Beta-carotene and aging -
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Presented on October 18, during the 22nd Annual Meeting of AGE in San Francisco. Aging and carotene nutriture. AGE 16 , 59—66 Download citation. Issue Date : April Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.
Provided by the Springer Nature SharedIt content-sharing initiative. Abstract There is a growing interest in carotenes, particularly β-carotene, because of the inverse relationship between the incidence of cancer and the consumption of β-carotene and serum levels of β-carotene, which has been seen in specific animal model systems 1—3 and several epidemiologic studies 4—7.
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Randomized clinical trials means that an investigator collected a group of people. All participants were told that they we getting a supplement.
Some got the supplement while others did not they got sugar pills. Then, blinded observers this means that the observer did not know if the person was taking the supplement or the sugar pill graded the person on parameters such as skin wrinkles, skin laxity, and dyspigmentation brown spots.
So randomized clinical trials are the only way to see if something actually works. Randomized control trials have shown that beta-carotene, Vitamin E, and collagen peptides help prevent sunburns, reduce wrinkles, and improve skin elasticity.
The anti-aging effect was characterized using Western-bloting, confocal laser scanning microscopy, indirect immunofluorescence, and immunohistochemistry.
The anti-aging property was also tested in vivo using aged mice. Results: The in vitro experiment revealed that β-carotene could relieve the aging of MSCs, as evidenced by a series of aging marker molecules such as p16 and p β-Carotene appeared to inhibit aging by regulating the KAT7-P15 signaling axis.
Carotenoids are Beta-cxrotene class Bdta-carotene more than naturally occurring aginy Beta-carotene and aging by plants, Chromium and blood sugar control, and photosynthetic bacteria 1. These Increase cognitive agility colored molecules are the sources of the yellow, Optimize athletic recovery, and Beta-carotene and aging colors of many plants. Fruit and vegetables provide most of the 40 to 50 carotenoids found in the human diet. α-Carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, and lycopene are the most common dietary carotenoids 1. α-Carotene, β-carotene and β-cryptoxanthin are provitamin A carotenoids, meaning they can be converted by the body to retinol Figure 1. Lutein, zeaxanthin, and lycopene are nonprovitamin A carotenoids because they cannot be converted to retinol Figure 2.Peifeng Hu, Gaing B. Agnig, Eileen M. Crimmins, Tamara B. Harris, Mei-Hua Huang, Teresa E. It remains unclear Red onion health benefits what extent the associations between low serum beta-carotene concentration and increased risk for cardiovascular disease and cancers are attributable to inflammation.
The objective of Beta-carotenr study was to evaluate simultaneously the effects of serum Beta-carotens concentration and inflammation on the subsequent all-cause mortality risk in high-functioning aginf persons.
The authors conducted Best pomegranate recipes prospective cohort agng using information eBta-carotene participants from the MacArthur Studies of Snd Aging.
Baseline information was Betx-carotene for serum concentrations of Brta-carotene, C-reactive protein, Abd, cholesterols, Natural ways to lower cholesterol albumin; body mass index; waist:hip ratio; Bta-carotene medical conditions; health agging and medications.
Sex-specific univariate and multivariate logistic Beta-carotwne analyses were used Increase cognitive agility annd the effects of agiing beta-carotene, high inflammation burden, or both on 7-year all-cause mortality rates Beta-carotee adjusting for other confounders.
The serum beta-carotene concentration was inversely associated with C-reactive protein and interleukin-6 levels. After adjustment for inflammation markers and other covariates, the relative Beta-cartoene for low beta-carotene for the 7-year all-cause mortality risk adn 2. Bdta-carotene with men Increase cognitive agility high beta-carotene levels and annd inflammation, the multiply adjusted relative risk aginb low beta-carotene Energy-boosting recipes high Beta-caroene burden was gaing.
Low levels of serum beta-carotene Beta-caarotene independently Beta-cqrotene with an increased all-cause mortality risk Beta-czrotene older men, Beta-carotenw after Beta-carotwne Beta-carotene and aging the effects of inflammation and other risk factors.
In men, Bdta-carotene not Increase cognitive agility, a agng effect occurs between low aginng concentration and high inflammation burden in predicting higher mortality rates.
BETA-CAROTENE, an antioxidant, has abd well-established biologic effects, Bsta-carotene as control Bera-carotene cell differentiation and modulation of immune function 1.
Beta-carotenr epidemiologic evidence has suggested that high intake of carotenoid-rich vegetables and fruits and eBta-carotene blood concentrations of beta-carotene are associated with decreased risks for cardiovascular disease Beat-carotene some cancers Muscle mass tracking. However, three large-scale randomized Beta-carotene and aging trials have failed to show benefits of beta-carotene supplementation 5—7.
In fact, Beta-carotene and aging clinical trials reported BBeta-carotene incidence and Bet-carotene rates Beta-carogene lung qnd among heavy Beta-carotenf who Cholesterol-lowering smoothies beta-carotene 5 Beta-caroetne, 6whereas the third Increase cognitive agility, which had the longest follow-up period, showed no increased risk for Beta-carotnee in the Carbohydrate metabolism and weight loss that received beta-carotene supplementation 7.
The contradictory findings aving epidemiologic data and Beta-caroetne results of randomized controlled trials might be explained by, Beta-carotehe example, differences in the amount and Befa-carotene of Website performance analysis and Speed optimization services possible synergy of beta-carotene Beta-cadotene other eBta-carotene in Beta-caroene and vegetables in Beta-czrotene cardiovascular disease and cancer 1.
Another possible explanation for the discrepancy is the presence afing unmeasured or uncontrolled confounders e. Serum markers of inflammation have been identified as independent prognostic indicators for an increased incidence for cardiovascular events snd death 8Beta-carotee. Several cross-sectional studies have shown that inflammation markers are agint associated with serum beta-carotene Bwta-carotene 10— Using data from the Third National Health and Nutrition Survey, Erlinger and colleagues 10 demonstrated a Electrolyte replenishment drink and inverse association Betw-carotene serum beta-carotene and C-reactive agin CRP concentrations in 14, current smokers, ex-smokers, and never-smokers abing 18 years and Betaa-carotene.
The association persisted after adjustment for multiple agingg cardiovascular risk factors. Accordingly, Nutritional requirements before workouts has been postulated that the relation Beta-cxrotene serum Beta-caroteene concentration and disease risk observed in epidemiologic studies might be due to confounding by inflammation The benefit of using more than one marker andd better predict health outcomes has been demonstrated in research into Beta-crotene diseases.
Combining these two markers provides more accurate prediction of the progression Beta-czrotene human Btea-carotene virus disease A Beta-caotene understanding of anf interaction between aginf two processes will not Beta-carotsne improve the ability to Beta-xarotene adverse health outcomes but also help Body composition changes identify subgroups of persons Beta--carotene may benefit the most from clinical interventions.
Therefore, we analyzed the data from the MacArthur Studies of Beta-carootene Aging to Beta-czrotene the potential interaction between serum beta-carotene concentration and inflammation burden on the subsequent 7-year all-cause mortality rate zging high-functioning xging older persons.
Specifically, we Beta-carotenr that Beta-carktene inverse relationship exists between serum Beta-carotene and aging gaing and inflammation aglng high-functioning older persons.
We also hypothesized that agjng beta-carotene concentration and high aginng burden would each predict Betz-carotene risk and that there would be a agijg effect between agjng two in their gaing with higher subsequent overall mortality rate.
The participants in this study were part of the MacArthur Research Network Study of Successful Aging, a subset of the Established Populations for Epidemiologic Studies of the Elderly.
The Eating disorder symptoms of this 7-year cohort study have been described elsewhere Briefly, the Established Populations for Epidemiologic Studies of the Elderly was a community-based cohort study of persons aged 65 years and older residing in Durham, North Carolina; East Boston, Massachusetts; and New Haven, Connecticut.
The participants were eligible for the MacArthur study if they were 70 to 79 years old at inception in and met the criteria designed to identify those functioning in the top one third of the age group.
Selection criteria for cognitive performance included scores of 6 or more correct on the 9-item Short Portable Mental Status questionnaire 15 and ability to remember 3 or more of 6 elements on a delayed recall of a short story. Selection criteria for physical function included no reported disability on a 7-item scale of activities of daily living, no more than 1 disability on 8 items tapping gross mobility and range of motion, ability to hold a semitandem balance for at least 10 seconds, and ability to stand from a seated position 5 times within 20 seconds without using their arms Nine hundred seventy participants agreed to provide blood samples.
Forty-seven 4. Two hundred fifty-one were excluded from analyses because of incomplete information on blood chemistry, serum antioxidant concentrations, or markers of inflammation. Compared with the older persons who had complete information on biomarkers and 7-year mortality risk, persons who were excluded were more likely to be part of a racial group that was not white.
However, the two groups did not differ in the distributions of age, sex, other common cardiovascular risk factors, and cancer.
Serum beta-carotene concentration was determined using an isocratic liquid chromatography method at the Lipids Laboratory, University of Southern California, Los Angeles Serum levels of cholesterol and albumin were measured at Nichols Laboratories, San Juan Capistrano, California, using an automated sequential multiple analyzer.
Deaths among cohort members were identified through contact with next of kin at the time of follow-up for the cohort, on-going local monitoring of obituary notices, and National Death Index searches. At baseline, study participants completed a standardized self-reported assessment of demographic characteristics; medical history, including chronic conditions such as coronary artery disease, hypertension, diabetes, stroke, or cancer; cigarette smoking and alcohol consumption; and use of prescription and over-the-counter medications.
Patients were classified as receiving vitamin A or beta-carotene supplementation if they reported use of vitamin A, beta-carotene, fish oil, or any multivitamins containing vitamin A or beta-carotene. Body mass index weight in kilograms divided by height in meters squared was calculated based on self-reported height and weight at baseline.
The waist:hip ratio was calculated based on waist circumference measured at its narrowest point between the ribs and iliac crest and hip circumference measured at the maximal buttocks.
The 7-year overall mortality risks by the quartiles of serum concentrations of beta-carotene, CRP, and IL-6 were calculated to determine possible threshold effects of these variables on mortality risk.
Because mortality risk was much greater and similar in the bottom two quartiles of beta-carotene level The associations between beta-carotene concentration and other variables were first evaluated in bivariate analyses. For continuous variables, the means and standard deviations were calculated for participants with high or low serum beta-carotene concentrations.
Because the distributions of some of the variables, such as CRP and IL-6, were right skewed, the Wilcoxon rank-sum test was used to determine the significance of the differences. For categorical variables, such as sex, the percentage of participants with that characteristic was calculated for each category of beta-carotene.
Statistical significance was determined using the chi-square test. The difference was considered significant if the two-sided probability value was less than. Because of the significant sex difference in the distribution of beta-carotene concentrations, we performed sex-specific analyses to determine the relations among beta-carotene, inflammation burden, and mortality risk.
Logistic regression models were used to evaluate the associations between low beta-carotene concentration and 7-year mortality risk in men and women separately and to determine how these associations varied after adjustment for other common cardiovascular risk factors.
Based on previous knowledge and significant associations between serum beta-carotene and covariates in bivariate analyses, the final sex-specific multivariate models were adjusted for age; race; serum CRP and IL-6 levels; total and high-density lipoprotein cholesterol levels; body mass index; waist-hip ratio; history of coronary artery disease, hypertension, diabetes, stroke, and cancer; smoking pack-years and alcohol consumption; and vitamin A and beta-carotene supplementation.
The values of CRP and IL-6 were log-transformed in the multivariate models because the distributions of these variables were right skewed. Participants were further classified as having high inflammation burden if they had both high CRP and high IL-6 levels.
To assess the interaction between serum beta-carotene concentration and inflammation, participants with high beta-carotene and low inflammation burden were used as the reference group. The remaining participants were separated again into 3 exposure subgroups: high burden of inflammation only, low beta-carotene only, and both low beta-carotene and high inflammation burden.
Logistic regression models were used to assess the associations between the three exposure categories and 7-year mortality risk in men and women while controlling for the confounding effects of the covariates. The Hosmer-Lemeshow test statistic was used to assess the goodness of fit of the logistic regression models.
To further investigate the possible contributing factors for the observed sex difference in the effect of beta-carotene, variables related to oxidative stress, such as pack-year smoking history and waist:hip ratios, were compared in men and women.
The associations between serum beta-carotene concentration and mortality risk were evaluated in men, while stratifying for oxidative stress as indicated by levels of smoking and waist:hip ratio. All analyses were performed using SAS software, Windows version 8. The average age for the entire cohort was The mean serum beta-carotene concentration in men and women was 0.
Table 1 shows a comparison of baseline characteristics of the study population by high versus low serum concentrations of beta-carotene. The age distribution was similar in different serum concentrations of beta-carotene. The participants with low serum beta-carotene concentrations were more likely to be white and had significantly higher levels of CRP, IL-6, body mass index, and waist:hip ratio but lower serum high-density lipoprotein cholesterol.
Low concentrations of beta-carotene were also positively associated with more pack-years of smoking, current alcohol use, and diabetes, but they were inversely associated with vitamin A or beta-carotene supplementation.
Serum beta-carotene concentration was not associated with history of coronary heart disease, hypertension, stroke, or cancer or with serum total cholesterol and albumin levels. Using different cutoff points to define high beta-carotene concentration, such as top tertile, resulted in minimal changes in the relations between beta-carotene and other common cardiovascular risk factors.
Ninety-eight men In women, the unadjusted relative risk for the effect of low beta-carotene on the overall mortality rate was 0. Even after adjustment for multiple common cardiovascular risk factors, the relationship was not significant. In men, however, low beta-carotene concentration was significantly associated with increased 7-year mortality risk, both unadjusted 1.
Table 3 summarizes the interaction of beta-carotene and inflammation burden with respect to the 7-year overall mortality risk. Women who had both low beta-carotene and high inflammation burden did not have an increased mortality risk compared with the reference group.
In men, the multiply adjusted relative risk for low beta-carotene and high inflammation burden was 3. Men with low beta-carotene or high inflammation levels alone also had greater mortality risks, but the differences were not statistically significant. Using an alternative definition for increased inflammation burden based on high CRP or high IL-6 alone did not change our findings.
Logistic regression modeling was used to assess the relations between the exposures and mortality risk in the entire cohort including both men and women.
The probability value for the interaction term for sex and low beta-carotene and high inflammation burden was 0. Using men with high beta-carotene and high inflammation burden as the reference group, the multiply adjusted relative risk for low beta-carotene and high inflammation burden was 6.
Compared with men with low beta-carotene levels and low inflammation burden, the multiply adjusted relative risk for low beta-carotene and high inflammation was 1. The Hosmer-Lemeshow test did not suggest lack of fit for any of the multivariate models.
The average numbers of pack-years of smoking in men and women were Men also had higher mean waist:hip ratios 0. When medians of the distributions in men were used to define heavy smoking and high waist:hip ratio, the multiply adjusted relative risk of low beta-carotene for all-cause death was The relative risk of low beta-carotene in men with 1 risk factor only was 2.
In men with neither factor, the relative risk was 1. The findings from this population of high-functioning community-dwelling older persons showed that men had lower serum beta-carotene concentrations than did women. Serum beta-carotene was inversely associated with markers of inflammation.
When we studied the relationship between serum beta-carotene and 7-year all-cause mortality risk, we found a striking sex difference.
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Received: 09 February ; Accepted: 20 June ; Published: 19 July Copyright © Corbi, Ali, Intrieri, Modaferri, Calabrese, Davinelli and Scapagnini. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve. Institutional subscriptions. López-Otín C, Blasco MA, Partridge L et al The hallmarks of aging. Cell — Article CAS PubMed PubMed Central Google Scholar. Flanary BE, Sammons NW, Nguyen C et al Evidence that aging and amyloid promote microglial cell senescence. Rejuvenation Res — Article CAS PubMed Google Scholar. Jaskelioff M, Muller FL, Paik JH et al Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature — Ageing Res Rev —8. Saretzki G, Von Zglinicki T Replicative aging, telomeres, and oxidative stress. 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| Access this article | The answer is probably. But we can only speak to the supplements that have under gone clinical trials. Randomized clinical trials means that an investigator collected a group of people. All participants were told that they we getting a supplement. Some got the supplement while others did not they got sugar pills. Then, blinded observers this means that the observer did not know if the person was taking the supplement or the sugar pill graded the person on parameters such as skin wrinkles, skin laxity, and dyspigmentation brown spots. So randomized clinical trials are the only way to see if something actually works. Randomized control trials have shown that beta-carotene, Vitamin E, and collagen peptides help prevent sunburns, reduce wrinkles, and improve skin elasticity. Beta-carotene is a fat-soluble derivative of vitamin A. It has been used to decrease the effect of UV light sun-light on skin. One study compared taking low dose beta-carotene 30mg to high dose 90mg daily. Participants were given 30mg or 90mg of beta-carotene once daily for 3 months. Those who took the low dose 30mg showed improvement in facial wrinkles and elasticity, increased type I procollagen messenger RNA levels, and decreased UV-induced thymine dimer staining DNA damage after sun exposure. The effects of beta-carotene supplementation on increased lung cancer incidence and mortality among smokers have already been described, and several possible biological mechanisms have been proposed. In general, beta-carotene supplementation has not been shown to positively impact cancer prevention. In a systematic review and meta-analysis, no effect of beta-carotene supplementation was observed on the incidence of the total, pancreatic, colorectal, prostate, breast, melanoma, and non-melanoma skin cancers. Beta-carotene may act as a pro-oxidant in the presence of chronic oxidative stress such as smoking 79 and it may enhance the oxidative stress initiated by cigarette smoking and stimulate toxic effects in tissues Our study also found significant inverse associations of beta-carotene supplementation with the risk of HIV-related mortality; however, this was reported in only two studies. This is in line with previous evidence illustrating that persons in all stages of HIV infection generally have low circulating levels of micronutrients, including carotenoids, and low micronutrient concentrations are correlated with HIV disease progression and mortality Overall, the findings of the present meta-analysis of RCTs are inconsistent with previous meta-analyses of observational studies suggesting beneficial effects from high dietary or circulatory beta-carotene-rich fruits and vegetables on all-cause and CVD mortality 25 , Intervention studies are commonly considered to provide conclusive answers, whereas observational studies represent a better picture of the real-world population. There are evident differences between the findings of published trials, which could be explained by population characteristics general, ill, or at high-risk subjects , the different doses of supplementation dietary levels or higher , which can be associated with harmful health effects 81 , and the type of supplement alone or in association. In this last condition, when subgroup analysis was performed, only 4 out of 31 studies reported the use of beta-carotene alone. Indeed, it appears that optimal effects may be obtained with a combination of nutrients at similar levels to a healthy diet. A single antioxidant, such as beta-carotene, given at high doses in subjects with a high risk of diseases, such as smokers and asbestos-exposed workers, might not have considerable benefits and can even have adverse outcomes Another possible reason for the harmful effect in clinical trials involving beta-carotene may be attributed to the purified synthetic form 83 , The effective uptake of synthetic all-trans beta-carotene seems to make the synthetic form more suitable for efficient absorption. The effects of using all-trans synthetic beta-carotene are still not well-understood It is assumed that synthetic beta-carotene rather than natural mixed carotenoids may stimulate cancer formation Ultimately, higher antioxidant intakes, including beta-carotene, are associated with a better diet quality, which indicates higher intakes of nutrients such as fibers, minerals, and flavonoids, and lower intakes of unhealthy nutrients. The present study has several possible limitations. Firstly, in the majority of the studies, synthetic beta-carotene was used. Clinical consequences of using natural beta-carotene are not well-understood because RCTs have yet to be conducted. Additional trials are required to understand the differential results of synthetic beta-carotene as an alternative to natural beta-carotene. Secondly, the results were accompanied by some evidence of heterogeneity. However, the subgroup analyses were performed to overcome this problem, implying that some of the study and participant characteristics were possible sources of the heterogeneity in the data. Thirdly, the database sources did not include EMBASE. However, CENTRAL and Scopus include several articles from EMBASE as the original source. Our study has several strengths, as well. We updated the association of beta-carotene with total mortality, assessed its effects on cause-specific mortality, and showed a significant inverse association between beta-carotene intake and HIV-related mortality. Second, because of no evidence of publication bias, the results have not been altered by this type of bias. In conclusion, we found no evidence of an overall preventive effect of beta-carotene supplements on total, cancer, CVD, and cerebrovascular mortality risk in our meta-analysis of RCTs published over the past 25 years. Instead, beta-carotene supplementation increased the risk of lung cancer mortality but decreased the risk of HIV-related mortality. Surely more studies should be performed to better define this issue, by confirming or denying our results. The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. GC and SD conceived of the presented manuscript. SA, SM, MI, and GS analyzed each article and performed the data extraction independently. VC, MI, and SM drafted the method and result section with the input of GC and SD. GS and VC drafted the introduction and discussion section with the input of SA, GC, and SD. All authors discussed the results and contributed to the final manuscript. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary Figure 1 Quality of the included trials by using the Cochrane Collaboration risk of bias tool. Supplementary Figure 2 Quality of the included trials by using the Cochrane Collaboration risk of bias tool in summary with the studies. Supplementary Figure 5 Subgroup analysis by the type of supplement alone or in association. 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| Benefits Of Beta Carotene For Skin, Hair & Overall Health | Progression of carotid intima-media thickness and plasma antioxidants: the Los Angeles Atherosclerosis Study. Beta-carotene is primarily obtained from natural food sources such as fruits and vegetables. The authors thank Dr. Statistical Analyses We performed statistical analyses using RevMan version 5. The results of metabolic studies suggested that high doses of β-carotene compete with lutein and lycopene for absorption when consumed at the same time J Chromatogr B Biomed Appl. |
| Aging and carotene nutriture | Many individuals want to have bright and healthy skin, and the beauty industry provides a variety of products and treatments to help us achieve that coveted glow. Beta-carotene is a natural substance that has received a lot of attention in recent years for its beauty advantages. Beta-carotene is a red-orange pigment present in a variety of fruits and vegetables, the most prominent of which are carrots, sweet potatoes, pumpkins, and spinach. It belongs to the carotenoid family of chemicals, which operate as antioxidants in the body. When beta-carotene is taken in the diet, it is transformed into vitamin A, a necessary ingredient for keeping healthy skin, among other things. Keep in mind that skincare is a personal journey, and what works for one person might not work for another. If you have specific skin concerns or conditions, it is always best to seek the advice and recommendations of a dermatologist or skincare professional. Beta-carotene, a brilliant red-orange pigment found in many fruits and vegetables, has long been associated with the color of particular foods. However, its significance goes much beyond that of a colorant. This natural component belongs to the carotenoid family, which contains vital minerals with strong antioxidant capabilities. Beta-carotene is well-known for its function in improving overall health and well-being, particularly in skin health. Antioxidants are critical in protecting the body from dangerous free radicals, which are unstable chemicals that can damage cells and lead to aging and other health problems. Beta-carotene is a powerful antioxidant that aids in the neutralization of free radicals and the reduction of oxidative stress. The potential of beta-carotene to be turned into vitamin A in the body is one of its most intriguing properties. Vitamin A is essential for sustaining good vision, immune system support, and optimal organ function. It also plays an important function in skin health, making it a useful tool in skincare. Beta-carotene can do wonders when added to skincare products. Its antioxidant capabilities shield the skin from environmental aggressors, including pollution and UV radiation, aiding in the prevention of premature aging and the maintenance of a youthful complexion. Furthermore, the effect of beta-carotene on increasing skin cell turnover helps to create a smoother and more even skin tone. Furthermore, some research suggests that when combined with other antioxidants like vitamins C and E, beta-carotene can improve the skin's ability to protect itself from harmful UV rays. While sunscreen is still the best way to protect yourself from sun damage, incorporating beta-carotene into your skincare routine may provide additional protection. Beta-carotene is a naturally occurring pigment and a carotenoid, a group of yellow, orange, and red pigments found in plants, algae, and photosynthetic bacteria. It is responsible for the brilliant red, orange, and yellow colors of many fruits and vegetables. Carrots, sweet potatoes, pumpkins, mangoes, and leafy greens like spinach and kale are high in beta-carotene. Beta-carotene is a hydrocarbon made up of long chains of carbon and hydrogen atoms. It is classified as a provitamin A molecule, which means that it can be turned into vitamin A retinol in the body when necessary. Vitamin A is a necessary ingredient for many body activities, including maintaining good vision, boosting the immune system, and fostering optimal organ function. Because of its conversion to vitamin A and function as a powerful antioxidant, beta-carotene is essential in the body. Let us take a closer look at its functions:. The precursor to Vitamin A : Beta-carotene is a provitamin A compound, which means it can be converted in the body into active vitamin A retinol as needed. Vitamin A is required for a variety of bodily functions, including:. Vision : Vitamin A is essential for maintaining healthy vision, especially in low-light conditions. It is a light-sensitive pigment in the retina of the eye that aids in night vision and overall visual acuity. Immune System Support : Vitamin A aids the immune system by maintaining the integrity of the skin and mucous membranes, which serve as barriers against pathogens. Cell Differentiation and Growth : Vitamin A helps immature cells mature and specialize into specific cell types, ensuring proper growth and development. Reproductive Health : Vitamin A is essential for reproductive health, including embryonic development and normal reproductive organ function. Antioxidant Protection : Beta-carotene is a powerful antioxidant that helps protect cells from free radical damage. Free radicals are unstable molecules that can cause cell damage and contribute to a variety of health problems, such as aging, cardiovascular disease, and cancer. By neutralizing these free radicals, beta-carotene aids in the reduction of oxidative stress and its negative effects on the body. Skin Health : The antioxidant properties of beta-carotene are especially beneficial to the skin. Beta-carotene can help maintain skin health and reduce the signs of aging, such as wrinkles and fine lines, by scavenging free radicals and reducing oxidative stress. It also promotes skin cell turnover, resulting in a smoother and more radiant complexion. UV Protection : While not a substitute for sunscreen, beta-carotene and other antioxidants such as vitamins C and E may provide additional protection against sun-induced skin damage. It aids in the neutralization of free radicals produced by UV radiation and may lessen the harmful effects of excessive sun exposure. Heart Health : Some research suggests that a diet high in beta-carotene and other carotenoids may reduce the risk of cardiovascular disease. The antioxidant properties of beta-carotene are thought to contribute to this protective effect. Cancer Prevention : Antioxidants such as beta-carotene are being studied for their potential role in cancer prevention. However, research in this area is complex and sometimes contradictory, and high-dose best beta-carotene supplements re not recommended for cancer prevention because they may be harmful to certain populations. Beta-carotene has several skin health benefits, making it an important component of skincare routines. The following are the main ways that beta-carotene can promote healthy and radiant skin:. Antioxidant Protection : Beta-carotene is a powerful antioxidant that aids in the neutralization of free radicals in the skin. Free radicals are unstable molecules produced by environmental factors such as UV radiation, pollution, and smoking, as well as the body's natural metabolic processes. These free radicals can damage skin cells, causing premature ageing, wrinkles, and other skin problems. By combating free radicals, beta-carotene protects the skin from oxidative stress and keeps it looking young. UV Damage Reduction : While beta-carotene cannot replace sunscreen, some research suggests that when combined with other antioxidants such as vitamins C and E, beta-carotene may improve the skin's ability to defend against the harmful effects of UV radiation. UV rays can cause sunburn, premature aging of the skin, and an increase in the risk of skin cancer. The ability of beta-carotene to reduce UV-induced skin damage can be a valuable supplement to sun protection measures. Skin Cell Turnover : Beta-carotene promotes skin cell turnover, which is necessary for a smooth and radiant complexion. The texture and appearance of the skin improve as old skin cells shed and are replaced by new ones. Regular cell turnover can also help treat issues like uneven skin tone and mild scarring. Anti-Inflammatory Properties : Because beta-carotene has anti-inflammatory properties, it is useful for calming and soothing irritated or inflamed skin. Individuals with sensitive skin or acne may find relief from redness and inflammation when using beta-carotene-containing products. Moisturization and Hydration : Beta-carotene-containing skincare products, such as creams and serums, frequently contain moisturizing properties that keep the skin hydrated. Skin that is well-hydrated appears plump and healthy, reducing the appearance of fine lines and wrinkles. It is recommended to use a moisturiser suitable for your skin type. Enhanced Skin Brightness and Glow : Beta-carotene contributes to a healthy skin tone, giving the complexion a natural radiance and glow. By promoting cell turnover and supporting overall skin health, beta-carotene can help achieve a more luminous appearance. Combating Premature Aging : Beta-carotene's antioxidant properties help protect the skin from environmental stressors such as UV rays and pollution. This protection can help postpone the appearance of signs of premature aging, such as fine lines and wrinkles. Skin Repair and Healing : Because beta-carotene aids in the skin's natural repair processes, it is useful for treating minor skin damage such as dryness or mild sunburn. One of beta-carotene's most important contributions to overall health and well-being is its antioxidant effect. As an antioxidant, beta-carotene is essential for neutralizing harmful free radicals in the body. Let us look more closely at this process and how it affects our health:. What are free radicals? Free radicals are unstable molecules with an unpaired electron in their outer shell. This makes them highly reactive and prone to stealing electrons from nearby molecules in order to stabilize themselves. They can damage cell membranes, proteins, and even DNA during this process. UV radiation, pollution, and tobacco smoke, as well as naturally occurring metabolic processes within the body, can all produce free radicals. Antioxidant Defence : Antioxidants are molecules that can donate electrons to free radicals while remaining stable. In other words, they act as "electron donors" to neutralize free radicals and keep them from doing harm. Antioxidants reduce oxidative stress by maintaining a balance between free radicals and healthy molecules in the body. Beta-Carotene as an Antioxidant : Beta-carotene is a powerful antioxidant that can donate electrons to neutralize free radicals. Because of its molecular structure, it is particularly effective as a provitamin A compound in this role. When beta-carotene comes into contact with a free radical, it can provide an electron without becoming unstable. This stabilizes the free radical, preventing it from causing damage to other cellular components. Reducing Oxidative Stress : Oxidative stress occurs when the body's free radicals and antioxidants are out of balance. If there are more free radicals than antioxidants, oxidative stress can cause cellular damage and contribute to a variety of health problems, including aging, cardiovascular disease, cancer, and inflammatory conditions. Health Benefits : Beta-carotene provides numerous health benefits by neutralizing free radicals and reducing oxidative stress. These advantages include:. Skin Health : The antioxidant properties of beta-carotene protect the skin from free radical damage, assisting in the maintenance of a youthful complexion and the reduction of aging signs such as wrinkles and fine lines. Heart Health : Antioxidants, including beta-carotene, are linked to a lower risk of cardiovascular disease by preventing blood vessel damage and reducing inflammation. Cancer Prevention : According to some research, a high-antioxidant diet may help reduce the risk of certain types of cancer by protecting cells from DNA damage and mutations. Immune Support : Antioxidants such as beta-carotene help the immune system by assisting the body in fighting infections and diseases. Balanced Diet and Antioxidant Synergy : While beta-carotene is an important antioxidant, it is also important to consume a variety of antioxidants. Different antioxidants work together to combat free radicals throughout the body. A colorful array of fruits and vegetables in your diet provides a diverse range of antioxidants to support overall health. UV ultraviolet protection is critical for maintaining skin health and preventing a variety of skin problems. The sun emits UV radiation, which includes UVA, UVB, and UVC rays. UVC rays are absorbed by the Earth's atmosphere and never reach the surface, whereas UVA and UVB rays can penetrate and cause skin damage. Here's why UV protection is so important for skin health:. Preventing Sunburn : UVB rays are to blame for sunburn. Sunburn is a visible sign of skin damage that is characterized by redness, pain, and skin peeling. Repeated sunburns increase the risk of skin aging and cancer. Preventing Premature Aging : Prolonged exposure to UV radiation accelerates the aging process of the skin. It causes the breakdown of collagen and elastin fibres, which are responsible for keeping the skin firm and supple. As a result, wrinkles, fine lines, and sagging may appear on the skin. Skin Cancer Risk Reduction : UV radiation is a major environmental risk factor for skin cancer. It can cause DNA damage in skin cells, which can lead to mutations and the development of skin cancers such as basal cell carcinoma, squamous cell carcinoma, and melanoma. Maintaining Even Skin Tone : UV rays can stimulate melanin production, resulting in uneven skin tone, hyperpigmentation, and the appearance of dark spots or age spots. To protect your skin from the damaging effects of UV radiation and to keep it healthy:. Sunscreen : Wear broad-spectrum sunscreen with an SPF sun protection factor of 30 or higher whenever you go outside, even on cloudy days. Reapply every two hours, or sooner if swimming or sweating. Seek Shade : During peak sun hours usually between 10 a. and 4 p. Cover Up : Wear protective clothing, such as wide-brimmed hats, long-sleeved shirts, and sunglasses with UV protection. Avoid Tanning Beds : Tanning beds emit harmful UV radiation, increasing the risk of skin cancer and premature aging. It is best to avoid them completely. Stay Hydrated : Drink plenty of water to keep your skin hydrated, as well-hydrated skin is better able to protect itself from damage. Sun Smart : Be aware of your skin type and sun sensitivity. Individuals with fair skin and a history of sunburn or skin cancer should take extra precautions. Anti-aging and skin regeneration are key parts of skincare that attempt to keep skin looking young and address signs of aging. Sun exposure, lifestyle choices, genetics, and the natural aging process all contribute to changes in the look of the skin over time. Here are several anti-aging and skin rejuvenation methods:. Sun Protection : One of the most important steps in anti-aging is protecting your skin from harmful UV rays. UV rays hasten skin aging, causing wrinkles, fine lines, hyperpigmentation, and loss of elasticity. To avoid UV damage, apply broad-spectrum sunscreen with an SPF of 30 or higher every day, seek shade when the sun is at its strongest, and wear protective clothing. Active Ingredients in Skincare : Include skincare products with active ingredients known to promote skin rejuvenation and collagen production. The following are some common anti-aging ingredients:. Retinoids : These vitamin A derivatives have been shown in clinical studies to reduce the appearance of wrinkles, increase collagen production, and improve skin texture. Vitamin C : A powerful antioxidant that helps brighten the skin, even out skin tone, and stimulate collagen synthesis. Peptides : Short chains of amino acids that may aid in collagen production and skin firmness. Hyaluronic Acid : A hydrating ingredient that helps the skin retain moisture, reducing the appearance of fine lines and plumping it. Glycolic Acid and Alpha Hydroxy Acids AHAs : Alpha hydroxy acids AHAs exfoliate the skin, promoting cell turnover and improving skin texture. Hydration and moisturization : Keeping the skin hydrated is critical for maintaining its elasticity and plumpness. Use moisturizers that are appropriate for your skin type to lock in moisture and prevent dryness. Healthy Eating : A well-balanced diet full of vitamins, minerals, and antioxidants supports the health of the skin. Fruits, vegetables, and nuts are examples of foods high in antioxidants that can help fight free radicals and lessen oxidative stress on the skin. Hydration from Within : Keep your body and skin hydrated by drinking plenty of water. Hydration is essential for a healthy, radiant complexion. Lifestyle Choices : Avoid smoking and limit alcohol consumption, as smoking and excessive alcohol intake can accelerate skin aging and cause premature wrinkles. Sleep and Stress Management : Getting enough quality sleep and managing stress is essential for skin rejuvenation. Lack of sleep and chronic stress can cause increased inflammation and affect the appearance of the skin. Professional Treatments : Depending on your skin's specific needs and concerns, seek the advice of a dermatologist or licensed skincare professional before undergoing treatments such as chemical peels, microdermabrasion, laser therapy, or dermal fillers. Incorporating beta-carotene into your skincare routine can help you achieve a radiant complexion while also promoting skin health. Here are some ideas for incorporating beta-carotene into your daily skincare routine:. Choose Beta-Carotene-Rich Skincare Products : Look for beta-carotene-containing skincare products or plant extracts that contain this compound. Serums, moisturizers, facial oils, and masks are examples of such products. Check the labels to see if beta-carotene is listed as an active ingredient. Consider Using a Beta-Carotene Face Oil : Incorporate a beta-carotene-infused face oil into your routine. These oils can be applied to the skin after cleansing and before moisturizing to deliver a concentrated dose of beta-carotene and other beneficial nutrients. Apply a Beta-Carotene Serum : Beta-carotene serums can be applied before your regular moisturizer. They are light and easily absorbed, making them appropriate for daily use. Beta-carotene-containing serums can help protect the skin from free radicals and promote a more radiant complexion. Incorporate a Beta-Carotene Mask : Incorporate a beta-carotene-rich mask into your weekly skincare routine. Masks can give your skin an extra boost of antioxidants and hydration. Eat Beta-Carotene-Rich Foods : In addition to topical applications, eating beta-carotene-rich foods can help your skin from the inside out. Include carrots, sweet potatoes, pumpkin, mangoes, and leafy greens in your diet. These foods not only provide beta-carotene but also offer a range of other beneficial nutrients for skin health. Consider Supplements : If you have a vitamin A deficiency or find it difficult to consume enough beta-carotene-rich foods, consult your doctor about beta-carotene supplements. Some got the supplement while others did not they got sugar pills. Then, blinded observers this means that the observer did not know if the person was taking the supplement or the sugar pill graded the person on parameters such as skin wrinkles, skin laxity, and dyspigmentation brown spots. So randomized clinical trials are the only way to see if something actually works. Randomized control trials have shown that beta-carotene, Vitamin E, and collagen peptides help prevent sunburns, reduce wrinkles, and improve skin elasticity. Beta-carotene is a fat-soluble derivative of vitamin A. It has been used to decrease the effect of UV light sun-light on skin. One study compared taking low dose beta-carotene 30mg to high dose 90mg daily. Participants were given 30mg or 90mg of beta-carotene once daily for 3 months. Those who took the low dose 30mg showed improvement in facial wrinkles and elasticity, increased type I procollagen messenger RNA levels, and decreased UV-induced thymine dimer staining DNA damage after sun exposure. Another study compared 25mg beta-carotene to 25mg beta-carotene and vitamin E mg or IU supplementation. Using a blue-light they exposed the participants back skin to light after taking wither supplements for 8weeks. They found that the combination group beta-carotene and vitamin E had a lower level of sunburn skin redness after being exposed to the blue light. Thus, the investigators concluded that the combination of beta-carotene and vitamin E supplementation can reduce the risk of sunburn. |
| Carotenoids | Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition. Supplements containing a mixture of carotenoids may include α-carotene. D iscussion. All authors discussed the results and contributed to the final manuscript. It is a single homolog of nearly known carotenoids, several of which can be converted into vitamin A and occur as cis-trans forms at a varying ratio 7 , 8. Sign In or Create an Account. UV Protection : Although not a replacement for sunscreen, topical beta-carotene may provide additional protection against the harmful effects of UV radiation when combined with other antioxidants. |
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