One time Purchase £ Subscribe and save. Frequency Deliver every month. Add to cart. NATURAL NOOTROPIC. Allergen information. Product guide. Each bottle contains 60 capsules. This product is not made with any ingredients containing gluten, wheat, dairy, soya, eggs, fish, shellfish, tree nuts or peanuts.

Our manufacturing facilities have strict allergen management procedures in place, however we cannot guarantee that our products are made in allergen-free facilities without the very small risk of trace amounts of cross contamination.

No artificial colours or flavours; not tested on animals; non-GMO; suitable for vegetarians and vegans; c ompatible with halal and kosher diets. We often get asked many questions about our products, so our nutritionists have compiled this downloadable product information guide to ensure you get the most from taking FOCUS.

Find out when to take it, at what dose and how to maximise absorption for optimum results. Synergistic caffeine and brain-boosting amino acids. B-vitamins support the production of ATP - the energy source of the body and brain.

Together with zinc and copper, B-vitamins support the production of neurotransmitters, required for a balanced mood, whilst vitamin B5 supports mental alertness.

Feel the benefits for over 4-hours. Whilst herbal ingredients require a build-up of ingredients over time for benefits, we use nutrients that support quick-action.

Simply take capsules minutes before desired effects and preferably on an empty stomach. For longer-lasting action, the dose can be repeated after hours.

Keep the brain energised. The brain relies on an adequate supply of B-vitamins to support the production of ATP, the body's energy currency.

We provide a full-spectrum of B-vitamins in bioactive forms for maximum benefits. Additionally, zinc and caffeine play important roles in brain function by influencing neurotransmission and increasing acetylcholine.

Caffeine at low to moderate doses has been shown to improve attention and reaction time, and in combination with L-Theanine, increases accuracy when switching between tasks.

L-Theanine increased brain-derived neurotrophic factor BDNF levels, which positively affects moods, whilst reducing cortisol levels, the body's stress hormone. At doses as low as 50mg, L-Theanine has been shown to increase relaxation while improving focus and attention.

Taurine also acts as a calming neurotransmitter by activating GABA and glycine receptors to positively influence mood. Fatigue is also linked with low levels of ATP and may result from a reduction in the supply of oxygen to the brain and muscles.

All of the B-vitamins are essential for the production of ATP and support oxygen transport in the body. Expertly formulated in-house to offer superior bioavailability. Exceptional ingredients, GMP manufactured with finished product testing.

Be kind to your health with advanced everyday nutrition. The world is changing. We are leading fuller, longer lives but we are also being challenged in new and unexpected ways. Gradually, the foundations of great health are being eroded: nourishment from local, seasonal food; clean air and water; rejuvenating sleep; regular, natural movement; living a low-stress life.

Staying healthy now requires a commitment to healthy nutrition and an active outdoor lifestyle. At Igennus, we believe in the power of food coupled with careful supplementation to boost, protect and manage our health throughout our lifetime. Scientifically developed by our in-house team, our expertly formulated nutrition supplements optimise bioavailability and work in harmony with your body for superior results.

Customer Reviews Based on 16 reviews Write a review. Related products. Sale Off. Pharmepa RESTORE - mg Pure EPA Omega-3, 1-Month Supply, 60 Softgels. There are, however, some negative side effects to still keep in mind. Each day, billions of people rely on caffeine to wake up, or to get through that night shift or an afternoon slump.

In fact, this natural stimulant is one of the most commonly used ingredients in the world 1. Caffeine is a natural stimulant most commonly found in tea, coffee, and cacao plants. It works by stimulating the brain and central nervous system, helping you stay alert and prevent the onset of tiredness.

Historians track the first brewed tea as far back as B. Coffee was reportedly discovered many years later by an Ethiopian shepherd who noticed the extra energy it gave his goats.

Caffeinated soft drinks hit the market in the late s and energy drinks soon followed. It helps you stay awake and can stave off tiredness.

From there, it travels to the liver and is broken down into compounds that can affect the function of various organs. It functions by blocking the effects of adenosine, which is a neurotransmitter that relaxes the brain and makes you feel tired 2. Normally, adenosine levels build up over the day, making you increasingly more tired and causing you to want to go to sleep.

Caffeine helps you stay awake by connecting to adenosine receptors in the brain without activating them. This blocks the effects of adenosine, leading to reduced tiredness 3.

It may also increase blood adrenaline levels and increase brain activity of the neurotransmitters dopamine and norepinephrine 3. This combination further stimulates the brain and promotes a state of arousal, alertness, and focus.

Because it affects your brain, caffeine is often referred to as a psychoactive drug. For instance, the amount found in one cup of coffee can take as little as 20 minutes to reach the bloodstream and about 1 hour to reach full effectiveness 1.

It stimulates the brain by blocking the effects of the neurotransmitter adenosine. These natural sources are then harvested and processed to produce caffeinated foods and beverages. Here are the amounts of caffeine expected per 8-ounce mL serving of some popular beverages 1 , 4 :.

Some foods also contain caffeine. For instance, 1 ounce 28 grams of milk chocolate contains 1—15 mg, whereas 1 ounce of dark chocolate has 5—35 mg 4. You can also find caffeine in some prescription or over-the-counter drugs like cold, allergy, and pain medications.

This causes a relative increase in other signaling molecules, such as dopamine and norepinephrine 5 , 6. One review reports that after participants ingested A study found that a second cup of coffee produced no further benefits unless it was consumed at least 8 hours after the first cup 9.

Practically speaking, consuming mg of caffeine per day may allow you to burn an extra 79 calories daily However, a year study on caffeine and weight gain noted that the participants who drank the most coffee were, on average, only 0.

Caffeine may boost metabolism and promote fat loss, but these effects are likely to remain small over the long term. When it comes to exercise , caffeine may increase the use of fat as fuel. This is beneficial because it can help the glucose stored in muscles last longer, potentially delaying the time it takes your muscles to reach exhaustion 20 , Caffeine may also improve muscle contractions and increase tolerance to fatigue 1.

Researchers observed that doses of 2. Doses as low as 1. Finally, it may also reduce perceived exertion during exercise by up to 5. Consuming small amounts of caffeine about an hour before exercise is likely to improve exercise performance.

One thing to keep in mind is that caffeine may slightly raise blood pressure in some people. However, this effect is generally small 3—4 mmHg and tends to fade for most individuals when they consume coffee regularly 32 , 33 , 34 , It may also protect against diabetes.

This indicates that other beneficial compounds in coffee can also protect against type 2 diabetes Caffeinated beverages like coffee and tea may reduce the risk of heart disease and type 2 diabetes, although this may depend on the individual.

Keep in mind that coffee also contains other substances that improve health. Some benefits listed above may be caused by substances other than caffeine. Drinking coffee may promote a healthy liver, skin, and digestive tract. It may also prolong life and help prevent several diseases. Some side effects linked to excess intake include anxiety, restlessness, tremors, irregular heartbeat, and trouble sleeping Too much caffeine may also promote headaches, migraine, and high blood pressure in some individuals 54 , In addition, caffeine can easily cross the placenta, which can increase the risk of miscarriage or low birth weight.

Pregnant women should limit their intake 54 , 56 , Individuals taking the muscle relaxant Zanaflex or the antidepressant Luvox should avoid caffeine because these drugs can increase their effects Caffeine can have negative side effects in some people, including anxiety, restlessness, and trouble sleeping.

Both the U. Department of Agriculture USDA and the European Food Safety Authority EFSA consider a daily intake of mg of caffeine to be safe. This amounts to 2—4 cups of coffee per day According to the American College of Obstetricians and Gynecologists, pregnant women should limit their daily intake to mg A caffeine intake of mg per dose, and up to mg per day, is generally considered safe.

Pregnant women should limit their daily intake to mg or less. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Independent of conditions, the whole brain analysis indicated a significant difference in BOLD activity between 3- and 0-back Fig. However, these load-dependent activities did not show a significant difference among the three conditions.

The effects of workload and conditions on blood-oxygen-level-dependent BOLD activity. a brain regions showing increased activities during 3-back compared to 0-back.

b brain regions showing decreased activities during 3-back compared to 0-back. e Eigenvariates of the significant clusters in hippocampus and left and right middle frontal gyri. The black asterisks and black lines indicate the statistically significant contrast, while the grey asterisk and the grey line indicate the contrast only exhibited at trend differences.

We did not observe a significant difference in the regional activation between the withdrawal and the placebo conditions. Based on the reduced hippocampal activity and the at-trend increased activation in the middle frontal gyrus, we hypothesized that caffeine might strengthen the anticorrelation between these two regions.

We exploratorily examined the functional connectivity between the bilateral hippocampus and the middle frontal gyri. However, we did not find a significant difference in the hippocampus-middle frontal gyrus correlations among conditions, irrespective of workloads. Our previous analysis 40 on the same participants revealed a significant association between a larger reduction in the right hippocampal volume and a higher area under the curve of caffeine plus its main metabolite, paraxanthine AUC-CAPX.

Based on the similarity of a reduced hippocampal activity in the current analysis, we examined the association between the reduction of hippocampal BOLD activity and the AUC-CAPX during the 12 h between the pre-caffeine- and the scan time methodology details see Similar to the volumetric changes reported previously, we found a larger reduction in the hippocampal BOLD activity associated with a higher AUC-CAPX h.

We address the statistics and results in the Supplement Fig. Here we investigated working memory performance and underlying cerebral correlates after 10 days of regular caffeine intake and after caffeine withdrawal, compared to a day placebo condition. Our data suggest that daily moderate-dose caffeine intake leads to a compromised working memory function, which may remain reduced during acutely withdrawing from the daily intake.

However, similar to earlier studies 17 , 18 , 19 , changes in behavioral performance did not appear commensurately or similar as in brain activity patterns, which did not show clear-cut differences among conditions. Considering that acute caffeine might increase the neural metabolic demand for the same performance as suggested by the earlier evidence 17 , 18 , 19 , we speculate that such a demand may not be fulfilled during daily intake and therefore lead to a worse behavioral outcome.

In addition, the reaction time in 0-back in our data confirm that daily intake leads to a tolerance to caffeine in the classical psychostimulation, e. reducing reaction time. Caffeine withdrawal, on the other hand, leads to an impaired attention process.

Finally, potentially reflecting the functional expression of the reduced right hippocampal grey matter volume previously reported 40 , our data further add that daily caffeine intake may inhibit the hippocampal activity during memory task performance.

Compared with the neuroprotective evidence of chronic caffeine intake in disease models, our findings suggest that daily caffeine intake can lead to a divergent outcome a healthy central neural system.

The performance in a N-back task involves multiple hierarchical cognitive processes which heavily depend on different workloads. Earlier similar fMRI studies examining acute effects of caffeine using working memory tasks with high versus low-workload contrasts reported an increased task-related activity in the medial frontal region 17 , DLPFC 18 , and parietal regions 19 after acute caffeine intake without behavioral improvement or even with a worse outcome in the demanding workload trials i.

The evidence implicates that caffeine may not increase the brain activity as to enhancing the capacity but rather increasing the neural metabolic demands for the same level of behavioral performance. Our findings on a poorer working memory performance without a significant change in the task-related activity therefore might be reflecting a failure in fulfilling such increased demands, thereby decreasing performances.

Furthermore, the intermediate level of working memory reduction in the withdrawal between caffeine and placebo conditions further indicates that the presence and the dissipation of caffeine may be the key contributors to the changes of working memory performance.

Notably, since participants took only 9 days of caffeine before the discontinuation in the withdrawal condition, the less reduction in the working memory performance in the withdrawal relative to the caffeine condition can be either due to a mitigation from the caffeine effect or simply because of a shorter caffeine exposure.

In any case, working memory function seems to be altered in close response to the caffeine exposure and its dissipation, which appears to be contrary to the basic attention process and motor control which express the typical adaptions in the adenosine signaling over daily caffeine intake and caffeine withdrawal detailed in the next section.

The absence of the classic psychostimulation of caffeine and the impaired attention in caffeine withdrawal, as indexed by the performance in 0-back, corroborate earlier results in a psychomotor vigilance task 42 suggesting a tolerance to daily caffeine intake in the vigilance enhancement as well as an impairment in vigilance in caffeine withdrawal Such responses correspond to the cumulated evidence on an adapted adenosine system during chronic caffeine exposure.

The inhibitory adenosine A1R and facilitatory A2AR modulate the striatal neurotransmission through the allosteric interactions in the G-protein coupled receptor heterodimers, such as A1-dopamine D1 receptor heterodimer, A2A-dopamine D2 receptor heterodimer, as well as A2A-D2-metabolic glutamate receptors 5 mGluR5 heterotetramer 51 , 52 , Caffeine, by non-selectively blocking adenosine receptors, acutely facilitates dopamine and glutamate transmission 22 , 54 , 55 , 56 , 57 , 58 and behaviorally reduces fatigue 13 , 59 as well as enhances attention 8.

However, daily caffeine intake can instead lead to an adaption in the adenosinergic properties, specifically an upregulation in the A1R signaling by increasing genetic expressions 27 , upregulating affinity for agonists 60 , 61 , 62 , 63 and downregulating affinity for antagonists 23 , 26 , as well as an accumulation in the extracellular endogenous adenosine concentration Such adaptions not only attenuate the behavioral effects of caffeine as a tolerance effect 26 , 27 , 28 but also result in an strengthened inhibitory adenosine signaling after withdrawing from caffeine.

The increased adenosine signaling may underlie the poorer attention in caffeine withdrawal through the inhibited striatal dopamine and glutamate transmission 64 , 65 , Furthermore, ample in vitro evidence shows that, in contrast to the propensity of A1R in developing tolerance to caffeine, A2AR properties and the behavioral effects of A2AR antagonism are rather resistant over daily caffeine intake 26 , 67 , 68 , 69 , As elaborated earlier, the responses of working memory and attention processes to daily caffeine intake and caffeine withdrawal seem to follow distinct patterns.

It is possible that the changes in the attention process is in expression of the adapted adenosine properties underlying the behavioral tolerance to caffeine and an upregulated inhibitory signal in caffeine withdrawal, while the changes in working memory function is primarily in expression of the A2AR antagonism by caffeine and the reduced antagonism in caffeine withdrawal.

The resistance of A2AR antagonism may further explain the reduced hippocampal activity during daily caffeine intake. Caffeine intake was found to reduce hippocampal long-term potentiation LTP , a marker of synaptic plasticity, in freely behaving rodents 71 and LTP-like cortical excitation in healthy people It is believed that the inhibited LTP by caffeine is primarily mediated by the antagonism of A2AR 73 , 74 , 75 through the A2AR-modulated glutamate transmission in hippocampus 76 , Adenosine A2AR in the hippocampus is found to control the presynaptic glutamate release 78 and modulate the postsynaptic N-methyl-D-aspartate receptor NMDAR signaling through the co-localization between A2AR and mGluR5 Behaviorally, chronic caffeine administration can lead to a cross-tolerance to the NMDAR antagonist, MK, in the MKinduced hyperlocomotion in rodents 80 , Hence, during daily caffeine exposure, the maintained reduced LTP by hippocampal A2AR antagonism might underlie the inhibited hippocampal activity as observed in the current study.

Notably, there is evidence in non-caffeine consumers that decaffeinated espresso can impede the increase in cortical excitability triggered by a transcranial alternating current stimulation in a placebo condition The evidence implicates that other biocompounds e.

Indeed, the selection of non-caffeine consumers, who most likely bear a genetic trait in the A2AR encoding gene ADORA2A for an extreme sensitivity to caffeine 84 , 85 , 86 , 87 , 88 , may also be a critical factor enabling the minor amount of caffeine contained in the decaffeinated espresso to reduce cortical excitability.

Nevertheless, our data acquired in regular caffeine consumers highlights that solely caffeine, when consuming daily, may also lead to an inhibited activity as well as structural plasticity 40 in hippocampus. The predominance of A2AR antagonism underlying the effects of daily caffeine intake might also serve as a neurobiological fundament of the divergent impacts of caffeine on healthy versus clinical populations.

Overexpressed A2ARs are found to be associated with a working memory deficit 95 , impaired motor control 96 and catalepsy 97 , as well as depression and anxiety Normalizing the A2AR signals with chronic administration of caffeine or selective A2AR antagonist therefore may lead to an amelioration of the behavioral alterations.

However, a constant A2AR antagonism with a decreased counteraction from A1R antagonism due to the daily caffeine-induced adaptions may imbalance the originally healthy dopamine and glutamatergic transmission 22 , 24 , 54 , 98 , leading to compromised neurobehavioral functions.

More studies are warranted to stratify different populations and identify those who may be benefited most from a regular use of caffeine. We observed a reduced BOLD activity in the medial frontal gyrus encompassed by dorsolateral prefrontal cortex, DLPFC in the withdrawal condition compared to caffeine.

The DLPFC is critical for the execution of attention procesess 99 , Yet, daily caffeine intake elevates the neural engagement in DLPFC without improving attention performance, which is strikingly similar to the earlier evidence on the increased task-related brain activity with an absence of working memory improvement 17 , 18 , Furthermore, the reduced DLPFC activity in the withdrawal condition supports the observed poorer attention performance.

Neocortex, including DLPFC, is predominantly abundant with A1Rs and scarcely expresses A2Rs , Therefore, in DLPFC, the physiological expressions of adapted A1R signaling in response to daily caffeine exposure may prevail.

As elaborated in the earlier paragraph, A1R signaling is prone to be upregulated over the caffeine exposure, leading to a behavioral tolerance to caffeine and a strengthened inhibitory adenosine signal after caffeine cessation. These characteristics of A1R-mediated neurobehavioral effects may explain the elevated DLPFC activity without an improved attention process in the caffeine condition as well as the reduced DLPFC activity and the poorer attention process in the withdrawal condition.

To summarize in a perspective of the hierarchical cognitive functions, caffeine intake in general seems to gain difficulty in cognitive engagement: at a behavioral level, pure attentional processing can be enhanced by acute caffeine 8 but not by daily caffeine except for increasing the associated neural activity.

Working memory performance, on the other hand, cannot be enhanced by acute caffeine intake except for increasing the associated neural activity 17 , 18 , 19 , furthermore, it is hindered by daily caffeine intake with no effects on associated neuroactivity.

More studies are warranted to explore the molecular mechanism underlying the caffeine effects on different levels of cognitive functions as well as the dissociated neural and behavioral outcomes. A few limitations in our study should be considered when interpreting our data.

First, caffeine can induce neurovascular uncoupling by reducing baseline CBF and increasing baseline cerebral metabolic rate of oxygen consumption CMRO2 Although we mitigated the deviation by statistically adjusting for the variances of resting cerebral blood flow, if one were to resolve the issue more precisely, a simultaneous acquisition of CBF and BOLD activities would be recommended Second, despite a crossover design, the results might still be restricted by a relatively small sample size.

In addition, due to a confined sample size, we limited the investigation on a male-only population in order to reduce the variability in caffeine metabolism derived from hormonal fluctuations 43 , 44 and contraceptives 45 , 46 in females. The minimization of variances may yield a better power for true pharmacological effects, but it is also at the expense of a good generalizability of the findings.

Since we also found an association between the individual caffeine metabolism, as indexed by the AUC of caffeine and paraxanthine, and hippocampal activity, it is important to note that the observed caffeine effects in the current study might vary among females exhibiting different metabolism of caffeine or its metabolites due to influence of the estrus cycle 43 , 44 or hormonal contraceptives Lastly, it is of importance to be aware that the observed effects in the current study were yielded from pure caffeine administration.

The common caffeinated dietary, e. Thus, one should not exclude a potential beneficial effect which caffeinated dietary may bring. In conclusion, daily moderate-dose caffeine intake might lead to a compromised working memory performance, which remains reduced after withdrawing caffeine for 36 h.

The impaired behavioral performance, together with the absence of changes in the task-related neural activity, suggest that the increased neural metabolic demand for working memory execution by acute caffeine 17 , 18 , 19 may be impeded over daily intake.

Furthermore, daily caffeine intake, potentially through a maintained A2AR antagonism, may inhibit hippocampal activity, which is implicated as a functional consequence of the hippocampal grey matter plasticity in our earlier report Nevertheless, the crossover design in the current study also suggests that the caffeine-associated responses may be restorable within 10 days of abstinence.

Taken together, our findings, comparing to earlier evidence, reveal that the impacts of daily caffeine intake in young healthy adults might be divergent from an acute intake or from a deficient or pathological neural system.

The divergency warrants more systematic investigations on the caffeine effects on different adenosine properties and functions in a stratified study population in order to provide precise recommendations on the caffeine use as a neuroprotective agent.

All the data reported in this manuscript is available for research purpose upon requests. Please contact Lin. YuShiuan16 gmail. com for the request. Barone, J. in Caffeine: Perspectives from Recent Research.

Dews 59—73 Springer, Frary, C. Food sources and intakes of caffeine in the diets of persons in the United States. Article Google Scholar.

Mitchell, D. Beverage caffeine intakes in the U. Food Chem. Article CAS Google Scholar. Urry, E. Adenosine, caffeine, and performance: From cognitive neuroscience of sleep to sleep pharmacogenetics.

Barry, R. et al. Caffeine effects on resting-state arousal. Federation Clin. Clark, I. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Med. Nehlig, A. Is caffeine a cognitive enhancer?. JAD 20 Suppl 1 , S Einother, S. Caffeine as an attention enhancer: Reviewing existing assumptions.

Psychopharmacology , — Diamond, A. Executive functions. Malenka RC, N. in Molecular Neuropharmacology: A Foundation for Clinical Neuroscience ed Brown RY Sydor A — McGraw-Hill Medical, Morava, A. Effects of caffeine and acute aerobic exercise on working memory and caffeine withdrawal. Article ADS CAS Google Scholar.

Haskell, C. The effects of L-theanine, caffeine and their combination on cognition and mood. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Smith, A. Breakfast cereal and caffeinated coffee: Effects on working memory, attention, mood, and cardiovascular function.

Schmitt, J. Memory functions and focussed attention in middle-aged and elderly subjects are unaffected by a low, acute dose of caffeine.

Health Aging 7 , — CAS Google Scholar. García, A. Acute effects of energy drinks in medical students.

Koppelstaetter, F. Does caffeine modulate verbal working memory processes? An fMRI study. Neuroimage 39 , — Klaassen, E. The effect of caffeine on working memory load-related brain activation in middle-aged males.

Neuropharmacology 64 , — Haller, S. Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study.

Neuroscience , — Caffeine impact on working memory-related network activation patterns in early stages of cognitive decline.

Neuroradiology 59 , — Conlay, L. Caffeine alters plasma adenosine levels. Nature , Quarta, D. Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens: Effects of chronic caffeine exposure. x Kaplan, G. Caffeine treatment and withdrawal in mice: Relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding.

Ciruela, F. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1—A2A receptor heteromers. Ferre, S.

Adenosine A1—A2A receptor heteromers: New targets for caffeine in the brain. Front Biosci. Karcz-Kubicha, M. Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.

College Neuropsychopharmacol. Svenningsson, P. The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions.

Newland, M. Behavioral characterization of caffeine and adenosine agonists during chronic caffeine exposure. Espinosa, J. Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia.

JAD 34 , — Kaster, M. Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Prediger, R. Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats: Involvement of adenosine A1 and A2A receptors.

Aging 26 , — Laurent, C. Aging 35 , — Temido-Ferreira, M. Age-related shift in LTD is dependent on neuronal adenosine A 2A receptors interplay with mGluR5 and NMDA receptors.

Psychiatry 25 , — Varani, K. FASEB J. Federation Am. Cunha, R. How does adenosine control neuronal dysfunction and neurodegeneration?. Canas, P. Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Aging 30 , — Diógenes, M. Influence of age on BDNF modulation of hippocampal synaptic transmission: Interplay with adenosine A2A receptors.

Hippocampus 17 , — Rebola, N. Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. Viana da Silva, S. Lin, Y. Daily caffeine intake induces concentration-dependent medial temporal plasticity in humans: A multimodal double-blind randomized controlled trial.

Cortex 31 , — Juliano, L. A critical review of caffeine withdrawal: Empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology , 1— Weibel, J. Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake.

Psychiatry 99 , Lane, J. Menstrual cycle effects on caffeine elimination in the human female. Bruguerolle, B. Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics. Interindividual differences in caffeine metabolism and factors driving caffeine consumption.

Arnaud, M. in Caffeine, Coffee and Health ed S. Garattini 43—95 Raven Press, Schmidt, C. Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area. Science , — Henrik Singmann, B. afex: Analysis of Factorial Experiments.

Bates, D. Fitting linear mixed-effects models using lme4. i01 Time to recover from daily caffeine intake. Beggiato, S. Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission. Bonaventura, J. Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer.

Borroto-Escuela, D. Multiple adenosine-dopamine A2A—D2 Like heteroreceptor complexes in the brain and their role in schizophrenia.

Role of the central ascending neurotransmitter systems in the psychostimulant effects of caffeine. Kaasinen, V. Dopaminergic effects of caffeine in the human striatum and thalamus. NeuroReport 15 , — Volkow, N. Psychiatry 5 , e An update on the mechanisms of the psychostimulant effects of caffeine.

Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation. James, J. Acute and chronic effects of caffeine on performance, mood, headache, and sleep. Neuropsychobiology 38 , 32—41 Circulation , — Caffeine alters A2A adenosine receptors and their function in human platelets.

Circulation 99 , — Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors. Life Sci. Jacobson, K. Adenosine receptor ligands: Differences with acute versus chronic treatment. Trends Pharmacol. Ott, T. Dopamine and cognitive control in prefrontal cortex.

Trends Cogn. Nieoullon, A. Dopamine: A key regulator to adapt action, emotion, motivation and cognition. Dopamine and the regulation of cognition and attention. Popoli, P. Effects of SCH , an adenosine A 2A receptor antagonist, on quinpirole-induced turning in 6-hydroxydopamine-lesioned rats: Lack of tolerance after chronic caffeine intake.

Halldner, L. Lack of tolerance to motor stimulant effects of a selective adenosine A 2A receptor antagonist. Johansson, B. A1 and A2A adenosine receptors and A1 mRNA in mouse brain: Effect of long-term caffeine treatment.

Brain Res. Effect of long term caffeine treatment on A1 and A2 adenosine receptor binding and on mRNA levels in rat brain. Naunyn Schmiedebergs Arch. Blaise, J. Caffeine consumption disrupts hippocampal long-term potentiation in freely behaving rats.

Hanajima, R. Effect of caffeine on long-term potentiation-like effects induced by quadripulse transcranial magnetic stimulation. Costenla, A. Enhanced role of adenosine A 2A receptors in the modulation of LTP in the rat hippocampus upon ageing.

Jerónimo-Santos, A. Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP. Neuropharmacology 83 , 99— Lopes, J. The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A 1 and A 2A receptors.

Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus.

Neuroscience , 79— Mouro, F. Adenosine A 2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons. Martins, R. Caffeine has a dual influence on NMDA receptor-mediated glutamatergic transmission at the hippocampus.

Tebano, M. Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: A possible key mechanism in the modulation of N-methyl-D-aspartate effects. Chronic treatment with caffeine blunts the hyperlocomotor but not cognitive effects of the N-methyl-D-aspartate receptor antagonist MK in mice.

de Oliveira, R. Effect of subchronic caffeine treatment on MKinduced changes in locomotion, cognition and ataxia in mice. Zulkifly, M. Transcranial alternating current stimulation induced excitatory aftereffects are abolished by decaffeinated espresso and reversed into inhibition by espresso with caffeine.

Socała, K. Neuroprotective effects of coffee bioactive compounds: A review. Retey, J. A genetic variation in the adenosine A2A receptor gene ADORA2A contributes to individual sensitivity to caffeine effects on sleep. Cornelis, M.

Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. Rogers, P. Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.

Childs, E. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Bodenmann, S. Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation. Casetta, I.

Acta Neurol. Luan, Y. Chronic caffeine treatment protects against alpha-synucleinopathy by reestablishing autophagy activity in the mouse striatum. Kim, Y. Chronic sleep restriction induces long-lasting changes in adenosine and noradrenaline receptor density in the rat brain.

Sleep Res. Hansen, D. Randomized, double-blind, placebo-controlled, crossover study of the effects of repeated-dose caffeine on neurobehavioral performance during 48 h of total sleep deprivation. Baur, D. Psychiatry , Giménez-Llort, L. Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain.

Coelho, J. Overexpression of adenosine A2A receptors in rats: Effects on depression, locomotion, and anxiety. Ferré, S. Essential control of the function of the striatopallidal neuron by pre-coupled complexes of adenosine A 2A -dopamine D 2 receptor heterotetramers and adenylyl cyclase.

Heterodimeric adenosine receptors: A device to regulate neurotransmitter release. CMLS 63 , — Bahmani, Z. Caffeine pills are an option if you're looking for an energy boost and may not or don't want to drink coffee.

There are some potential benefits like improved exercise performance or decreased sugar intake when taking caffeine pills. However, caffeine pill use could also result in side effects like rapid heartbeat, agitation, and nervousness if you have too much caffeine.

Consult a healthcare provider if you want to try caffeine pills; they can help determine if you can take them and how much to take. Caffeine overdose. Caffeine tablet. National Library of Medicine.

Belbis MD, Camic CL, Howell SM, Zhang S, Chomentowski PJ. The effects of acute caffeine supplementation on repeated-sprint ability in healthy young non-athletes. Int J Exerc Sci. Centers for Disease Control and Prevention. Know your limit for added sugar.

Walter K. Caffeine and health. Food and Drug Administration. Spilling the beans: how much caffeine is too much?

FDA warns consumers about pure and highly concentrated caffeine. Department of Agriculture FoodData Central. Anas Sohail A, Ortiz F, Varghese T, et al. The cognitive-enhancing outcomes of caffeine and l-theanine: a systematic review.

American College of Gastroenterology. Digestive health tips. Evans J, Richards JR, Battisti AS. In: StatPearls. StatPearls Publishing; Use limited data to select advertising.

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learn more. Trending Videos. Caffeine Content in Different Sources Source Caffeine Content Caffeine Pills to mg Black or Green Tea, 8 ounces oz 30 to 50mg Caffeinated Sodas, 12 oz 30 to 40mg Coffee, 8 oz 80 to mg Dark chocolate, 1 bar Was this page helpful?

They say that it works well and provides a great focused rush without any jittery crash. Some mention that it lasts the whole day and does not come with the shakiness feeling that they have experienced with other products. I do not have jitters or any side effects.

I like this product. No crashes and no jittery effects. Perfect for long work days requiring intense focus and before the gym There's no jitters for me. The first time I tried it I felt like I was on something illegal Customers are satisfied with the focus of the product. For example, they mention it helps them focus and have more energy.

Some say that it helps with their attention span to detail. Overall, most are happy with the product's ability to improve their mental clarity. I feel that it gives me a little pick me up and yes, I do stay a little more focused.

It really works and does what is says. It helps me with mental focus and I feel more accomplished at the end of the day. Customers like the effect on headache. They mention that it does not give them headache or jitters, is not harsh, and does not upset their stomach.

It's the cleanest and most comfortable energy and alertness increasing product they've tried so far. It makes them feel normal and does so without any uncomfortable feeling. I can say this one feels a bit different. And it gives that extra boost of focus and energy I LOVE, LOVE, LOVE this product!!

GREAT BUY!! BUT if you are looking for a steady, alertness, wakefulness, and overall good feeling when you may normally feel tired and sluggish, this is it I will say that it can give me some stomach issues , regurgitation or what ever Customers like the value of the nutritional supplement.

They mention that it has a good price and is made with natural ingredients. Overall great value for money compared to others I have tried and it works great for me. Makes me feel smarter! A little pricey , but worth it. Customers are mixed about the performance of the product.

Some mention that the green tea leaves really enhance the mental boost, making them feel smarter. However, some customers say that it doesn't work well for them and that it has no effect whatsoever after 1.

I normally use either coffee, zero cal energy drinks or caffeine pills to get me thru some mornings But after about half the bottle was gone, I noticed my brain was more clear than it had been in years.

So I ordered another bottle They didnt initially seem to work quickly but I feel the effects fairly quick within a half an hour now it was great and really helped with energy, focus, and better brain functioning Customers are mixed about the side effects of the nutritional supplement. Some mention that the side effect are absent and they immediately feel the benefits with no jitters.

However, others say that they felt a little upset and it gave them headaches, severe heartburn, and felt so sick that they could not focus or study. If I don't take these for a day, I'm still perfectly fine and NO side effects I felt so sick and had such a headache that I could not focus or study and had to leave the library to lay down in my apartment No jitters, no side effects - just energy!

This gave a big headache. I am not going to take this ever again and am left with the entire bottle with only 5 consumed. So 55 pills are waste. Disclaimer : While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists.

We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease.

Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

com assumes no liability for inaccuracies or misstatements about products. Skip to main content. Buy new:. To see product details, add this item to your cart. Ships from: Amazon. Sold by: NutraChamps. You can always remove it later.

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Please try again. Sorry, there was a problem. There was an error retrieving your Wish Lists. List unavailable. Focused Energy Capsules NutraChamps. Image Unavailable Image not available for Color:. VIDEOS ° VIEW IMAGES. Visit the NutraChamps Store. Search this page. Purchase options and add-ons.

Brand NutraChamps Flavor Unflavored Unit Count 60 Count Item Form Capsule Special Ingredients Vegan Product Benefits Smoothening Age Range Description Adult Package Information Bottle Number of Items 1 Dosage Form Capsule. About this item Smooth Boost, Jitter-Free - When used together, L-Theanine and caffeine create synergistic benefits, amplifying and refining the effects that each produces on its own.

Our brain focus supplement provides natural brain boosters that help you stay sharp and engaged all day, ensuring you take your performance to the next level.

The Clean Alternative - Many of us turn to coffee when we need a boost. Unlike coffee, which can cause jitters, hyperactivity and an inevitable crash, Focused Energy is balanced and smooth, delivering a clean flow of energy, anytime you need it. Vegan, Non-GMO, Highest Quality Guaranteed - Focused Energy is carefully produced with premium global ingredients in the USA, with the highest cGMP manufacturing standards, and lab tested for purity.

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Previous page. Amazon's Choice. Zhou Natural Caffeine Pills mg with L-Theanine mg, Nootropic Supplement, Clean Energy, Endurance and MentalFocus, Non-GMO, Vegan, Gluten-Free, 60 Capsules. Next page. From the brand. Shop The Links Above Or: Visit the Store.

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Convenient Capsules Visit the Store. Product Description. Compare with similar items This Item. Nutricost Caffeine with L-Theanine, mg of Each, Capsules, Servings - Non-GMO and Gluten Free. ProLab Caffeine Tablets Count. Nature's Own Factory Store. LY Berditchev Co.

Nutrition Distributors. Energy Management,Weight Loss Support,Metabolism Management,Brain Health Support,Sleep Support. Energy Management. This is beneficial because it can help the glucose stored in muscles last longer, potentially delaying the time it takes your muscles to reach exhaustion 20 , Caffeine may also improve muscle contractions and increase tolerance to fatigue 1.

Researchers observed that doses of 2. Doses as low as 1. Finally, it may also reduce perceived exertion during exercise by up to 5. Consuming small amounts of caffeine about an hour before exercise is likely to improve exercise performance.

One thing to keep in mind is that caffeine may slightly raise blood pressure in some people. However, this effect is generally small 3—4 mmHg and tends to fade for most individuals when they consume coffee regularly 32 , 33 , 34 , It may also protect against diabetes.

This indicates that other beneficial compounds in coffee can also protect against type 2 diabetes Caffeinated beverages like coffee and tea may reduce the risk of heart disease and type 2 diabetes, although this may depend on the individual. Keep in mind that coffee also contains other substances that improve health.

Some benefits listed above may be caused by substances other than caffeine. Drinking coffee may promote a healthy liver, skin, and digestive tract. It may also prolong life and help prevent several diseases.

Some side effects linked to excess intake include anxiety, restlessness, tremors, irregular heartbeat, and trouble sleeping Too much caffeine may also promote headaches, migraine, and high blood pressure in some individuals 54 , In addition, caffeine can easily cross the placenta, which can increase the risk of miscarriage or low birth weight.

Pregnant women should limit their intake 54 , 56 , Individuals taking the muscle relaxant Zanaflex or the antidepressant Luvox should avoid caffeine because these drugs can increase their effects Caffeine can have negative side effects in some people, including anxiety, restlessness, and trouble sleeping.

Both the U. Department of Agriculture USDA and the European Food Safety Authority EFSA consider a daily intake of mg of caffeine to be safe. This amounts to 2—4 cups of coffee per day According to the American College of Obstetricians and Gynecologists, pregnant women should limit their daily intake to mg A caffeine intake of mg per dose, and up to mg per day, is generally considered safe.

Pregnant women should limit their daily intake to mg or less. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

How you prepare your tea and coffee affects their caffeine contents. This article compares the caffeine contents of different teas and coffees and…. Skipping your daily cup of coffee can lead to headaches, fatigue, and other symptoms of caffeine withdrawal. Read on for seven tips for easing the….

Caffeine can have impressive health benefits, but high doses can also lead to unpleasant side effects. Here are 9 side effects of too much caffeine. It's thought that caffeine's stimulating effects become less noticeable over time because your body becomes tolerant or less responsive to its effects.

If you've ever experienced jitteriness, anxiety, or sleeplessness after consuming too much caffeine, you may wonder whether there's a way to flush…. An average cup of coffee contains 95 mg of caffeine, but some types contain over mg.

This article lists the caffeine content in different coffee…. Caffeine is a fast-acting stimulant that works on your central nervous system.

It can increase your blood pressure and heart rate, boost your energy…. Coffee contains caffeine, a stimulant substance that is proven to increase the release of fats from the fat tissues and boost the resting metabolic….

Caffeine is the most commonly used "drug" in the world, but are coffee and caffeine addictive or dangerous? Here is a complete review. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based What Is Caffeine, and Is It Good or Bad for Health?

Medically reviewed by Kathy W. Warwick, R. Share on Pinterest. What is caffeine? How it works. What foods and drinks contain caffeine? May improve mood and brain function. May boost metabolism and fat burning. May enhance exercise performance. May protect against heart disease and diabetes.

Other health benefits of coffee. Safety and side effects.