, quercetin has strong antioxidant properties. But researchers are not sure whether taking quercetin and many other antioxidants has the same effects inside the body.

Quercetin and kidney health -

We recently read a review article by Chen et al. This comprehensive review paper on the protective effects of quercetin against kidney disease covers many aspects, from pharmacokinetics and bioavailability of quercetin in traditional herbal medicine to the protective effects of quercetin against different types of kidney disease, such as nephrotoxicity, acute and chronic kidney injury, diabetic nephropathy, renal aging, and other rare kidney diseases.

Overall, this is a systematic and detailed review aimed at showcasing the potential value of quercetin in the treatment of kidney disease. The most significant flaw of this study is that it summarizes multiple academic research results in a fragmented way, and the selected relevant studies are limited, and does not form a clear argument.

Firstly, the article focuses too much on listing results when analyzing different research findings, neglecting the discussion of the mechanisms themselves. For example, when discussing the relationship between chemical structure and biological activity, the corresponding relationship is not explained clearly and systematically enough.

At the same time, the discussion of renal fibrosis is more focused on the inhibition of transforming growth factor β TGF-β , but other mechanisms and factors that promote renal fibrosis are not further discussed.

Do these factors interact with quercetin? Secondly, there are limitations in selecting relevant studies in the article. For example, in the section on diabetic nephropathy, further clarifications on GluT4 and AMPK signaling and EFK-related mechanisms in recent years can be introduced for hypoglycemic effects; for antioxidant effects, the interaction between the peroxisome pathway and Nrf2 and other important antioxidant pathways in diabetic nephropathy DN and quercetin can be introduced; for autophagy promotion, the changes in autophagy-related LC3 and the expression of other related proteins can be systematically discussed.

In addition, there is a lack of analysis and comparison of different research results and opinions throughout the article, to form a more balanced and thorough conclusion.

Another drawback that has been highlighted is that the article downplays the fact that quercetin cannot yet be used for the clinical prevention and treatment of kidney disease, which may mislead clinical decision-making. Firstly, the review is too biased towards affirming the efficacy of quercetin, without fully demonstrating its toxicological characteristics and safe dosage range, and potential adverse reactions or risks.

Even if it is very promising, reliable pharmaceutical pathways are yet to be found, making it difficult to achieve safety and efficiency.

Secondly, most of the evidence in the review comes from animal experiments, and the judgment on human applicability is still inadequate. Appropriate clinical studies are still needed, and the conclusion appears to be too hasty. Thirdly, despite the excellent mechanistic evidence, it is still difficult to derive reasonable medication indications and differentiated treatment strategies in practical applications.

The lack of in-depth analysis of the interaction between different factors such as different races, types of diseases, and disease courses largely limits its practical application. Although this review presents a highly promising treatment concept, it still needs to overcome several significant obstacles before it can be recommended as standard treatment.

I hope that further research and rigorous testing can overcome its shortcomings and make the conclusion more reliable and cautious.

Overall, this is a groundbreaking study, but appropriate caution needs to be taken at different stages to maximize its potential while minimizing unnecessary risks.

In this process, further research and testing will be indispensable, and we look forward to it together. WK wrote the manuscript, and YZ and LL contributed to the reference search.

QT supervised the manuscript writing and approved the publication of the article. All authors contributed to the article and approved the submitted version. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Levey, A. Chronic kidney disease. Lancet , — PubMed Abstract CrossRef Full Text Google Scholar. The data were analyzed using the Statistical Package for the Social Sciences SPSS software version The level of TGF-β1 of quercetin treatments is shown in Fig.

The lowest TGF-β 1 The result data show that quercetin decreased TNF-α level significantly from the positive control Fig. The lowest TNF-α level Figure 3 shows MDA level of quercetin treatment. Quercetin could reduce MDA levels to Figure 4 show the results of gene expression values.

The treatment decreased the relative ratio of SMAD3 gene expression to Moreover, quercetin decreased the relative ratio of SMAD4 gene expression to 1.

The morphology of mesangial cells in this research is shown in Fig. The glucose-induced mesangial cells showed differences between positive control and negative control normal cell. The research showed that mesangial cells induced by glucose positive control caused visible high proliferating cells compared to mesangial cells without glucose induction negative control.

CKD is a condition when the function of the kidney is reduced. Quercetin is a natural compound having a wide range of biological effects. Quercetin has been shown to have antioxidant, anticancer, anti-aggregation, anti-inflammatory, and vasodilation activities.

The goal of this study is to see if quercetin can help in CKD treatment Rusmana et al. TNF-α is a powerful pro-inflammatory cytokine that aids the immune system during periods of inflammation Nair et al.

Pro-inflammatory cytokine influenced a lot in chronic inflammatory disorders by oxidative stress, and one of the highest is TNF-α. The previous study has shown that quercetin inhibits the production of TNF-α affected by the inhibition of NF-kB immunomodulatory cytokine transcription Asni et al.

Flavonoids can influence the immune response. Quercetin has anti-inflammatory properties by a decrease in the TNF-α production Nair et al. The result data show that quercetin in all concentrations reduced TNF-α levels in CKD cells model. MDA is a chemical that can be used to determine how free radicals behave in cells.

MDA is usually used as a free radical indicator Hojs et al. Another research confirms this argument by claiming that the MDA mediator is a final fat peroxidation product that can define the degree of oxidative stress as a biological biomarker of fat peroxidation Tualeka et al. The result shows that the level of MDA was decreased by quercetin treatment in CKD cell model.

Quercetin has antioxidant activity by regulating glutathione GSH. Previous researches have found a substantial association between GSH and MDA, and a reciprocal interaction between the two are backwards Lin et al. Furthermore, quercetin modulates enzymes or antioxidant substances to enhance antioxidant properties by affecting signal transduction pathways, thus preventing free radical production Lu et al.

TGF-β1 is a potent cytokine in playing a driving role in the development of fibrosis by promoting myofibroblasts formation. Except for SMAD7 gene expression, glucose stimulation in the positive control boosts all SMADS gene expression.

The SMAD2, SMAD3, and SMAD4 genes, notably SMAD2, are upregulated in glucose-induced mesangial cells. Both SMAD2 and SMAD3 are extensively proof-activated in fibrotic kidneys in people and animal models with CKD Quezada et al.

The expression of SMAD3, SMAD2, and SMAD4 genes increases with increasing TGF-β Wang et al. This is in line with the findings of this investigation, which is increasing the expression of SMAD2, SMAD3, and SMAD4 genes in accordance with increasing levels of TGF-β. Previous studies have shown that poricoic acid compound can inhibit the phosphorylation of SMAD3 induced by TGF-β induction Wang et al.

This result is in accordance with previous studies that found decreases in TGF-β1, SMAD2, SMAD3, and SMAD4 after the treatment. TGF-β1 is inhibited by SMAD7, which is a nonspecific antagonist. Thus, decreasing TGF-β1 causes an increase the SMAD7 gene expression Hidayat et al.

As explained before, the anti-inflammatory drug and antioxidant could be used as CKD therapy. Tripterygium Wilfordii Polyglycosides TWPs is the main compound of Tripterygium Wilfordii Hook. TWHF showing anti-fibrosis activity by reducing IL-1, IL, interferon-γ IFN-γ , and TNF-α Liu et al.

Previous studies show that Abelmoschus manihot reduces proteinuria and lessens kidney damage and tubulointerstitial fibrosis so that it improves kidney function. These beneficial effects are related to the anti-inflammatory and antioxidant properties of A.

manihot Cai et al. Compounds that have good anti-inflammatory and antioxidant properties can act as antifibrosis in CKD therapy. According to the present study, quercetin has antioxidant activity by decreasing MDA level and has anti-inflammatory activity by decreasing TNF-α level.

Therefore, quercetin can act as anti-fibrosis with its anti-inflammation and antioxidant activities. Quercetin treatment could reduce cells proliferation. It was indicated by the lower density of the cells compared to that of positive control. The higher quercetin concentration showed higher inhibition to cell proliferation.

The previous studies showed that TGF-β1 could induce fibroblast proliferation Kamejima et al. The results of this study proved that quercetin was able to inhibit the cells proliferation of CKD cells model by reducing the TGF-β1 level.

In conclusion, this work has proven that quercetin has anti-inflammation, antioxidant, and antifibrosis properties in the CKD cells model. Thus, quercetin is a promising compound for CKD therapy and further research in CKD animal models is suggested to be examined.

Previous researches have demonstrated that quercetin suppressed a TNF-α production. Quercetin has been shown to have antioxidant properties by modulating GSH.

The antioxidant activity of quercetin was found to lower MDA levels in CKD models in this investigation. Common use cases Typos, corrections needed, missing information, abuse, etc. Our promise PeerJ promises to address all issues as quickly and professionally as possible.

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Queecetin effect of quercetin on Quercetni diseases: Quercetin and kidney health chemistry to herbal medicines. A Healt on Protective Quercetin and kidney health of quercetin on kidney diseases: from chemistry to Glycogen storage disorder medicines. by Chen Y-Q, Chen H-Y, Kieney Q-Q, Li Y-F, Liu Xnd, Lu F-H and Gu Y-Y Front. doi: Kidney disease is a life-threatening condition with a high mortality rate that can be caused by various factors, such as nephrotoxins, oxidative stress, or inflammation. These factors may be the main causes that promote renal injury towards fibrosis, ultimately leading to chronic kidney disease CKD or end-stage renal disease ESRD Levey and Coresh, However, the drugs and treatment strategies currently available for treating kidney injury are still very limited.