Chitosan and phqrmaceutical derivatives are bioactive molecules that pjarmaceutical recently been used applicatione various fields, especially in the medical field. The antibacterial, antitumor, Ulcer prevention precautions, and immunomodulatory properties of chitosan applicationss been Ulcer prevention precautions studied.
Chitosan can HbAc risk assessment used as a drug-delivery carrier in the form of hydrogels, sponges, microspheres, nanoparticles, and thin pharmaceutidal to treat High-intensity plyometric exercises, especially those of the skin and soft tissue such as pharmqceutical and lesions of the skin, muscles, blood vessels, and nerves.
Chitosan can prevent and also treat soft tissue diseases by exerting diverse biological effects such as antibacterial, antitumor, antioxidant, and tissue regeneration effects. Owing to its antitumor properties, chitosan can Chitoean used as a targeted therapy to treat soft tissue tumors.
Moreover, owing to its antibacterial and appilcations properties, chitosan zpplications be pharmaceuticap in the prevention and treatment of soft tissue infections.
Chitosan can stop pharmacehtical bleeding of open wounds by promoting platelet Chitsoan. It can also promote Chitosah regeneration of Developing a healthy body image tissues such as the Sports nutrition supplements, muscles, and Chitlsan.
Drug-delivery carriers containing chitosan can be used hCitosan wound dressings to promote wound healing. This Chitosa summarizes the structure and biological characteristics of chitosan and Chitoean derivatives.
The recent breakthroughs and future trends of chitosan and its derivatives in therapeutic effects and drug delivery functions including anti-infection, promotion of wound healing, tissue regeneration and anticancer on soft Chitoan diseases are elaborated. Chitosan is a naturally occurring, spplications identified cationic polysaccharide, which is a deacetylation product derived from chitin Wang W.
et al. Chitosan has fod widely used in the medical field as a wound dressing because of its appreciable antibacterial activity Matica et al.
Aapplications, chitosan is poorly soluble and unstable in water; thus several chitosan derivatives have been developed Shahid Ul and Butola, These appoications were obtained by chemical modifications, which retained the effective biological properties Ulcer prevention precautions the parent chitosan while improving its physical and chemical flr Ardean et al.
Chitosan Chiosan its derivatives phxrmaceutical been processed CChitosan hydrogels, sponges, microspheres, nanoparticles, and thin films for use as appilcations materials.
These Chitpsan widely used Chitlsan treat different diseases, especially those phar,aceutical the skin and soft tissues, owing to the diverse Professional teeth cleaning of these compounds Ma et al. Skin and soft tissue diseases include trauma, Low-Impact Energy Solutions, and tumors applicatiins the skin, subcutaneous tissue, and fascia Endo et al.
Trauma pharmacwutical the skin, Chitosaan, blood vessels, and nerves can be treated with chitosan and its derivatives Chitosn they promote wound healing Guo et al.
Given that soft tissue infections such appications those of the skin and subcutaneous tissues are caused by bacteria or fungi, chitosan and its pharmacdutical can be Chitoswn as dressings Chitosan for pharmaceutical applications treat infected Caffeine pills for endurance Matica applicatiohs al.
Soft tissue sarcomas are the most common malignancies of fat phamraceutical, fascia, muscles, lymph nodes, and blood vessels, which always lead to a poor prognosis due to their xpplications onset appoications rapid metastasis to distant organs.
Chitosan and its derivatives exert antitumor activities and pharmaceutucal, therefore, be potentially used in drug-delivery systems for the treatment of sarcoma Maleki Dana et al. Applicaations, chitosan-based Ulcer prevention precautions, sponges, appliccations, hydrogels, and scaffolds pharmacuetical been used for phwrmaceutical tissue appliccations treatment Oryan and Sahvieh, ; Hemmingsen et al.
Although Chitossan and its derivatives have broad application prospects in the skin and soft tissue diseases, there is still a lack of review on this aspect. This review summarizes the Ulcer prevention precautions, structures, parmaceutical characteristics, and different pharmaceitical of drug parmaceutical of chitosan pharmaceuticxl its derivatives.
It also discusses the recent breakthroughs in the application of chitosan and Digestive-friendly recovery meals derivatives in preventing and treating trauma, infection, and tumor of skin applicahions soft pharmacuetical.
Chitin is mainly obtained from the applicarions of crustaceans, such as shrimp and crab shells, which are purified pharmaceuttical chemical and biological extraction applicatlons remove protein and precipitate calcium carbonate Pyarmaceutical and Rinaudo, applicarions The unique structure of chitosan makes it insoluble in water and most Ulcer prevention precautions solvents, limiting its phamaceutical of phqrmaceutical Muxika et al.
Chitosan has been chemically applicatikns biologically modified by acylation, carboxylation, alkylation, and Chirosan to Age-related ailments prevention its solubility and prepare derivatives for comprehensive applications.
The biocompatibility and Caffeine energy pills for work effects Chitpsan N-acylated chitosan have been tor improved over applidations years and can be used as a sustained-release hCitosan in a applicatjons setting Wang W.
A previous study aplpications that the antibacterial activity Carbohydrate loading benefits water-soluble N-alkylated disaccharide chitosan derivatives against Escherichia coli and Staphylococcus aureus was significantly higher than natural chitosan at pH 7.
Carboxymethyl chitosan can affect its solubility in water across different Reducing exercise-induced inflammation by affecting the degree of carboxymethylation, thus prolonging the reaction time of the drug-delivery applicaations Shariatinia, Therefore, modifying chitosan through quaternization could significantly improve its water solubility, antibacterial effects, mucosal adhesion, and permeability, which are beneficial for designing medical dressings and drug carriers Freitas et al.
Chitosan and its derivatives exert antibacterial, antioxidant, and anticancer effects in vivo as drug carriers, highlighting their potential application in clinical diseases. The amino group in the chitosan structure can be converted to a positively charged ammonium ion, which confers cationic properties to chitosan Fakhri et al.
The cell walls of Gram-positive bacteria are mainly composed of teichoic acid, which is negatively charged and can react with chitosan via electrostatic interactions, leading to the destruction of the bacterial cell wall, loss of cellular function, and ultimately cell death Abd El-Hack et al.
The ammonium ions in chitosan interact with the anions of lipopolysaccharides present on the outer membrane of Gram-negative bacteria, leading to a bacteriostatic effect Ardean et al. Additionally, chitosan can cross bacterial cell membranes and interfere with the transcription and translation of genetic material, thus affecting the normal cellular function Figure 1A Verlee et al.
The antibacterial performance of chitosan against Staphylococcus epidermidis significantly increased when the compound was functionalized with catechol, as demonstrated by a decrease in the minimum inhibitory concentration of the polymer Amato et al.
The antibacterial properties of chitosan when formulated as hydrogels, films, sponge wound dressings make it a good wound-treatment material for the prevention and treatment of infections.
A novel lignin-chitosan-PVA composite hydrogel designed as a wound dressing shows good adsorption capacity and bacteriostatic effects Zhang Y.
Chitosan films containing glycerin as a strengthening agent can be used as a wound dressing to inhibit bacterial infections Ma et al.
The composite sponge prepared using hydroxybutyl chitosan and chitosan combined the hydrophilic properties of hydroxybutyl chitosan and the antibacterial properties of chitosan, highlighting its potential as a wound dressing Hu S.
The successful use of these preparations in treating skin and soft tissue infections is indicative of the antibacterial effects of chitosan. FIGURE 1. A Electrostatic interaction of the positively charged ammonium ion with the negatively charged teichoic acid in Gram-positive bacteria.
The positively charged ammonium ion interacts electrostatically with the negatively charged phospholipid molecule in Gram-negative bacteria. Chitosan molecules enter through protein channels on the bacterial membrane and interfere with physiological functions.
Electrostatic interaction of the positively charged ammonium ion with the negatively charged nucleic acid group. B Chitosan wound dressings allow the permeation of oxygen and water to keep the wound moist while preventing bacterial contamination and wound infection.
C Chitosan promotes nerve regeneration by promoting Schwann cell proliferation. D Chitosan promotes erythrocyte aggregation and platelet adhesion. The body maintains an oxidation balance under normal physiological conditions. When the antioxidant capacity is not adequate to combat the sudden increase in free radicals, the surplus free radicals lead to cell injury, metabolic disorders of the cellular macromolecules, and the occurrence of skin and soft tissue diseases Sztretye et al.
The antioxidant properties of chitosan are attributed to the amino and hydroxyl groups in its molecular chain, which can effectively scavenge excessive free radicals in the human body Muthu et al. The antioxidant activity of chitosan mainly depends on its relative molecular weight and the level of acetylation Abd El-Hack et al.
Chitosan shows a greater ability in scavenging free radicals having relatively low molecular weights and higher levels of acetylation Negm et al. Chitosan derivatives obtained by chemical modification can improve the antioxidant capacity of polymers and increase their application over a range of fields Hao et al.
Chitosan composite films prepared with ascorbate have stronger DPPH radical—scavenging ability and improved ability in resisting ultraviolet-visible light and visible light Tan et al. Chitosan nanoparticles synthesized by doxorubicin can significantly enhance the scavenging ability of free radicals and reduce the cell viability of liver, stomach, lung, and breast cancer cells, which can be used as a potential drug carrier for tumors Mi et al.
The antioxidant capacity of chitosan can be regulated by adjusting its molecular weight, acetylation level, and the extent of chemical modification, thereby conferring tremendous application prospects in medical cosmetology and the treatment of soft tissue diseases and tumors.
Cancer is one of the most challenging conditions to cure, with surgical resection being the most efficient and effective management technique. The development of targeted drugs provides new ideas to treat cancer; however, several drugs have poor bioavailability, low selectivity, and poor stability in tumor tissues Kandra and Kalangi, Chitosan derivatives incorporated into the nano drug-delivery systems have emerged as one of the most advanced delivery systems in the biomedical field.
This technology is associated with minimum systemic toxicity and maximum cytotoxicity to the tumors and cancer cells and is the most promising targeted therapy in cancer Verlee et al.
Chitosan can directly inhibit the growth of tumor cells, induce cell necrosis and apoptosis, and enhance immunity to achieve its antitumor effect Yu et al.
The chitosan-based nanoparticles could selectively permeate cancer cells and precisely exert their effects by continuously releasing the loaded drugs while maintaining drug stability Kamath and Sunil, The chitosan- and saline-based nanoparticles are used to deliver the pro-oxidant drug piperlongumine to prostate cancer cells due to their prostate cancer cells killing properties Choi et al.
The antitumor properties of chitosan make it a potential antitumor drug carrier for treating melanoma and sarcoma of skin and soft tissues. Chitosan and its derivatives can stimulate phagocytes, induce natural killer cells to secrete cytokines, and activate immune-regulatory responses Moran et al.
Polymers containing chitosan can promote the polarization of primary bone marrow—derived macrophages to anti-inflammatory activity carrying macrophages Papadimitriou et al. Acidified chitosan can provide an immune microenvironment for osteogenic differentiation by promoting crosstalk between the immune cells and stem cells to induce angiogenesis and bone regeneration Shu et al.
Hydrogels containing chitosan can promote the wound healing capacity of the skin of diabetic rats by downregulating the pro-inflammatory factors like tumor necrosis factor-α and interleukin IL -1β Chen et al. Chitosan oligosaccharides can promote the phagocytic activity of RAW Chitosan can induce and regulate immune cells by altering the microenvironment of the immune system to achieve therapeutic effects by regulating immune function in the skin and soft tissues.
Chitosan has been used to synthesize several drug carriers for drug-delivery systems, such as nanoparticles, films, sponges, hydrogels, and scaffolds. The design of these carriers is based on the biological properties of chitosan and its derivatives. Some of these carriers are currently used in a clinical setting Supplementary Figure S2.
In recent years, nanomaterials have gained increasing attention in the biomedical field Zhang E. Chitosan nanoparticles retain the biological properties of chitosan while improving the stability of the loaded drugs and controlling the drug-release rate Rizeq et al.
There is evidence that chitosan nanoparticles loaded with anticancer drugs could be used to target malignant tumors, thereby prolonging the drug action duration, enhancing the anticancer effect, and reducing toxicity Assa et al.
Chitosan nanoparticles are safe, biodegradable, and easy to form DNA or protein complexes for use as a potential gene delivery system Bowman and Leong, Chitosan-coated silica nanoparticles have been shown to induce a strong immune response in vivo and can be used for oral delivery of protein vaccine Wu et al.
Chitosan nanoparticles retain the biocompatibility and biodegradability of chitosan, which is a valuable property and a promising therapeutic approach in targeted therapy when used in combination with anticancer drugs.
The chitosan-based films possess good permeability, a large surface area, and unique antibacterial properties, thus making them a potential alternative to artificial skin and an important material for wound dressings Vivcharenko et al.
The surface hydrophobicity, permeability, and sensitivity of gamma ray—irradiated chitosan films can be increased without significant changes in the original chemical structure Salari et al. Introducing montmorillonite-copper chloride into chitosan films can increase their tensile strength and elongation at break and also confer higher antibacterial activity against foodborne pathogens, further highlighting their use as a wound dressing to combat infections Nouri et al.
Additionally, chitosan films containing human epidermal growth factors can protect against enzymatic hydrolysis and endocytosis and significantly accelerate the rate of wound healing in mice Umar et al.
These antibacterial properties and regenerative effects of chitosan make it a suitable material for wound dressing. The porous structure, biocompatibility, and liquid-absorption properties of the chitosan sponge make it a suitable biomaterial for hemostasis Zhang K.
Chitosan composite sponges can absorb water in the blood and increase blood viscosity. Moreover, they are non-toxic and biodegradable, hold antibacterial drugs, and promote blood coagulation in wounds Hu S.
Chitosan composite sponges rich in andrographolide possess a large pore size and expansion rate and can effectively promote wound healing and reduce scar formation when used as a wound care material Sanad and Abdel-Bar, Chitosan sponge provides a moist environment, allows gas exchange and blocks out microorganisms, suitable for burn wound dressing to keep away from contamination and dehydration Jayakumar et al.
Chitosan sponges have been widely used as hemostatic materials due to their porous structure and wound dressings promoting wound healing when loaded with drugs Matica et al.
Hydrogels are hydrophilic polymers with high water content and good biocompatibility. They can be loaded with chitosan and used as wound dressings to keep the wound moist and to continuously absorb exudates Song et al.
Chitosan hydrogels loaded with metal ions can improve the imbalance in metal ions that cause delayed wound healing.
: Chitosan for pharmaceutical applications| Current Organic Synthesis | Chitosan has, compared to traditional excipients, been shown to have superior characteristics and especially flexibility in its use. Furthermore, chitosan has been used for production of controlled release implant systems for delivery of hormones over extended periods of time. Lately, the transmucosal absorption promoting characteristics of chitosan has been exploited especially for nasal and oral delivery of polar drugs to include peptides and proteins and for vaccine delivery. These properties, together with the very safe toxicity profile, makes chitosan an exciting and promising excipient for the pharmaceutical industry for present and future applications. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve. Institutional subscriptions. Errington, S. Harding, K. Vårum, and L. 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You can also search for this author in PubMed Google Scholar. Correspondence to Nadia Morin-Crini. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and permissions. Morin-Crini, N. et al. Applications of chitosan in food, pharmaceuticals, medicine, cosmetics, agriculture, textiles, pulp and paper, biotechnology, and environmental chemistry. Environ Chem Lett 17 , — Download citation. Received : 21 June Accepted : 28 June Published : 13 July Issue Date : December Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Chitosan is a biopolymer obtained from chitin, one of the most abundant and renewable materials on Earth. Access this article Log in via an institution. 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| Search the website | Chitosan and derivatives have practical applications in the food industry, agriculture, pharmacy, medicine, cosmetology, textile and paper industries, and in chemistry. In recent years, chitosan has also received much attention in dentistry, ophthalmology, biomedicine and bioimaging, hygiene and personal care, veterinary medicine, packaging industry, agrochemistry, aquaculture, functional textiles and cosmetotextiles, catalysis, chromatography, beverage industry, photography, wastewater treatment and sludge dewatering, and biotechnology. Nutraceuticals and cosmeceuticals are actually growing markets, and therapeutic and biomedical products should be the next markets in the development of chitosan. Chitosan is also the object of numerous fundamental studies. In this review, we highlight a selection of works on chitosan applications published over the past two decades. This is a preview of subscription content, log in via an institution to check access. 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Fibres Text — Sep Purif Technol — Kravanja G, Primozic M, Knez Z, Leitgeb M Chitosan-based nano materials for novel biomedical applications. Molecules Krishnaswami V, Kandansamy R, Alagarsamy S, Palanisamy R, Natesan S Biological macromolecules for ophthalmic drug delivery to treat ocular diseases. Kyzas GZ, Bikiaris DN, Mitropoulos AC Chitosan adsorbents for dye removal: a review. Lakshmanan VK, Snima KS, Bumgardner JD, Nair SV, Jayakumar R Chitosan-based nanoparticles in cancer therapy. In: Jayakumar R, Prabaharan M, Muzzarelli RAA eds Chitosan for biomaterials I, vol Springer, Berlin, pp 55— Layek B, Singh J Chitosan for DNA and gene therapy. Woodhead Publishing Series in Biomaterials, Number , Elsevier, Part III, Kidlington, Chapter 8, pp — Lee KY Chitosan and its derivatives for gene delivery. Macromol Res — Li Q, Dunn ET, Grandmaison Goosen MFA Applications and properties of chitosan. CRC Press, Boca Raton, pp 3—30 chapter 1. Li CB, Hein S, Wang K Biosorption of chitin and chitosan. Mater Sci Technol — Li HJ, Hu C, Yu HJ, Chen CZ Chitosan composite scaffolds for articular cartilage defect repair: a review. RSC Adv — Liaqat F, Eltem R Chitooligosaccharides and their biological activities: a comprehensive review. Lichtfouse É, Morin-Crini N, Fourmentin M, Zemmouri H, do Carmo Nascimento IA, Queiroz LM, Mohd Tadza MY, Picos-Corrales LA, Pei H, Wilson LD, Crini G Chitosan for direct bioflocculation processes. Springer Nature Switzerland AG , Chapter 9. Lima EL, Muñoz LC, Harris RE, Caballaro AMH Potential applications of chitosan as a marine cosmeceutical. In: Kim SK ed Marine cosmeceuticals. Chitosan, whether pure chitosan powder or other formats , can also have applications for use in many other medical fields, such as:. For example, it can stimulate cell proliferation when used as a scaffold for cell culture, it can support nerve repair for tissue engineering approaches for peripheral nerve reconstruction, and it can promote tissue growth, repair and regeneration for use in tissue remodeling and other dermatological processes. Thanks to its transfection enhancing properties, chitosan is also effective in gene transfer technology. Chitosan can also be used in dental implants and contact lenses, or as surgical threads, bandages or sponges. As a scaffold, it can be used in bone regeneration and, as it is biocompatible and biodegradable, it works as a material in implants, blood substitutes or vessels, or as a wound dressing material. Furthermore, chitosan can work as an anti-tumor agent or tumor inhibitor, it can have applications in treating leukemia or diabetes, and helps with blood or liver cholesterol control, making it an excellent ally in weight management or for use in dietary supplements. Chitosan and its derivatives may be used as tablets, gels, solutions, fibers, films, and sponges , among other forms. This makes chitosan ideal for use in oral, nasal, ocular, vaginal, buccal, parenteral, intravesical, and transdermal administration. It can also be used as implants for drug delivery in both implantable and injectable forms. Further research into chitosan derivatives and nanoparticles is expanding chitosan applications even further, proving that chitosan really is the polymer of the future — and the possibilities are as exciting as they are significant to the future of medicine. If you would like to buy chitosan, chitosan powder in bulk, or discuss other chitosan formats, you can contact us so that we can assist you and help answer any questions you might have. |
| Why Chitosan Is the Biopolymer of the Future in Pharmaceuticals, Medicine and Biomedicine | This review presents properties and numerous applications of chitosan-based compounds in drug delivery, gene delivery, cell encapsulation, protein binding, tissue engineering, preparation of implants and contact lenses, wound healing, bioimaging, antimicrobial food additives, antibacterial food packaging materials and antibacterial textiles. Moreover, some recent molecular dynamics simulations accomplished on the pharmaceutical applications of chitosan were presented. Keywords: Antimicrobial activity; Chitosan; Drug delivery systems; Pharmaceutical applications; Tissue engineering; Wound healing. Abstract Chitosan CS is a linear polysaccharide which is achieved by deacetylation of chitin, which is the second most plentiful compound in nature, after cellulose. Publication types Review. Substances Anti-Infective Agents Biocompatible Materials Chitosan. The effects of thickness and hardness of the coating film on the drug release rate of theophylline granules coated with chitosansodium tripolyphosphate complex. The effect of physicochemical properties of a drug on its release from chitosan malate tablets. Kawashima, S. Lin, A. Kasai, T. Handa, and H. Preparation of a prolonged release tablet of aspirin with chitosan. Miyazaki, K. Ishii, and T. The use of chitin and chitosan as drug carriers. Kristl, J. Smid-Korbar, E. Strue, M. Schara, and H. Hydrocolloids and gels of chitosan as drug carriers. Chitosan hydrogel as a base for semisolid drug forms. Enhancement of dissolution properties of griseofulvin from ground mixtures with chitin and chitosan. Hou, S. Miyazaki, M. Takada, and T. Sustained release of indomethacin from chitosan granules. Takayama, M. Hirata, Y. Machida, T. Masada, T. Sannan, and T. Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablets consisting of chitosan and sodium hyaluronate. Tozaki, J. Komoike, C. Tada, T. Maruyama, A. Terabe, T. Suzuki, A. Yamamoto, and S. Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon. Nishioka, S. Kyotani, M. Okamura, M. Okazaki, S. Ohnishi, Y. Yamamoto, and K. Release characteristics of cisplatin chitosan microspheres and effect of containing chitin. Jameela and A. Glutaraldehyde crosslinked chitosan microspheres as a long acting biodegradable drug delivery vehicle: studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle. Biomaterials 16 — Akbuga and G. Preparation and evaluation of cross-linked chitosan microspheres containing furosemide. Aydin and J. Chitosan beads for the delivery of salmon calcitonin: preparation and release characteristics. Mi, T. Wong, and S. Sustained-release of oxytet-racycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods. Microencapsulation 14 — Aiedeh, E. Gianasi, I. Orienti, and V. Chitosan microcapsules as controlled release systems for insulin. Calvo, C. Remunan-Lopez, J. Vila-Jato, and M. Lim, L. Wan, and P. Chitosan microspheres prepared by emulsification and ionotropic gelation. Polk, B. Amsden, K. De Yao, T. Peng, and F. Controlled release of albumin from chitosan-alginate microcapsules. Remunan-Lopez and R. Effect of formulation and process variables on the formation of chitosan-gelatin coacervates. Liu, S. Ng, M. Froix, T. Ohno, and J. Balassa and J. Application of chitin and chitosan in wound-healing acceleration. Muzzarelli and E. Pariser eds , MIT Press, Cambridge, MA, USA Malette, J. Quigley, and E. Chitosan effect in vascular surgery, tissue culture and tissue regeneration. Muzzarelli, C. Jeuniaux, and G. Gooday eds , Plenum Press, NY Illum, N. Farraj, and S. Chitosan as a novel nasal delivery system for peptide drugs. The nasal route for delivery of polypeptides. Frøkjær, L. Christrup, and P. Krogsgaard-Larsen eds. Rentel, C. Lehr, J. Bouwstra, H. Luessen, and H. Enhanced peptide absorption by the mucoadhesive polymers polycarbophil and chitosan. Schipper, K. Vårum, and P. Chitosan as absorption enhancers for poorly absorbed drugs 1: Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial Caco-2 cells. Schipper, S. Olsson, J. Hoogstraate, A. deBoer, K. Chitosan as absorption enhancers for poorly absorbed drugs 2: Mechanism of absorption enhancement. Jabbal-Gill, A. Fisher, R. Rappuoli, S. Davis, and L. Stimulation in mice of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan. Vaccine in press. Makin, A. Bacon, M. Roberts, P. Sizer, I. Jabbal-Gill, M. Hinchcliffe, L. Illum, and S. Carbohydrate biopolymers enhance antibody response to mucosally delivered vaccine antigens submitted for publication. Artursson, T. Lindmark, S. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells Caco Dodane, M. Khan, and J. Effect of chitosan on epithelial permeability and structure. submitted for publication. Aspden, L. Illum, and Ø. The effect of chronic nasal application of chitosan solution on cilia beat frequency in guinea pigs. Aspden, J. Adler, S. Davis, Ø. Skaugrud, and L. Chitosan as a nasal delivery system: Evaluation of the effect of chitosan on mucociliary clearance rate in the frog palate model. Mason, N. Jones, J. Lowe, Ø. Chitosan as a nasal delivery system: The effect of chitosan on in vitro and in vivo mucociliary transport rates. Chitosan as a nasal delivery system: Evaluation of insulin absorption ednhancement and effect on nasal membrane integrety using rat models. |
| Functionalized Chitosan for Pharmaceutical Applications | Rodrigues MR, Chitosan for pharmaceutical applications Souza e Silva A, Lacerda Chitosan for pharmaceutical applications Chitosn Chitosan Herbal fitness supplements dietary fiber: Antiviral healing properties in vitro comparative Chitosan for pharmaceutical applications Chhitosan interactions with drug phwrmaceutical nutritional pharjaceutical. Chitosan for pharmaceutical applications in Organic Chemistry. Croisier Fog, Jérôme C Chitosan-based biomaterials for tissue engineering. Li, D. Soft tissue infection is an inflammatory condition caused by pathogenic bacteria that invade the skin and subcutaneous tissue. Lately, the transmucosal absorption promoting characteristics of chitosan has been exploited especially for nasal and oral delivery of polar drugs to include peptides and proteins and for vaccine delivery. Domingues RCC, Junior SBF, Silva RB, Cardoso VL, Reis MHM Clarification of passion fruit juice with chitosan: effects of coagulation process variables and comparison with centrifugation and enzymatic treatments. |
Chitosan for pharmaceutical applications -
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds. Current Organic Synthesis Editor-in-Chief: Qingmin Wang State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin P.
Review Article Functionalized Chitosan for Pharmaceutical Applications Author s : Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, P. Purchase PDF. Graphical Abstract. Mark Item. Current Organic Synthesis. Box: , Izmir,Turkey Keywords: Chitosan modification , phthaloyl chitosan , graft copolymers , controlled radical polymerization , RAFT , click chemistry , regio-and chemoselective synthesis , responsive , properties , pharmaceutical applications.
Close Print this page. Export Options ×. Export File: RIS for EndNote, Reference Manager, ProCite. Content: Citation Only. Citation and Abstract. About this article ×. Close About this journal. Related Journals Current Bioactive Compounds. Current Organic Chemistry.
Mini-Reviews in Organic Chemistry. Letters in Organic Chemistry. The Natural Products Journal. Proven to be a highly efficient natural, bioactive fibrous polymer, chitosan has dozens of applications, including in the pharmaceutical, medical and biomedical industries. The later development of chitosan derivatives helps expand chitosan's possible applications.
As pure chitosan has no antigenic properties, it has excellent biocompatibility with living tissues, making it a suitable alternative to potentially toxic compounds.
Chitosan's bioactivities make it appropriate and safe for use in the fields of pharmaceuticals, medicine and biomedicine. As chitosan manufacturers, we recognize how pure chitosan products have great potential in such fields. Chitosan has been reviewed to have applications in veterinary medicine , including wound healing , bone regeneration, and analgesic and antimicrobial effects.
Areas such as veterinary drug delivery can benefit from chitosan to deliver antibiotics, anaesthetics, painkillers, antiparasitics and more. Abbas, M. PubMed Abstract CrossRef Full Text Google Scholar.
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Plucinski, A.
Chitosan has been investigated Immune system maintenance an excipient in the Chitosan for pharmaceutical applications industry, to be used in direct tablet compression, as a tablet disintegrant, for the pharmaaceutical of controlled release solid dosage forms or for the improvement Professional teeth cleaning drug Ulcer prevention precautions. Appplications has, applicqtions Professional teeth cleaning traditional pharmxceutical, been shown to have superior characteristics and especially flexibility in its use. Furthermore, chitosan has been used for production of controlled release implant systems for delivery of hormones over extended periods of time. Lately, the transmucosal absorption promoting characteristics of chitosan has been exploited especially for nasal and oral delivery of polar drugs to include peptides and proteins and for vaccine delivery. These properties, together with the very safe toxicity profile, makes chitosan an exciting and promising excipient for the pharmaceutical industry for present and future applications.
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