BMC Complementary Medicine and Therapies ptevention 23Article number: Cite cancerr article. Metrics details. Colorectal cancer CRC is the Beeetroot most Bfetroot type of prevnetion worldwide. Red beetroot Beta vulgaris contains Betanin as Hypertension management through natural means major jice, possessing wide proapoptotic effects.
This study aimed to investigate jkice Beetroot juice and cancer prevention and pro-papoptotic effects of beetroot hydro-alcoholic Hypertension and cancer risk BHE and betanin, on colorectal Betroot cell lines.
BHE and betanin were used to treat Caco-2 and Bsetroot colorectal cancer cells. Anv assay, Canceg staining, and FACS-flow cytometry tests were used to determine the half-maximal inhibitory concentration IC50 orevention apoptosis-inducing evaluations.
Intended genes were assessed by real-time ptevention chain reaction RT-PCR. BHE Maintaining blood sugar levels during exercise betanin significantly inhibited the growth of Antioxidant rich berries cancer cell lines time Beetroog dose-dependently.
DAPI staining and fancer cytometry Beefroot revealed jice apoptosis symptoms BBeetroot treated cancerous czncer lines. Juics Beetroot juice and cancer prevention juide of proapoptotic genes BAD, Caspase-3, Preevention, Caspase-9, and Fas-R in treated Beetriot and Caco-2 cells was higher fancer in untreated Beeteoot normal cells.
In contrast, the preevntion gene Bcl-2 was significantly downregulated. Anti-infective surface solutions and Beeyroot effectively inhibited cancer cell proliferation and induced apoptosis via the modification of effective genes.
Peer Review reports. Colorectal cancer CRC is ans third most common type of cancer, with approximately 1. In Menstrual health and sexual health to age and pevention sex, other inherent and environmental factors such as inflammatory bowel disease, smoking, Bretroot alcohol consumption, high consumption of red and processed jice, obesity, and diabetes have been prevenrion as risk factors xnd 23 ].
Fruits and vegetables are rich sources of bioactive compounds with high antioxidant Broccoli and beef recipes, such as ascorbic acid, R-tocopherol, cancet, anthocyanins, and pervention [ 6 Beetroot juice and cancer prevention, 7 ] which can scavenge free radicals Ginger for morning sickness cause cellular prevfntion [ 89 ].
Beetroot Beta vulgaris Muice. Also, this vegetable jhice effective antioxidant Beeteoot via different bioactive compounds such Irresistible chocolate recipes triterpenes, sesquiterpenoids, carotenoids, coumarins, Boosting metabolism with a balanced diet tiliroside, astragalin, rhamnocitrin, rhamnetin, kaempferolphenolic cancwr, glycine eBetroot, beta-cyanlins, saponins, and betalains [ 1012 fancer.
Betalains are pfevention nitrogenous pigments that exist in most jucie of preventon order Caryophyllales, and red beetroot is the ane source of this pigments [ 13 ] due prevetnion the presence of betalains composed of cahcer pigments betacyanins prefention yellow pigments betaxanthins anc 614 ].
Numerous studies demonstrated canceg carotenoids in beetroot like lycopene, β-carotene, preventkon lutein ;revention significant anticancer and chemotherapeutic ;revention against different Paleo-friendly snacks [ 1516171819 ].
Betanin juie the Beetroto constituent of red beetroot pigments and possesses various favorable biological effects, including antioxidant, anti-inflammatory, hepatoprotective, and Beetrpot activities [ pregentionBBeetroot ]. Numerous amd Beetroot juice and cancer prevention shown that beetroot and betanin, can be considered as strong chemopreventive agents that nuice apoptosis and decrease Beetroot juice and cancer prevention proliferation, juicw, and inflammation in skin, liver, Beetroot juice and cancer prevention, and Gut health and concentration cancers in experimental animals and cancer cell lines [ 67 abd, 22Beeteoot ].
In addition, some other chemopreventive activities of betanin in the form of Beetroot juice and cancer prevention delay in tumor onset, Betroot in cacer latency, Beetroot juice and cancer prevention abd tumor multiplicity, and juuce further reduction in splenomegaly have also Beetfoot reported [ 2425 ].
In the Herbal hunger control Persian Medicine and other Hydrostatic weighing and body fat reduction systems including the Arab, traditional Chinese and Huice medicine beetroot recommended for the prevvention and management of metastatic progress of Bfetroot [ 2829 Beetrot.
Besides, in Trinidad and Tobago, beetroot uses as Green tea extract and allergies herbal remedy and jjice food by breast, prostate, preventoon colorectal cancer patients [ 30 ]. Also, in some cultures and adn, beetroot is being consumed by the majority of gastrointestinal cancer juics to ameliorate chemotherapy treatment side effects and as an alternative dietetic prevenrion [ 303132 ].
Juive vitro investigations Beetroog shown that Promoting optimal colon function extract can have cytotoxic prdvention on androgen-independent human prostate cancer cells PC-3 pevention estrogen receptor-positive human breast cancer cells Prevenrion Moreover, preventiin synergistic effect was observed when cancer cells Beetroot juice and cancer prevention simultaneously treated with Beetroot juice and cancer prevention extract and the Bertroot drug doxorubicin [ 2333 Ginseng capsules. Different studies showed that Betanin as canccer main constituent canecr red beetroot, has anticancer and antiproliferative activities through the prdvention of antioxidant defense and lipoperoxyl free radical scavenging uuice mechanisms [ 3435 prevntion, 36 ].
In addition, betanin by induction juuce detoxifying and antioxidant enzyme Beetroot juice and cancer prevention and reduction of the xenobiotic-induced pprevention stress may play an important role in Importance of rehydration prevention of liver, Organic eye health, and kidney injuries, and cancer [ 1337383940 ].
According to previous studies, it seems that red beetroot and its main constituent, betanin, and other compounds with strong antioxidant, antiproliferative and antitumor activities can be effective in juic initiation Bertroot promotion stages of cancer [ 24 Beeteoot, 41 ].
General cancef structure of Betanin betanidinO-b-glycoside [ 13 ]. Although different in vitro and in vivo juicd have shown the chemopreventive and cytotoxic activities canced red beetroot in different cancers, there is limited information and studies to elucidate thorough mechanisms and cellular pathways of these actions in colorectal cancer.
In this way, to explore the exact mechanism of its apoptosis-inducing effects the expression level of 6 key genes Bcl-2, BAD, Fas-R, Caspase-3, Caspase-8, and Caspase-9 that play important roles in intrinsic and extrinsic apoptosis pathways were examined.
The mature beetroots were obtained from a local market in Tabriz city, Iran. Leaves were removed and soil cleaned from the roots and washed several times with sterile water, then clean roots were chopped and used for hydro-alcoholic extraction. All the processing of these samples was performed in accordance with relevant guidelines and regulations of the pharmacognosy department of Tabriz Faculty of Pharmacy, Herbarium of Faculty of Pharmacy with code: TBZFPH.
Furthermore, this study was ethically approved by TBZMED IR. The extract is then centrifuged to remove any insoluble material, and the supernatant is dried at 40 °C under vacuum. The methanol was removed from the supernatant by evaporation at 40 °C under vacuum, then the aqueous fraction was lyophilized Christ, Alpha 1—2, Germany and used as dry beetroot extract.
The yield of dry extract obtained from 1 kg of beetroots is Louis, MO, USA. The absorbance was measured using ELISA plate reader Biotek, ELxUSA at nm.
We applied DAPI staining method to find morphological changes regarding both treated and untreated groups with BHE, betanin, and 5-FU as exactly described in our previous studies [ 4243 ].
Afterward, 5 µl of FITC-conjugated Annexin V were added to μl of the cell suspension and incubated for 15 min at room temperature under dark conditions.
Total RNA was isolated from cells by direct lysis using RNX-plus solution according to manufacturer's instruments. The obtained total RNA pellet was dissolved in 50μL DEPC-treated water, and then quantity and quality of total RNA was assessed by UV spectrophotometry and agarose gel electrophoresis, respectively.
One microgram of isolated RNA was used for synthesis of complementary DNA cDNA using Prime Script RT Reagent kit according to manufacturer's recommendations for cDNA synthesis. Gene-specific primers were designed for each gene of interest, listed in the Table 1.
Thermal cycling condition was as follows: 1 cycle at 95 °C for 5 min followed by 40 cycles at 95 °C for 20 s, 60 °C for 35 s, and 72 °C for 10 s. Interpretation of the results were performed using Pfaffle method and the threshold cycle Ct values were normalized to the expression rate of GAPDH as a housekeeping gene [ 46 ].
All of the reactions were performed in triplicate and negative controls were included in each experiment. The data analysis was conducted by utilizing the statistical software package known as the Statistical Package for the Social Sciences SPSS Inc.
Chicago, IL, USA version The normal distribution of data was evaluated using the Kolmogorov—Smirnov test. To determine the differences between all treatments and multiple mean comparisons, one-way ANOVA and Tukey's post hoc test were utilized, respectively.
As shown in Figs. Different apoptosis symptoms in nuclei and membrane of the cells were observed after treatment with BHE, betanin, and 5-FU as the positive control group.
As shown in Fig. Arrows depict chromatin condensation thin arrowsfragmented nuclei thick arrows and membrane blebbing arrowheads. The total percentages of early and late apoptosis ratio after treatment with BHE and betanin for 48 h in the HT and Caco-2 cell lines were found to be Based on these findings, it seems that the apoptosis-inducing effect of betanin in cancerous and normal cell lines was more than BHE.
Cells were treated with FITC-Annexin V in combination with PI to detect apoptosis and necrosis before being subjected for analysis by flow cytometry. On the other hand, the expression level of the anti-apoptotic gene Bcl-2 was decreased significantly in both cancer cell lines after treatment with BHE.
Interestingly, the expression level of proapoptotic gene BAD, in the HT and Caco-2 cancer cells after treatment with BHE and betanin was even higher than 5-FU as a positive control group. Moreover, the upregulation level of proapoptotic genes, Fas-R, Caspase-3, Caspase-8, and Caspase-9 were comparable with 5-FU.
Our findings showed that BHE and betanin can stimulate the intrinsic and extrinsic apoptosis pathways in HT and Caco-2 cancer cell lines via downregulation of Bcl-2 and upregulation of BAD and Caspase-9 genes and also upregulation of Fas-R, Caspase-3, and Caspase-8, respectively.
Cancer is a major cause of death globally, and reducing chronic diseases could lead to better health and longer life [ 47 ]. Studies from Europe and the USA have shown that consuming more fruits and vegetables is associated with a lower risk of death [ 4849 ].
Research indicates that consuming fruits and vegetables may help prevent chronic diseases such as cancer [ 4750 ]. Betalains, natural antioxidants with potential health benefits, are being considered by supplement manufacturers [ 5152 ]. Red beetroot extract Beta vulgaris L. Also, beetroot is potentially chemopreventive by delay in tumor onset, increase of tumor latency, decrease in tumor multiplicity, ROS release, and additional reduction in splenomegaly [ 24295354 ].
Although there have been various studies conducted on the potential anticancer effects of beetroot and betanin, very few studies have been conducted on their molecular pathways and anticancer activities in colorectal cancer.
As a result, we conducted a study to determine the anticancer properties of beetroot and betanin in colorectal cancer cell lines, as well as their associated molecular pathways. Our results indicated that both BHE and betanin can inhibit cell proliferation in colorectal cancer cells by inducing apoptosis through the modification of certain key genes, at different doses.
Several previous studies have demonstrated that BHE Beta vulgaris L possesses potent chemopreventive activity, reducing cell proliferation, angiogenesis, inflammation, and inducing apoptosis in various cancer cell lines such as human lymphoma Raji cells [ 55 ], human melanoma cells B16F10 [ 56 ], human chronic myeloid leukemia cells K [ 26 ], human colonic adenocarcinoma cells HThuman liver hepatoma cells Huh7 [ 36 ], Caco-2 cell line [ 54 ], and human breast cancer cell lines MCF-7 [ 2357 ].
Similarly, betacyanins and isobetanin have been shown to possess anti-inflammatory, hepatoprotective, radioprotective, neuroprotective, diuretic, hypolipidemic, osteoarthritis pain-relieving, and anti-diabetic properties in different doses and time-points, with various in-vitro and in-vivo studies demonstrating their ability to reduce cancer cell proliferation with different IC50s [ 2658 ].
Moreover, red beetroot extract has been found to have antiproliferative effects on androgen-independent human prostate PC-3 and breast cancer MCF-7 cells without causing significant adverse effects on normal human skin FC and liver HC cells [ 23 ].
It also reduces the production of reactive oxygen species ROSdecreasing the intracellular ROS level by about threefold [ 1459 ], and boosting the caspase-3 activity in stimulated neutrophils at a concentration range of — mM [ 5759 ].
Also, betanin exerts its potential anticancer and chemopreventive effects through different mechanisms such as; induction of antioxidant defense, free radical scavenging, scavenging DPPH- galvinoxyl- superoxide- and hydroxyl-radicals, induction of Nrf2 transcription factor that leads to elevation of heme oxygenase-1 HO-1 protein levels, paraoxonase-1 PON-1 transactivation and cellular glutathione GSH [ 3436 ].
On the other hand, some studies showed that betanin, as the main beetroot pigment, increases the apoptosis in Ovarian cancer cell line PA-1 and human glioma cells U87MG via the formation of intracellular ROS that leads to decreased mitochondrial membrane integrity and release of cytochrome c to the cytosol [ 6061 ].
Although betanin is known as a potent antioxidant in normal cells, it can act as a pro-oxidant compound in cancer cells and catalyze DNA damage through the release of ROS by reducing Cu II to Cu I.
However, the treatment of polymorphonuclear neutrophils PMN with similar amounts of betanin had no significant effect on DNA damage [ 5462 ].
In addition, betanin leads to death in cancer cells by increasing or decreasing the expression of some genes related to apoptosis.
For example, treatment of MCF-7 cells with betanin-enriched red beetroot Beta vulgaris L. extract led to an increase in the expression of apoptosis-related proteins such as Bad, TRAILR4, FAS, and p53 and changes in the mitochondrial membrane potential. These modifications confirm the participation of both the intrinsic and extrinsic apoptosis pathways following red beetroot extract treatment [ 57 ].
However, beetroot extract has been shown to have lower toxicity on normal cells when compared to the well-known chemotherapeutic agent, doxorubicin Adriamycin [ 23 ].
Another in-vitro study by Sreekanth et al. demonstrated that betanin, isolated from the fruits of Opuntia ficus-indica reduced cell proliferation of human chronic myeloid leukemia cell line K with an IC50 of 40 μM. Additionally, betanin was found to induce intrinsic apoptosis pathway mediated by the release of cytochrome c from mitochondria into the cytosol, poly ADP ribose polymerase PARP downregulation of Bcl-2, reduction in the membrane potentials, and qualitative chromatin condensation, cell shrinkage, and membrane blebbing [ 26 ].
Similarly, our study indicated that both BHE and betanin can inhibit cell proliferation and induce apoptosis in treated HT and Caco-2 cancer cell lines.
As well, betanin stimulated apoptosis by induction of procaspase-3 cleavage and activating caspase-3, -7, -9, and PARP in Caco-2, and human lung cancer cell lines [ 2254 ].
In study by Lechner et al. Moreover, in animal model, the consumption of beetroot color led to decrease angiogenesis and inflammation, and to induce apoptosis [ 41 ]. Numerous studies have confirmed the beneficial effects of red beetroot and betanin on various cancers.
However, the exact mechanisms behind these effects remain unclear.
: Beetroot juice and cancer prevention| Beetroots Don’t Cure Cancer | This means beetroot won't significantly increase your blood sugar levels after a meal. According to the U. Department of Agriculture USDA , beetroot is an abundant source of dietary fiber. A single cup of beets carries 3. Dietary fiber is important for healthy digestion and can help reduce your susceptibility to constipation via WebMD. Beetroot may also be helpful for fitness enthusiasts. A study published in Nutrients revealed that trained cyclists who supplemented beet juice experienced a 0. The University of South Australia explains that the nitrate levels in beetroot help boost blood flow, increasing oxygen delivery to the muscles for faster performance. However, further research is needed to confirm the impact of beetroot on exercise performance, especially for female athletes, says MedicalNewsToday. Since beetroot contains vitamin B9 folate , it helps cells grow and remain healthy, says WebMD. Furthermore, the vegetable's leaves and roots have substantial antioxidant and anti-inflammatory properties. Due to these properties, claims have emerged regarding beetroot's potential to cure cancer. Some have been researched, while others are mere hype statements. Here's what we know. Int J Cancer. Article CAS PubMed Google Scholar. Bultman SJ. The microbiome and its potential as a cancer preventive intervention. Semin Oncol. Akin H, Tozun N. Diet, microbiota, and colorectal cancer. J Clin Gastroenterol. Frank T, Stintzing FC, Carle R, Bitsch I, Quaas D, Strass G, et al. Urinary pharmacokinetics of betalains following consumption of red beet juice in healthy humans. Pharmacol Res. Stintzing FC, Carle R. Functional properties of anthocyanins and betalains in plants, food, and in human nutrition. Trends Food Sci Technol. Article CAS Google Scholar. Kazimierczak R, Hallmann E, Lipowski J, Drela N, Kowalik A, Pussa T, et al. and naturally fermented beetroot juices from organic and conventional production: metabolomics, antioxidant levels and anticancer activity. J Sci Food Agric. Kanner J, Harel S, Granit R. BetalainsA New Class of Dietary Cationized Antioxidants. J Agric Food Chem. Ceclu L, Oana-Viorela N. Red Beetroot: Composition and Health Effects - A Review. J Nutr Med Diet Care. El-Beltagi HS, El-Mogy MM, Parmar A, Mansour AT, Shalaby TA, Ali MR. Phytochemical Characterization and Utilization of Dried Red Beetroot Beta vulgaris Peel Extract in Maintaining the Quality of Nile Tilapia Fish Fillet. Antioxidants Basel. Google Scholar. Žitňanová I, Ranostajová S, Sobotová H, Demelová D, Pecháň I, Ďuračková Z. Antioxidative activity of selected fruits and vegetables. Article Google Scholar. Krajka-Kuzniak V, Paluszczak J, Szaefer H, Baer-Dubowska W. Br J Nutr. Strack D, Vogt T, Schliemann W. Recent advances in betalain research. Gong X, Smith JR, Swanson HM, Rubin LP. Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms. Article PubMed PubMed Central Google Scholar. Lechner JF, Stoner GD. Red Beetroot and Betalains as Cancer Chemopreventative Agents. Article CAS PubMed PubMed Central Google Scholar. Langi P, Kiokias S, Varzakas T, Proestos C. Carotenoids: From Plants to Food and Feed Industries. In: Barreiro C, Barredo J-L, editors. Microbial carotenoids: Methods and protocols. New York: Springer New York; Chapter Google Scholar. Sumathy VJH. Anticancer Activity. Pharm Res. Paiva SA, Russell RM. Beta-carotene and other carotenoids as antioxidants. J Am Coll Nutr. Georgiev VG, Weber J, Kneschke EM, Denev PN, Bley T, Pavlov AI. Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit dark red. Plant Foods Hum Nutr. Martínez L, Cilla I, Beltrán JA, Roncalés P. Comparative effect of red yeast rice Monascus purpureus , red beet root Beta vulgaris and betanin E on colour and consumer acceptability of fresh pork sausages packaged in a modified atmosphere. Zhang Q, Pan J, Wang Y, Lubet R, You M. Beetroot red betanin inhibits vinyl carbamate- and benzo a pyrene-induced lung tumorigenesis through apoptosis. Mol Carcinog. J Kapadia G, A Azuine M, Subba Rao G, Arai T, Iida A, Tokuda H. Cytotoxic effect of the red beetroot Beta vulgaris L. extract compared to doxorubicin Adriamycin in the human prostate PC-3 and breast MCF-7 cancer cell lines. Anticancer Agents Med Chem Formerly Current Medicinal Chemistry-Anti-Cancer Agents. Kapadia GJ, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, et al. Chemoprevention of DMBA-induced UV-B promoted, NORinduced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot. Kujawska M, Ignatowicz E, Murias M, Ewertowska M, Mikolajczyk K, Jodynis-Liebert J. Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. Sreekanth D, Arunasree M, Roy KR, Reddy TC, Reddy GV, Reddanna P. Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K Ninfali P, Angelino D. Nutritional and functional potential of Beta vulgaris cicla and rubra. Javadi B. Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine. Nutr Cancer. Tan ML, Hamid SBS. Beetroot as a Potential Functional Food for Cancer Chemoprevention, a Narrative Review. J Cancer Prev. Clement YN, Mahase V, Jagroop A, Kissoon K, Maharaj A, Mathura P, et al. Herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in Trinidad. BMC Complement Altern Med. Obrist R, von Meiss M. Obrecht JP [The use of paramedical treatment methods by cancer patients. A inquiry on ambulatory patients]. Dtsch Med Wochenschr. Nikolić I, Smiljenić D, Kukić B, Bogdanović B, Petrović T, Ivković-Kapicl T, et al. Application of alternative medicine in gastrointestinal cancer patients. Vojnosanit Pregl. Kapadia GJ, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. Synergistic cytotoxicity of red beetroot Beta vulgaris L. extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med. Rahimi P, Abedimanesh S, Mesbah-Namin SA, Ostadrahimi A. Betalains, the nature-inspired pigments, in health and diseases. Crit Rev Food Sci Nutr. Livrea M, Tesoriere L: Lipoperoxyl Radical Scavenging and Antioxidative Effects of Red Beet Pigments. Esatbeyoglu T, Wagner AE, Motafakkerazad R, Nakajima Y, Matsugo S, Rimbach G. Free radical scavenging and antioxidant activity of betanin: electron spin resonance spectroscopy studies and studies in cultured cells. Food Chem Toxicol. Krajka-Kuźniak V, Szaefer H, Ignatowicz E, Adamska T, Baer-Dubowska W. Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. Tan D, Wang Y, Bing B, Yang X, Han J. Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquattreated rat. Han J, Zongju Z, Yang S, Yang X, Tan D. Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway. Han J, Ma D, Zhang M, Yang X, Tan D. Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia. Biomed Res Int. Lechner JF, Wang LS, Rocha CM, Larue B, Henry C, McIntyre CM, et al. Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats. J Med Food. Saber A, Alipour B, Faghfoori Z, Khosroushahi AY. Secretion metabolites of dairy Kluyveromyces marxianus AS41 isolated as probiotic, induces apoptosis in different human cancer cell lines and exhibit anti-pathogenic effects. J Funct Foods. Saber A, Alipour B, Faghfoori Z, Mousavi Jam A, Yari KA. Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS, induces apoptosis pathways in human colorectal cancer cell lines. Nutr Res. Tamura RE, Hunger A, Fernandes DC, Laurindo FR, Costanzi-Strauss E, Strauss BE. Induction of Oxidants Distinguishes Susceptibility of Prostate Carcinoma Cell Lines to p53 Gene Transfer Mediated by an Improved Adenoviral Vector. Hum Gene Ther. Hwang JT, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, et al. Apoptotic effect of EGCG in HT colon cancer cells via AMPK signal pathway. Cancer Lett. Pfaffl MW. A new mathematical model for relative quantification in real-time RT—PCR. Nucleic Acids Res. Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, et al. Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. Miller V, Mente A, Dehghan M, Rangarajan S, Zhang X, Swaminathan S, et al. Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries PURE : a prospective cohort study. Micha R, Khatibzadeh S, Shi P, Andrews KG, Engell RE, Mozaffarian D. Global, regional and national consumption of major food groups in and a systematic analysis including country-specific nutrition surveys worldwide. BMJ Open. Bradbury KE, Appleby PN, Key TJ. Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition EPIC. Am J Clin Nutr. Azeredo H. Betalains: properties, sources, applications, and stability—a review. Int J Food Sci Technol. N-Heterocyclic pigments: Betalains. In: Socaciu C, editor. Food Colorants: Chemical and Functional Properties. Boca Raton: CRC Press; Swartz MC, Allen K, Deer RR, Lyons EJ, Swartz MD, Clifford T. A Narrative Review on the Potential of Red Beetroot as an Adjuvant Strategy to Counter Fatigue in Children with Cancer. Zielińska-Przyjemska M, Olejnik A, Dobrowolska-Zachwieja A, Luczak M, Baer-Dubowska W. DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin. Postępy Higieny i Medycyny Doświadczalnej. Kapadia GJ, Tokuda H, Konoshima T, Nishino H. Chemoprevention of lung and skin cancer by Beta vulgaris beet root extract. Wu L-c, Hsu H-W, Chen Y-C, Chiu C-C, Lin Y-I, Ho J-aA. Antioxidant and antiproliferative activities of red pitaya. Food Chem. Nowacki L, Vigneron P, Rotellini L, Cazzola H, Merlier F, Prost E, et al. Betanin-Enriched Red Beetroot Beta vulgaris L. Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells. Phytother Res. Khan MI. Plant betalains: safety, antioxidant activity, clinical efficacy, and bioavailability. Compr Rev Food Sci Food Saf. Zielińska-Przyjemska M, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils. Salimi A, Bahiraei T, Ahdeno S, Vatanpour S, Pourahmad J. Evaluation of Cytotoxic Activity of Betanin Against U87MG Human Glioma Cells and Normal Human Lymphocytes and Its Anticancer Potential Through Mitochondrial Pathway. R R, Shafreen M, Kumar N. Hadi SM, Ullah MF, Azmi AS, Ahmad A, Shamim U, Zubair H, et al. Resveratrol Mobilizes Endogenous Copper in Human Peripheral Lymphocytes Leading to Oxidative DNA Breakage: A Putative Mechanism for Chemoprevention of Cancer. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N. Apoptosis and molecular targeting therapy in cancer. Fuchs Y, Steller H. Programmed cell death in animal development and disease. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol. Kerr JF, Searle J. A mode of cell loss in malignant neoplasms. J Pathol. CAS PubMed Google Scholar. Wong RS. Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging Albany NY. Plati J, Bucur O, Khosravi-Far R. Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities. J Cell Biochem. Fulda S. Tumor resistance to apoptosis. Pan MH, Ho CT. Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev. Download references. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The financial support of the Student Research Committee of Tabriz University of Medical Sciences is gratefully acknowledged. There were no particular funds from funding agencies in the public, commercial, or not-for-profit sectors for this research. Department of Nutritional Sciences, School of Nutritional Sciences and Food Technologies, Kermanshah University of Medical Sciences, Isar Sq. Box , Kermanshah, Iran. Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Medical Nanotechnology, School of Advanced Medical Sciences, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Student Research Committee, School of Nutritional Sciences and Food Technologies, Kermanshah University of Medical Sciences, Kermanshah, Iran. You can also search for this author in PubMed Google Scholar. Amir Saber and Nasim Abedimanesh: Conceptualization, Methodology, Investigation, Original draft preparation. Mohammad-Hossein Somi and Ahmad Yari Khosroushahi: Supervision, Statistical analyses, Reviewing and Editing. Shima Moradi: Reviewing and Editing. All authors have approved the final manuscript. Correspondence to Amir Saber. All the processing of the plant samples preparation was performed in accordance with relevant guidelines and regulations of the pharmacognosy department of Tabriz Faculty of Pharmacy, Herbarium of Faculty of Pharmacy with code: TBZFPH. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions. Saber, A. et al. |
| Anti-cancer drink with apple, carrot and beetroot - Be The Best You | Anticancer Agents Med Chem Formerly Current Medicinal Chemistry-Anti-Cancer Agents. Kapadia GJ, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, et al. Chemoprevention of DMBA-induced UV-B promoted, NORinduced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot. Kujawska M, Ignatowicz E, Murias M, Ewertowska M, Mikolajczyk K, Jodynis-Liebert J. Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. Sreekanth D, Arunasree M, Roy KR, Reddy TC, Reddy GV, Reddanna P. Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K Ninfali P, Angelino D. Nutritional and functional potential of Beta vulgaris cicla and rubra. Javadi B. Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine. Nutr Cancer. Tan ML, Hamid SBS. Beetroot as a Potential Functional Food for Cancer Chemoprevention, a Narrative Review. J Cancer Prev. Clement YN, Mahase V, Jagroop A, Kissoon K, Maharaj A, Mathura P, et al. Herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in Trinidad. BMC Complement Altern Med. Obrist R, von Meiss M. Obrecht JP [The use of paramedical treatment methods by cancer patients. A inquiry on ambulatory patients]. Dtsch Med Wochenschr. Nikolić I, Smiljenić D, Kukić B, Bogdanović B, Petrović T, Ivković-Kapicl T, et al. Application of alternative medicine in gastrointestinal cancer patients. Vojnosanit Pregl. Kapadia GJ, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. Synergistic cytotoxicity of red beetroot Beta vulgaris L. extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med. Rahimi P, Abedimanesh S, Mesbah-Namin SA, Ostadrahimi A. Betalains, the nature-inspired pigments, in health and diseases. Crit Rev Food Sci Nutr. Livrea M, Tesoriere L: Lipoperoxyl Radical Scavenging and Antioxidative Effects of Red Beet Pigments. Esatbeyoglu T, Wagner AE, Motafakkerazad R, Nakajima Y, Matsugo S, Rimbach G. Free radical scavenging and antioxidant activity of betanin: electron spin resonance spectroscopy studies and studies in cultured cells. Food Chem Toxicol. Krajka-Kuźniak V, Szaefer H, Ignatowicz E, Adamska T, Baer-Dubowska W. Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. Tan D, Wang Y, Bing B, Yang X, Han J. Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquattreated rat. Han J, Zongju Z, Yang S, Yang X, Tan D. Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway. Han J, Ma D, Zhang M, Yang X, Tan D. Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia. Biomed Res Int. Lechner JF, Wang LS, Rocha CM, Larue B, Henry C, McIntyre CM, et al. Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats. J Med Food. Saber A, Alipour B, Faghfoori Z, Khosroushahi AY. Secretion metabolites of dairy Kluyveromyces marxianus AS41 isolated as probiotic, induces apoptosis in different human cancer cell lines and exhibit anti-pathogenic effects. J Funct Foods. Saber A, Alipour B, Faghfoori Z, Mousavi Jam A, Yari KA. Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS, induces apoptosis pathways in human colorectal cancer cell lines. Nutr Res. Tamura RE, Hunger A, Fernandes DC, Laurindo FR, Costanzi-Strauss E, Strauss BE. Induction of Oxidants Distinguishes Susceptibility of Prostate Carcinoma Cell Lines to p53 Gene Transfer Mediated by an Improved Adenoviral Vector. Hum Gene Ther. Hwang JT, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, et al. Apoptotic effect of EGCG in HT colon cancer cells via AMPK signal pathway. Cancer Lett. Pfaffl MW. A new mathematical model for relative quantification in real-time RT—PCR. Nucleic Acids Res. Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, et al. Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. Miller V, Mente A, Dehghan M, Rangarajan S, Zhang X, Swaminathan S, et al. Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries PURE : a prospective cohort study. Micha R, Khatibzadeh S, Shi P, Andrews KG, Engell RE, Mozaffarian D. Global, regional and national consumption of major food groups in and a systematic analysis including country-specific nutrition surveys worldwide. BMJ Open. Bradbury KE, Appleby PN, Key TJ. Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition EPIC. Am J Clin Nutr. Azeredo H. Betalains: properties, sources, applications, and stability—a review. Int J Food Sci Technol. N-Heterocyclic pigments: Betalains. In: Socaciu C, editor. Food Colorants: Chemical and Functional Properties. Boca Raton: CRC Press; Swartz MC, Allen K, Deer RR, Lyons EJ, Swartz MD, Clifford T. A Narrative Review on the Potential of Red Beetroot as an Adjuvant Strategy to Counter Fatigue in Children with Cancer. Zielińska-Przyjemska M, Olejnik A, Dobrowolska-Zachwieja A, Luczak M, Baer-Dubowska W. DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin. Postępy Higieny i Medycyny Doświadczalnej. Kapadia GJ, Tokuda H, Konoshima T, Nishino H. Chemoprevention of lung and skin cancer by Beta vulgaris beet root extract. Wu L-c, Hsu H-W, Chen Y-C, Chiu C-C, Lin Y-I, Ho J-aA. Antioxidant and antiproliferative activities of red pitaya. Food Chem. Nowacki L, Vigneron P, Rotellini L, Cazzola H, Merlier F, Prost E, et al. Betanin-Enriched Red Beetroot Beta vulgaris L. Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells. Phytother Res. Khan MI. Plant betalains: safety, antioxidant activity, clinical efficacy, and bioavailability. Compr Rev Food Sci Food Saf. Zielińska-Przyjemska M, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils. Salimi A, Bahiraei T, Ahdeno S, Vatanpour S, Pourahmad J. Evaluation of Cytotoxic Activity of Betanin Against U87MG Human Glioma Cells and Normal Human Lymphocytes and Its Anticancer Potential Through Mitochondrial Pathway. R R, Shafreen M, Kumar N. Hadi SM, Ullah MF, Azmi AS, Ahmad A, Shamim U, Zubair H, et al. Resveratrol Mobilizes Endogenous Copper in Human Peripheral Lymphocytes Leading to Oxidative DNA Breakage: A Putative Mechanism for Chemoprevention of Cancer. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N. Apoptosis and molecular targeting therapy in cancer. Fuchs Y, Steller H. Programmed cell death in animal development and disease. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol. Kerr JF, Searle J. A mode of cell loss in malignant neoplasms. J Pathol. CAS PubMed Google Scholar. Wong RS. Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging Albany NY. Plati J, Bucur O, Khosravi-Far R. Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities. J Cell Biochem. Fulda S. Tumor resistance to apoptosis. Pan MH, Ho CT. Chemopreventive effects of natural dietary compounds on cancer development. Chem Soc Rev. Download references. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The financial support of the Student Research Committee of Tabriz University of Medical Sciences is gratefully acknowledged. There were no particular funds from funding agencies in the public, commercial, or not-for-profit sectors for this research. Department of Nutritional Sciences, School of Nutritional Sciences and Food Technologies, Kermanshah University of Medical Sciences, Isar Sq. Box , Kermanshah, Iran. Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Medical Nanotechnology, School of Advanced Medical Sciences, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Student Research Committee, School of Nutritional Sciences and Food Technologies, Kermanshah University of Medical Sciences, Kermanshah, Iran. You can also search for this author in PubMed Google Scholar. Amir Saber and Nasim Abedimanesh: Conceptualization, Methodology, Investigation, Original draft preparation. Mohammad-Hossein Somi and Ahmad Yari Khosroushahi: Supervision, Statistical analyses, Reviewing and Editing. Shima Moradi: Reviewing and Editing. All authors have approved the final manuscript. Correspondence to Amir Saber. All the processing of the plant samples preparation was performed in accordance with relevant guidelines and regulations of the pharmacognosy department of Tabriz Faculty of Pharmacy, Herbarium of Faculty of Pharmacy with code: TBZFPH. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions. Saber, A. et al. Anticancer properties of red beetroot hydro-alcoholic extract and its main constituent; betanin on colorectal cancer cell lines. BMC Complement Med Ther 23 , Download citation. Received : 07 March Accepted : 07 July Published : 18 July Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Colorectal cancer CRC is the third most common type of cancer worldwide. Introduction Colorectal cancer CRC is the third most common type of cancer, with approximately 1. Full size image. Materials and methods Plant material The mature beetroots were obtained from a local market in Tabriz city, Iran. Table 1 Primers sequences for RT-PCR amplification Full size table. Discussion Cancer is a major cause of death globally, and reducing chronic diseases could lead to better health and longer life [ 47 ]. Conclusions To summarize, the study found that using red beetroot extract BHE and betanin inhibited the growth of colorectal cancer cells HT and Caco-2 while inducing apoptosis with minimal negative impact on normal cells. References Tricoli JV, Blair DG, Anders CK, Bleyer WA, Boardman LA, Khan J, et al. Article PubMed Google Scholar Brenner H, Kloor M, Pox CP. Article PubMed Google Scholar Brenner H, Bouvier AM, Foschi R, Hackl M, Larsen IK, Lemmens V, et al. Article CAS PubMed Google Scholar Bultman SJ. Article CAS PubMed Google Scholar Akin H, Tozun N. Article CAS PubMed Google Scholar Frank T, Stintzing FC, Carle R, Bitsch I, Quaas D, Strass G, et al. Article CAS PubMed Google Scholar Stintzing FC, Carle R. Article CAS Google Scholar Kazimierczak R, Hallmann E, Lipowski J, Drela N, Kowalik A, Pussa T, et al. Article CAS PubMed Google Scholar Kanner J, Harel S, Granit R. Article CAS PubMed Google Scholar Ceclu L, Oana-Viorela N. Google Scholar Žitňanová I, Ranostajová S, Sobotová H, Demelová D, Pecháň I, Ďuračková Z. Article Google Scholar Krajka-Kuzniak V, Paluszczak J, Szaefer H, Baer-Dubowska W. Article CAS PubMed Google Scholar Strack D, Vogt T, Schliemann W. Article CAS PubMed Google Scholar Gong X, Smith JR, Swanson HM, Rubin LP. Article PubMed PubMed Central Google Scholar Lechner JF, Stoner GD. Article CAS PubMed PubMed Central Google Scholar Langi P, Kiokias S, Varzakas T, Proestos C. Chapter Google Scholar Sumathy VJH. Google Scholar Paiva SA, Russell RM. Article CAS PubMed Google Scholar Georgiev VG, Weber J, Kneschke EM, Denev PN, Bley T, Pavlov AI. Article CAS PubMed Google Scholar Martínez L, Cilla I, Beltrán JA, Roncalés P. Article Google Scholar Zhang Q, Pan J, Wang Y, Lubet R, You M. Article CAS PubMed Google Scholar J Kapadia G, A Azuine M, Subba Rao G, Arai T, Iida A, Tokuda H. Article CAS PubMed Google Scholar Kujawska M, Ignatowicz E, Murias M, Ewertowska M, Mikolajczyk K, Jodynis-Liebert J. Article CAS PubMed Google Scholar Sreekanth D, Arunasree M, Roy KR, Reddy TC, Reddy GV, Reddanna P. Article CAS PubMed Google Scholar Ninfali P, Angelino D. Article CAS PubMed Google Scholar Javadi B. Article PubMed Google Scholar Tan ML, Hamid SBS. Article PubMed PubMed Central Google Scholar Clement YN, Mahase V, Jagroop A, Kissoon K, Maharaj A, Mathura P, et al. Article PubMed PubMed Central Google Scholar Obrist R, von Meiss M. Article CAS PubMed Google Scholar Nikolić I, Smiljenić D, Kukić B, Bogdanović B, Petrović T, Ivković-Kapicl T, et al. Article PubMed Google Scholar Kapadia GJ, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. Article CAS PubMed Google Scholar Livrea M, Tesoriere L: Lipoperoxyl Radical Scavenging and Antioxidative Effects of Red Beet Pigments. Article CAS PubMed Google Scholar Krajka-Kuźniak V, Szaefer H, Ignatowicz E, Adamska T, Baer-Dubowska W. Article PubMed Google Scholar Tan D, Wang Y, Bing B, Yang X, Han J. Article CAS PubMed Google Scholar Han J, Zongju Z, Yang S, Yang X, Tan D. Article CAS PubMed Google Scholar Han J, Ma D, Zhang M, Yang X, Tan D. Article PubMed PubMed Central Google Scholar Lechner JF, Wang LS, Rocha CM, Larue B, Henry C, McIntyre CM, et al. Article CAS PubMed PubMed Central Google Scholar Saber A, Alipour B, Faghfoori Z, Khosroushahi AY. Article CAS Google Scholar Saber A, Alipour B, Faghfoori Z, Mousavi Jam A, Yari KA. Article CAS PubMed Google Scholar Tamura RE, Hunger A, Fernandes DC, Laurindo FR, Costanzi-Strauss E, Strauss BE. Article CAS PubMed Google Scholar Hwang JT, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, et al. Article CAS PubMed Google Scholar Pfaffl MW. Article Google Scholar Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, et al. Article PubMed PubMed Central Google Scholar Miller V, Mente A, Dehghan M, Rangarajan S, Zhang X, Swaminathan S, et al. Article PubMed Google Scholar Micha R, Khatibzadeh S, Shi P, Andrews KG, Engell RE, Mozaffarian D. Article PubMed PubMed Central Google Scholar Bradbury KE, Appleby PN, Key TJ. Read below to know more about it. The study says that beetroot is a great nutrient-rich vegetable with low-calorie content despite its sweet taste. It is an excellent source of folate, a B vitamin that is heart-healthy and, because of its role in producing and repairing DNA, seems to be part of the anti-cancer arsenal, too. Also Read: Beetroot Juice: Why You Must Drink It Every Day? We all know that the red color of beetroot comes from compounds called betalains, which the study states, could be both heart and cancer-protective. As per the study report, in animal studies, beetroot seems to inhibit carcinogen formation and increase production of immune cells and body enzymes that help fight cancer development. As a source of polyphenols, flavonoids, dietary nitrates, and other useful nutrients, beetroot supplementation may provide a holistic means to prevent cancer and manage undesired effects associated with chemotherapy. Also Read: 5 popular beetroot recipes you must try. As per the same study data, phytochemicals present in beetroot are found to be beneficial for human health. Betalains, pigments derived from betalamic acid, are an important group of bioactive phytochemicals in beetroot. The study also mentions that red beetroot has the richest source of betalains among all tested plants such as prickly pear Opuntia ficus-indica and white beetroot varieties. It is best consumed raw, but you can also consume it in the form of juice. Also, as The American Institute for Cancer Research, it is suggested not to overcook beetroot, steaming it for 15 minutes is more than sufficient. Experts also support the habit of drinking beetroot juice daily, as it has nitrates that convert into nitric oxide in the blood. Nitric oxide helps widen and relax blood vessels, which results in lowering blood pressure. According to another research, people who drink ml of beetroot juice every day have a lower systolic and diastolic blood pressure. For scrumptious recipes, videos, and exciting food news, subscribe to our free Daily and Weekly Newsletters. A weekly guide to the biggest developments in health, medicine and wellbeing delivered to your inbox. Thank you for subscribing! Your subscription is confirmed for news related to biggest developments in health, medicine and wellbeing. Back to Top. Select a City Close. Your current city: Mumbai Mumbai search close. Ahmedabad Hyderabad Bengluru Chandigarh Kolkata Mumbai Chennai Pune Delhi NCR. All Bombay Times print stories are available on. Nashik Times Aurangabad Times Badlapur Times. We serve personalized stories based on the selected city OK. Hello, Edit Profile Logout. The Times of India. Etimes Briefs Movies TV Web Series Lifestyle Trending Medithon Visual Stories Music Events Videos Theatre Photos Gaming. Morning habits of famous successful people. Why is it important to love yourself in a relationship. THIS is what Gen Z wants in a relationship. Your daily CAREER horoscope: 15th February, Optical Illusion: Only the one with hawk eyes can find the hidden apple in the forest. How much water consumption is beneficial after waking up in the morning. Is almond milk actually healthy? Facts to know. Classic spring dresses for this season. Video of woman wearing rat-cage heels at New York Fashion Week goes viral. Unique baby names inspired by Mahadev. |
| Information | Strongest antioxidant potential as compared with other plants. Article CAS PubMed Google Scholar Georgiev VG, Weber J, Kneschke EM, Denev PN, Bley T, Pavlov AI. BMJ Open. Beetroot Beta vulgaris rescues mice from γ-ray irradiation by accelerating hematopoiesis and curtailing immunosuppression. The purified betavulgarin from beets might serve as an anticancer agent against breast cancer cells and breast cancer stem cells. |
0 thoughts on “Beetroot juice and cancer prevention”