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: Powerful weight loss supplements| Dietary Supplements for Weight Loss - Health Professional Fact Sheet | The Food and Drug Administration FDA has approved several drugs for losing weight with overweight and obesity. These medications require a prescription from a doctor and should only be taken under medical supervision. These currently include :. Most work by reducing your food intake, decreasing fat absorption, or increasing fat-burning, resulting in significant weight loss over time. However, this can vary depending on several factors, including the specific medication that you take. Keep in mind that these medications should be used alongside dietary changes and lifestyle modifications, such as regular physical activity. Not only will adopting dietary and lifestyle changes help increase the effectiveness of weight loss drugs, they can also help minimize weight regain, which often occurs after you stop taking these medications. Three GLP-1 agonists have been approved for weight loss, including liraglutide Saxenda , semaglutide Wegovy , and tirzepatide Zepbound. All three are available as a self-administered injection, but liraglutide is administered once daily , while semaglutide and tirzepatide are only injected once per week. Though not approved specifically for weight loss, some other GLP-1 agonists intended to treat type 2 diabetes are sometimes prescribed off-label for weight management, including :. GLP-1 agonists are only available through a prescription from a doctor or other qualified healthcare professional. Several telehealth services and weight loss programs may also provide prescriptions if you meet the eligibility criteria, including Ro Body Program and Calibrate. How it works: GLP-1 agonists work by slowing the emptying of the stomach, increasing feelings of fullness, and reducing the secretion of glucagon , a hormone involved in regulating appetite. Effectiveness: Several studies have found that GLP-1 agonists could be beneficial for weight management. For instance, one study with 1, adults found that taking 2. Another small study found that people taking liraglutide lost an average of Side effects: Common side effects include constipation, nausea, vomiting, diarrhea, dizziness, headaches, increased heart rate, infections, and indigestion. Though uncommon, severe side effects have also been reported, which may require medical attention. These include kidney problems, thyroid C-cell tumors , gallbladder disease, low blood sugar, and suicidal ideation. Contraindications: This medication is not recommended for people with multiple endocrine neoplasia MEN syndrome type 2, history of thyroid cancer or pancreatitis, pregnancy, and current use of certain prescription medications. It can also be purchased over the counter as the brand Alli. After a medical consultation, a doctor can prescribe orlistat. Certain telehealth services may also provide a prescription for this medication. How it works: Orlistat works by blocking the activity of certain enzymes used to break down fats in the digestive tract, which helps to reduce the amount of calories you absorb. Effectiveness: According to a study of 80 people with obesity, those who took orlistat lost an average of They also experienced significant reductions in body mass index BMI , belly fat, and total and LDL bad cholesterol levels. Side effects: Orlistat often causes digestive issues like loose or oily stools, gas, and frequent bowel movements, making the medication difficult for some people to tolerate. It could also contribute to nutrient deficiencies, including in fat-soluble vitamins A, D, E, or K. Following a low fat diet is typically recommended while taking this medication to help minimize adverse side effects. Contraindications: chronic malabsorption, cholestasis a type of liver disease , pregnancy, renal impairment, and current use of certain prescription medications. It requires a prescription from a doctor and is sold under the brand Qsymia. How it works: This medication includes phentermine , a central nervous system stimulant and appetite suppressant with similar mechanisms to amphetamine. It also includes topiramate , an anticonvulsant that helps reduce appetite and enhance satiety feeling full to promote weight loss. It could also cause increased body temperature, an inability to sweat, and psychiatric or cognitive disturbances. Contraindications: This medication is not recommended for people with glaucoma eye conditions that can lead to blindness , a history of hyperthyroidism, pregnancy, recent use of monoamine oxidase inhibitors, and current use of certain prescription medications. This medication, sold under the name Contrave, is an oral medication that combines bupropion, an antidepressant, and naltrexone, which is used to manage opioid or alcohol use disorder. A doctor can determine whether Contrave may be a good option for you and then provide a prescription. Some online services may also prescribe Contrave following a virtual consultation with a healthcare professional. Over 1 year, participants lost an average of 11—22 lb 5—9 kg. It might also increase heart rate and blood pressure. Contraindications: This medication is not recommended for people with a history of seizures, end-stage renal disease, pregnancy, and current use of monoamine oxidase inhibitors, opioids, or certain other prescription medications. Setmelanotide, sold as Imcivree, is in a class of medications known as melanocortin 4 MC4 receptor agonists. How it works: People with specific genetic mutations may experience insufficient activation of the MC4 receptor in the brain, which could contribute to obesity. Setmelanotide works by increasing the activation of this receptor, leading to reduced hunger, decreased calorie intake, and increased metabolism , all of which could promote weight loss. Participants also experienced a significant reduction in hunger with no serious treatment-related adverse events reported. Another small study in children, adolescents, and adults found that setmelanotide significantly improved quality of life as early as 5 weeks after starting treatment, which could be related to reduced hunger and body weight. Side effects: Some of the most common side effects of setmelanotide include injection site reactions, hyperpigmentation , nausea, headache, diarrhea, and stomach or back pain. Fatigue, vomiting, and depression have also been reported. Contraindications: This medication is not recommended for people with renal impairment, and those who are pregnant or breastfeeding. There are several anorectics, or appetite suppressants , available. However, phentermine Adipex-P or Lomaira is the most commonly prescribed. Phentermine is taken orally and requires a prescription from a doctor or other healthcare professional. How it works: These medications reduce appetite by altering levels of certain neurotransmitters in the brain, which can lead to weight loss. Effectiveness: One study in 3, people compared the effectiveness of several medications for obesity and found that people taking phentermine lost the highest percentage of body weight over 12 weeks. Those taking phentermine lost an average of 8. However, keep in mind that these medications are only recommended for short-term use, as you can build up a tolerance after several weeks, resulting in decreased effectiveness. Side effects: Potential side effects may include nausea, vomiting, diarrhea, and stomach cramps. Other severe side effects have been reported and require immediate medical attention, including shortness of breath, chest pain, and swelling of the lower extremities. Contraindications: This medication is not recommended for people with a history of heart disease, hypertension, hyperthyroidism, glaucoma, diabetes, pregnancy, and certain prescription medications. Most weight loss medications are approved for adults with obesity or overweight and at least one weight-related condition, such as:. Similarly, setmelanotide Imcivree , is intended to treat obesity caused by certain genetic disorders. Keep in mind that weight loss medications are not suitable for everyone, including people who are pregnant, those with certain health conditions, or individuals taking specific medications. A healthcare professional can provide guidance on whether you might be a candidate for a prescription, depending on your personal goals, medical history, and health status. Contact a trusted healthcare professional, like your OB-GYN, before taking any weight loss medications or supplements. Some digital weight loss platforms, including Ro and Calibrate, include GLP-1 medications in their treatment plans for people who meet certain eligibility criteria. You can read our comprehensive reviews of Calibrate and Ro Health to learn more. Studies also suggest that people with higher body weights are disproportionately more likely to experience disordered eating and eating disorder symptoms. These behaviors may indicate a disordered relationship with food or an ED. Disordered eating and EDs can affect anyone, regardless of gender identity, race, age, body size, socioeconomic status, or other identities. They can be caused by any combination of biological, social, cultural, and environmental factors — not just by exposure to diet culture. GLP-1 agonists are currently the most effective anti-obesity medications and are considered safe for long-term use. Currently, only liraglutide Saxenda , semaglutide Wegovy , and tirzepatide Zepbound are approved for weight loss, though some other GLP-1 drugs may be prescribed off-label. Still, keep in mind that individual results can vary based on many factors, including your diet, health status, and activity level. In addition to maximizing your potential results, it can increase the likelihood of maintaining weight loss in the long term. If considered medically necessary, insurance companies may cover certain prescription weight loss medications. Some manufacturers also offer savings cards, which can help lower your copay. The treatment has experienced increased media attention since the rise of GLP-1 receptor agonists. It consists of a capsule that releases a biodegradable, super-absorbent hydrogel into the stomach. The gel helps to increase satiety, enabling the person to eat less. With fervent consumer demand for weight loss medications, combined with rising obesity rates, more medications are bound for the market in the coming years. Lilly is developing orforglipron, an oral GLP-1 inhibitor. Retatrutide, another injectible, targets GLP-1, GIP, and glucagon. Pfizer is also developing two GLP-1 inhibitors that can be administered as pills. Meanwhile, Amgen is trialing a drug candidate that is both a GLP-1 receptor agonist and a GIP receptor antagonist, as opposed to a dual agonist like semaglutide. Researchers continue to seek hormones that play a role in appetite, such as peptide YY, for other ways to target obesity with medication. For example, the monoclonal antibody bimagrumab is being studied as an infusion to increase muscle mass while decreasing fat. With more options available, doctors will be increasingly able to personalize treatments as they match patients to the medications that will work best for them. FDA-approved anti-obesity medications AOMs are safe, evidence-based therapies that target specific physiology to improve the disease and are most effective when they are used as part of a comprehensive treatment plan. The amount of weight a person loses depends on the medication they take, their overall health, and other individual factors. Even as the range of weight loss medications has expanded, some drugs have been withdrawn based on their lack of efficacy as well as safety concerns. The amount of weight loss possible with semaglutide, according to clinical studies, is significant. A study of individuals showed 5. A larger study published in the New England Journal of Medicine showed even greater average loss— However, drawbacks of semaglutide include high cost, side effects, and the long-term to indefinite length of treatment. As with all obesity treatment, a person might experience better results with one medication over another. Each person, in partnership with their doctor, should try to find the right combination of treatments that work best for them. In , The American Gastroenterological Association released recommendations for weight loss medications among patients with obesity who do not respond adequately to lifestyle interventions alone. They listed four first-line options:. They also recommended phentermine and diethylpropion. Note that these recommendations were made before the approval of Zepbound. They work primarily by regulating hormones in the brain, digestive system, and adipose tissue to suppress appetite and cravings and promote satiety. Some medications are administered orally and others as subcutaneous injections. When patients ask about weight-loss pills vs. injections, they tend to refer to the two options for GLP-1 RAs. Data released in May , separately by Novo Nordisk and Pfizer, stated that pills and injections are about equally effective. There are many medications that can be obesogenic or can cause weight gain. Following medications can potentially cause variable weight gain in some individuals. All weight loss medications work best in the context of a healthy eating plan and exercise. Even when a patient is engaging in exercise and other lifestyle adjustments, medications can help with hunger, cravings, and metabolic preservation. Some weight management medications are designed for short-term use and others for long-term use. For example, some are approved by the FDA for up to 12 weeks. Those approved by the FDA for long-term use include orlistat Xenical, Alli , phentermine-topiramate Qsymia , naltrexone-bupropion Contrave , liraglutide Saxenda , semaglutide Wegovy, Ozempic , and tirzepatide Zepbound, Mounjaro. The dosing for some of these includes a long ramp-up period—up to five months—to reach full dosage. While GLP-1 RAs have grabbed a lot of headlines, they are only the latest in a long history of evolving weight loss medications. A article in Life Science explains :. Additionally, drugs targeting hunger or satiety signaling have been actively studied and have shown increased adoption by physicians. Studies have also evaluated drugs that target metabolic tissues—such as adipose tissue or muscle—to promote weight loss, however to-date nothing has carried on into clinical practice. As with any medications, some weight loss drugs have been on the market longer, have generic alternatives, and tend to be more affordable. GLP-1 RAs are notoriously costly. Medicare does not cover weight loss drugs. AOMs may counter the effects of metabolic adaptation and prevent weight regain. After weight reduction, the body metabolically adapts, often causing an increase in hunger hormones and a decrease in satiety hormones and resting metabolic rate, all of which can contribute to weight regain. If the patient achieves clinically meaningful weight reduction with anti-obesity medications and if the clinician and patient feel that the medication is helping to avoid weight regain, then a weight reduction plateau should not be considered a point where medication should be discontinued, but rather the medication should be continued for weight reduction maintenance. The only over-the-counter medicine for weight loss currently approved by the FDA is Alli orlistat. Other over-the-counter products are considered supplements. They are not regulated by the FDA and do not have proper studies to confirm their safety and effectiveness. This relationship can allow for dosage adjustments or alternative medications if one seems like a better fit for the patient. Many antidepressants are weight-positive cause weight gain , some are weight-neutral, and at least one is weight-negative causes weight loss. Antidepressants are broken down into categories: selective serotonin reuptake inhibitors SSRIs , serotonin and norepinephrine reuptake inhibitors SNRIs , tricyclic antidepressants, monoamine oxidase inhibitors MAO inhibitors , and others. Medications within each of these categories can cause weight gain. In the SSRI group, Paroxetine shows the highest associated weight gain. Other SSRIs, including Citalopram Celexa , Escitalopram Lexapro , Fluoxetine Prozac , and Sertraline Zoloft , have variable effects on weight, and some do not show weight gain until after six months of use. Weight-positive medications in the tricyclic antidepressant category include Amitriptyline, Doxepin, and Imipramine. Desipramine, Nortriptyline, and Protriptyline have variable effects on weight. Bupropion Wellbutrin , an aminoketone, is considered weight-negative and is prescribed both to assist in weight loss and to treat depression. However, people respond to antidepressants differently. Each medicine impacts appetite differently. To learn more, check out our webinar on Optimizing Use of FDA Approved Anti-Obesity Medications. Are you seeking obesity treatment? Click to find an obesity medicine specialist near you who can assist you in finding the best weight loss medications for you. Family physician and Obesity Medicine physician at Dignity Health Medical Group, Bakersfield, California. Obesity Medicine Director, Mercy Weight Loss Surgery Program, Bakersfield, California. Top Weight Loss Medications. January 26, Top Weight Loss Medications Share this post. Criteria for Weight Loss Medication Prescriptions Determining whether someone is a candidate for weight loss medications begins with BMI. Currently Available Weight Loss Medications Some weight loss medications have been on the market for many years, and new ones emerge frequently. Commonly prescribed weight loss medications include: Semaglutide Wegovy, Ozempic Wegovy is a brand name for semaglutide, a GLP-1 receptor agonist. Ozempic is the same medication but is approved to treat type 2 diabetes. Tirzepatide Zepbound, Mounjaro Tirzepatide was previously approved to treat type 2 diabetes as Mounjaro. Liraglutide Saxenda Liraglutide is a daily injectable medication that acts on hormones from the gut that send signals to the brain to make the patient feel full quicker and decrease hunger signals. Phentermine Adipex, Suprenza Phentermine is the oldest and most widely used weight loss medication. Phentermine-topiramate Qsymia Topiramate can be combined with phentermine to decrease appetite and cravings. Naltrexone-bupropion Contrave Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain and thereby decrease cravings and appetite. Setmelanotide Imcivree Setmelanotide is a melanocortin-4 receptor agonist indicated for chronic weight management in adult and pediatric patients 6 years of age and older with obesity due to one of several specific rare genetic disorders. Orlistat Xenical and Alli Orlistat is a lipase inhibitor that comes in a capsule and works by blocking the enzyme that breaks down fats consumed through food. Hydrogel Plenity A medical device rather than a medication, Plenity was FDA-cleared in for people with a BMI of 24 to Upcoming Weight Loss Medications With fervent consumer demand for weight loss medications, combined with rising obesity rates, more medications are bound for the market in the coming years. Frequently Asked Questions About Weight Loss Medications How effective are weight loss medications? What is the strongest weight loss prescription medication? They listed four first-line options: Semaglutide Liraglutide Phentermine-topiramate extended-release ER Naltrexone-bupropion extended-release ER They also recommended phentermine and diethylpropion. How do weight loss medications work? Are there medications that can cause weight gain? Some beta-blockers and calcium channel blockers Anti-diabetes medications such as insulins, sulfonylureas, thiazolidinediones, and meglitinides Hormone therapies such as glucocorticoids and injectable progestins Anti-seizure medications, including carbamazepine, gabapentin, valproate, and pregabalin A wide variety of different antidepressants Some mood stabilizers Migraine medications such as amitriptyline and paroxetine Some antipsychotics Chemotherapeutic and anti-inflammatory agents How should weight loss medications be used in conjunction with other forms of treatment? How long do weight-loss medications need to be taken? How have options in weight loss medications changed in recent years? How do the different categories of weight loss medications compare in terms of cost? How do they affect weight regain? |
| Are Weight Loss Medications Effective? A Dietitian Explains | Some beta-blockers and calcium channel blockers Anti-diabetes medications such as insulins, sulfonylureas, thiazolidinediones, and meglitinides Hormone therapies such as glucocorticoids and injectable progestins Anti-seizure medications, including carbamazepine, gabapentin, valproate, and pregabalin A wide variety of different antidepressants Some mood stabilizers Migraine medications such as amitriptyline and paroxetine Some antipsychotics Chemotherapeutic and anti-inflammatory agents How should weight loss medications be used in conjunction with other forms of treatment? Medications within each of these categories can cause weight gain. For example, the monoclonal antibody bimagrumab is being studied as an infusion to increase muscle mass while decreasing fat. More Weight Loss Drugs Are Coming, and They Could Be Even More Effective. Caffeine as added caffeine or from guarana, kola nut, yerba maté, or other herbs. Many dietary supplements promoted for weight loss contain added caffeine or an herbal source—such as guarana Paullinia cupana , kola or cola nut Cola nitida , and yerba maté Ilex paraguariensis —that naturally contains caffeine. |
| Best Weight Loss Supplements (2024): 10 Products That Can Actually Help | Bottom Line Transparent Labs Casein Protein provides 25 grams of protein per scoop and is extremely popular among users. Undigested fat is then passed through the body. This is a difficult-to-pronounce ingredient derived from plants that have been cultivated for medicine in China for a long time. Dietary supplements are minimally regulated by the FDA and may or may not be suitable for you. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. That may not seem like a lot. |
Powerful weight loss supplements -
When diet and exercise feel fruitless, people turn to popular weight loss supplements, including prescription medications. Unfortunately, many weight loss products are questionable at best and downright dangerous at worst. We encourage consumers to be skeptical of any product that promises quick fat loss or an increased metabolic rate.
As a certified personal trainer and certified sports nutrition coach, clients often come to me wanting to lose weight and inquiring about fat burners and appetite suppressants. My job is to gently steer them toward safer, scientifically-supported products and refer them to a registered dietitian for personalized nutrition advice.
Speaking of registered dietitians, I consulted with Destini Moody, RD , who has years of experience in dietetics, to help me create this guide to the best weight loss supplements that are actually safe and good for you. We also leaned into our detailed supplement testing methodology to assess important factors to consider when shopping for these products, including:.
RELATED: Best Weight Loss Programs. Medical disclaimer: This article is intended for educational and informational purposes only. It is not intended as a substitute for medical advice. For health advice, contact a licensed healthcare provider. GGR also recommends choosing a product that has been third-party tested for quality.
And proclaimed belly fat-burning diet pills can be really dangerous. In fact, according to a systematic literature review in the Journal of Medical Toxicology 2 , 11 popular weight loss products are associated with adverse side effects ranging from mildly uncomfortable to severe and requiring medical attention.
Some of those have since been removed from the market by the FDA. However, there are many products that can serve as effective weight loss supplements when taken in conjunction with a healthy diet and exercise program.
RELATED: High-Protein Foods List for Weight Loss. The best diet supplements are not the popular weight loss pills that promise to help you lose weight fast or act as a thermogenic fat burner or off-market prescription weight loss drugs. The best products to help you achieve weight loss goals are primarily nutrients that you need in your daily diet.
The supplements we recommend in this guide can provide a host of health benefits other than weight loss, too. By filling nutritional gaps in your diet and resolving any nutrient deficiencies you may have as a result of low calorie intake, you may well see your energy levels and overall wellness improve.
Good for: Anyone who is trying to lose weight, to fill nutritional gaps and avoid deficiencies. Pure Encapsulation O. E Multivitamins for Men and Women are formulated to support healthy cognitive function, cellular health, and eye health. Losing weight requires consuming fewer calories than you burn: That is the fundamental principle of weight loss.
When you eat fewer calories, you eat less food in general, and less food equals fewer nutrients. Being deficient in certain nutrients can cause symptoms such as low energy, brain fog, physical fatigue, poor sleep, and low or swinging moods.
Feeling positive effects from supplements takes some time, so stay consistent with your daily multivitamin for a few weeks before jumping ship. Ready to start taking a multivitamin? We have dietitian-verified guides to the best multivitamins for women and the best multivitamins for men.
Good for: Weight loss warriors looking for a tasty supplement that also helps with appetite control and metabolism support. Kaged Whey Protein Isolate is a fast-digesting protein available in five flavors with 25 grams of protein per serving.
Whey protein can help you lose weight in two primary ways: Protein in general is known to increase satiety, or the feeling of fullness something we want when we are trying to lose weight , and it is critical for muscle growth.
RELATED: How Much Protein Should I Eat to Lose Weight? What does muscle growth have to do with weight loss? In a systematic review and meta-analysis 3 , researchers concluded that increasing protein intake can result in increased lower-body muscle mass and strength.
A systematic review in the journal Sports Medicine 4 reported that supplemental protein that is, protein shakes was shown to increase muscle mass in conjunction with resistance training. This is hugely important because losing muscle can negatively impact your metabolism in the long run.
Protein is not a magic supplement, but it has a lot of merit. Ultimately, the important thing is getting enough protein see how much protein you need , whether that comes entirely in the form of whole foods or you need a supplement to get you there.
If you do, check out our guide to the best whey protein powder. The Vega Sport Protein has mixed reviews on taste and blendability, but a higher protein content than most other vegan protein powders.
For vegan, vegetarian, and lactose-intolerant people on a weight loss journey, vegan protein powder could be just what you need to reduce or manage your body weight. Vegan protein is still protein, and it comes with the same benefits as whey protein, so long as all nine essential amino acids are present in the blend.
Even better, many vegan protein powders are made with mostly or entirely natural ingredients, making it a wonderful option for individuals prioritizing their overall wellbeing. Vegan protein powder is often fortified with vitamins and minerals, too, which can help close nutrient gaps that you might experience from a lower-calorie diet.
So again, protein can help keep your metabolism humming along as you lose fat mass. See our guide to the best vegan protein powder for our top picks. Metamucil is a plant-based fiber supplement with good reviews for taste and effectiveness.
Fiber is a type of carbohydrate that your body cannot digest. There are soluble fibers can dissolve in water and insoluble fibers cannot dissolve in water. The recommended daily intake for fiber is 25 grams per day for women and 30 for men. As for what type of fiber supplement to choose, research 10 suggests that glucomannan, a viscous fiber extract from konjac plant root, is more effective than other types of fiber supplements including guar gum 11 and psyllium 12 for weight loss.
Glucomannan is in many popular weight loss pills, including Leanbean and Trimtone. Nopal fiber 13 from cactus plants is another type thought to induce weight loss; it binds to dietary fat, causing more fats to be excreted as waste.
However, more research is needed to determine the efficacy and safety of this fiber supplement. For ideas, take a look at our guide to the best fiber supplements. If you are looking for a basic daily probiotic Culturelle Digestive Daily is a great option to help occasional stomach discomfort.
Many studies show probiotics to be efficacious at promoting weight loss. In a trial 14 , researchers concluded that probiotic supplementation reduced abdominal fat by an average of 4. In a trial 15 , participants who took a synbiotic capsule prebiotic and probiotic together lost significantly more body mass than the placebo group.
The participants who took the synbiotic also experienced other health benefits, including lowered cholesterol. Registered dietitian Destini Moody says that Lactobacillus and Bifidobacterium strains have been shown to be most effective for weight management, with L.
gasseri being the most effective. Sure enough, a review 16 in the journal Nutrients concluded exactly that. By the way, that review looks at 23 separate studies that show how probiotics aid weight loss. Again, I want to point out that a probiotic is much more than a weight loss aid.
Taking one consistently at an effective dosage 2 to plus billion CFUs also has potential to improve your overall health.
A healthy microbiome strengthens the immune system, and poor microbiome environments have been linked to 17 chronic diseases including diabetes, metabolic syndrome, and cardiovascular disease. On the flip side, a healthy gut is linked to a lower incidence of such conditions.
A thriving microbiome is even thought to combat mental health disorders like anxiety and depression, according to research in Frontiers in Microbiology Need a probiotic?
We have a guide to the best probiotics to support your health. Transparent Labs Casein Protein provides 25 grams of protein per scoop and is extremely popular among users. Unfortunately, it may be sold out when you try to buy it, but you can sign up to be notified when it is available again.
Losing weight is hard no matter what, but it can be even more difficult for those who struggle with snacking. A handful of this and a pinch of that can quickly add up and take you out of your calorie deficit.
As such, casein protein digests more slowly than whey, says registered dietitian Destini Moody. A review in the American Journal of Clinical Nutrition 20 concluded that consuming 25 to 30 grams of protein at each meal may improve appetite control and body weight management, as well as cardiometabolic disease risk factors such as high blood pressure.
Casein provides the same benefits as whey in terms of lean mass maintenance, too, Destini says. See our picks for the best casein protein. Transparent Labs' Magnesium Bisglycinate tablets provide grams of reportedly highly bioavailable, non-laxative magnesium supplement intended to improve sleep, recovery, and energy levels.
As a vegan-friendly product, this affordable supplement receives raves reviews. While the vast majority of users report very positive benefits when taking this magnesium, there are a few outliers who did not appreciate the inclusion of silicone dioxide.
In particular, magnesium is very important for sleep health. Meaning, better magnesium status was associated with fewer indicators of poor sleep. According to the published results, total sleep time improved by about 16 minutes in the magnesium supplementation group.
Why does this matter? Because not getting enough good sleep can dramatically impact your food choices, says registered dietitian Destini Moody.
Additionally, the review reports data from intervention studies that suggests sleep deprivation can lead to more snacking behavior, especially if sleep restriction is recurrent multiple nights in a row. So we know that poor sleep can mean poor food choices; magnesium may help improve sleep; and magnesium is important for many other body functions.
See the best magnesium supplements. You may also consider a ZMA supplement , which includes magnesium with the addition of zinc for a potentially more potent effect on sleep. Vitamin B12 is a nutrient required for making blood cells and it can only be obtained from animal foods, says registered dietitian Destini Moody.
Many Americans are deficient in this vitamin, which is also known as cobalamin, she says. According to the Cleveland Clinic 27 , deficiency in vitamin B12 can bring about symptoms such as intense fatigue, feeling very weak, feelings of depression and irritability, and gastrointestinal problems like nausea and diarrhea.
B12 deficiency may also bring about low appetite and weight loss, but not in a healthy way. Because deficiency can impact your mood and energy levels, it can affect your weight loss efforts, Destini says.
The U. Office of Dietary Supplements 28 classifies vegetarians as a group of people who are susceptible to vitamin B12 deficiency, along with older adults, infants of vegan women, people with pernicious anemia, and those who have gastrointestinal health conditions or have had gastrointestinal surgery.
If you suspect you are deficient in B12, ask your doctor for a blood test to check your levels. Additionally, many plant foods, such as cereals and breads, are fortified with vitamin B12 today, so one option is to buy such foods at the store.
In fact, no tolerable upper limit has been set for B12 because of the low level of toxicity. Still, Kitchens says to be aware of your intake, especially if you take prescription medications with potential B12 interactions Thorne Iron Bisglycinate claims to give your body iron in an optimal form to reap the benefits while making it easy to absorb.
It is also formulated to lessen the belly problems that are often associated with taking an iron supplement. Iron is perhaps one of the most important nutrients for active women who are looking to lose weight, says registered dietitian Destini Moody, especially if they adhere to a plant-based diet.
Plant-based diets are typically low in iron, especially when compared to omnivorous diets. Iron deficiency 31 can cause many unfavorable symptoms, including weakness, extreme fatigue, headaches, and shortness of breath. Additionally, iron is extremely important for exercise performance, according to research in the American Journal of Clinical Nutrition One important note: Iron supplementation is only recommended for those who are deficient.
If you suspect you have iron deficiency, talk to your healthcare provider. While the taste is questionable, the product works well for most users. Coffee is often considered a natural metabolism booster. While the jury is still out on that, we do think caffeine can play a role in a healthy weight loss plan.
Specifically, we recommend downing a bit of caffeine before a workout. Caffeine, a well-known performance enhancer, is found in most pre-workout supplements for a reason. It can significantly boost energy levels depending on the amount and your tolerance to the substance.
As such, you may be able to put forth more intense efforts in the gym and work out for longer before tapping out. There is growing interest in the pharmacological treatment of obesity. Before , there were few weight loss medications approved by the FDA. The top medications at that time were phentermine, marketed as Lomaira and Adipex-P, and orlistat, marketed as Xenical and Alli.
The advent of Glucagon-like peptide-1 receptor agonists GLP-1 receptor agonists , with brand names like Wegovy and Ozempic, has attracted explosive media attention. According to a study published in in Frontiers in Cardiovascular Medicine , online searches and prescriptions for GLP-1 receptor agonists are rising in tandem.
With a wider selection of weight loss medications now available, patients may ask what the strongest or most effective weight loss prescription medication is. The answer is complicated. It is not always easy to determine which medication is right for a particular individual. The market is also rapidly changing, so it is important to keep pace with the available options and their pros and cons.
Determining whether someone is a candidate for weight loss medications begins with BMI. Most medications are prescribed for someone with a BMI of 30 or greater, or a BMI of 27 or greater if the person has weight-related health conditions.
Zepbound was approved in November for adults with a BMI of 30 or greater. While some weight loss medications are approved by the FDA only for adults, semaglutide, liraglutide, and orlistat are approved for children aged 12 and older.
All of the medications discussed here are contraindicated for pregnancy. Some weight loss medications have been on the market for many years, and new ones emerge frequently. Commonly prescribed weight loss medications include:.
Wegovy is a brand name for semaglutide, a GLP-1 receptor agonist. It was FDA approved in The dose must be increased gradually over 16 to 20 weeks to arrive at the 2. This progression can help to alleviate side effects, which include gastrointestinal symptoms, headache, dizziness, and fatigue.
Tirzepatide was previously approved to treat type 2 diabetes as Mounjaro. As Zepbound, it is approved to treat obesity in adults with a BMI of 30 or greater. It is both a GLP-1 and a GIP receptor agonist and, like semaglutide, works by reducing appetite and is meant to be used in combination with diet and exercise to lose weight.
It is also administered as an injection. Liraglutide is a daily injectable medication that acts on hormones from the gut that send signals to the brain to make the patient feel full quicker and decrease hunger signals.
Doses start at 0. Side effects include nausea, diarrhea, constipation, vomiting, headache, decreased appetite, dyspepsia, fatigue, dizziness, abdominal pain, increased lipase, and renal insufficiency.
It is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Phentermine is the oldest and most widely used weight loss medication. It was originally used as a short-term medication to jump-start weight loss, but now newer medical guidelines have added it to long-term therapy.
In the US, phentermine is almost exclusively available in the HCl formulation — available in 15 mg and 30 mg strength. Side effects include headache, overstimulation, high blood pressure, insomnia, rapid or irregular heart rate, and tremor.
Interactions may occur during or within 14 days following the use of monoamine oxidase MAO inhibitors, sympathomimetics, alcohol, adrenergic neuron-blocking drugs, and possibly some anesthetic agents.
Topiramate can be combined with phentermine to decrease appetite and cravings. Having the combination of two drugs increases efficacy. Adults with migraines and obesity are good candidates for this weight-loss medication.
Daily doses with four strengths start at 3. Side effects include abnormal sensations, dizziness, altered taste, insomnia, constipation, and dry mouth.
Contraindications include uncontrolled hypertension and coronary artery disease, hyperthyroidism, glaucoma, and sensitivity to stimulants. Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain and thereby decrease cravings and appetite.
The most common side effects include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
This medication should not be prescribed to a patient who has a seizure disorder or who takes opioids for chronic pain. Setmelanotide is a melanocortin-4 receptor agonist indicated for chronic weight management in adult and pediatric patients 6 years of age and older with obesity due to one of several specific rare genetic disorders.
The condition must be confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic, likely pathogenic, or of a variant of uncertain significance VUS. Orlistat is a lipase inhibitor that comes in a capsule and works by blocking the enzyme that breaks down fats consumed through food.
In this way, it inhibits the absorption of dietary fats. Undigested fat is then passed through the body. It is intended for use in conjunction with a reduced-calorie diet and is also indicated to reduce the risk of weight regain.
Dosage is one mg capsule three times a day with each main meal containing fat during or up to 1 hour after the meal. An over-the-counter formulation is available at 60 mg capsule with each meal containing fat. The most common adverse reactions to orlistat are oily discharge from the rectum, flatus with discharge, increased defecation, and fecal incontinence.
A medical device rather than a medication, Plenity was FDA-cleared in for people with a BMI of 24 to The treatment has experienced increased media attention since the rise of GLP-1 receptor agonists.
It consists of a capsule that releases a biodegradable, super-absorbent hydrogel into the stomach. The gel helps to increase satiety, enabling the person to eat less. With fervent consumer demand for weight loss medications, combined with rising obesity rates, more medications are bound for the market in the coming years.
Lilly is developing orforglipron, an oral GLP-1 inhibitor. Retatrutide, another injectible, targets GLP-1, GIP, and glucagon. Pfizer is also developing two GLP-1 inhibitors that can be administered as pills.
Meanwhile, Amgen is trialing a drug candidate that is both a GLP-1 receptor agonist and a GIP receptor antagonist, as opposed to a dual agonist like semaglutide. Researchers continue to seek hormones that play a role in appetite, such as peptide YY, for other ways to target obesity with medication.
For example, the monoclonal antibody bimagrumab is being studied as an infusion to increase muscle mass while decreasing fat. With more options available, doctors will be increasingly able to personalize treatments as they match patients to the medications that will work best for them.
FDA-approved anti-obesity medications AOMs are safe, evidence-based therapies that target specific physiology to improve the disease and are most effective when they are used as part of a comprehensive treatment plan.
The amount of weight a person loses depends on the medication they take, their overall health, and other individual factors. Even as the range of weight loss medications has expanded, some drugs have been withdrawn based on their lack of efficacy as well as safety concerns.
The amount of weight loss possible with semaglutide, according to clinical studies, is significant. A study of individuals showed 5. A larger study published in the New England Journal of Medicine showed even greater average loss— However, drawbacks of semaglutide include high cost, side effects, and the long-term to indefinite length of treatment.
As with all obesity treatment, a person might experience better results with one medication over another. Each person, in partnership with their doctor, should try to find the right combination of treatments that work best for them. In , The American Gastroenterological Association released recommendations for weight loss medications among patients with obesity who do not respond adequately to lifestyle interventions alone.
They listed four first-line options:. They also recommended phentermine and diethylpropion. Note that these recommendations were made before the approval of Zepbound.
They work primarily by regulating hormones in the brain, digestive system, and adipose tissue to suppress appetite and cravings and promote satiety. Some medications are administered orally and others as subcutaneous injections. When patients ask about weight-loss pills vs. injections, they tend to refer to the two options for GLP-1 RAs.
Data released in May , separately by Novo Nordisk and Pfizer, stated that pills and injections are about equally effective.
There are many medications that can be obesogenic or can cause weight gain. Following medications can potentially cause variable weight gain in some individuals.
All weight loss medications work best in the context of a healthy eating plan and exercise. Even when a patient is engaging in exercise and other lifestyle adjustments, medications can help with hunger, cravings, and metabolic preservation.
Some weight management medications are designed for short-term use and others for long-term use. For example, some are approved by the FDA for up to 12 weeks.
Those approved by the FDA for long-term use include orlistat Xenical, Alli , phentermine-topiramate Qsymia , naltrexone-bupropion Contrave , liraglutide Saxenda , semaglutide Wegovy, Ozempic , and tirzepatide Zepbound, Mounjaro.
The dosing for some of these includes a long ramp-up period—up to five months—to reach full dosage. While GLP-1 RAs have grabbed a lot of headlines, they are only the latest in a long history of evolving weight loss medications.
A article in Life Science explains :.
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