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Creatine for improving exercise capacity

Creatine for improving exercise capacity

Article CAS Exerrcise Google Scholar Deldicque L, Decombaz J, Zbinden Foncea H, Vuichoud J, Poortmans JR, Francaux Ccapacity. Therefore, blood creatinine levels can be used as a proxy marker of kidney function. Article CAS PubMed Google Scholar Chang CT, Wu CH, Yang CW, Huang JY, Wu MS. Rawson ES, Clarkson PM. Creatine for improving exercise capacity

Creatine for improving exercise capacity -

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The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. Br J Nutr. Burke DG, et al.

Effect of creatine and weight training on muscle creatine and performance in vegetarians. Med Sci Sports Exerc. Kreider RB, et al. Long-term creatine supplementation does not significantly affect clinical markers of health in athletes.

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Tarnopolsky MA, et al. Creatine transporter and mitochondrial creatine kinase protein content in myopathies. Muscle Nerve. Santacruz L, Jacobs DO. Structural correlates of the creatine transporter function regulation: the undiscovered country. Braissant O. Creatine and guanidinoacetate transport at blood—brain and blood-cerebrospinal fluid barriers.

J Inherit Metab Dis. Campos-Ferraz PL, et al. Exploratory studies of the potential anti-cancer effects of creatine. Balestrino M, et al.

Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease.

Saraiva AL, et al. Creatine reduces oxidative stress markers but does not protect against seizure susceptibility after severe traumatic brain injury. Brain Res Bull. Rahimi R. Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise.

J Strength Cond Res. Riesberg LA, et al. Beyond muscles: the untapped potential of creatine. Int Immunopharmacol. Candow DG, Chilibeck PD, Forbes SC. Creatine supplementation and aging musculoskeletal health. Tarnopolsky MA. Clinical use of creatine in neuromuscular and neurometabolic disorders.

Kley RA, Tarnopolsky MA, Vorgerd M. Creatine for treating muscle disorders. Cochrane Database Syst Rev. Google Scholar.

Potential benefits of creatine monohydrate supplementation in the elderly. Curr Opin Clin Nutr Metab Care. Candow DG, et al. Strategic creatine supplementation and resistance training in healthy older adults. Appl Physiol Nutr Metab. Moon A, et al. Creatine supplementation: can it improve quality of life in the elderly without associated resistance training?

Curr Aging Sci. Rawson ES, Venezia AC. Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Candow DG. Sarcopenia: current theories and the potential beneficial effect of creatine application strategies.

Candow DG, Chilibeck PD. Potential of creatine supplementation for improving aging bone health. J Nutr Health Aging. Kreider RB. Effects of creatine supplementation on performance and training adaptations.

Casey A, et al. Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Greenhaff PL, et al. Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man.

Steenge GR, Simpson EJ, Greenhaff PL. Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. Greenwood M, et al. Differences in creatine retention among three nutritional formulations of oral creatine supplements.

J Exerc Physiol Online. Vandenberghe K, et al. Long-term creatine intake is beneficial to muscle performance during resistance training. Kim HJ, et al. Studies on the safety of creatine supplementation. Jager R, et al. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine.

Article PubMed PubMed Central CAS Google Scholar. Howard AN, Harris RC. Compositions containing creatine, U.

Office, Editor. United States: United States Patent Office, United States Government; Edgar G, Shiver HE. The equilibrium between creatine and creatinine, in aqueous solution: the effect of hydrogen ion. J Am Chem Soc. Deldicque L, et al.

Kinetics of creatine ingested as a food ingredient. Eur J Appl Physiol. Persky AM, Brazeau GA, Hochhaus G. Pharmacokinetics of the dietary supplement creatine.

Clin Pharmacokinet. Effects of serum creatine supplementation on muscle creatine content. J Exerc Physiologyonline. Spillane M, et al. The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels.

Jagim AR, et al. A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate. Galvan E, et al. Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance.

Cornish SM, Chilibeck PD, Burke DG. The effect of creatine monohydrate supplementation on sprint skating in ice-hockey players.

J Sports Med Phys Fitness. Dawson B, Vladich T, Blanksby BA. Effects of 4 weeks of creatine supplementation in junior swimmers on freestyle sprint and swim bench performance. PubMed Google Scholar. Grindstaff PD, et al. Effects of creatine supplementation on repetitive sprint performance and body composition in competitive swimmers.

Int J Sport Nutr. Juhasz I, et al. Creatine supplementation improves the anaerobic performance of elite junior fin swimmers. Acta Physiol Hung.

Silva AJ, et al. Effect of creatine on swimming velocity, body composition and hydrodynamic variables. Effects of creatine supplementation on body composition, strength, and sprint performance. Stone MH, et al. Effects of in-season 5 weeks creatine and pyruvate supplementation on anaerobic performance and body composition in American football players.

Bemben MG, et al. Creatine supplementation during resistance training in college football athletes. Hoffman J, et al. Int J Sport Nutr Exerc Metab. Chilibeck PD, Magnus C, Anderson M. Effect of in-season creatine supplementation on body composition and performance in rugby union football players.

Claudino JG, et al. Creatine monohydrate supplementation on lower-limb muscle power in Brazilian elite soccer players.

Kerksick CM, et al. Impact of differing protein sources and a creatine containing nutritional formula after 12 weeks of resistance training. The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations.

Volek JS, et al. Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J Am Diet Assoc. Physiological responses to short-term exercise in the heat after creatine loading. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching.

Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults-a meta-analysis.

Lanhers C, et al. Creatine supplementation and lower limb strength performance: a systematic review and meta-analyses. Wiroth JB, et al. Effects of oral creatine supplementation on maximal pedalling performance in older adults. McMorris T, et al. Creatine supplementation and cognitive performance in elderly individuals.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. Rawson ES, Clarkson PM. Acute creatine supplementation in older men. Int J Sports Med. Aguiar AF, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Tarnopolsky MA, MacLennan DP.

Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Ziegenfuss TN, et al. Effect of creatine loading on anaerobic performance and skeletal muscle volume in NCAA division I athletes.

Ayoama R, Hiruma E, Sasaki H. Effects of creatine loading on muscular strength and endurance of female softball players.

Johannsmeyer S, et al. Effect of creatine supplementation and drop-set resistance training in untrained aging adults. Exp Gerontol. Ramirez-Campillo R, et al. Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players.

J Sci Med Sport. Rodriguez NR, et al. Position of the American Dietetic Association, dietitians of Canada, and the American college of sports medicine: nutrition and athletic performance.

Article PubMed CAS Google Scholar. Thomas DT, Erdman KA, Burke LM. Position of the academy of nutrition and dietetics, dietitians of Canada, and the American college of sports medicine: nutrition and athletic performance.

J Acad Nutr Diet. Fraczek B, et al. Prevalence of the use of effective ergogenic aids among professional athletes. Rocz Panstw Zakl Hig. Brown D, Wyon M. An international study on dietary supplementation use in dancers. Med Probl Perform Art. McGuine TA, Sullivan JC, Bernhardt DT. Creatine supplementation in high school football players.

Clin J Sport Med. Mason MA, et al. Use of nutritional supplements by high school football and volleyball players. Iowa Orthop J. CAS PubMed PubMed Central Google Scholar.

LaBotz M, Smith BW. Creatine supplement use in an NCAA division I athletic program. Sheppard HL, et al.

Use of creatine and other supplements by members of civilian and military health clubs: a cross-sectional survey. Knapik JJ, et al. Prevalence of dietary supplement use by athletes: systematic review and meta-analysis. Supplement use by UK-based British army soldiers in training.

Huang SH, Johnson K, Pipe AL. The use of dietary supplements and medications by Canadian athletes at the Atlanta and Sydney olympic games.

Scofield DE, Unruh S. Dietary supplement use among adolescent athletes in central Nebraska and their sources of information. NCAA National Study of Substance Use Habits of College Student-Athletes.

Accessed 22 Apr Nelson AG, et al. Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Cooke MB, et al. Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals.

Santos RV, et al. The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30 km race. Life Sci. Deminice R, et al. Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans.

Effects of ingesting supplements designed to promote lean tissue accretion on body composition during resistance training. Effects of nutritional supplementation during off-season college football training on body composition and strength.

Earnest CP, et al. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand. Creatine supplementation during college football training does not increase the incidence of cramping or injury.

Cramping and injury incidence in collegiate football players Are reduced by creatine supplementation. J Athl Train. PubMed PubMed Central Google Scholar.

Cancela P, et al. Creatine supplementation does not affect clinical health markers in football players. Br J Sports Med. Schroder H, Terrados N, Tramullas A. Risk assessment of the potential side effects of long-term creatine supplementation in team sport athletes.

Eur J Nutr. Rosene JM, Whitman SA, Fogarty TD. A comparison of thermoregulation with creatine supplementation between the sexes in a thermoneutral environment. Twycross-Lewis R, et al. The effects of creatine supplementation on thermoregulation and physical cognitive performance: a review and future prospects.

Watson G, et al. Creatine use and exercise heat tolerance in dehydrated men. Weiss BA, Powers ME. Creatine supplementation does not impair the thermoregulatory response during a bout of exercise in the heat.

Wright GA, Grandjean PW, Pascoe DD. The effects of creatine loading on thermoregulation and intermittent sprint exercise performance in a hot humid environment.

Beis LY, et al. The effects of creatine and glycerol hyperhydration on running economy in well trained endurance runners. Easton C, et al.

Easton C, Turner S, Pitsiladis YP. Creatine and glycerol hyperhydration in trained subjects before exercise in the heat. Kilduff LP, et al. The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans.

Polyviou TP, et al. Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters. The effects of hyperhydrating supplements containing creatine and glucose on plasma lipids and insulin sensitivity in endurance-trained athletes.

J Amino Acids. Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists. Lopez RM, et al.

Does creatine supplementation hinder exercise heat tolerance or hydration status? a systematic review with meta-analyses. Rosene JM, et al. The effects of creatine supplementation on thermoregulation and isokinetic muscular performance following acute 3-day supplementation.

Dalbo VJ, et al. Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration. Hespel P, Derave W.

Ergogenic effects of creatine in sports and rehabilitation. Hespel P, et al. Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans.

Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Jacobs PL, et al. Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury.

Arch Phys Med Rehabil. Tyler TF, et al. The effect of creatine supplementation on strength recovery after anterior cruciate ligament ACL reconstruction: a randomized, placebo-controlled, double-blind trial.

Am J Sports Med. Perret C, Mueller G, Knecht H. Influence of creatine supplementation on m wheelchair performance: a pilot study. Spinal Cord. Kley RA, Vorgerd M, Tarnopolsky MA. Sullivan PG, et al.

Dietary supplement creatine protects against traumatic brain injury. Ann Neurol. Hausmann ON, et al. Protective effects of oral creatine supplementation on spinal cord injury in rats. Prass K, et al. Improved reperfusion and neuroprotection by creatine in a mouse model of stroke. J Cereb Blood Flow Metab.

Adcock KH, et al. Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia. Dev Neurosci. Zhu S, et al. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice.

J Neurosci. Allah Yar R, Akbar A, Iqbal F. Brain Res. Kingsley M, Cunningham D, Mason L, Kilduff LP, McEneny J. Role of creatine supplementation on exercise-induced cardiovascular function and oxidative stress.

Oxid Med Cell Longev. Kley RA, Tarnopolsky MA, Vorgerd M. Creatine for treating muscle disorders. Cochrane Database Syst Rev.

Korzun WJ. Oral creatine supplements lower plasma homocysteine concentrations in humans. Clin Lab Sci. McMorris T, Harris RC, Swain J, et al. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol.

Psychopharmacology Berl. Metzl JD, Small E, Levine SR. Gershel JC. Creatine use among young athletes. Patra S, Ghosh A, Roy SS, et al. A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy.

Amino Acids. Persky AM, Rawson ES. Safety of creatine supplementation. Subcell Biochem. Sheth NP, Sennett B, Berns JS. Rhabdomyolysis and acute renal failure following arthroscopic knee surgery in a college football player taking creatine supplements. Clin Nephrol. Simon DK, Wu C, Tilley BC, et al.

Caffeine and progression of Parkinson disease: a deleterious interaction with creatine. Clin Neuropharmacol. Sullivan PG, Geiger JD, Mattson MP, Scheff SW.

Dietary supplement creatine protects against traumatic brain injury. Ann Neurol. Tarnopolsky MA, Beal MF. Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders [Review]. Tyler TF, Nicholas SJ, Hershman EB, Glace BW, Mullaney MJ, McHugh MP.

The effect of creatine supplementation on strength recovery after anterior cruciate ligament ACL reconstruction: a randomized, placebo-controlled, double-blind trial.

Am J Sports Med. Willer B, Stucki G, Hoppeler H, Bruhlmann P, Krahenbuhl S. Effects of creatine supplementation on muscle weakness in patients with rheumatoid arthritis. Witte KK, Clark AL, Cleland JG.

Chronic heart failure and micronutrients. J Am Coll Cardiol. Share Facebook Twitter Linkedin Email Home Health Library.

Creatine Phosphocreatine. Uses Athletic performance Most human studies have taken place in laboratories, not in people actually playing sports. Heart disease Preliminary studies suggest that creatine supplements may help lower levels of triglycerides fats in the blood in men and women with high concentrations of triglycerides.

Cancer Preliminary studies suggest that creatine may have anticancer properties. Chronic Obstructive Pulmonary Disease COPD One study found that people with COPD who took creatine increased muscle mass, muscle strength and endurance, and improved their health status compared with those who took placebo.

Muscular dystrophy People who have muscular dystrophy may have less creatine in their muscle cells, which may contribute to muscle weakness. Parkinson disease People with Parkinson disease PD have decreased muscular fitness, including decreased muscle mass, muscle strength, and increased fatigue.

Amyotrophic Lateral Sclerosis ALS or Lou Gehrig's disease Creatine appears to slow the progression of ALS and improves patients' quality of life. Dietary Sources About half of the creatine in our bodies is made from amino acids in the liver, kidney, and pancreas.

Available Forms Supplements are commonly sold as powders. How to Take It Pediatric Creatine supplements are not recommended for children or teens. Adult Sample doses are below.

You should ask your doctor to help determine the right dose for you. Maintenance dose in exercise performance for adults ages 19 and older : Take 2 g daily. Precautions Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable health care provider.

Side effects of creatine include: Weight gain Muscle cramps Muscle strains and pulls Stomach upset Diarrhea Dizziness High blood pressure Liver dysfunction Kidney damage Most studies have found no significant side effects at the doses used for up to 6 months.

People with kidney disease, high blood pressure, or liver disease should not take creatine. Possible Interactions If you are being treated with any of the following medications, you should not use creatine without talking to your doctor first. Non steroidal anti-inflammatory drugs NSAIDs Taking creatine with these pain relievers may increase the risk of kidney damage.

One study found that creatine supplementation reduced mental fatigue during sustained mental effort. Maintaining concentration and decision-making abilities during long races, such as triathlons, is crucial for optimal performance. Further, recent research has shown that creatine supplementation can improve cognition and memory, especially in older adults or during metabolic stress i.

Interestingly, higher doses of creatine may be required. This should be considered and discussed with your health professional if brain function is a priority. Concerns have been raised about creatine causing dehydration and cramping.

Total injuries, muscle tightness, and muscle strains were also found to be less in the athletes supplementing with creatine monohydrate.

This has been in conjunction with findings supporting improved total body, extracellular, and intracellular water volumes in those athletes supplementing with creatine monohydrate. The key takeaway is that creatine monohydrate does not enhance the likelihood of cramping or dehydration, and it appears to reduce the risk of heat injury.

An interesting systematic review concluded a negative correlation between creatine monohydrate supplementation and VO2 max. The authors acknowledge a risk of bias with the study designs due to a need for more clarity over randomization with nearly all studies included.

Only three of the nineteen studies thoroughly detailed the assessment of VO2 max. So as weight goes up, VO2 max goes down. While creatine appears to impair VO2 max, it may result from slight weight change.

Nonetheless, the study findings warrant further investigation to determine if there are specific reasons why any adverse effects on VO2 max might occur. Ensuring that the supplementation protocol and training and testing processes are repeatable, reliable and valid is essential for future research.

One concern often associated with creatine monohydrate supplementation is fluid retention, which may result in temporary weight gain. This is often undesirable for athletes aiming to maintain a lean physique. This was one of the primary negative consequences highlighted in an article published in Sports Medicine.

This varies from athlete to athlete, though. If weight gain through fluid retention is an issue, stop taking creatine weeks before racing to offset fluid retention while retaining increased creatine stores. Some people experience gastrointestinal discomfort when taking creatine, such as bloating, cramping, or diarrhea.

This is more common when taking higher doses, or not letting it fully dissolve in water before ingestion. Additionally, the form of creatine can influence GI complaints.

Concerns about the long-term effects of creatine monohydrate supplementation on renal kidney function have been raised. Be sure to stay within the recommended dosage guidelines and consult a healthcare professional if you have pre-existing kidney conditions. The response to creatine varies among individuals.

Genetic factors, training status, diet, and baseline creatine levels all influence your response. Some athletes might experience significant performance benefits, while others might not notice any discernible improvements, as explained in an article published in Sports Medicine.

There appears to be a training status effect associated with creatine monohydrate. This may be due to the additional benefits of increased training through supplementation not being as enhanced for those athletes. Plant-based athletes and vegans are likely to benefit more than other athletes regardless of training status since most naturally occurring sources of creatine are derived from animal sources.

The ages of the participants included in the studies were all under 35, with most being in their mid-twenties. Eight of the studies involved a loading phase shorter phase with much higher dosages and the duration of supplementation ranged from five to 70 days.

Seven studies only had athletes take creatine for seven days or less. Interestingly, the study that showed the most significant effect was the only study where athletes supplemented for over fifty days 70 days total , which were found in rowers only.

Journal of Crfatine International Fr of Sports Improvin volume 14Article number: 18 Fat blocker for maintaining weight this article. Metrics details. Creatine is one of the exervise popular nutritional Creatune Creatine for improving exercise capacity for athletes. Studies have consistently Chitosan for natural remedies that creatine supplementation increases intramuscular creatine concentrations which may help explain the observed improvements in high intensity exercise performance leading to greater training adaptations. Additionally, a number of clinical applications of creatine supplementation have been studied involving neurodegenerative diseases e. Additionally, researchers have identified a number of potentially beneficial clinical uses of creatine supplementation. Moreover, significant health benefits may be provided by ensuring habitual low dietary creatine ingestion e. Creatine Imporving your muscles Creatinw energy during heavy Fat blocker for maintaining weight or high intensity exercise. Athletes often caoacity creatine supplements to enhance Pharmaceutical-certified ingredient sourcing and improve performance, but older adults and vegetarians may also benefit. Studies show that it can increase muscle mass, strength, and exercise performance. Additionally, it may help lower blood sugar and improve brain functionalthough more research is needed in these areas. Some people believe that creatine is unsafe and has many side effects. However, scientific evidence does not support these claims. Creatine is a substance found naturally in muscle cells.

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