Sign In or Create Sugar alternatives for diabetics Account. Another Hypoglycemai [ Finction ] published by the same authors in also demonstrated a statistically significant increased risk of dementia with prior hypoglycemic events OR: 1. Memory and insulin dependent diabetes mellitus IDDM : effects of childhood onset and severe hypoglycemia. J Diabetes Res.

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Hypoglycemia and cognitive function -

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Download references. Department of Neurology, University of California at San Francisco and Veterans Affairs Medical Center, San Francisco, CA, USA. Department of Neurosurgery, University of California San Francisco and Veterans Affairs Medical Center, San Francisco, CA, USA.

Department of Anesthesiology, Inje Paik Hospital, Inje University, School of Medicine, Seoul, Korea. Department of Nursing, Inha University, Incheon, Korea. Department of Physiology, Hallym University, College of Medicine, Chuncheon, , Korea.

You can also search for this author in PubMed Google Scholar. Correspondence to Sang Won Suh. SW, BY, TK, BC, JK, BJ, ML, and JL researched data. MS performed the data analysis; SW, MS, JL, RS, and SS reviewed and edited the manuscript. RS and SS contributed to the discussion.

SS wrote the manuscript. All authors read and approved the final manuscript. Additional file 1: Figure S1. One week after STZ injection, diabetic rats were subjected to either moderate hypoglycemia for 5 consecutive days A or severe hypoglycemia once B. For moderate hypoglycemia, rats were unanesthetized during entire experiment.

For severe hypoglycemia, rats were anesthetized by isoflurane during entire hypoglycemia surgery. TIFF KB. Additional file 2: Figure S2.

EEG and blood glucose changes during hypoglycemia in diabetic rats. Insulin injection increases amplitude and reduces frequency of cortical EEG.

This blood glucose concentration was quickly decreased immediately after insulin injection. During the iso-EEG, blood glucose concentration was below 0. Open Access This article is published under license to BioMed Central Ltd.

Reprints and permissions. Won, S. et al. J Neuroinflammation 9 , Download citation. Received : 30 April Accepted : 06 July Published : 25 July Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Methods The experiments were conducted in normal and in diabetic rats.

Materials and methods The surgical and animal care procedures were in accordance with the guidelines of the Institutional Animal Care and Use Committee of the San Francisco Veterans Affairs Medical Center animal welfare assurance number A and of the Hallym University Hallym — Type 1 diabetes rat For the type 1 diabetes model, rats received repeated intraperitoneal injections of streptozotocin STZ.

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Subject Area: Endocrinology , Women's and Children's Health. Michal Nevo-Shenker ; Michal Nevo-Shenker. a Jesse Z.

This Site. Google Scholar. Shlomit Shalitin Shlomit Shalitin. b Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. shomits2 clalit.

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T1 - Consistent effects of hypoglycemia on cognitive function in people with or without diabetes. and Harry B. Helmsley Charitable Trust under grant agreement no. N2 - ObjectiveHypoglycemia poses an immediate threat for cognitive function.

ConclusionsIHSG level 2 hypoglycemia impairs cognitive function in people with and without diabetes, irrespective of type of diabetes or hypoglycemia awareness status.

AB - ObjectiveHypoglycemia poses an immediate threat for cognitive function. Consistent effects of hypoglycemia on cognitive function in people with or without diabetes.

Medical and Clinical Psychology. Overview Fingerprint. Abstract Objective Hypoglycemia poses an immediate threat for cognitive function. Conclusions IHSG level 2 hypoglycemia impairs cognitive function in people with and without diabetes, irrespective of type of diabetes or hypoglycemia awareness status.

Access to Document MCP Nefs consistent effects of hypoglycemia DC Final published version, 18 MB. Fingerprint Dive into the research topics of 'Consistent effects of hypoglycemia on cognitive function in people with or without diabetes'.

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Background: Severe Athlete weight loss can cause cognitive impairment in diabetic patients, but the underlying molecular Hydration for athletes remains unclear. Objective: To Athlete weight loss the effect covnitive severe hypoglycemia functlon cognitive function in diabetic mice vognitive clarify the relationship between Hypoylycemia mechanism and Hypoglycsmia of pericytes and BMR and fitness blood—brain cognitiv BBB. Further intraperitoneal injection of short-acting insulin induced severe hypoglycemia. Pericyte and BBB morphology and function were detected by histological and western blot analyses, BBB permeability was detected by Evans blue staining, and cognitive function was detected with the Morris water maze. Results: Severe hypoglycemia aggravated the histological damage, BBB damage, brain edema, and pericyte loss in the diabetic mice. It also reduced the expression of the BBB tight junction proteins occludin and claudin-5, the expression of the pericyte-specific markers PDGFR-β platelet-derived growth factor receptor-β and α-SMA, and increased the expression of the inflammatory factor MMP9. At the same time, diabetic mice with severe hypoglycemia had significantly reduced cognitive function. Funcfion RAHypoglycemia and cognitive function AJHypoglycemia and cognitive function KFundtion CPSelby Cognitice. Hypoglycemic Episodes cofnitive Risk of Dementia in Older Patients With Type 2 Nutrition periodization for team sports Mellitus. Cognltive Affiliations: Division of Research, Metformin for Type diabetes of Etiology and Prevention, Kaiser Permanente, Oakland, California Drs Whitmer, Functjon, Hypoglycemia and cognitive function, dunction Selby BMR and fitness Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco Dr Yaffe. Context Although acute hypoglycemia may be associated with cognitive impairment in children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a risk factor for dementia in older patients with type 2 diabetes. Objective To determine if hypoglycemic episodes severe enough to require hospitalization are associated with an increased risk of dementia in a population of older patients with type 2 diabetes followed up for 27 years. Design, Setting, and Patients A longitudinal cohort study from of 16 patients with a mean age of 65 years and type 2 diabetes who are members of an integrated health care delivery system in northern California.