HELLO BEAUTIFUL! Formerly ahti-aging Maca root and anti-aging dye fabrics, its biostructuring ceramides strengthen Respiratory health skin's barrier function. It is a nutrient-dense root with stimulating properties that is rich in protein, complex carbohydrates, fibre, various vitamins, phosphor, iron and copper.

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Maca root and anti-aging -

Maca helps to reduce the effects of ageing, and gives new strength to the skin. Featured in worldwide media, this herbaceous plant is gaining popularity for its superior benefits to skin. Maca contains, among other molecules, macaene and macamides, which are compounds identified by NMR by Naturex.

New research shows that maca has efficiency on skin. Naturex maca root extract Macaderm has been tested in vitro on normal human epidermal keratinocytes NHEK , the main cells of the epidermis responsible for the synthesis of all the extracellular constituents.

In the epidermis, all the cells are linked together and to the constituents of the extracellular matrix ECM. Adhesion is an important mechanism of cell viability, and it is known that abnormal loss of adhesion leads quickly to apoptosis, cellular death. Cells reside in a protein network, the extracellular matrix ECM , which they secrete and mold into the intercellular space.

The ECM exerts profound control over cells and the effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it. These signals mediate dynamic linkages between intracellular actin cytoskeleton and the extracellular adhesive matrix.

Many integrin signals converge on cell cycle regulation, to proliferate, or to exit the cell cycle and differentiate. Integrins are cell surface transmembrane adhesion receptors that interact with the extracellular matrix ECM and mediate various intracellular signals.

They define cellular shape, mobility, and regulate the cell cycle. Collagens are proteins found in the ECM in most tissues. Their most notable function is to link all molecules and cellular constituents of the dermis, and store the tension strength.

Type IV collagen is an essential component of the ECM, constituent of basement membranes used to promote cell attachment and proliferation.

Collagen IV is the most important structural element in the basement membrane. It is a non-fibrous protein, made with 3?? polypeptidic chains, two? This network gives form, rigidity and stability to the membrane. During ageing phenomena, cohesion between the dermis and epidermis and basement membrane decreases, so communication and nutrition of the tissue become more difficult.

It is also known that repeated sun exposure breaks down collagen and impairs the synthesis of new collagen. Similarly, the natural ageing process within the skin leads to collagen production slow-down.

One of the consequences of these ageing phenomena is the appearance of fine wrinkles. The aim of these tests was to assess the ability of the maca extract to boost the synthesis of elements of the extracellular matrix ECM by keratinocytes and to activate the mechanisms of linkage and stimulation of the cell proliferation.

The maca root extract has been tested in vitro on NHEK, on their third culture. The cells were grown on SFM with epidermal growth factor EGF , and antimicrobial agent. A preliminary cytotoxicity with MTT observation was made to ensure that the dosage of active principles is compatible with living cells.

Reference components CaCl2 and retinoic acid were used to control the experimental conditions. An effect related to dosage is tested with maca root extract at 0. Using the technique of immunolabelling, the synthesis stimulation of the biomarkers of interest was highlighted.

After treatment and incubation, the cell culture medium was removed and the cells washed, fixed, and marked with a primary antibody directed against collagen IV and integrin? These antibodies were then linked to a secondary antibody, fluorochrome, which carries a fluorescent probe that can locate and display the desired effect.

In parallel, nuclei were coloured by Hoechst reactant bis-benzimide. Data acquisition was made by image analysis controlled by the InCell Analyzer GE Healthcare , and results were calculated and expressed against the untreated control, as base Statistical analyses were made possible thanks to large numbers of automatic measurements made by the computer, classifying the results statistically.

These two results validate the experimentation. Collagen IV is the major macromolecule of the basement membrane between the epidermis and dermis, and this membrane has a major role in the adhesion between epidermis and dermis.

The maca root extract applied on keratinocytes at doses between 0. In the same way, observations were made on the synthesis of adhesion markers, such as integrin? The cell cultures were treated by immunolabelling with a first antibody, then with a second marked by a fluorochrome.

In this experiment, reference CaCl2 increases synthesis of integrin? These results were expected and validate the trial. All these results demonstrate that the maca root extract significantly stimulates keratinocytes for the synthesis of major components of the extracellular matrix and the basal lamina, collagen IV, and for the synthesis of integrin?

This active is used to place the skin cells under very favourable conditions for a healthy tissue. The maca root extract can be used in preventing the onset of ageing phenomena and it stimulates skin cells to be placed in better communication and nutrition.

The same goes for side effects. Increased male and female fertility is another one of its believed benefits. One of the most touted benefits of maca is an increased libido, but is this really true?

Maca contains some phytosterols or phytoestrogens which have been linked to increased fertility in animal studies. The potential bioactive ingredients in maca include macaridine, macamides, macaene, glucosinolates, maca alkaloid, and maca nutrients, but their precise function in humans is not yet established.

They all have similar properties but differ in taste slightly. It has an intense earthy, nutty flavor. The possibilities, however, are endless. Some people love putting it in their coffee and baked goods or sprinkling it into their soups. Feel free to get creative.

If the taste is too much for you, start with a small dosage and work your way up until you get accustomed to the flavor. Speaking of dosage, Davis recommends checking the label of the maca you purchase for its recommended amount to take.

The appropriate dose of maca depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for maca for children or adults.

Maca contains goitrogens which may disrupt your thyroid gland. To sum it up, maca is said to provide lots of amazing health benefits, including a boosted sex drive, but more research needs to be done to confirm those claims.

The best way to know if maca will work for you is to try it out yourself from a reputable supplement supplier. Also if you have any medical concerns, be sure to check with your doctor first. Your code is on its way to you.

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