It might also reduce oxidative stress, which could improve oocyte growth and maturation [ 50 ]. Therefore, researchers are examining whether supplemental carnitine improves sperm count, concentration, and motility as well as pregnancy rates. Compared to placebo, supplemental carnitine improved sperm motility by 7.

A Cochrane Review assessed the effectiveness of carnitine supplementation on male subfertility delays in conception due to low sperm concentration [ 52 ]. In some trials, carnitine was compared with placebo, whereas in others, it was compared with antioxidants such as vitamin C or vitamin E or a control group that received no treatment.

Carnitine supplementation increased sperm motility and concentration at some timepoints e. Researchers have also examined whether carnitine might improve ovulation and pregnancy rates in females with polycystic ovary syndrome PCOS , a condition that commonly causes infertility.

Individuals in the group taking L-carnitine had In addition, more participants in the L-carnitine group became pregnant than those who took placebo, and they had fewer miscarriages. In a 3-month randomized controlled trial, women with PCOS received either 3 g L-carnitine or placebo [ 54 , 55 ].

Participants who took L-carnitine supplements had improved menstrual cycle regularity and higher ovulation and pregnancy rates, but miscarriage rates did not differ between the groups. More research is needed to determine whether carnitine supplements affect male infertility or pregnancy rates in women with PCOS.

Some research suggests that carnitine reduces levels of C-reactive protein, a biomarker of systemic inflammation, and levels of malondialdehyde, a lipid peroxidation product that induces pain and disability in patients with osteoarthritis [ 56 ].

In addition, levels of acylcarnitines conjugated carnitine esters are lower in people with osteoarthritis than in age- and gender-matched healthy individuals [ 57 ]. For these reasons, investigators are studying whether L-carnitine supplements can relieve osteoarthritis symptoms [ 56 , 58 ], but study results have been mixed.

A randomized clinical trial examined the anti-inflammatory effects of L-carnitine supplementation for osteoarthritis management in 69 women age 40 to 60 years with mild to moderate osteoarthritis in both knees [ 59 ]. The women took mg L-carnitine three times a day or placebo for 8 weeks.

Serum levels of several inflammation biomarkers and pain scores were lower in the carnitine group than in the placebo group: Interleukinbeta levels decreased 5.

In comparison with placebo, carnitine did not reduce osteoarthritis pain or stiffness or increase physical function. Larger studies with samples that include both men and women are needed to determine whether carnitine supplementation helps manage osteoarthritis symptoms.

Carnitine helps preserve muscle glycogen and promote fat oxidation. It also spares the use of amino acids as energy sources during exercise, making them potentially available for new protein synthesis [ 6 ], and decreases the accumulation of lactate [ 60 ].

However, research findings on the effectiveness of supplemental carnitine on athletic performance are mixed [ 6 ]. One study randomly assigned 14 recreational athletes age 24—28 years with an average body mass index BMI of 23 to consume a carbohydrate solution with or without 2.

In another study, 24 men age 18—40 years eight omnivores and 16 vegetarians took 1 g L-carnitine twice daily for 12 weeks [ 62 ].

Carnitine supplementation had no significant effect on VO2max, blood lactate concentration, skeletal muscle energy metabolism, or physical performance in either the vegetarians or the omnivores. A comprehensive review summarized the effects of supplemental L-carnitine on exercise performance and recovery in well-trained athletes age 16—36 years and recreationally active adults age 18—50 years [ 63 ].

The review included 11 clinical trials one of which was the trial described above in a total of well-trained athletes who took 1 to 4 grams L-carnitine or placebo a single time or once or twice daily for up to 6 months. L-carnitine supplements reduced lactate levels and heart rate; increased lipid metabolism, VO2max, oxygen consumption, and L-carnitine plasma concentrations; improved performance; and hastened recovery in some of the studies.

However, the supplements did not affect performance or maximal exercise test results in other studies. In 17 studies that included recreationally active adults, a total of participants took 2 g L-carnitine once or 2 to 4 g L-carnitine or placebo once or twice daily for up to 3 months.

L-carnitine decreased plasma lactate concentrations, pyruvate concentrations, and muscle soreness and increased VO2max and recovery in some studies.

However, in other studies, L-carnitine did not affect lactate, heart rate, VO2max, endurance, performance time, or perceived exertion during exercise. A systematic review of 11 randomized clinical trials examined the effects of oral L-carnitine supplementation on high- and moderate-intensity exercise performance in a total of physically active and untrained adults age 18 to 46 years [ 64 ].

The studies had mixed results. Some studies found significant improvements in VO2max, peak power, maximum sprinting power, perceived exertion, and number of repetitions and volume lifted in a leg press in the L-carnitine group. However, other studies found no differences in VO2max, fatigue, maximum and average power, or total work on a cycle ergometer.

No studies found that L-carnitine supplementation improved moderate-intensity exercise performance. Because carnitine transports fatty acids into the mitochondria and acts as a cofactor for fatty acid oxidation, researchers have proposed using L-carnitine supplements to promote weight loss, often in conjunction with a low-calorie diet, exercise, or prescription weight-loss drugs [ 65 ].

Weight loss has been a secondary outcome in most studies, and these studies have had equivocal results. The trials included a total of participants. In eight trials, doses ranged from 1. Study participants who took carnitine supplements lost an average of 1. Carnitine does not have an established tolerable upper intake level.

It can also cause muscle weakness in people with uremia and seizures in those with seizure disorders. Some research indicates that intestinal bacteria metabolize unabsorbed carnitine to form TMAO and gamma-butyrobetaine [ 68 ], which might increase the risk of CVD [ 38 , 39 , 69 , 70 , 71 ].

This effect appears to be more pronounced in people who consume meat than in vegans or vegetarians. The implications of these findings are not well understood and require more research.

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Löse It Metabolism Support Supplement is an all-natural supplement that promotes fat loss by supporting estrogen metabolism and thermogenesis.

At Aeryon Wellness, providing customers with scientifically backed products to improve overall health and well being is the main philosophy. This Löse It Metabolism Support Supplement contributes to your overall health by helping support weight management.

How does Löse It work? Löse It Metabolism support works by promoting estrogen metabolism and a healthy balance of estrogen in the body, while supporting fat loss through increased thermogenesis and calorie burning. What is Löse It made of? Löse It is a scientifically backed, all-natural formula that works to promote a healthy endocrine hormonal system by balancing estrogen in the body and stimulating the metabolism to burn off excess fat.

By using ingredients like Indolcarbinol, Red Pepper Extract, L-Carnitine, Vitamin B12, Olive Leaf, Caffeine and Green Tea this herbal support supplement can promote weight loss, balance hormones, suppress appetite and enhance your workouts. Is Löse It right for me? If you find yourself at a weight loss plateau, suffering from low energy, experiencing estrogen dominance weight gain in your stomach and mid section or needing that extra motivation to get through your workouts, Löse It will provide you the relief you need.

The Löse It Metabolism Support Supplement can also be used alongside Water B Gone for the ultimate weight loss stack. What makes Löse It Unique? Löse It works with the female body to reduce and balance estrogen while activating metabolic pathways for enhanced fat burning.

Estrogen is the dominant sex hormone in the female body. Subcutaneous fat, which is the fat you develop just under your skin, has estrogen receptors. When your estrogen levels are too high and not in balance your body is more likely to store fat instead of burning it off.

Löse It Works by promoting estrogen metabolism and a healthy balance of estrogen in the body, while supporting fat loss through increased thermogenesis and calorie burning.

Löse It works on the first dose. Take 1 capsule 2 to 3 times daily, every 3 to 4 hours. Make sure to check out your FREE Lose It Meal Planner and Exercise Tips using the QR Code on the bottle.

IndolCarbinol: Indolcarbinol is a unique compound isolated from cruciferous vegetables such as broccoli, and it has been shown to have a positive effect on estrogen metabolism, neutralizing harmful estrogen metabolites and balancing the ratio of estrogen in the body.

Red Pepper Extract: Red pepper extract is a non-pungent non-spicy cultivar of red pepper and contains compounds that can boost fat burning. Red pepper extract can enhance core body temperature, oxygen consumption, uncoupling proteins 1 and 2 UCP1 and UCP2 and even gene transcription of UCP2 mRNA in fat tissue!

Caffeine: Caffeine stimulates the nervous system, this sends direct signals to the fat cells, telling them to break down fat. Additionally, caffeine can increase your resting metabolic rate and is also a powerful antioxidant.

L-Carnitine: L-Carnitine is a naturally occurring amino acid. It plays a crucial role in transport of fatty acids info your cells mitochondria leading to a the production of energy. With an increase of movement of fatty acids into cells to be burned for energy will lead to an improved ability to burn more calories.