Resveratrol and heart health -
Chen, Q. BMC Cardiovasc. Chen, S. Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK. Chen, T. Heart Circ. Chen, W. In vitro electrophysiological mechanisms for antiarrhythmic efficacy of resveratrol, a red wine antioxidant. Cieslik, K. Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart.
Colin, S. Macrophage phenotypes in atherosclerosis. de Almeida, A. Effects of mast cells on the behavior of isolated heart fibroblasts: Modulation of collagen remodeling and gene expression. de Ligt, M.
No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: A randomized trial. Deddens, J. Modeling the human scarred heart in vitro : Toward new tissue engineered models.
Delucchi, F. Resveratrol treatment reduces cardiac progenitor cell dysfunction and prevents morpho-functional ventricular remodeling in type-1 diabetic rats. PLoS One 7 6 , e Dewald, O. Diaz, M. Acute resveratrol supplementation in coronary artery disease: Towards patient stratification.
Dobaczewski, M. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells.
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Guan, P. Gutlapalli, S. The effects of resveratrol on telomeres and post myocardial infarction remodeling. Cureus 12 11 , e Hagemann, T. Regulation of macrophage function in tumors: The multifaceted role of NF-kappaB. Blood 14 , — Hamidzadeh, K. Macrophages and the recovery from acute and chronic inflammation.
Han, S. Resveratrol inhibits IgE-mediated basophilic mast cell degranulation and passive cutaneous anaphylaxis in mice. He, Y. Resveratrol protects against myocardial ischemic injury via the inhibition of NF-κB-dependent inflammation and the enhancement of antioxidant defenses.
Heidt, T. Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction. Henning, R. Stem cells in cardiac repair. Future Cardiol. Hoseini, A. The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease.
Food Funct. Hsu, C. Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide. Hu, J. Inhibition of microRNA attenuates sympathetic neural remodeling following myocardial infarction via reducing M1 macrophage polarization and inflammatory responses in mice.
Hu, Q. Increased Drp1 acetylation by lipid overload induces cardiomyocyte death and heart dysfunction. Hu, Y. Acta Biochim. Resveratrol attenuates left ventricular remodeling in old rats with COPD induced by cigarette smoke exposure and LPS instillation.
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Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation. Jäger, S. AMP-activated protein kinase AMPK action in skeletal muscle via direct phosphorylation of PGC-1alpha. Jakus, P.
TRAF6 is functional in inhibition of TLR4-mediated NF-κB activation by resveratrol. Joseph, J. Protective role of mast cells in homocysteine-induced cardiac remodeling.
Kamann, S. Resveratrol-coated balloon catheters in porcine coronary and peripheral arteries. Kanamori, H. Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway. Kanellakis, P. A pro-fibrotic role for interleukin-4 in cardiac pressure overload.
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Kim, J. Shear stress-induced mitochondrial biogenesis decreases the release of microparticles from endothelial cells. Knowlton, A. Estrogen and the cardiovascular system. Koh, T. Inflammation and wound healing: The role of the macrophage. Expert Rev. Kologrivova, I. Cells of the immune system in cardiac remodeling: Main players in resolution of inflammation and repair after myocardial infarction.
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Matsumura, N. Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites. Co-administration of resveratrol with doxorubicin in young mice attenuates detrimental late-occurring cardiovascular changes. Mazza, A.
The short-term supplementation of monacolin K improves the lipid and metabolic patterns of hypertensive and hypercholesterolemic subjects at low cardiovascular risk.
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Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. Nahrendorf, M. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
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Park, S. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Penumathsa, S. Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat.
Pillai, V. Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway. Pitt, B. Because of its antioxidant properties, resveratrol could be a promising supplement for lowering blood pressure 9. A review concluded that high doses may help reduce the pressure exerted on artery walls when the heart beats 3.
That type of pressure is called systolic blood pressure, and appears as the upper number in blood pressure readings. Systolic blood pressure typically goes up with age, as arteries stiffen. Resveratrol may accomplish this blood-pressure-lowering effect by helping to produce more nitric oxide, which causes blood vessels to relax 10 , However, the authors of that study say more research is needed before specific recommendations can be made about the best dose of resveratrol to maximize blood pressure benefits.
Resveratrol supplements may help lower blood pressure by increasing the production of nitric oxide. Several studies in animals have suggested that resveratrol supplements may change blood fats in a healthy way 12 , A study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements.
Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production LDL oxidation contributes to plaque buildup in artery walls 9 , In one study, participants were given grape extract that had been boosted with extra resveratrol.
After six months of treatment, their LDL had gone down by 4. Resveratrol supplements may benefit blood fats in animals. As an antioxidant, they may also decrease LDL cholesterol odixation. It works to achieve this in the same way as calorie restriction, which has shown promise in lengthening lifespans by changing how genes express themselves 18 , Resveratrol supplements have lengthened lifespan in animal studies.
Several studies have suggested that drinking red wine can help slow down age-related cognitive decline 21 , 22 , 23 , Additionally, the compound may set off a chain of events that protects brain cells from damage While this research is intriguing, scientists still have questions about how well the human body is able to make use of supplemental resveratrol, which limits its immediate use as a supplement to protect the brain 1 , 2.
A potent antioxidant and anti-inflammatory compound, resveratrol shows promise in protecting brain cells from damage.
These benefits include increasing insulin sensitivity and preventing complications from diabetes 26 , 27 , 28 , One explanation for how resveratrol works is that it may stop a certain enzyme from turning glucose into sorbitol, a sugar alcohol. When too much sorbitol builds up in people with diabetes, it can create cell-damaging oxidative stress 30 , Here are a few more benefits resveratrol may have for people with diabetes 28 :.
Researchers say the compound could be used to treat diabetes and its complications in the future, but more research is needed. Resveratrol has helped mice develop better insulin sensitivity and fight complications of diabetes. In the future, humans with diabetes might also benefit from resveratrol therapy.
Arthritis is a common affliction that leads to joint pain and loss of mobility Plant-based supplements are being studied as a way to treat and prevent joint pain. When taken as a supplement, resveratrol may help protect cartilage from deteriorating 33 , Cartilage breakdown can cause joint pain and is one of the main symptoms of arthritis One study injected resveratrol into the knee joints of rabbits with arthritis and found that these rabbits suffered less damage to their cartilage Other research in test tubes and animals has suggested that the compound has potential to reduce inflammation and prevent damage to joints 33 , 35 , 36 , Resveratrol has been studied, especially in test tubes, for its ability to prevent and treat cancer.
However, results have been mixed 30 , 38 , Prediction of cardiovascular outcomes with left atrial size: is volume superior to area or diameter? González A, Schelbert EB, Díez J, Butler J. Myocardial interstitial fibrosis in heart failure: biological and translational perspectives. Lau ES, Liu E, Paniagua SM, Sarma AA, Zampierollo G, López B, et al.
Galectin-3 inhibition with modified citrus pectin in hypertension. JACC Basic Transl Sci. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction.
Simmonds SJ, Cuijpers I, Heymans S, Jones EAV. Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding.
Download references. Department of Cardiovascular Medicine, Saga University, Saga, Japan. You can also search for this author in PubMed Google Scholar.
Correspondence to Atsushi Tanaka or Koichi Node. KJ declares no competing interests. AT has received honoraria from Boehringer Ingelheim and research funding from GlaxoSmithKline, Takeda, Bristol Myers Squibb, and Novo Nordisk. KN has received honoraria from MSD, Astellas, AstraZeneca, Novartis, Ono, Daiichi Sankyo, Mitsubishi Tanabe, Eli Lilly, Boehringer Ingelheim, and Takeda; research grants from Asahi Kasei, Astellas, Mitsubishi Tanabe, Teijin, Terumo, Boehringer Ingelheim, Eli Lilly, and Company, Mochida, and Fuji; and scholarships from Daiichi Sankyo Healthcare, Teijin, Medtronic, and Bayer.
Reprints and permissions. Jojima, K. Resveratrol supplementation: a therapeutic potential for cardiac remodeling in hypertensive heart disease. Hypertens Res 46 , — Download citation. Received : 07 March Accepted : 17 March Published : 10 April Issue Date : June Anyone you share the following link with will be able to read this content:.
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nature hypertension research comment article. Download PDF. Full size image. References Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, et al. Article PubMed Google Scholar Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK.
Article CAS PubMed Google Scholar SPRINT Research Group, Wright JT Jr. Article Google Scholar Bonnefont-Rousselot D. Article PubMed PubMed Central Google Scholar Rivera L, Morón R, Zarzuelo A, Galisteo M. Article CAS PubMed Google Scholar Rimbaud S, Ruiz M, Piquereau J, Mateo P, Fortin D, Veksler V, et al.
Article CAS PubMed PubMed Central Google Scholar Xuehui Z, Jinghan H, Yuhang Y, Chen Z, Xiangping M, Binghui K, et al. Article CAS PubMed Google Scholar Japanese Circulation Society Joint Working Group, Ohte N, Ishizu T, Izumi C, Itoh H, Iwanaga S, Okura H, et al. Article Google Scholar Tsang TS, Abhayaratna WP, Barnes ME, Miyasaka Y, Gersh BJ, Bailey KR, et al.
Article PubMed Google Scholar González A, Schelbert EB, Díez J, Butler J. Article PubMed Google Scholar Lau ES, Liu E, Paniagua SM, Sarma AA, Zampierollo G, López B, et al. Article PubMed PubMed Central Google Scholar Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Article CAS PubMed Google Scholar Simmonds SJ, Cuijpers I, Heymans S, Jones EAV.
Article CAS PubMed PubMed Central Google Scholar Download references. View author publications.
The skins Optimal waist measurement seeds of grapes and berries hsart resveratrol, Alpha-lipoic acid and mental clarity red wine high in this compound. Research shows amd health benefits, xnd more is needed regarding how Time-restricted dieting supplementation Alpha-lipoic acid and mental clarity neart. But beyond being a healthful part of red wine and other foods, resveratrol has health-boosting potential in its own right. In fact, resveratrol supplements have been linked to many exciting health benefits, including protecting brain function and lowering blood pressure 1234. This article explains what you need heaalth know about resveratrol, including seven of its main potential health benefits.Resveratrol and heart health -
But there are still ongoing trials, so one must keep an open mind about possible benefits. You may already consume a fair amount of resveratrol.
It's found in foods such as peanuts, pistachios, grapes, red and white wine, blueberries, cranberries, and even cocoa and dark chocolate. The plants from which these foods come make resveratrol to fight fungal infection, ultraviolet radiation, stress, and injury. An army of researchers is scrambling to see if that protective power can be extended beyond plants.
An early resveratrol researcher was Dr. David Sinclair, now a professor of genetics at Harvard Medical School. He and his colleagues discovered in that resveratrol could increase cell survival and slow aging in yeast and later in mice by activating a "longevity" gene known as SIRT1. But the dose of resveratrol administered in experiments is always much higher than you'd normally consume in a daily diet.
Sinclair, who was named one of this year's Time magazine Most Influential People for his anti-aging research. He wasn't surprised about the results in the JAMA Archives study. Still, the disappointing results don't mean that resveratrol and other molecules like it won't help extend the lifespan or protect against the development of aging-related diseases.
Sinclair points out that drug companies have now created thousands of new synthetic molecules, "that are up to a thousand times better than resveratrol. They prevent cardiovascular disease and neurodegeneration. They also extend lifespan in mice.
The molecules don't have catchy names yet—with current such as SRT and SRT—but they're showing promising results in mice. Sinclair is again helping to pioneer much of this research. If we can't get enough resveratrol from food, should we try to get it from supplements?
As you might expect, Dr. Sinclair takes resveratrol in supplement form, and has for the last ten years. He's not an MD, so he says he can't recommend it to you and me.
That makes taking a resveratrol supplement a bit of an experiment—sort of like the tests on lab mice. A big difference is that mice have researchers assessing their response to resveratrol, but we don't. If you take a resveratrol supplement, or plan to, let your doctor know so you both can be alert for any possible harms.
If you want to get some resveratrol from red wine, go ahead but keep it moderate: no more than one drink day for women, and no more than two drinks a day for men.
The same advice holds true for other alcoholic beverages. But if you're looking for longevity from resveratrol, you won't find it at the bottom of your wine glass or, at least for now, in a supplement bottle.
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PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts. Sign up now and get a FREE copy of the Best Diets for Cognitive Fitness. Furthermore, it is suggested that increased myocardial stiffness derived from the excessive accumulation of collagen and extracellular matrix causes LVDD [ 11 ].
Thus, their findings are extremely promising for the development of drugs to mitigate the progression of LVDD. Globally, the number of patients with HF, a terminal cardiovascular disease, is increasing. HF is characterized by high mortality and rehospitalization rates.
Hence, the most important medical and social strategy is to prevent the development of HF. The number of hospitalizations due to HFrEF has not changed significantly, whereas the number of hospitalizations due to HFpEF has increased significantly [ 13 ], possibly due to the fact that the pathogenesis of HFpEF is still unknown and effective treatments are currently unavailable.
Recently, a complex combination of microvascular inflammation, myocardial hypertrophy, fibrosis, endothelial dysfunction, and increased myocardial stiffness has been shown to result in a variety of clinical forms of HFpEF [ 14 ]. Until now, the only drug that has demonstrated cardioprotective effects against HFpEF is the sodium-glucose co-transporter-2 inhibitor.
Therefore, it is necessary to further develop therapeutic agents with new mechanisms that can ameliorate the complex pathogenesis of HFpEF while also treating comorbidities. Zheng et al. However, the limitation of the study is the small number of patients and the short follow-up period.
Hence, further studies are needed to determine the long-term prognosis, safety, and efficacy of RES replacement therapy in HF, as well as its appropriate dosage in humans. We believe that their work could provide a novel perspective on the future treatment of LVDD and HFpEF Fig.
Possible mechanisms of action of resveratrol on left ventricular diastolic dysfunction LVDD and heart failure with preserved ejection fraction HFpEF. ECM extracellular matrix; eNOS endothelial nitric oxide synthase; HFpEF heart failure with preserved ejection fraction; LVDD left ventricular diastolic dysfunction; NO nitric oxide; ROS reactive oxygen species.
Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension JSH Hypertens Res. Article PubMed Google Scholar. Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK.
The progression from hypertension to congestive heart failure. Article CAS PubMed Google Scholar. SPRINT Research Group, Wright JT Jr. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med.
Article Google Scholar. Bonnefont-Rousselot D. Resveratrol and cardiovascular diseases. Article PubMed PubMed Central Google Scholar. Rivera L, Morón R, Zarzuelo A, Galisteo M. Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats.
Biochem Pharmacol. Rimbaud S, Ruiz M, Piquereau J, Mateo P, Fortin D, Veksler V, et al. Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
PLoS One. Article CAS PubMed PubMed Central Google Scholar. Xuehui Z, Jinghan H, Yuhang Y, Chen Z, Xiangping M, Binghui K, et al. Effects of resveratrol supplementation on cardiac remodeling in hypertensive patients: a randomized controlled clinical trial. Soma J, Widerøe TE, Dahl K, Rossvoll O, Skjaerpe T.
J Am Coll Cardiol. Japanese Circulation Society Joint Working Group, Ohte N, Ishizu T, Izumi C, Itoh H, Iwanaga S, Okura H, et al. JCS guideline on the clinical application of echocardiography. Circ J. Tsang TS, Abhayaratna WP, Barnes ME, Miyasaka Y, Gersh BJ, Bailey KR, et al. Prediction of cardiovascular outcomes with left atrial size: is volume superior to area or diameter?
González A, Schelbert EB, Díez J, Butler J. Myocardial interstitial fibrosis in heart failure: biological and translational perspectives. Lau ES, Liu E, Paniagua SM, Sarma AA, Zampierollo G, López B, et al.
Galectin-3 inhibition with modified citrus pectin in hypertension. JACC Basic Transl Sci. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction.
Simmonds SJ, Cuijpers I, Heymans S, Jones EAV. Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding. Download references. Department of Cardiovascular Medicine, Saga University, Saga, Japan.
You can also search for this author in PubMed Google Scholar. Correspondence to Atsushi Tanaka or Koichi Node.
KJ declares no competing interests. AT has received honoraria from Boehringer Ingelheim and research funding from GlaxoSmithKline, Takeda, Bristol Myers Squibb, and Novo Nordisk.
KN has received honoraria from MSD, Astellas, AstraZeneca, Novartis, Ono, Daiichi Sankyo, Mitsubishi Tanabe, Eli Lilly, Boehringer Ingelheim, and Takeda; research grants from Asahi Kasei, Astellas, Mitsubishi Tanabe, Teijin, Terumo, Boehringer Ingelheim, Eli Lilly, and Company, Mochida, and Fuji; and scholarships from Daiichi Sankyo Healthcare, Teijin, Medtronic, and Bayer.
Reprints and permissions. Jojima, K. Resveratrol supplementation: a therapeutic potential for cardiac remodeling in hypertensive heart disease. Hypertens Res 46 , — Download citation.
Received : 07 March Accepted : 17 March Published : 10 April Issue Date : June Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.
Time-restricted dieting you Lean Body Conditioning visiting nature. You haert using healtj browser ane with limited support for Heartt. To obtain the best experience, we recommend you use a more up to Resveratrol and heart health browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Hypertension HT is the leading risk factor for life-threatening cardiorenovascular diseases, such as stroke, heart disease, and kidney disease. To prevent the onset and progression of these complications, proper management is required. Resveratroo manifestation was particularly marked with Resveratrol and heart health over 12 or more weeks in subjects Natural weight loss recipes type 2 mellitus Resveratrol and heart health. Positive results were Heart healthy lifestyle dose-dependent, Alpha-lipoic acid and mental clarity said. The study adds to Reseratrol ever-growing RResveratrol of science supporting potential health benefits of resveratrol, a powerful polyphenol Time-restricted dieting anti-fungal heakth often touted as the Resverztrol compound in grapes and red wine. Interest in the polyphenol exploded in when research from Dr David Sinclair and his team from Harvard reported that resveratrol was able to increase the lifespan of yeast cells. Given the evidence and current trend for nutraceutical solutions, researchers in China aimed to provide a comprehensive view of the regulation of lipids by resveratrol to inform future clinical policy. A total of 17 articles were assessed to determine outcomes of resveratrol intake on TC, HDL-C, LDL-C, and TG levels. One of these was divided into two trials, where resveratrol was administered at a dosage of mg daily for 48 weeks followed by mg for a similar period.Video
Studying resveratrol and heart failure
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