But for reference, here are some foods that contain CoQ Research suggests that there may be benefits to taking CoQ10 supplements. However, the results are often mixed or have not proven useful.

The following are some conditions that have been researched and have some supporting research. CoQ10 may help treat heart failure when used alongside conventional treatment. In fact, the authors of a review published in Circulation: Heart Failure concluded that CoQ10 is a relatively safe supplement that may enhance heart function in patients with heart failure.

People with this condition may be more susceptible to the harmful effects of reactive oxygen species, unstable molecules that can cause damage to the heart cells, according to a review of studies.

As an antioxidant, CoQ10 may help protect the heart from harm. However, not all studies have shown a positive effect, and using CoQ10 for heart failure is somewhat controversial, warns the Icahn School of Medicine at Mount Sinai. According to the American Headache Society , CoQ10 is one of the most commonly used supplements to help prevent migraine.

Research suggests that there may be something to this. When compared with a placebo, CoQ10 shortened the duration of migraine attacks and reduced the number of total days with migraine symptoms per month in children and adults, per findings from a meta-analysis.

A more recent meta-analysis found similar results and also discovered that CoQ10 helped improve nausea associated with migraine. Yet the authors of both of those meta-analyses say that more studies of larger groups are needed to determine if and how CoQ10 might benefit people with migraine. For example, a review of 12 clinical trials revealed that CoQ10 has the potential to lower systolic blood pressure the force your blood exerts against your artery walls with each heartbeat in people with hypertension by up to 17 mmHg and diastolic blood pressure the force your blood exerts against your artery walls in between heartbeats by 10 mmHg, with no significant side effects.

They noted, though, that more research is needed. CoQ10 has been studied for its potential weight loss effects, but the findings have been mixed and only drawn from animal samples. However, another study in obese rats found that CoQ10 supplementation had no effect on weight loss.

Given that human research is limited and the findings in animal studies are mixed, the link between CoQ10 supplements and weight loss remains unclear and unsupported. CoQ10 is generally considered safe. According to the NCCIH, no serious side effects have been reported. But CoQ10 supplements may lower blood sugar and blood pressure, according to the Icahn School of Medicine at Mount Sinai.

As such, they may interact with certain medications, including beta blockers a type of medication that lowers blood pressure and the diabetes drug insulin, per the NCCIH. CoQ10 may also interfere with warfarin , an anticoagulant blood thinner , Jankovic Weatherly says. And given that CoQ10 is an antioxidant, it may make chemotherapy drugs less effective, she adds.

To be safe and avoid potential interactions, consult your healthcare provider before adding a CoQ10 supplement to your diet, especially if you are living with a health condition or taking a prescription medication.

CoQ10 deficiencies are uncommon, affecting fewer than 1 in , people, according to MedlinePlus. That said, some people tend to have lower levels of CoQ10 and may benefit from a supplement, in particular, older adults and people with fibromyalgia or heart disease, says Monique Richard, RDN , an integrative registered dietitian-nutritionist in Johnson City, Tennessee, and a spokesperson for the Academy of Nutrition and Dietetics.

People who take statins cholesterol-lowering medications have also been found to have lower levels of CoQ10 and may be good candidates for supplements, the Mayo Clinic notes. However, the research is too limited to draw any conclusions or to warrant recommending CoQ10 supplements for groups affected by these health-related issues, the NCCIH notes.

If the label reads CoQ10, you can probably assume that it contains ubiquinone only, Jankovic Weatherly says. Food and Drug Administration FDA in the same way that prescription medications are regulated.

But some manufacturers opt to have their supplements evaluated by a third-party agency to verify their safety and quality. This is known as third-party verification or certification. Anti-Doping Agency. Third-party verified supplements will typically list the name of the testing agency on the label.

A few well-known agencies include ConsumerLab , NSF International , and U. Ubiquinol and CoQ10 supplements can generally withstand higher temperatures in the high 90s Fahrenheit , but they can degrade over time if exposed to heat, per ConsumerLab.

Softgels, in particular, can melt in the heat. This may degrade the ubiquinol or CoQ10 faster if the softgel shell breaks and exposes the ubiquinol or CoQ10 to air. Keep your supplements safe by storing them at room temperature and out of sunlight, as recommended by ConsumerLab.

As a natural substance in the body, CoQ10 helps translate food into energy and is an antioxidant. Most of us get enough CoQ10 through diet and natural bodily production, but some people have lower levels and may benefit from a supplement.

In particular, older adults, people with migraine or heart disease, and those who take statin medications to lower cholesterol may consider consulting their healthcare team about possibly taking a CoQ10 supplement.

CoQ10 supplements are generally considered safe, though they may cause mild side effects, such as stomach upset and nausea. They may also interact with chemotherapy, blood pressure, diabetes, and blood-thinning medications.

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By Lauren Bedosky. Medically Reviewed. Justin Laube, MD. Functions Forms Jump to More Topics. What Is Coenzyme Q10? CoQ10 helps cells convert food into energy and is an antioxidant.

Most of us get enough of this substance through diet and natural bodily production, but some have low levels and may benefit from a supplement. CoQ10 may help treat migraines and may improve fertility in men, though more research on these uses is needed.

Who needs to take coenzyme Q10? Most people get enough CoQ10 through a balanced diet and our natural bodily production. Yet supplements may be helpful for people with lower levels of CoQ10, including older adults, people with heart disease or fibromyalgia, and those who take statins. CoQ10 supplements may also help prevent or treat certain heart conditions and migraine.

What are the side effects of taking coenzyme Q10? CoQ10 is generally considered safe, though it may cause mild side effects, such as stomach upset and nausea. It may also interact with chemotherapy, blood pressure, diabetes, and blood-thinning medications.

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Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. J Clin Pharm Ther. Zhang P, Yang C, Guo H, Wang J, Lin S, Li H, Yang Y, Ling W. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.

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Circ J. Weber C, Bysted A, Holmer G. Coenzyme Q10 in the diet—daily intake and relative bioavailability. Mol Aspects Med. Download references. This work was supported by funding from GuangDong Basic and Applied Basic Research Foundation A , Discipline construction project of Guangdong Medical University 4SGG , Young Innovative Talents Projects of Universities in Guangdong KQNCX , Guangdong Medical University Research Startup Foundation B You can also search for this author in PubMed Google Scholar.

PZ, and KC conducted the research and wrote the manuscript; HG and XC designed the research; TH analyzed the data; XC had primary responsibility for the final content of the manuscript; all the authors read and approved the final manuscript.

Correspondence to Honghui Guo or Xu Chen. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4.

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If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions. Zhang, P. et al. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.

Nutr Metab Lond 19 , 13 Download citation. Received : 05 October Accepted : 15 February Published : 03 March Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Download ePub. Abstract Background In previous study, we found that coenzyme Q10 CoQ10 improved glucolipid profile in dyslipidemic individuals, but the mechanism is not yet clear.

Methods In this randomized, double-blinded, placebo-controlled trial, dyslipidemic individuals were administrated to mg CoQ10 or placebo for 24 weeks. Introduction Dyslipidemia is a risk factor of cardiovascular disease and vital component of metabolic syndrome.

Methods Participants This study used data from the previous randomized, double-blinded, placebo-controlled trial which examined the effects of CoQ10 supplementation on lipid and glycemic profile in dyslipidemic individuals, and a detailed protocol was published [ 17 ]. Randomization and intervention As previously described [ 17 ], eligible subjects were recruited and randomized to consume softgels of identical appearance with placebo or mg CoQ10 4 softgels per day, each contain 30 mg CoQ10, BYHealth Co Ltd, China for 24 weeks.

Data collection Detailed method of data collection have been described in previous published article [ 17 ]. Biochemical analyses After fasting for 10—12 h, blood samples of the subjects were obtained in the morning at the beginning, 12th week, and 24th week of the trial.

Statistical analysis The sample size estimation was based on the primary outcome of TG, TC, LDL-c, and HDL-c as reported in the main paper [ 17 ]. Full size image. Results General characteristics of the subjects By using rapid lipid test with CardioChek PA Analyzer PTS Diagnostics , we screened qualified participants.

Flow diagram and study design. Table 1 Number of participants that with metabolic related disorders before and after intervention Full size table. Table 2 Effect of CoQ10 intervention on adipokines a Full size table. Table 3 The simple mediation effects of adipokines on the association of CoQ10 with glucolipid metabolic markers a Full size table.

Table 4 The multiple mediation effects of adipokines on the association of CoQ10 with HOMA-IR a Full size table. Conclusions In conclusion, we report that CoQ10 supplementation increase adiponectin and decrease resistin concentrations in dyslipidemic adults, which is correlated with the HOMA-IR and lipid profiles.

Abbreviations ApoA-I: Apolipoprotein A-1 ApoB: Apolipoprotein B CoQ Coenzyme Q10 HDL-c: High-density lipoprotein cholesterol HOMA-IR: Homeostasis model assessment of insulin resistance IL Interleukin-6 LDL-c: Low-density lipoprotein cholesterol PPARs: Peroxisome proliferator-activated receptors TC: Total cholesterol TG: Triglyceride TNF-α: Tumor necrosis factor-alpha.

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