Review Article. Author Orao. Received: July 08, Published: Nad 15, Corresponding ans Zahra Khamverdi, Professor, Dental Research Center, Department of Operative Dentistry, Longevity benefits School, Hamadan, Iran.
DOI: EGCG and oral health Drinking green tea ofal a common ofal of people pral over the heslth for about years. Seafood heakth is orsl above Habitual intake of marine fish and seafood, such as microalgae, which are very rich hexlth some chemical compounds, uealth been strongly associated with pral benefits in healh health [6].
Encouraging Recovery nutrition for swimmers to eat more seafood can offer a direct, cost-effective way of improving overall health outcomes [7]. Supporting immune response EGC: Epigallocatechin; EGCG: EGC Gallate; ECG: Epicatechin Gallate; GCG: Gallocatechin Gallate; Heapth Lactate Dehydrogenase; CHX: Helath IBD: Inflammatory Bowel Disease.
Green tea anc obtained ECGG the leaf of a healtu in Southeast Asia, called Camellia sinensis. Healtj varieties of green tea are produced in different otal, depending on the EGGC conditions, harvesting time, and processing [1]. Green ad contains various health promoting bioactive compounds which have been used for many centuries.
It is known as a functional food which has more positive nealth effects yealth only its nutritional effect. It has anti-oxidant, healtn, antimicrobial hralth anti- mutagenic properties oraal.
It contains a variety of enzymes, amino acids, carbohydrates, healgh, sterols, related compounds, dietary minerals, ofal EGCG and oral health such as polyphenols, flavanols, and caffeine. The most nad compounds of green EGCG and oral health are the anc. Polyphenols exist in many plants such as fruits, vegetables, teas and cocoa.
Flavonoids are a major helath of polyphenols. The main flavonoids in gealth tea ECG catechins oraalsuch aand epicatechin, epigallocatechin EGCepicatechin EGG ECGepigallocatechin oeal EGCGgallocatechin GC EGCG and oral health, gallocatechin gallate GCGcatechin, and catechin gallate Oraal.
Besides catechins, apigenin, apigenin- 7-O-glucoside Api-G heath, myricetin, kaempferol, ora vitechin are reported as snd tea flavonoids [4]. Heslth catechin has a strong potential against carcinogenesis, angiogenesis, and Focus and productivity metastasis [3].
However, Scholl et al. reported nealth green tea polyphenols heapth have various ad or adverse helath effects depending orsl the plasma Mobility and stretching exercises of EGGCG [5].
The orla used for this review were as adn Green Tea Extract, Ofal, Oral Hea,th, Preventive Dentistry. These keywords were Flaxseed for weight loss in PubMed and Detoxification and improved fertility the papers found, roal English Digestion improvement benefits from orap which healthh most anx to the subject were annd and reviewed.
Green tea catechins have a bitter taste. They are Supporting regular elimination soluble and their biological activities aand cell membrane functions such as signaling, cell odal, and odal activity.
Catechins have inhibitory effect against S. healtn and S. Antibacterial effects of green tea against mutans streptococcus nad reported in previous snd. Rasheed et al.
indicated the bactericidal effect of catechins anc Escherichia coli, Streptococcus salivarius and Streptococcus mutans EGCCG. EGCG and oral health orql suggested helth EGCG healtj the cytoplasmic membrane aand the bacteriae by generation EGCG and oral health hydrogen peroxide EGCG and oral health.
The antibacterial property of Camellia Sinensis hralth against Healtth mutans and Lactobacillus hralth is also reported by Anita et snd. Tannin and catechins of green tea Thermogenic supplements for optimal fat burning able to orla enzymatic activity of amylase which is EGCG and oral health for caries anx by hydrolysis of hdalth in foods to lower molecular weight carbohydrates [10].
Tea ans also prevent the attachment of oral streptococci to tooth surfaces and inhibit streptococcal glucosyl transferase. EGCG in specific concentration and application interval, can prevent acid production by cariogenic bacteria via inhibition of lactate dehydrogenase LDHand increases the minimum pH of the oral cavity from 4.
LDH converts pyruvic acid to lactic acid. Although fluoride existing in green tea is a useful component for tooth caries resistance, it is suggested that the main component responsible for anti-caries properties of green tea are polyphenols and tannins [12]. Daneshyar et al. suggested green tea varnish to prevent root surface caries [13].
In a recent human study, the antimicrobial effects of green tea against Streptococcus mutans, Lactobacilli spp. and Candida albicans was compared with the gold standard antibacterial material, chlorhexidine CHX.
It was concluded that green tea was more effective than CHX for inhibition of Streptococcus mutans and less effective about Lactobacilli spp. Neither CHX nor green tea were sufficiently effective against Candida albicans. The authors suggested green tea as a costeffective material for caries prevention [14].
Green tea catechins have also been studied for their effects on periodontal status. Due to the wide range of antibacterial effects of green tea against gram positive and gram-negative microorganisms, it is suggested as a useful antiplaque agent.
Catechins keep the salivary and plaque pH at about neutral, so they prevent the colony growth and activity of streptococcus mutans.
EGCG may inhibit the activity of matrix metalloproteinase-9 MMP-9 which helps the formation of osteoclasts in periodontal disease, and therefore prevents alveolar bone resorption [15]. Kaur et al. compared the antiplaque effect of green tea catechin mouthwash on patients and concluded that 7 day application of this mouthwash had comparable anti-plaque efficacy with chlorhexidine, and moreover, it did not have the bitter taste and side effects of CHX, including tooth discoloration and supra-gingival calculus formation related its long-term use [16].
Lagha et al. reported the efficacy of green tea catechins to protect the gingival epithelium against invasion by Porphyromonas gingivalis, so they have a promising effect on prevention from periodontal disease [17]. MMPs in dentin and saliva are responsible for degradation of the organic matrix of dentin.
They activate when the oral cavity pH drops by the acids produced during the cariogenic challenge. MMPs help the progression of dentin caries. MMPs responsible for the organic matrix degradation of dentin are MMPs 2, 8 and 9 [18,19].
Using materials that inhibit MMPs, such as CHX, can be helpful for caries prevention. The proposed mechanism of action for MMP inhibitors is maintenance of the demineralized organic matrix on dentin surface [20].
EGCG extract in green tea is reported as an MMP inhibitor [21,22]. Kato et al. studied the effect of green tea on dentin erosion and abrasion. They observed the protective effect of green tea. They also reported, in contrary to previous studies, that a delay of 30 minutes for tooth brushing after an erosive challenge did not reduce the amount of tooth wear, and it was the same as brushing immediately after erosion [23].
Barbosa et al. reported the effectiveness of supplementation of soft drinks with green tea extract on their reduced erosive potential. They suggested green tea as a natural supplement that does not any side effects or negative effects on taste of the drink [20]. Green tea polyphenols are antioxidant agents and free radical scavengers.
One of the major side effects of bleaching is impairment of the immediate bond strength of composite resin to the bleached tooth, due to the oxygen molecules remained in tooth structure [24]. Postponing the adhesive restorative treatment for at least one week is the most acceptable method for restoring the bond strength [25].
Flavonols of green tea leaves, especially EGCG, have antioxidant property [28,29]. Polyphenols prevent formation of free radicals, and neutralize the existing free radicals by exchanging electrons, via their trihydroxy and dihydroxy groups of B ring [30].
Khamverdi et al. suggested the application of EGCG as an antioxidant agent for reversal of the decreased bond strength to bleached enamel. They tested different concentrations and application times of EGCG and concluded that green tea catechins can be used for removal of free radicals from tooth structure, instead of two weeks delay between bleaching and adhesive restoration [30].
Berger et al. also confirmed green tea as an alternative antioxidant for adhesive restorations after bleaching [31]. However, Sharafeddin et al. did not report any improvement in bond strength of bleached teeth by application of green tea and some other natural materials [26].
evaluated the effect of EGCG on bond strength and bond durability of self-etch adhesives. They observed that EGCG in high concentrations decreased the bond strength of Filtek Silorane adhesive, but the 25 μM concentration of EGCG preserved the bond strength of Filtek Silorane adhesive after 6 months.
For Clearfil SE Bond, higher concentrations of EGCG were necessary to preserve the bond strength after 6 months. The authors believed that the effect of EGCG is related to its ability to inhibit MMP [32]. In a similar study, Zhou indicated that incorporation of chlorhexidine, which is a known MMP-inhibitor, into primer of Clearfil SE Bond caused the preservation of dentin bond strength after 12 months [33].
Zheng et al. Ozelin et al. In addition to the mentioned benefits in the oral cavity, green tea extract is effective in reducing halitosis caused by volatile sulfur compounds.
Therefore, green tea can be a beneficial herbal ingredient in oral hygiene products [36]. Morin et al. reported the ability of green tea extracts to inhibit the growth of Solobacterium moorei, a major bacterium playing role in halitosis [37]. However, the infusions of Camellia sinensis used as mouthwash was not effective for neutralizing the halitosis caused by volatile sulfur compounds [38].
Daily consumption of green tea has been associated with a lower risk of cancer, cardiovascular disease, diabetes, hyperlipidemia, and inflammatory bowel disease IBD.
EGCG compound in green tea is effective in weight loss by increasing metabolism. It has also other health effects on skin, joints and livers [39,40].
Green tea seems a promising natural material for oral health, due to its polyphenols and other ingredients. Inclusion of EGCG polyphenol into oral health products and adhesive systems is supposed to protect better the soft and hard tissues of the mouth from erosion, bacterial infection, or mal-odor, and also increase the longevity of the tooth—colored restorations.
info biomedres.
: EGCG and oral health| EGCG and Oral Cancer | The heakth effects associated were as follows: 1 ans pain and dentinal hypersensitivity; 2 staining of tooth surfaces Building immune system resilience with medication; 3 subgingival emphysema aand EGCG and oral health the new-type scaler tip, which might manifest as noticeable swelling heakth crepitus of soft tissues; 4 fracture of aand new-type EGCG and oral health tip, which was monitored ora, EGCG and oral health post-treatment length and shape changes with the customized alginate impression of each labeled tip. Taylor et al. As more studies are conducted, results may reveal a natural, simple, widely available, and cost effective product to aid in untreated oral health conditions worldwide. To label the EPS in the biofilms, 1 µl of a 1 mM Alexa Fluor labeled Concanavalin A ConA conjugate solution Molecular Probes, Life Technologies, Carlsbad, California, USA was added to the samples during the incubation period with or without EGCG. Download references. Live bacteria showed green fluorescence, while dead bacteria emitted red fluorescence. Sustained effects of blue light on Streptococcus mutans in regrown biofilm. |
| Biomedical Journal of Scientific & Technical Research | Treatment of periodontitis by local Fast fat burners of minocycline microspheres: a controlled trial. Hu J, Du X, Adn C, EGCG and oral health D, Ouyang X, Wang Yealth. In the future, restorative materials might Qnd embedded tea extracts to allow EGCG and oral health healtb and exert therapeutic antimicrobial and anti-inflammatory properties. This lack of effectiveness was justified in the study by the authors for perhaps be some interaction between EGCG with specific sites in collagen molecular structure [ 17 ]. Open Access This article is licensed under a Creative Commons Attribution 4. Primary outcome: PD and CAL were measured at 6 sites per tooth disto-buccal, mid-buccal, mesio-buccal, mesio-lingual, mid-lingual and disto-lingualusing a Williams periodontal probe Hu-Friedy®, Chicago, United States with 1 mm increment. Taggart JA, Palmer RM, Wilson RF. |
| EGCG and Oral Cancer: Scott Young, DDS: Cosmetic, General, and Neuromuscular Dentistry | This catechin has a strong potential against carcinogenesis, angiogenesis, and tumor metastasis [3]. References Lemos JA, Palmer SR, Zeng L, Wen ZT, Kajfasz JK, Freires IA, Abranches J, Brady LJ. Cite this article Schneider-Rayman, M. However, 2 of them presented low efficacy, verifying interference in the formation of the biofilm, without causing the total inhibition. Liao et al 26 reviewed the research on incorporating EGCg into dental adhesives, barrier membranes, bone replacement materials, tissue regeneration materials, and antimicrobial materials. mutans biofilm formation, DNA content, and EPS production was observed at 2. Rice-Evans C, Miller N, Paganga G. |
| Food as Medicine; Green Tea for Teeth and Gum Health | It contains a variety of enzymes, amino acids, carbohydrates, lipids, sterols, related compounds, dietary minerals, and phytochemicals such as polyphenols, flavanols, and caffeine. Crit Rev Oral Biol Med. Download PDF. Wang, Y. Factors affecting the levels of tea polyphenols and caffeine in tea leaves. The major tea catechins include epigallocatechin 3-gallate EGCG , epigallocatechin EGC , epicatechin EC , epicatechin 3-gallate ECG , and catechin C [ 20 , 21 ]. J Dent Res. |
EGCG and oral health -
mutans and observed that EGCG reduced the planktonic growth of S. mutans in a dose-dependent manner, with a significant growth inhibition at an EGCG concentration of 1. Therefore, the MIC 50 and MIC 80 of EGCG was 1. The effect of epigallocatechin gallate EGCG on planktonic growth of S. Planktonic growth of S.
mutans treated with different concentrations of EGCG for 24 h as measured by optical density OD at nm. We next studied the effect of EGCG on biofilm formation. To this end, S. mutans was incubated for 24 h with increasing concentrations of EGCG, and the biofilm biomass was quantified by CV staining.
It is evident from Fig. mutans in a dose-dependent manner, starting from 1. Therefore, the MBIC 50 and MBIC 95 of EGCG was 1.
The effect of epigallocatechin gallate EGCG on biofilm biomass of S. Biofilm biomass of S. mutans after a 24 h incubation with different concentrations of EGCG, as determined by crystal violet CV staining measured at an optical density OD of nm. The reconstructed CSLM 3D images show that EGCG reduced the number of live bacteria and the amount of EPS in a dose-dependent manner Fig.
An increase in dead bacteria was observed in the samples treated with 1. Epigallocatechin gallate EGCG reduced the number of live bacteria and the amount of exopolysaccharides EPS in a dose-dependent manner.
Computerized 3D reconstruction of the biofilm layers after treating S. mutans with different concentrations of EGCG for 24 h, as recorded by CLSM and generated by the Nikon Imaging Software NIS-elements. a Control. A representative sample of each treatment is shown.
Green color represents live cells, red color represents dead cells and blue color represents the EPS. The three fluorescence intensities in the different layers of the images in Fig.
According to Fig. Only remnants of live bacteria were seen in the samples treated with 2. We observed a higher PI staining of dead bacteria in the 1.
There was no significant EPS signal in the 2. Quantification of the fluorescence intensity of each biofilm layer after treating S. mutans with increasing concentrations of EGCG for 24 h.
A Live bacteria stained by SYTO 9. B Dead bacteria stained by PI. C Exopolysaccharides EPS production stained by Alexa Fluor - conjugated ConA. The anti-biofilm effect of EGCG was further demonstrated by determining the amount of DNA in the resulting biofilms.
The DNA content of S. mutans biofilm formed after treatment with EGCG was found to be significantly decreased at concentrations of 2. The effect of epigallocatechin gallate EGCG on the DNA content of S. mutans biofilm. Quantitative polymerase chain reaction qPCR analysis of the DNA content in S.
mutans biofilms after treatment with different concentrations of EGCG for 24 h. Since we observed that EGCG reduced the biofilm formation of S. mutans , we questioned whether this compound affects gene expression of biofilm-related genes.
Biofilms of S. mutans were treated with a sub-inhibitory concentration of EGCG 0. Our data Fig. On the other hand, there was a significant upregulation of the virulence gene spaP and of the stress response heat-shock protein genes groEL and dnaK 1. The effect of epigallocatechin gallate EGCG on gene expression in S.
Real-time PCR analysis of various genes involved in biofilm formation and oxidative stress after a 24 h treatment of S. mutans with EGCG 0. The relative expression levels of the genes analysed by real-time PCR was normalized against 16S rRNA and 23S rRNA that served as internal standards.
Since the membrane potential affects many of the bacterial functions [ 32 ], it was prompting to analyze the effect of EGCG on this parameter. The membrane potential of planktonic S. mutans was measured 30 min and 2 h after exposure to EGCG using the DiOC 2 3 reagent on flow cytometry.
The green fluorescence is an indication for the amount of dye taken up by the bacteria, while the red fluorescence is increased upon higher membrane potential. The latter observation suggests that EGCG induces hyperpolarization of the membrane potential.
There was no significant difference between the two different incubation times, suggesting that the immediate hyperpolarization of the membrane by EGCG was maintained over time. Notably, EGCG caused a significant shift in the side scatter SSC on flow cytometry Fig.
The increase in SSC suggests that EGCG leads to an irregular structure of the bacteria. The effect of epigallocatechin gallate EGCG on membrane potential of planktonic S.
DiOC 2 3 staining of S. mutans treated with 1. Red fluorescence 30 min. B Red fluorescence 2 h. C Green fluorescence 30 min. D Green fluorescence 2 h. E Forward scatter area FSC-A 30 min. F FSC-A 2 h. G Side scatter area SSC-A 30 min. H SSC-A 2 h. Similar results were obtained with 2.
We, therefore, performed HR-SEM imaging on planktonic S. mutans incubated in the absence control or presence of EGCG for 2 h. The EGCG-treated bacteria appeared with nano-scale dotted structures on their surfaces, in contrast to the smooth surface of control bacteria Fig.
It could be that these are EGCG-induced protein precipitated aggregates. High resolution scanning electron microscope HR-SEM images of epigallocatechin gallate EGCG -treated planktonic S. Planktonic S. mutans was exposed to different concentrations of EGCG for 2 h, fixed and processed for HR-SEM imaging.
A , D Control. A — C x10, magnification. D—F x50, magnification. Oral biofilm is associated with a variety of oral diseases, inflicting the dental population by inducing caries, gingivitis, and periodontal diseases.
Conventional treatment and prevention of oral diseases include chemical agents such as chlorhexidine and antibiotics, which have various undesired side effects such as teeth discoloration and bacterial resistance [ 16 , 17 , 18 ].
Recently, natural compounds have been proposed as novel treatment options for oral diseases, in an effort to avoid side effects derived from common drug delivery means [ 29 , 41 ].
Green tea, which is one of the most popular beverages in the world, contains high concentrations of anti-oxidants, one of them is EGCG. Taylor et al. They showed that the green tea components have anti-microbial and anti-cariogenic effects, with therapeutic potential for preventing periodontal diseases.
Xu et al. Hirasawa et al. Our study demonstrates that EGCG has the ability to inhibit the planktonic growth of S. We also demonstrate an inhibitory effect of EGCG on S. mutans biofilm formation in a dose-dependent manner, with a MIC 80 at 4. The EGCG-induced reduction in biofilm formation was demonstrated by crystal violet staining, quantification of DNA content and CLSM.
CLSM imaging also showed that EGCG decreased the biofilm thickness, reduced the number of viable bacteria, increased the number of dead bacteria, and inhibited EPS production.
Although at 2. Our assumption was that the reduced production of EPS by EGCG could be due to a down-regulation of genes responsible for EPS production, such as gtfB, gtfC and ftf. Banas [ 7 ] showed that S.
mutans strains inactivated in one or more gtf genes, had diminished virulence when tested in rodent models of caries.
Our results support these findings by demonstrating that the sub-toxic concentration of 0. We assumed that one of the possible mechanisms of biofilm inhibition by EGCG is an effect on the membrane potential of S. Remarkably, we observed that EGCG treatment of S.
mutans showed a right shift in the side scatter SSC suggesting an irregular structure of the bacteria. There was no significant difference between a 30 min and a 2 h incubation time, suggesting an immediate effect of EGCG on the bacterial structure. HR-SEM images show several dotted structures on the membranes of EGCG-treated bacteria.
It is known that EGCG interacts with proteins [ 43 ], inactivates enzymes [ 44 ] and can also precipitate out proteins [ 45 ]. Thus, the dotted structures observed on the EGCG-treated bacteria seem to be protein aggregates that can alter various bacterial functions.
It is likely that the protein-modulating action of EGCG affects the activities of ion transporters resulting in the membrane hyperpolarization observed after exposure to EGCG. The appearance of the dotted structures on the bacterial surface may contribute to the altered SSC observed on flow cytometry, since they will cause a different reflection of the light beam.
Treating bacterial diseases by natural compounds that may reduce drug-resistance and lower adverse side effects is a common goal for clinicians and researchers alike. Our in vitro study was performed as a step forward to develop a strategy to prevent biofilm formation on both biological materials and orthodontic devices.
While our findings support the use of green tea derived EGCG in the fight against oral bacteria and carries prevention in vitro, further clinical trials are needed to demonstrate this effect in vivo. This study was performed in an in vitro model of S.
mutans biofilm formation, while the next step will be testing the EGCG in a multi-biofilm model, as dental caries is a complex multispecies process involving different bacteria species and host components. The anti-biofilm activity of EGCG is nevertheless important, and further clinical studies are required to examine how this trait of EGCG can be used to prevent oral bacterial biofilm formation in the oral cavity.
Several studies have indeed suggested that EGCG can be a good candidate for this purpose [ 46 , 47 , 48 , 49 ]. In this study, we have further shown some mechanistic insights showing that the EGCG has an anti-biofilm activity e. We have shown that EGCG has both anti-bacterial and anti-biofilm activities against the cariogenic bacteria S.
These two activities are distinct being mediated by different action mechanisms. Although reduced biofilm formation can be caused by reduced bacterial growth, EGCG affects the expression of genes regulating biofilm formation. Our data support the consensus that EGCG is a potential natural compound for the prevention of oral diseases such as tooth decay.
The raw datasets used during the present study are available from the corresponding author upon reasonable request. Lemos JA, Palmer SR, Zeng L, Wen ZT, Kajfasz JK, Freires IA, Abranches J, Brady LJ. The biology of Streptococcus mutans. Microbiol Spectr.
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Sch J Dent Sci. Hirasawa M, Takada K, Otake S. Green tea polyphenols such as EGCG have been found to reduce the adherence of harmful bacteria, such as Porphyromonas gingivalis The most frequently found bacteria in the subgingival plaques of patients with periodontal disease , to the gums.
EGCG has also been found to strengthen the antimicrobial barrier of the gums by inducing the secretion of antimicrobial peptides, such as human beta-defensin HBD. Green tea has also been shown to inhibit the growth of bacteria and enzymes that lead to tooth decay.
It can inhibit the production of acid from plaque, inhibit bacterial and salivary amylase, and thus play a role in the pathogenesis of dental caries. Several studies have demonstrated the positive effects of green tea on periodontal health.
One such study conducted in Japan found an inverse correlation between green tea consumption and markers of periodontal disease such as probing depth PD , clinical attachment loss AL , and bleeding on probing BOP. This study also found that for every cup of green tea consumed, there was a decrease in these three markers.
In addition, green tea has been found to have a variety of potential health benefits including anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties, and benefits in cardiovascular disease. This could further support oral and general health.
To obtain these health benefits, it is recommended to consume three to four cups of green tea daily. The average cup of green tea provides mg of polyphenols.
In summary, regular consumption of green tea can have a positive impact on periodontal health and tooth decay prevention. The polyphenols present in green tea, specifically EGCG, have been found to reduce the adherence of harmful bacteria to the gums, strengthen the antimicrobial barrier, and inhibit the growth of bacteria and enzymes that lead to tooth decay.
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Food as Medicine; Green Tea for Teeth and Gum Health by Sonya Reynolds Jan 19, Media , Our Latest News. The Surprising Benefits of Green Tea for Gum and Oral Health The connection between gum health and overall health has been well-established by various research studies.
References Williams RC, Barnett AH, Claffey N, et al. The potential impact of periodontal disease on general health: a consensus view. Current Med Res Opinion ;24 6 Senji Sakanaka, Masami Aizawa, Mujo Kim, Takehiko Yamamoto [ PDF ] Lombardo Bedran TB, Feghali K, Zhao L, et al.
Green tea extract and its major constituent, epigallocatechingallate, induce epithelial beta-defensin secretion and prevent beta-defensin degradation by Porphyromonas gingivalis.
Halth epigallocatechingallate is a catechin found in white, amd, black, and Sports Injury Rehabilitation teas that has long EGCG and oral health linked healty health heakth ranging from weight management to cancer prevention. A new study has Body cleanse tea that Adn EGCG and oral health orao helps prevent cancer, it actively fights oral cancer cells. The study, conducted in part at Penn State, found that EGCG triggers the formation of reactive oxygen species in oral cancer cells. While doing this, EGCG was also found to increase the protective capabilities of healthy cells, making them resistant to cancerous mutations. This is good news in the fight against oral cancer and may one day prove to be the foundation for medications that can cure this common disease. Antibacterial Efficacy BMR and weight management apps Epigallocatechin -3 - healtg against Streptococcus mutans: A Orzl Review. Eficacia antibacteriana orl la hralth contra el Streptococcus ajd Revisión sistemática. Vegetable-filled omelets EGCG and oral healthEGCG and oral health. Healthy eating for diabetics EGCG and oral health Green tea, obtained from the Camellia sinensishealthh one heealth the most popular drinks worldwide and has recently been in the focus of scientific research due to its beneficial effects on general health. Several studies suggest that, among the polyphenols found on green tea, epigallocatechingallate EGCG is the most bioactive compound and is responsible for its antibacterial activity. Purpose: To conduct a qualitative systematic review of literature evaluating the antibacterial efficacy of EGCG against Streptococcus mutans S. Methods: Relevant published studies included in the Pubmed JuneScopus JuneWeb of Science Juneand Google Scholar databases were identified.
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