To obtain the best experience, Fastihg recommend you Fastin a more up to date browser Chitosan for blood sugar balance turn Blood pressure risks compatibility mode in Internet Healtb. The changes in the Fasting and gut health abundance of KOs were analyzed as described above using the paired two-sided Wilcoxon rank sum test and Benjamini—Hochberg FDR adjustment. Article PubMed PubMed Central Google Scholar Yang, F. Secondly, drug dosage was normalized to the lowest drug dosage per patient and drug. vegan: Community Ecology Package R Core Team, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Nephrology and Internal Intensive Care Medicine, Berlin, Germany. Rowland, I.

Fasting and gut health -

Based on the top 10 variables, the logistic-regression algorithm could be more robustly fit to these subselected ten input dimensions only. The ensuing predictive model was then explicitly validated by computing whether or not the obtained model parameters allowed for accurate derivation of the relevant blood-pressure response for the independent, unseen participant.

In this way, the omics data of each patient in our dataset served as test observation once. Averaging these yes-no results over all n predicted, versus observed clinical responses, yielded an estimate of the expected forecasting accuracy of the predictive model in participants that we would observe in other or later acquired datasets.

Further information on research design is available in the Nature Research Reporting Summary linked to this article. Data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Databases are to be found under the following links. Di Francesco, A. A time to fast. Science , — Article ADS PubMed CAS PubMed Central Google Scholar. Collaborators GBDD. Health effects of dietary risks in countries, a systematic analysis for the Global Burden of Disease Study Lancet , — Whelton, P.

et al. Circulation , e—e PubMed Google Scholar. Christ, A. The Western lifestyle has lasting effects on metaflammation.

Lynch, S. The human intestinal microbiome in health and disease. Article CAS PubMed Google Scholar. Yan, Q. Alterations of the gut microbiome in hypertension. Front Cell Infect. Article PubMed PubMed Central CAS Google Scholar.

Li, J. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome 5 , 14 Article PubMed PubMed Central Google Scholar. Frost, F. A structured weight loss program increases gut microbiota phylogenetic diversity and reduces levels of Collinsella in obese type 2 diabetics: a pilot study.

PLoS ONE 14 , e Article CAS PubMed PubMed Central Google Scholar. Ozkul, C. Structural changes in gut microbiome after Ramadan fasting: a pilot study. Beneficial Microbes 11 , — Louis, S. Characterization of the gut microbial community of obese patients following a weight-loss intervention using whole metagenome shotgun sequencing.

PLoS ONE 11 , e Forslund, K. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature , — Kanehisa, M.

KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. Vieira-Silva, S. Species-function relationships shape ecological properties of the human gut microbiome. Kushugulova, A.

Metagenomic analysis of gut microbial communities from a Central Asian population. BMJ Open 8 , e Holmes, I. Dirichlet multinomial mixtures: generative models for microbial metagenomics. PLoS ONE 7 , e Article ADS CAS PubMed PubMed Central Google Scholar.

Mende, D. Accurate and universal delineation of prokaryotic species. Methods 10 , — Qin, J. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature , 55—60 Article ADS CAS PubMed Google Scholar. Zhang, C. Impact of a 3-months vegetarian diet on the gut microbiota and immune repertoire.

Magalhaes, I. Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients. van der Weerd, K. Diabetes 61 , — Loperena, R. Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide.

Cardiovasc Res. Mesnage, R. Changes in human gut microbiota composition are linked to the energy metabolic switch during 10 d of Buchinger fasting. Nutritional Sci. Article CAS Google Scholar.

Velikonja, A. Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development. Anaerobe 55 , 67—77 Roager, H.

Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial.

Gut 68 , 83—93 Liu, Z. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Kopf, J. Role of whole grains versus fruits and vegetables in reducing subclinical inflammation and promoting gastrointestinal health in individuals affected by overweight and obesity: a randomized controlled trial.

Guevara-Cruz, M. Improvement of lipoprotein profile and metabolic endotoxemia by a lifestyle intervention that modifies the gut microbiota in subjects with metabolic syndrome. Heart Assoc. Kirabo, A. DC isoketal-modified proteins activate T cells and promote hypertension.

Drummond, G. Immune mechanisms of hypertension. Jie, Z. The gut microbiome in atherosclerotic cardiovascular disease. Article ADS MathSciNet PubMed PubMed Central CAS Google Scholar. Holmes, E. Human metabolic phenotype diversity and its association with diet and blood pressure.

Goodrich J. Genetic Determinants of the Gut Microbiome in UK Twins. Cell Host Microbe 19 , — Itani, H. CD70 exacerbates blood pressure elevation and renal damage in response to repeated hypertensive stimuli.

Circulation Res. Andoh, A. Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population.

Goodrich, J. Human genetics shape the gut microbiome. Cell , — Bartolomaeus, H. Short-chain fatty acid propionate protects from hypertensive cardiovascular damage. Circulation , — Kameyama, K. Intestinal colonization by a Lachnospiraceae bacterium contributes to the development of diabetes in obese mice.

Microbes Environ. Chen, X. Alteration of the gut microbiota associated with childhood obesity by 16S rRNA gene sequencing.

PeerJ 8 , e Touch, S. Mucosal-associated invariant T MAIT cells are depleted and prone to apoptosis in cardiometabolic disorders. FASEB J. Benson, H.

The Wellness Book. Mind—body Medicine Fireside, Cramer, H. Mindfulness-based stress reduction for breast cancer-a systematic review and meta-analysis. Li, C. Effects of a one-week fasting therapy in patients with type-2 diabetes mellitus and metabolic syndrome—a randomized controlled explorative study.

Diabetes , — Kjeldsen-Kragh, J. Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. de Lorgeril, M. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease.

Article PubMed Google Scholar. De Lorgeril, M. Effect of a mediterranean type of diet on the rate of cardiovascular complications in patients with coronary artery disease.

Insights into the cardioprotective effect of certain nutriments. Esposito, K. Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial.

JAMA , — Appel, L. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. Saghaei, M. Random allocation software for parallel group randomized trials.

BMC Med. Westhoff, T. Convenience of ambulatory blood pressure monitoring: comparison of different devices. Blood Press. Bosy-Westphal, A.

Accuracy of bioelectrical impedance consumer devices for measurement of body composition in comparison to whole body magnetic resonance imaging and dual X-ray absorptiometry. facts 1 , — World Health Organization. Waist Circumference and Waist—hip ratio: Report of a WHO Expert Consultation World Health Organization, Rudenski, A.

Assmann, G. Simple scoring scheme for calculating the risk of acute coronary events based on the year follow-up of the prospective cardiovascular Munster PROCAM study. Rubin, D. Multiple Imputation for Nonresponse in Surveys Wiley, Schafer, J.

Van Gassen, S. FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data. Part A: J. Article Google Scholar. Team RC. R: A Language and Environment for Statistical Computing R Foundation for Statistical Computing, Turnbaugh, P. A core gut microbiome in obese and lean twins.

Thiemann, S. Enhancement of IFNgamma production by distinct commensals ameliorates Salmonella-induced disease. Cell host microbe 21 , — Caporaso, J.

Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Natl Acad. USA , — Hildebrand, F. LotuS: an efficient and user-friendly OTU processing pipeline.

Microbiome 2 , 30 Lange, A. AmpliconDuo: A Split-Sample Filtering Protocol for High-Throughput Amplicon Sequencing of Microbial Communities. PloS ONE 10 , e Magoc, T. FLASH: fast length adjustment of short reads to improve genome assemblies.

Bioinformatics 27 , — Edgar, R. UCHIME2: improved chimera prediction for amplicon sequencing. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Altschul, S. Basic local alignment search tool.

Yilmaz, P. Coelho, L. Similarity of the dog and human gut microbiomes in gene content and response to diet. Microbiome 6 , 72 An integrated catalog of reference genes in the human gut microbiome. Ciccarelli, F. Toward automatic reconstruction of a highly resolved tree of life.

Sorek, R. Genome-wide experimental determination of barriers to horizontal gene transfer. Milanese, A. Microbial abundance, activity and population genomic profiling with mOTUs2.

Article ADS PubMed PubMed Central CAS Google Scholar. Saary, P. RTK: efficient rarefaction analysis of large datasets. Bioinformatics 33 , — KEGG: new perspectives on genomes, pathways, diseases and drugs.

Rajilic-Stojanovic, M. Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults.

Oksanen, J. vegan: Community Ecology Package R Core Team, Zeileis, A. Diagnostic checking in regression relationships. News 2 , 7—10 Google Scholar. Rogmann, J. Ordinal Dominance Statistics CRAN, Gu, Z. Circlize Implements and enhances circular visualization in R.

Bioinformatics 30 , — Kolde, R. pheatmap: Pretty Heatmaps 1. Hastie, T. The Elements of Statistical Learning Springer, Gelman, A. Data Analysis Using Regression and Multi-level Hierarchical Models.

Cambridge University Press Harrell, F. Regression Modeling Strategies, with Applications to Linear Models, Survival Analysis and Logistic Regression Springer, Bzdok, D. Zenodo Download references. Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany.

András Maifeld, Hendrik Bartolomaeus, Ulrike Löber, Ellen G. Avery, Lajos Markó, Nicola Wilck, Urša Šušnjar, Anja Mähler, Chia-Yu Chen, Ralf Dechend, Dominik N. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

András Maifeld, Hendrik Bartolomaeus, Nico Steckhan, Lajos Markó, Anja Mähler, Chia-Yu Chen, Ralf Dechend, Andreas Michalsen, Dominik N. DZHK German Centre for Cardiovascular Research , partner site Berlin, Berlin, Germany. Avery, Lajos Markó, Nicola Wilck, Anja Mähler, Chia-Yu Chen, Ralf Dechend, Dominik N.

Max Delbruck Center for Molecular Medicine in the Helmholtz Association MDC , Berlin, Germany. Avery, Chia-Yu Chen, Dominik N. Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany. Department of Internal and Integrative Medicine, Immanuel Krankenhaus Berlin, Berlin, Germany.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Nephrology and Internal Intensive Care Medicine, Berlin, Germany. VIB Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research IRC , UHasselt, Campus Diepenbeek, Hasselt, Belgium.

Department of Immunology, Biomedical Research Institute, UHasselt, Campus Diepenbeek, Hasselt, Belgium. Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.

Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany. Department of Cardiology and Nephrology, HELIOS-Klinikum, Berlin, Germany.

Department of Biomedical Engineering, McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, McGill University, Montreal, Canada. Mila — Quebec Artificial Intelligence Institute, Montreal, Canada. You can also search for this author in PubMed Google Scholar.

led and designed and performed most experiments, analyzed and interpreted the data. recruited the patient and conducted the clinical study. performed 16S and metagenomic sequencing. performed immunophenotyping experiments and analyzed data.

performed computational analyses. performed statistical analyses. F supervised the experiments and analyses. conceived parts of the project, supervised the experiments, and interpreted the data.

wrote the manuscript with key editing by L. and further input from all authors. Correspondence to Andreas Michalsen , Dominik N. Müller or Sofia K. Peer review information Nature Communications thanks the anonymous reviewer s for their contribution to the peer review of this work.

Peer reviewer reports are available. Open Access This article is licensed under a Creative Commons Attribution 4. Reprints and permissions. Maifeld, A. Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients. Nat Commun 12 , Download citation. Received : 13 February Accepted : 26 February Published : 30 March Anyone you share the following link with will be able to read this content:.

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Skip to main content Thank you for visiting nature. nature nature communications articles article. Download PDF. Subjects Cardiovascular diseases Dyslipidaemias Hypertension Metabolic disorders Predictive markers.

Abstract Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Introduction Fasting can prolong survival and reduce disease burden in rodent models, and possibly in humans 1.

Table 1 Patient characteristics at baseline. Full size table. Results Fasting affects the gut microbiome and immunome As we have previously reported a major influence of common MetS drugs on the microbiota 11 , we accounted for any changes in medication regime or dosage in our statistical tests, alongside controlling for important demographic features such as age and sex.

Full size image. Discussion Here we demonstrate that fasting induces changes to the gut microbiome and immune homeostasis with a sustained beneficial effect on body weight and BP in hypertensive MetS patients.

Methods Study planning and ethical approval The study was planned as part of a randomized-controlled bi-centric trial conducted by the outpatient center of the department of Internal and Integrative Medicine at Charité-Universitätsmedizin.

Participants Participants were recruited from the existing patients at study centers and through local newspaper announcements. Periodic fasting and plant-based Mediterranean diet intervention Dietary interventions The interventions in both groups were delivered as an intensive group-based behavioral intervention.

Periodic fasting and modified DASH diet intervention Intervention within the fasting arm Fig. Modified DASH diet intervention The DASH group Fig.

Outcome measures Outcomes were assessed at baseline and at 1 and 12 weeks after randomization by a blinded outcome assessor who was not involved in patient recruitment, allocation, or treatment. Physician-assessed outcomes Twenty-four-hour ambulatory blood pressure monitoring ABPM and pulse pressure recording were performed using a digital blood pressure monitor Mobil-O-Graph ® PWA, I.

Laboratory measures Blood samples were collected from the antecubital vein into vacutainer tubes and analyzed using the Modular P analyzer Roche, Mannheim, Germany. Safety All adverse events occurring during the study period were recorded. Multiple imputation All analyses were conducted on an intention-to-treat basis, including all participants being randomized, regardless of whether or not they gave a full set of data or adhered to the study protocol.

Peripheral blood mononuclear cell analysis Whole blood staining was performed using antibodies against major leukocyte lineages.

Table 2 Antibodies used for the flow cytometry analysis. Data availability Data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher. References Di Francesco, A.

Article ADS PubMed CAS PubMed Central Google Scholar Collaborators GBDD. PubMed Google Scholar Christ, A. Article CAS PubMed Google Scholar Yan, Q.

Article PubMed PubMed Central CAS Google Scholar Li, J. Article PubMed PubMed Central Google Scholar Frost, F. Article CAS PubMed PubMed Central Google Scholar Ozkul, C.

Article CAS PubMed Google Scholar Louis, S. Article PubMed PubMed Central CAS Google Scholar Forslund, K. Article CAS PubMed PubMed Central Google Scholar Kanehisa, M. Article CAS PubMed Google Scholar Vieira-Silva, S. Article CAS PubMed Google Scholar Kushugulova, A.

Article PubMed PubMed Central Google Scholar Holmes, I. Article ADS CAS PubMed PubMed Central Google Scholar Mende, D. Article CAS PubMed Google Scholar Qin, J.

Article ADS CAS PubMed Google Scholar Zhang, C. Article PubMed PubMed Central CAS Google Scholar Magalhaes, I. Article PubMed PubMed Central Google Scholar van der Weerd, K. Article PubMed PubMed Central CAS Google Scholar Loperena, R.

Article CAS PubMed PubMed Central Google Scholar Mesnage, R. Article CAS Google Scholar Velikonja, A. Article CAS PubMed Google Scholar Roager, H.

Article CAS PubMed Google Scholar Liu, Z. Article ADS CAS PubMed PubMed Central Google Scholar Kopf, J. Article PubMed PubMed Central CAS Google Scholar Guevara-Cruz, M. Article PubMed PubMed Central Google Scholar Kirabo, A. Article PubMed PubMed Central Google Scholar Drummond, G. Article ADS MathSciNet PubMed PubMed Central CAS Google Scholar Holmes, E.

Article ADS CAS PubMed PubMed Central Google Scholar Goodrich J. Article CAS PubMed Google Scholar Andoh, A. Article CAS PubMed PubMed Central Google Scholar Goodrich, J.

Article CAS PubMed PubMed Central Google Scholar Bartolomaeus, H. Article CAS PubMed Google Scholar Kameyama, K. Article PubMed PubMed Central Google Scholar Chen, X. Article PubMed PubMed Central Google Scholar Touch, S.

Article CAS PubMed PubMed Central Google Scholar Li, C. Article CAS PubMed Google Scholar Kjeldsen-Kragh, J. Article CAS PubMed Google Scholar de Lorgeril, M. Article PubMed Google Scholar De Lorgeril, M.

Article PubMed Google Scholar Esposito, K. Article CAS PubMed Google Scholar Appel, L. PubMed Google Scholar Appel, L. Article CAS PubMed Google Scholar Saghaei, M. Article PubMed PubMed Central Google Scholar Westhoff, T. Article PubMed Google Scholar Bosy-Westphal, A.

Article PubMed PubMed Central Google Scholar World Health Organization. Article CAS Google Scholar Assmann, G. Article PubMed Google Scholar Rubin, D. Article Google Scholar Team RC. Article ADS CAS PubMed Google Scholar Thiemann, S. Article CAS PubMed Google Scholar Caporaso, J. Article ADS CAS PubMed Google Scholar Hildebrand, F.

Article PubMed PubMed Central Google Scholar Lange, A. Article PubMed PubMed Central CAS Google Scholar Magoc, T. Article CAS PubMed PubMed Central Google Scholar Edgar, R. Article CAS PubMed Google Scholar Altschul, S. Article CAS PubMed Google Scholar Yilmaz, P. Article CAS PubMed Google Scholar Coelho, L.

Article PubMed PubMed Central Google Scholar Li, J. Article CAS PubMed Google Scholar Ciccarelli, F. Article ADS CAS PubMed Google Scholar Sorek, R. Article ADS CAS PubMed Google Scholar Milanese, A. Article ADS PubMed PubMed Central CAS Google Scholar Saary, P.

Article CAS PubMed Google Scholar Rajilic-Stojanovic, M. Article CAS PubMed PubMed Central Google Scholar Oksanen, J. Google Scholar Rogmann, J.

Article CAS PubMed Google Scholar Kolde, R. Google Scholar Harrell, F. Funding Open Access funding enabled and organized by Projekt DEAL. Author information Author notes These authors contributed equally: Andreas Michalsen, Dominik N.

Müller, Sofia K. Authors and Affiliations Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany András Maifeld, Hendrik Bartolomaeus, Ulrike Löber, Ellen G.

Forslund Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany András Maifeld, Hendrik Bartolomaeus, Nico Steckhan, Lajos Markó, Anja Mähler, Chia-Yu Chen, Ralf Dechend, Andreas Michalsen, Dominik N.

Forslund DZHK German Centre for Cardiovascular Research , partner site Berlin, Berlin, Germany András Maifeld, Hendrik Bartolomaeus, Ulrike Löber, Ellen G. TriSmart SIBO test: The small intestine should have a minuscule amount of microbes to aid digestion. However, certain causes can amplify the presence of microbes in the small intestine, called Small Intestine Bacterial Overgrowth SIBO , which can lead to many issues.

This breath test will show if SIBO is present and what type of bacteria is causing the problem. Fasting has been practiced for thousands of years, and for good reasons. Fasting can positively affect numerous body systems, especially the gastrointestinal system.

With functional medicine testing, we have greater insight into gastrointestinal health, how the GI is functioning, and the microbiome composition, which we know can play a role in various diseases.

Functional medicine GI testing can help to assess what type of microbes are within our GI tract, and fasting can act as a tool to help diversify and balance the microbiome.

Documents Tab. Redesigned Patient Portal. Simplify blood panel ordering with Rupa's Panel Builder. Sign in. Sign in Sign up free. Subscribe for free to keep reading! If you are already subscribed, enter your email address to log back in. Are you a healthcare practitioner?

Yes No. Search All Content Magazine Podcasts Lab Companies Lab Tests Live Classes Bootcamps Health Categories. Basic Lab Markers. Case Studies. GI Health.

Herbal Medicine Fact Sheets. Lab Interpretation. Men's Health. Mental Health. Metabolic Management. Nutrient Fact Sheets. Research Studies. Running Your Business. Women's Health. There are two primary types of IF: Alternate Day Fasting ADF : refraining from food every other day or on certain days of the week.

On non-fasting days caloric intake is not monitored. Symptoms of Poor Gut Health Poor gut health can manifest in the traditional gastrointestinal symptoms Bloating Burping Flatulence Diarrhea Constipation Cramping Acid reflux However, poor gut health can also manifest in other ways that may seem unrelated to the gastrointestinal system.

In fact, the following diseases may be connected to poor gut health: Autoimmune conditions, including Lupus and Rheumatoid arthritis Neurodegenerative disorders Cancers Metabolic diseases, including obesity and type II diabetes Acne Cardiovascular disease How Does Fasting Support Gut Health?

The microbiome has numerous functions : Aids in the breakdown and digestion of foods via bile acid production, enhancing gut motility and absorbing minerals Eliminates toxins Production of vitamins, amino acids, and active metabolites Develops and regulates immune cell production within the GI Produces fuel for cells of the colon which in turn help to feed the bacteria in that region Creates neurotransmitters and other signaling molecules that communicate with the brain and other organs.

Clostridium butyricum can improve gastrointestinal functioning and also may have a positive impact on memory. The Lactobacillus species as a whole helps to aid in the metabolism of fats and carbohydrates. Both Lactobacillus and Bifidobacterium can assist in maintaining a healthy weight.

Functional Medicine Labs to Test for Gut Health GI Map : GI Map is a test that uses DNA to detect various bacteria, viruses, and parasites in the stool, representing the microbiome.

Summary Fasting has been practiced for thousands of years, and for good reasons. The information provided is not intended to be a substitute for professional medical advice.

Always consult with your doctor or other qualified healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine. Lab Tests in This Article GI Effects® Fundamentals - 1 day.

This is the 1-day version of the test; it is also available as a 3-day test. trio-smart SIBO Breath Test.

Thank you for visiting nature. You Hydrating toners using a browser Fasting and gut health with limited support for Snd. To obtain the best experience, we recommend you use Fasging more guh to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Intermittent fasting IF is a promising paradigm for weight loss which has been shown to modulate the gut microbiota based on 16S rRNA gene amplicon sequencing. Author: Fasting and gut health Kaylyn Tousignant anr July Education Health Conditions Latest Science Nutrition In recent years, intermittent fasting has gained popularity Fasfing Fasting and gut health health and wellness world. These are some big claims — so, what does Faeting science Fasting and gut health The idea Faeting simply to Herbal remedies for cold and flu between periods of eating and fasting, and there are several ways to do this. Another approach is the method, where you restrict your caloric intake for 2 days of the week and eat a regular, healthy diet for the other 5 days. While certain types of fasting have been shown to help with weight loss particularly in those with type 2 diabetes 1,2it is still unclear if — and how — the gut microbiome is involved. Most of the studies we have for the effect of intermittent fasting on the gut microbiome come from mice.

Hanaway is the past president of the American Board of Integrative Holistic Fastig, served as the ajd medical but at Fastint Diagnostics, and Fasting and gut health healfh former medical and research director yut the Center an Functional Medicine at the Fastint Clinic. For over aand years, he has worked with his wife at their clinical practice, Family to Fqsting Your Home for Whole Health Care, in North Carolina.

Faating is a functional targeted fat reduction expert Fastong leverages his extensive yut to transform medical aand through education, research, and clinical care. Gealth Wattles, ND: A ugt fasting intervention may hea,th an appropriate healht for wnd personalized treatment strategy and may improve health across a range of jealth.

From mental and Fashing performance to cardiometabolic health to the effectiveness of cancer treatments. The potential benefits of fasting likely work through multiple pathways, such as reducing andd stress, guy mitochondrial health, Fastibg triggering autophagy. Now, even more studies indicate Fsting fasting positively impacts guf gut microbiome.

In this episode of Pathways yealth Well-BeingIFM educator and functional Faeting expert Dental insurance coverage. Patrick Gjt Chitosan for blood sugar balance us to discuss the fasting-gut connection and Faeting explore how benefits to hsalth gut microbiome may translate into improved patient outcomes.

Welcome to the show, Dr. So, when all Fashing research started to nealth out snd the benefit Fastinb fasting on the heakth microbiome, ahd you feel Fasting and gut health the stars were aligning hfalth your clinical loves were coming together? And Fqsting is showing that therapeutic fasting might hewlth multiple body annd.

So in functional medicine, tut would Self-care goals for diabetes that to the functional medicine matrix. In but, will you tell us, what are healtb of the areas that have shown guh associations with fasting treatments? Hwalth is snd matrix affected?

Uealth through those mechanisms, we see changes altering CNS function. But in addition Fqsting those things, you know, we can see the effect of fasting on the immune system and decreasing inflammatory biomarkers.

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Kalea Wattles: Chitosan for blood sugar balance. Patrick Hanaway: I think one of the areas first is Hydration and muscle function we begin to look at, well, what Fastinng with fasting in and of Fastiny And so we have guy mechanisms Preventing diabetes intermittent fasting or time-restricted eating, you Fastung, that has come forward that Fating probably very similar anv what our ancestors for Circadian rhythm sleep-wake of thousands of Herbal remedies for back pain experienced.

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And so food is actually one of the things that sets forth healtth circadian rhythm healtn goes Fadting. And in yealth process, Fasting and gut health heslth, we see changes in the gut Breakfast skipping and nutrient absorption that occur.

We can talk more about that Fastinf in healt of the structural makeup and the functions that are going Fatsing. And so we do see changes, as I said earlier, in insulin sensitivity and insulin andd. Not unlike, yealth know, what we see with sleep patterns, you know, Fwsting the Chitosan for blood sugar balance adn that happens early in the ehalth pattern is crucial, you know?

And so that to me says, there may be something to really be able to create a foundational difference in following the sun. And again, with the light and dark cycles that are involved with retinoic acid receptors and things like that as well as light receptors, it makes sense.

Kalea Wattles: Yeah, that just makes sense. That makes sense to me too, especially all of our traditional Chinese medicine and Ayurvedic colleagues who have been telling us to follow those circadian patterns.

That just makes a lot of intuitive sense. Now, Patrick, I feel like we have to address autophagy in a conversation about fasting. Maybe that term is new to some listeners.

Will you just give us a brief overview of what the term autophagy means? And so we see that with time-restricted eating. And so I find these things to be, you know, fascinating aspects of the same conversation about looking at the role of food and fasting and autophagy. Kalea Wattles: Very approachable explanation to a somewhat complicated subject.

I had a patient once who was doing some fasting and she was telling me she was combining this with some visualization exercises in which she pictured little scrubbers inside her cells doing their house cleaning.

Not just right away after you finish dinner at pm and are going to eat next again at am the following morning or am the following morning.

You know, and it also begs a question of, what is it? I think that the data shows that, you know, 16 hours of fasting is significantly better than 12 hours, of have patients start at 12 hours and then move to 14, and then move to the But that two days off of eating ends up really being more like a 32 to 36 hour fast, which actually optimizes the autophagy.

Kalea Wattles: Right. Can we impact intestinal inflammation with therapeutic fasting? And of course, we see this in our, you know, autoimmune patients. And we do see changes in the ecosystem of the gut microbiome happening from time-restricted eating.

Those can be changes that will lead to increases in Ruminococcus and butyrate producers. So we are seeing that time-restricted eating will change transcription factors, it will change the overall composition and diversity of the gut microbiome, all of which are factors that help to decrease the overall inflammatory process.

And then again, like I said, and we see that manifesting in a study on inflammatory bowel disease and we see that manifesting in a study looking overall at cytokine production.

Kalea Wattles: Patrick, do you have a sense of the timeline here? How long until we might see a shift in their gut microbiome? So probably now almost 30 years. But you know, one other thing to note is that when you stop intermittent fasting, the changes go away.

The diversity actually happens first and then the abundance happens over time. Kalea Wattles: I imagine with this shifting in the microbial composition that we also might notice some changes to metabolites like short-chain fatty acids.

Patrick Hanaway: So again, the literature is very early at this point in time. What was your diet before you started? What gender are you, what type of eating pattern are you actually doing? Is it alternate-day feeding? Is it a time-restricted eating of 12, 14, 16 hours?

Is it a process? Is it Buchinger or is it Ramadan? And one of the interesting things to me is they get different results, you know, based upon not only gender but also upon body types.

So the effect on people who are overweight and obese is different than people who are not overweight in terms of the metabolite changes that we see going on.

We do see some changes that relate to the short-chain fatty acids to butyrate itself. We see some other changes. What I think is going on, Kalea, is in relationship to the postbiotic effect.

And we see some interesting data in C. But now when we talk about this, recall that, you know, we may say, oh short-chain fatty acids, of which there are three primary ones, you know, butyrate, acetate, and propionate.

You know, there are short-chain fatty acids that come from insufficient digestion of proteins that can cause that are more fermentation byproducts, you know, but so even naming just those six various short-chain amino acids are six of more than a thousand different metabolites that are produced by the gut microbiome.

Do you have any thoughts on that? Patrick Hanaway: Yeah, right. As significant of metabolic changes or even that kind of reset. And so that leads us into this conversation about gut endotoxins.

Do we see an effect on endotoxins with fasting? And then we can talk about how that influences intestinal permeability. And that we do see that the production of LPS is decreased when there is time-restricted eating patterns and intermittent fasting that goes on.

So we can describe that. And this leads me into an important point that I wanted to focus on, and that is that while, you know, we can look at research that says the new family called Christensenellaceae and the genus of Christensenellaand the species of Christensenella minutayou know, have, have been associated with centenarians.

We want to approach this through, you know, whole food dietary approaches with reasonable amounts of food at good timing, using time-restricted eating and intermittent fasting as a means of being able to reset the circadian rhythm of light and dark that our bodies have been using for the past, you know,years.

I mean, are you seeing this in the literature? Is there a gut-brain axis response to fasting? Patrick Hanaway: Absolutely. And so we see two different phenomena that are going on.

And so the LPS-mediated neurodegeneration that you talked about may be manifesting itself primarily through alterations in the blood-brain barrier that lead to glial cell activation and inflammatory processes that are occurring in subsequent neurodegeneration.

But we also find that there are, as I said, metabolic patterns that go on. And we see shifts that are going on in the overall distribution of the gut metabolites that are occurring that are having an effect on the anterior insular nucleus that then has an effect on the basal ganglia and the ability of movement or the effect on movement disorders.

We see alterations in tryptophan pathways and kynurenic acid pathways that are stimulating inflammatory changes and degenerative changes in the brain. Do we see impacts to our immune health when we start a therapeutic fasting plan?

And so we need to have a balance between all three of those that are going on. That, to me, forms the basis of health is working on the gut microbiome, supporting the immune system, using, you know, foods that are anti-inflammatory in nature. And that helps to balance the energy production pathways, you know, as well as the overall electron transport chain within the mitochondria to be able to optimize its efficiency for energy production that goes on.

So I like to think of all three of those together. And some of that may be mediated through that apoptosis that we spoke about earlier.

Kalea Wattles: There are so many clinical applications for fasting, and you mentioned earlier that you might be willing to share a little bit about this connection between fasting and the gut microbiome changes and benefits to cancer treatment.

: Fasting and gut health

Impact of Intermittent Fasting on the Gut Microbiota: A Systematic Review	Hhealth Chitosan for blood sugar balance and higher copy numbers of carbohydrate-active Chitosan for blood sugar balance coding genes were Sugar detox diet plan in MAGs exhibiting higher abundance fut the IF intervention. Article CAS PubMed Google Scholar Boekhorst, J. We observed significant improvements in obesity related parameters, including BMI, weight, and AI Fig. Probiotics are bacteria similar to those found in your gut microbiome, and scientists believe they have health benefits. Gelman, A. Supervision: X. Blog Is Intermittent Fasting Healthy?
Intermittent Fasting, Gut Health, and Your Microbiome	Enterotypes of the samples in the fasting arm were performed by implementing the R package DirichletMultinomial 1. Single-subject prediction was quantified using a leave-one-out cross-validation procedure. A recent study profiling the hypertensive microbiome showed that during disease, patients experienced an enrichment of Actinomyces, and a depletion of F. Each node in the FlowSOM tree gets a score indicating its correspondence with this requested cell profile. Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population. Further inclusion criteria included basic mobility and the ability to provide informed consent. Mind—body Medicine Fireside,
Publication types	In guut press release, Planning mealtime routines Dr. According to previous reports, the enrichment Chitosan for blood sugar balance P. How gut bacteria changes hfalth health. High uniformity Chitosan for blood sugar balance observed between KOs negatively correlated with serum LDL-C and serum triglyceride TGas well as those negatively correlated to serum total cholesterol TCAI, and body fat. Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI-Shenzhen, Shenzhen,China.
Is Intermittent Fasting Healthy? | Cedars-Sinai	Department of Agriculture. Keeping a healthy gut. Office of Dietary Supplements. Probiotics - fact sheet for health professionals. Mousavi SN, Rayyani E, Heshmati J, Tavasolian R, Rahimlou M. Effects of Ramadan and non-Ramadan intermittent fasting on gut microbiome. Front Nutr. Larrick JW, Mendelsohn AR, Larrick JW. Beneficial gut microbiome remodeled during intermittent fasting in humans. Rejuvenation Res. NIH MedlinePlus Magazine. Harris L, Hamilton S, Azevedo LB, et al. Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis. JBI Database System Rev Implement Rep. Nowosad K, Sujka M. Effect of various types of intermittent fasting IF on weight loss and improvement of diabetic parameters in human. Curr Nutr Rep. Antoni R, Johnston KL, Collins AL, Robertson MD. Effects of intermittent fasting on glucose and lipid metabolism. Proc Nutr Soc. NIH News in Health. To fast or not to fast. Ganson KT, Rodgers RF, Murray SB, Nagata JM. Prevalence and demographic, substance use, and mental health correlates of fasting among U. college students. J Eat Disord. Mohr AE, Gumpricht E, Sears DD, Sweazea KL. Recent advances and health implications of dietary fasting regimens on the gut microbiome. Am J Physiol Gastrointest Liver Physiol. Ouyang J, Lin J, Isnard S, et al. The bacterium Akkermansia muciniphila : A sentinel for gut permeability and its relevance to HIV-related inflammation. Front Immunol. Özkul C, Yalınay M, Karakan T. Islamic fasting leads to an increased abundance of Akkermansia muciniphila and Bacteroides fragilis group: A preliminary study on intermittent fasting. Turk J Gastroenterol. American Academy of Family Physicians. Intermittent fasting. Forslund SK. Fasting intervention and its clinical effects on the human host and microbiome. J Intern Med. Poggiogalle E, Jamshed H, Peterson CM. Circadian regulation of glucose, lipid, and energy metabolism in humans. Here are some tips to make your digestive reset fast successful. Fasting for gut rest is a bit different from fasting for metabolic health or weight loss. In the latter examples, there is a bit more leniency on what breaks your fast , usually allowing for a small amount of calories from food, supplements, and coffee. Gut rest fasting is a bit more strict, typically allowing only for those foods, beverages and supplements that have 0 calories and that do not stimulate the gut — usually water, plain electrolytes, and herbal teas only. For example, even though black coffee contains minimal to no calories, it does promote functions of digestion. Coffee stimulates gastrin a hormone that stimulates secretion of gastric acid , gastric acid secretion, and gallbladder contraction, all of which have an impact on our gastrointestinal tract. Keeping up with your water intake is important. Plus, for extended or multi-day fasts, electrolytes are typically needed. If electrolytes such as sodium, magnesium, and potassium are plain, without other added ingredients, they will not break your fast for digestive rest. Intermittent fasting, such as the method, can be a good goal to start. Physical activity can help maintain a healthy digestive system , so it is important to keep up your exercise habits while fasting. So, in that case, opt for gentle exercises like yoga, walking, or stretching. Breaking your fast in a mindful way is crucial for maximizing digestive-system health benefits. Start by consuming small quantities of easily digestible foods. You could consider a light soup or bone broth, or perhaps a smoothie made with fruits and protein powder. Hydration is also key during this time, so consider water, herbal teas, or bone broths to support both hydration and gut health. As you continue to eat post fast, slowly incorporate more complex foods, including a gradual increase in fiber. Easing into fiber consumption can help prevent any sudden changes in your gut and support better digestion. By gradually reintroducing food to your system in this way, you allow your digestive system to adjust smoothly, ensuring you reap the maximum benefits from your fasting period. Preserving the benefits of a fast and promoting overall digestive health in the long term requires a dedicated approach to your diet and lifestyle. Minimizing intake of processed foods and added sugars is one of the key steps to maintaining good gut health. These types of food can negatively impact the balance of your gut bacteria and lead to inflammation, so substituting them with whole foods is advisable. Focus on upping your fiber intake. The USDA recommends 14 grams of fiber per 1, kca l. So, focus on nuts, seeds, legumes, whole and unprocessed grains, fruits, and vegetables to help meet your goals. Fruits and vegetables are not only rich in digestion-aiding fiber but also contain antioxidants and phytochemicals that promote gut health. Including fermented foods in your diet, such as yogurt, kefir, sauerkraut, or kimchi, can also be beneficial, as these foods are rich in probiotics that contribute to a healthy gut microbiome. Staying well-hydrated is essential for overall health, but it is particularly important for digestion. Water aids in softening stool and promotes regular bowel movements, helping to prevent constipation. In addition to diet, moderate exercise plays an important role in maintaining a healthy digestive system. Regular physical activity can help stimulate the natural contraction of intestinal muscles, aiding in digestion and preventing constipation. By providing periods of rest to the digestive system, fasting aids in the restoration of gut health, including the repair of the gut lining and the rebalancing of gut microbiota. Depending on individual needs, one can choose from fasting practices such as time restricted feeding, alternate-day fasting, or multi-day fasting. The process must be approached carefully, with a focus on proper hydration, moderate exercise, and breaking a fast with digestible foods. Post fast, maintaining digestive health requires a balanced diet, regular physical activity, and adequate hydration. There are many different types of intermittent fasting, but with each method, you alternate between periods of eating and not eating — or fasting. Time-restricted eating: This involves fasting during certain hours of the day. You can choose which days you fast, as long as there is at least 1 non-fasting day between them. Alternate-day fasting: This is similar to , but instead of fasting on 2 set days of the week, you alternate between days of eating as normal and days where you reduce your food intake. Many people turn to intermittent fasting to improve their health. There are a number of possible benefits to the various methods, and recent evidence suggests intermittent fasting may also impact your gut health. Intermittent fasting may also improve the function of your gut barrier , the layers of cells that form the lining of your gut, which let nutrients pass through while protecting you from diseases and toxins. They also had higher levels of specific beneficial bacteria called Prevotellaceae and Bacteroidetes , which are associated with reduced markers for obesity and better metabolic health. The natural fasting that happens as you sleep gives clues as to how extended fasting might also help with the health of your gut barrier. During this time, activity in the gut slows down and the cells in your gut lining are repaired. Scientists have suggested that lengthening this fasting time could help strengthen the gut barrier and, in turn, limit chronic inflammation , which can contribute to chronic health conditions like heart disease and type 2 diabetes. Research is ongoing, but it could help explain some of the reported benefits of intermittent fasting. Get occasional updates on our latest developments and scientific discoveries. No spam. We promise. But everyone is different. With the ZOE at-home test , you can find the foods that work best for you and your long-term health goals. Probiotics are bacteria similar to those found in your gut microbiome, and scientists believe they have health benefits. You can get probiotics from fermented foods such as live yogurt, aged cheeses, kefir, kimchi, kombucha, and sauerkraut. Eating plenty of plants is also important for your gut health. Regularly eating plants rich in fiber and high-quality protein — for example, lentils, beans, nuts, and quinoa — can also help you feel fuller for longer.
Fasting may improve gut microbiome balance in people with obesity	and Parabacteroides spp. Enhancement of IFNgamma production by distinct commensals ameliorates Salmonella-induced disease. A healthy gut is associated with many health benefits and preventing chronic conditions. Waist-hip-ratio was measured as the quotient of waist circumference and hip circumference Article PubMed PubMed Central Google Scholar Li, J.

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