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Common side effects seen with Wegovy may include:. Let your healthcare provider know if you are taking any other medications, as Wegovy can affect their concentrations in the body.

Do not start Wegovy if you:. Zepbound is a dual-acting glucose-dependent insulinotropic polypeptide GIP and glucagon-like peptide-1 GLP-1 receptor agonist. Zepbound activates these hormones, making you feel full.

Zepbound is a medication injected subcutaneously and is approved for adults with obesity. The recommended maintenance dosage of Zepbound is mg, injected once weekly. Two large trials evaluated Zepbound in individuals who were overweight or obese.

By the end of the study 72 weeks , people who dieted, exercised and took Zepbound reported statistically significant weight loss compared to those who took the placebo. Common side effects seen with Zepbound may include:. Zepbound terzepatide is an injectable weight-loss medication for adults with obesity.

Terzepatide is also the active ingredient in Mounjaro, which is approved to treat diabetes. Zepbound may interact with Synthroid and increase the risk of MTC. Those with a personal or family history of medullary thyroid carcinoma MTC or with multiple endocrine neoplasia syndrome type 2 MEN 2 should avoid it.

Medications like the ones mentioned above may be beneficial when diet and exercise are not enough to reach your weight goal.

Your healthcare provider can help you find the best option based on your health goals, medical history, and personal preferences. Lifestyle changes are strongly recommended in obesity treatment.

Continue eating a healthy, well-balanced diet and engaging in a consistent exercise routine, even after achieving weight loss goals.

It is not recommended to take more than one weight loss medication at the same time before speaking with your healthcare provider, as doing so may worsen possible side effects of the medication. Weight loss during pregnancy may cause complications for the fetus.

Therefore, you should not take any weight loss medications while pregnant. No, these medications are indicated only if you are overweight or obese and should not be used with a BMI less than Tak YJ, Lee SY.

Long-term efficacy and safety of anti-obesity treatment: where do we stand? Curr Obes Rep. doi: Label: Xenical- orlistat capsule. Torgerson JS, Hauptman J, Boldrin MN, Sjöström L. XENical in the prevention of diabetes in obese subjects XENDOS study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients.

Diabetes Care. Finer N, James WP, Kopelman PG, Lean ME, Williams G. One-year treatment of obesity: a randomized, double-blind, placebo-controlled, multicentre study of orlistat, a gastrointestinal lipase inhibitor.

Int J Obes Relat Metab Disord. Jain SS, Ramanand SJ, Ramanand JB, Akat PB, Patwardhan MH, Joshi SR. Evaluation of efficacy and safety of orlistat in obese patients. Indian J Endocrinol Metab. Gorgojo-Martínez JJ, Basagoiti-Carreño B, Sanz-Velasco A, Serrano-Moreno C, Almodóvar-Ruiz F.

Effectiveness and tolerability of orlistat and liraglutide in patients with obesity in a real-world setting: the XENSOR study. Int J Clin Pract. Label: Alli- orlistat capsule.

Anderson JW. Orlistat for the management of overweight individuals and obesity: a review of potential for the mg, over-the-counter dosage. Expert Opin Pharmacother. Food and Drug Administration. Contrave label. Apovian CM. Future Cardiol. Sherman MM, Ungureanu S, Rey JA. Saxenda label.

Pi-Sunyer X, Astrup A, Fujioka K, et al. A randomized, controlled trial of 3. N Engl J Med. Astrup A, Carraro R, Finer N, et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int J Obes Lond.

Qsymia label. Lei XG, Ruan JQ, Lai C, Sun Z, Yang X. Obesity Silver Spring. Imcivree label. Wegovy label. Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity.

Aroda VR, Bain SC, Cariou B, et al. Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin with or without sulfonylureas in insulin-naive patients with type 2 diabetes SUSTAIN 4 : a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial.

Lancet Diabetes Endocrinol. Zepbound label. Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity.

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Table of Contents View All. Table of Contents. Xenical Orlistat. Alli Orlistat. Contrave Bupropion-Naltrexone. Saxenda Liraglutide.

Qsymia Phentermine-Topiramate. Imcivree Setmelanotide. Wegovy Semaglutide. Zepbound tirzepatide. Frequently Asked Questions.

Safety Warning Like other antidepressants, bupropion comes with the risk of increased suicidal thinking and behaviors, especially in children, adolescents, and young adults.

Taking Qysmia Safely Qysmia is categorized as a Schedule IV controlled substance because it contains phentermine. Risk of Depression or Suicidal Thinking Imcivree has caused new or worsening depression and suicidal thinking.

What to Watch for While taking Wegovy, watch for the following side effects: When starting treatment, contact your healthcare provider if you develop abdominal pain, nausea, or vomiting that does not go away, as it could be a sign of a more serious side effect. Wegovy can also cause depression or suicidal ideation.

If this occurs, see your healthcare provider as soon as possible. They may need to take you off of the medication. If you have type 2 diabetes, monitor for any changes in eyesight or a drop in your blood sugar.

Frequently Asked Questions Can I take more than one weight loss medication at the same time? Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles.

Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. See Our Editorial Process. Meet Our Medical Expert Board.

Share Feedback. Similarly, setmelanotide Imcivree , is intended to treat obesity caused by certain genetic disorders. Keep in mind that weight loss medications are not suitable for everyone, including people who are pregnant, those with certain health conditions, or individuals taking specific medications.

A healthcare professional can provide guidance on whether you might be a candidate for a prescription, depending on your personal goals, medical history, and health status. Contact a trusted healthcare professional, like your OB-GYN, before taking any weight loss medications or supplements.

Some digital weight loss platforms, including Ro and Calibrate, include GLP-1 medications in their treatment plans for people who meet certain eligibility criteria.

You can read our comprehensive reviews of Calibrate and Ro Health to learn more. Studies also suggest that people with higher body weights are disproportionately more likely to experience disordered eating and eating disorder symptoms.

These behaviors may indicate a disordered relationship with food or an ED. Disordered eating and EDs can affect anyone, regardless of gender identity, race, age, body size, socioeconomic status, or other identities. They can be caused by any combination of biological, social, cultural, and environmental factors — not just by exposure to diet culture.

GLP-1 agonists are currently the most effective anti-obesity medications and are considered safe for long-term use.

Currently, only liraglutide Saxenda , semaglutide Wegovy , and tirzepatide Zepbound are approved for weight loss, though some other GLP-1 drugs may be prescribed off-label. Still, keep in mind that individual results can vary based on many factors, including your diet, health status, and activity level.

In addition to maximizing your potential results, it can increase the likelihood of maintaining weight loss in the long term. If considered medically necessary, insurance companies may cover certain prescription weight loss medications.

Some manufacturers also offer savings cards, which can help lower your copay. Ozempic and Wegovy are two different brands of the same drug, semaglutide. However, there are differences in the recommended dosage and how each is administered. Additionally, Wegovy is FDA approved for weight management.

Saxenda liraglutide , Wegovy semaglutide , and tirzepatide Zepbound are three GLP-1 medications recently approved for weight loss. Other GLP-1 medications, such as Ozempic semaglutide , are also sometimes prescribed off-label for weight management.

Prescription medications have strong evidence to support their effectiveness for meaningful weight loss. Additionally, though they can promote weight loss and may even offer other health benefits, note that these medications are not suitable for everyone and can lead to weight regain once you stop taking them.

A doctor or other trusted healthcare professional can help you determine which is right for you and how to incorporate it into a healthy weight management plan.

Obesity is a chronic condition, and medications are just one part of a treatment plan to help achieve and maintain weight loss. Instead, they should be used only as directed and paired with a balanced diet, healthy lifestyle, and regular physical activity for best results.

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

VIEW ALL HISTORY. This article tells you all you need to know about GLP-1 agonists like Wegovy, including whether they are safe and effective for weight loss. Alli diet pills are the over-the-counter version of a weight loss drug called orlistat.

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Here are 18 effective tips to lose belly fat, based on studies. Though fad diets typically promise quick and easy weight loss, they seldom live up to the hype.

However, these 8 fad diets actually work. If losing weight is your goal, this article covers 18 foods that may help support a healthy and sustainable weight loss journey, according to science. Sabudana, also known as tapioca pearls or sago, is a high-carbohydrate food. It may not be good for weight loss.

To lose weight long-term, you don't need crash diets or boot camp. Instead, start by simply replacing processed foods with real foods.

Patients with diabetes who used GLP-1 drugs, including tirzepatide, semaglutide, dulaglutide, and exenatide had a decreased chance of being diagnosed…. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep?

Health Conditions Discover Plan Connect. Nutrition Evidence Based Are Weight Loss Medications Effective? A Dietitian Explains.

Medically reviewed by Jerlyn Jones, MS MPA RDN LD CLT , Nutrition — By Rachael Ajmera, MS, RD and Kris Gunnars, BSc — Updated on November 20, On this page Approved drugs Effectiveness Prescription drugs Who should use When to talk with a doctor FAQs Bottom line.

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To establish that the product manufacturers addressed safety and efficacy standards, we: Evaluate ingredients and composition: Do they have the potential to cause harm?

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We do the research so you can find trusted products for your health and wellness. Read more about our vetting process. Was this helpful? What medications are FDA approved for weight loss? How effective are prescription weight loss drugs? Pros and cons of weight loss medications. Pros effective for weight loss when used alongside dietary changes and regular physical activity approved by FDA for weight management might offer other health benefits, including improved blood sugar, blood pressure, or cholesterol levels many medications available through telehealth platforms.

Cons not suitable for everyone some medications may be expensive, depending on insurance coverage can cause side effects, some of which may be serious weight regain is possible once medication is discontinued more research needed on long-term health effects.

Prescription weight loss drugs. Who are weight loss drugs for? When to talk with a doctor. Frequently asked questions. The bottom line. How we reviewed this article: Sources. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations.

We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Nov 20, Written By Rachael Ajmera, MS, RD, Kris Gunnars. Nov 17, Medically Reviewed By Jerlyn Jones, MS MPA RDN LD CLT.

Share this article. Read this next. GLP-1 Medications for Weight Loss and Type 2 Diabetes This article tells you all you need to know about GLP-1 agonists like Wegovy, including whether they are safe and effective for weight loss.

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