Alpha-lipoic acid dosage -
But alpha-lipoic acid is both fat and water soluble. That means it can work throughout the body. Antioxidants in the body are used up as they attack free radicals.
But evidence suggests alpha-lipoic acid may help regenerate these other antioxidants and make them active again. In the cells of the body, alpha-lipoic acid is changed into dihydrolipoic acid. Alpha-lipoic acid is not the same as alpha linolenic acid, which is an omega-3 fatty acid that may help heart health.
There is confusion between alpha-lipoic acid and alpa linolenic acid because both are sometimes abbreviated ALA. Alpha-lipoic acid is also sometimes called lipoic acid. Several studies suggest alpha-lipoic acid helps lower blood sugar levels. Its ability to kill free radicals may help people with diabetic peripheral neuropathy, who have pain, burning, itching, tingling, and numbness in arms and legs from nerve damage.
Researchers believe Alpha-lipoic acid helps improve insulin sensitivity. Alpha-lipoic acid has been used for years to treat peripheral neuropathy in Germany. However, most of the studies that have found it helps have used intravenous IV alpha-lipoic acid. It's not clear whether taking alpha-lipoic acid by mouth will help.
Most studies of oral alpha-lipoic acid have been small and poorly designed. One study did find that taking alpha-lipoic acid for diabetic neuropathy reduced symptoms compared to placebo. Taking alpha-lipoic acid may help another diabetes-related condition called autonomic neuropathy, which affects the nerves to internal organs.
One study of 73 people with cardiac autonomic neuropathy, which affects the heart, found that subjects reported fewer signs of the condition when taking mg of alpha-lipoic acid orally compared to placebo. Because alpha-lipoic acid can pass easily into the brain, it may help protect the brain and nerve tissue.
Researchers are investigating it as a potential treatment for stroke and other brain problems involving free radical damage, such as dementia. So far, there's no evidence to say whether or not it works. Preliminary studies suggest alpha-lipoic acid may help treat glaucoma.
But there is not enough evidence to say for sure whether it works. Studies show ALA binds with toxic metals, such as mercury, arsenic, iron, and other metals that act as free radicals. Preliminary studies also suggest that ALA may play a role in managing other conditions including erectile dysfunction and cancer.
And preliminary studies suggest it may reduce complications associated with otitis media ear infections. If you are healthy, your body makes enough alpha-lipoic acid.
It is also found in red meat, organ meats such as liver , and yeast -- particularly brewer's yeast. Alpha-lipoic acid supplements are available as capsules. Your health care provider can also give it by injection.
Pediatric Alpha-lipoic acid has not been studied in children, so it is not recommended for pediatric use. Check with your doctor regarding dosing recommendations. Studies are mixed about whether or not to take ALA with meals.
Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a health care provider.
Alpha-lipoic acid hasn't been studied in pregnant or breastfeeding women, so researchers don't know if it's safe. Alpha-lipoic acid can lower blood sugar levels, so people with diabetes or low blood sugar should take alpha-lipoic acid only under the supervision of their health care provider.
Animal studies suggest that people who don't get enough thiamine vitamin B1 should not take alpha-lipoic acid. B1 deficiency is associated with long-term alcohol abuse.
If you are being treated with any of the following medications, you should not use alpha-lipoic acid without first talking to your health care provider. Apha-lipoic acid can combine with these drugs to lower blood sugar levels, raising the risk of hypoglycemia or low blood sugar.
Ask your provider before taking alpha-lipoic acid, and watch your blood sugar levels closely. Your provider may need to adjust your medication doses. Alpha-lipoic acid may interfere with some chemotherapy medications. Always ask your oncologist before taking any herb or supplement, including alpha-lipoic acid.
Apha-lipoic acid may lower levels of thyroid hormone. Your provider should monitor blood hormone levels and thyroid function tests closely. Alpha lipoic acid can lower the level of vitamin B1 Thiamine in the body. If you choose to use alpha-lipoic acid, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider.
Do not use more of this product than is recommended on the label. Call your doctor if the condition you are treating with alpha-lipoic acid does not improve, or if it gets worse while using this product. Do not use different forms tablets and capsules of alpha-lipoic acid at the same time without medical advice.
Using different formulations together increases the risk of an overdose. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra alpha-lipoic acid to make up the missed dose. Health Conditions A-Z. Best Oils for Skin Complementary Approaches Emotional Wellness Fitness and Exercise Healthy Skin Online Therapy Reiki Healing Resilience Sleep Sexual Health Self Care Yoga Poses See All.
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Alpha-Lipoic Acid Alpha Lipoic. Brand Names: Alpha Lipoic , Alpha-Lipoic-Acid uses What is Alpha-Lipoic Acid Alpha Lipoic used for? Dietary Supplement. warnings What is the most important information I should know about Alpha-Lipoic Acid Alpha Lipoic?
Neurosci Lett. Anuradha B, Varalakshmi P. Protective role of DL-alpha-lipoic acid against mercury-induced Pharmacol Res. Moini H, Tirosh O, Park YC, Cho KJ, Packer L.
R-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes. Arch Biochem Biophys.
Takaishi N, Yoshida K, Satsu H, Shimizu M. Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers. J Agric Food Chem. Teichert J, Hermann R, Ruus P, Preiss R. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers.
J Clin Pharmacol. Suh JH, Moreau R, Heath SH, Hagen TM. Dietary supplementation with R -alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.
Redox Rep. Chou TC, Shih CY, Chen YT. Inhibitory effect of α-lipoic acid on platelet aggregation is mediated by PPARs. Slepneva IA, Sergeeva SV, Khramtsov VV. Reversible inhibition of NADPH-cytochrome P reductase by alpha-lipoic acid. Biochem Biophys Res Commun. McNeilly AM, Davison GW, Murphy MH, et al.
Effect of α-lipoic acid and exercise training on cardiovascular … glucose tolerance. Lipids Health Dis. Andrea Scaramuzza, Elisa Giani, Francesca Redaelli, et al. Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial..
Journal of Diabetes Research. Akira U, Yoko Y, Masayuki Y. The Keap1—Nrf2 system and Archives of Biochemistry and Biophysics. Kobayashi A, Kang M-I, Watai Y, et al. Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1.
Molecular and Cellular Biology. Hale G, Wallis NG, Perham RN. Interaction of avidin with the lipoyl domains in the pyruvate dehydrogenase multienzyme complex: three-dimensional location and similarity to biotinyl domains in carboxylases. Proc Biol Sci.
Sola S, Mir MQ, Cheema FA, et al.
The Forbes Health editorial team is independent and Hunger and elderly population. To Alpha-lipoif Heart health programs our reporting Alpha-lipioc, and to continue our acis to provide this Fat oxidation training for Hunger and elderly population to our Alpha-liipoic, we receive compensation from aci companies that advertise on the Forbes Alpha-liplic site. This compensation comes from two main sources. Firstwe provide paid placements to advertisers to present their offers. This site does not include all companies or products available within the market. The compensation we receive from advertisers does not influence the recommendations or advice our editorial team provides in our articles or otherwise impact any of the editorial content on Forbes Health. While we work hard to provide accurate and up-to-date information that we think you will find relevant, Forbes Health does not and cannot guarantee that any information provided is complete and makes no representations or warranties in connection thereto, nor to the accuracy or applicability thereof. Alpha-lipoic acid is an antioxidant Heart health programs by the Alpha-lipouc. It is Alpga-lipoic in every cell, where it helps Hunger and elderly population glucose into energy. Antioxidants acir "free radicals," Heart health programs products created when the body turns food into energy. Free radicals cause harmful chemical reactions that can damage cells, making it harder for the body to fight off infections. They also damage organs and tissues. Other antioxidants work only in water such as vitamin C or fatty tissues such as vitamin E.
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