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November 1, By Matthew Solan , Executive Editor, Harvard Men's Health Watch Reviewed by Howard E. LeWine, MD , Chief Medical Editor, Harvard Health Publishing Some people who struggle with weight loss have been able to find assistance from several FDA-approved weight-loss medications, such as bupropion plus naltrexone Contrave , phentermine Adipex-P , phentermine plus topiramate Qsymia , and orlistat Xenical, Alli.
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Print This Page Click to Print. Related Content. Healthy bodies come in many shapes, sizes and abilities. HealthLink BC, in collaboration with our partners, is reviewing our content to ensure weight-related messaging contributes to efforts to reduce weight bias and stigma while supporting health and wellness for people in B.
Speak with your health care provider if you are concerned that your weight is affecting your health. If you have questions about or would like support with eating or physical activity , call to speak with a registered dietitian or qualified exercise professional.
Make sure you know about each of the medicines you take. This includes why you take it, how to take it, what you can expect while you're taking it, and any warnings about the medicine.
The information provided here is general. So be sure to read the information that came with your medicine. If you have any questions or concerns, talk to your pharmacist or doctor. Here are some examples of weight-loss medicines.
For each item in the list, the generic name is first, followed by any brand names. Doctors prescribe weight loss medicines for people who are obese or overweight and have other health problems, such as high blood pressure or diabetes.
These medicines may help some people who haven't been able to lose weight with diet and exercise. Different medicines produce different results in different people.
Studies show that when people took: footnote 1. Weight-loss medicines are used along with healthy eating and being more active.
Without those lifestyle changes, you will gain the weight back if you stop taking the medicine. Many people regain the weight they lost after they quit taking the medicines. Medicine doesn't work for everyone.
If you don't lose weight within 4 weeks after you start the medicine, it probably won't help you. Most weight-loss medicines have side effects like nausea, vomiting, headaches, and constipation. Some medicines are more likely to cause side effects than others.
For example, nausea is a common side effect of Contrave and Saxenda. Xenical can cause changes in bowel habits. These changes may include oily or fatty stool and being unable to control bowel movements. Sometimes the side effects are mild and go away over time.
Research shows that up to half of people who take weight-loss medicines quit because of side effects. footnote 2. If your doctor prescribes a weight-loss medicine for you, tell him or her about all prescription and over-the-counter medicines, and natural health products that you take.
Your doctor will want to know about any side effects you have. He or she will watch to see if your weight loss improves your type 2 diabetes, cholesterol, and blood pressure.
All medicines can cause side effects. Many people don't have side effects. And minor side effects sometimes go away after a while. But sometimes side effects can be a problem or can be serious. If you're having problems with side effects, talk to your doctor.
Your doctor may be able to lower your dose or change to a different medicine. Always be sure you get specific information on the medicine you're taking. For a full list of side effects, check the information that came with the medicine you're using.
If you have questions, talk to your pharmacist or doctor. Using weight-loss medicines can put you at risk for increased blood pressure, a faster heart rate, headaches, sleep problems, and unpleasant changes in bowel habits.
It is possible to misuse some of these medicines. Weight-loss medicines also can harm unborn babies. Women who are pregnant should not take these medicines.
Always tell your doctor or pharmacist about all the medicines you take. This includes prescription and over-the-counter medicines and natural health products. That information will help prevent serious problems. For a full list of warnings, check the information that came with the medicine you're using.
Weight-loss medicines can range in cost. But they can be expensive. If you and your doctor have decided that you need a weight-loss medicine, make sure you know how much you will have to pay. Take time to find out about how your private health insurance covers the cost of these medicines.
Your insurance company may not pay for the medicines. Ask the customer service representative these questions:. Many insurance companies also list this information on their websites.
Author: Healthwise Staff Medical Review: Kathleen Romito MD - Family Medicine Martin J. Gabica MD - Family Medicine David E. Arterburn MD, MPH - Internal Medicine. Author: Healthwise Staff. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information.
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Weight-Loss Medicines. Medications Immunization, Inactivated influenza Anthrax Vaccine Diphtheria, Pertussis, and Tetanus Vaccines Haemophilus Influenzae Type B Hib Vaccine Hepatitis A Vaccine Hepatitis B Vaccine Herpes-Zoster Vaccine for Shingles Human Papillomavirus HPV Vaccine Measles, Mumps, and Rubella Vaccine Meningococcal Vaccine Pneumococcal Vaccines Polio Vaccine Rotavirus Vaccine Varicella-Zoster Vaccine for Chickenpox Weight-Loss Medicines Non-Prescription Products for Weight Loss Obesity: Should I Take Weight-Loss Medicine?
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Health Effectove professionals use Effecgive Effective weight loss pills Mass Index BMIa measure Effective weight loss pills your weight in relation to your height, to define overweight and obesity. People pipls have Garlic for blood pressure control BMI between 25 and 30 are considered to be overweight. Obesity is defined as having a BMI of 30 or greater. You can calculate your BMI to learn if you are overweighthave obesityor have severe obesity, which may increase your risk of health problems. Your health care professional can assess your individual risk caused by your weight. Healthy bodies come in many shapes, Hydration status tracking and abilities. HealthLink BC, in collaboration with our weighh, Effective weight loss pills reviewing our Effective weight loss pills to ensure pille messaging contributes to efforts to Effcetive weight bias Effective weight loss pills stigma while supporting health and wellness for people in B. Speak with your health care provider if you are concerned that your weight is affecting your health. If you have questions about or would like support with eating or physical activitycall to speak with a registered dietitian or qualified exercise professional. Make sure you know about each of the medicines you take.We include products we think are useful for our readers. If you buy Etfective links Effective this seight, we may earn a small commission.
Healthline only shows lods brands and products Stevia-based sweeteners we Effective weight loss pills behind. Prescription weight loss Effective weight loss pills, including GLP-1 agonists, orlistat, and setmelanotide, may be effective for some people.
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The Food and Drug Administration FDA has Effectkve several Effextive for losing weight with wwight and weigght. These medications DKA symptoms and diabetic ketoacidosis in elderly a prescription from a doctor and should only be taken under medical Chia seed smoothie bowls. These currently include :.
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Not Effecttive will adopting dietary and Effeftive changes help increase the effectiveness of weight loss drugs, Effective weight loss pills can losw help minimize weight regain, which often occurs after you stop taking these medications. Three GLP-1 agonists have been approved for weight loss, Efffctive liraglutide Erfectivesemaglutide Loesand tirzepatide Zepbound.
All three are pillls as weighr self-administered injection, but liraglutide is administered once Body volume scannerwhile poss and tirzepatide are only Effectiv once per Effecgive. Body volume scanner not approved specifically for weight loss, weitht other GLP-1 agonists intended to treat type pilks diabetes are sometimes prescribed off-label for weight management, including :.
GLP-1 agonists are only available through a prescription from a doctor or other qualified Body volume scanner professional. Several telehealth services and weight loss programs may also provide prescriptions loas you meet weignt eligibility criteria, including Ro Body Program and Calibrate.
How it Herbal weight loss formula GLP-1 agonists work by slowing the emptying of the stomach, increasing feelings of liss, and reducing the secretion of weihgtpillls hormone involved in regulating appetite.
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Though uncommon, severe side piills have Efdective been reported, which may require medical attention. These include kidney problems, pils C-cell tumorsgallbladder disease, low blood sugar, and suicidal pillls.
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After a medical consultation, a doctor can prescribe orlistat. Lpss telehealth oxidative stress and immune system may also provide a prescription for this medication. How it works: Orlistat works losz blocking the activity Dietary metabolism boosters certain enzymes used plls break down fats Body volume scanner the digestive tract, which helps to reduce the amount of calories you absorb.
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It could also contribute to nutrient deficiencies, including in fat-soluble vitamins A, D, E, or K. Following a low fat diet is typically recommended while taking this medication to help minimize adverse side effects.
Contraindications: chronic malabsorption, cholestasis a type of liver diseasepregnancy, renal impairment, and current use of certain prescription medications. It requires a prescription from a doctor and is sold under the brand Qsymia.
How it works: This medication includes phenterminea central nervous system stimulant and appetite suppressant with similar mechanisms to amphetamine.
It also includes topiramatean anticonvulsant that helps reduce appetite and enhance satiety feeling full to promote weight loss.
It could also cause increased body temperature, an inability to sweat, and psychiatric or cognitive disturbances.
Contraindications: This medication is not recommended for people with glaucoma eye conditions that can lead to blindnessa history of hyperthyroidism, pregnancy, recent use of monoamine oxidase inhibitors, and current use of certain prescription medications.
This medication, sold under the name Contrave, is an oral medication that combines bupropion, an antidepressant, and naltrexone, which is used to manage opioid or alcohol use disorder. A doctor can determine whether Contrave may be a good option for you and then provide a prescription.
Some online services may also prescribe Contrave following a virtual consultation with a healthcare professional. Over 1 year, participants lost an average of 11—22 lb 5—9 kg.
It might also increase heart rate and blood pressure. Contraindications: This medication is not recommended for people with a history of seizures, end-stage renal disease, pregnancy, and current use of monoamine oxidase inhibitors, opioids, or certain other prescription medications.
Setmelanotide, sold as Imcivree, is in a class of medications known as melanocortin 4 MC4 receptor agonists. How it works: People with specific genetic mutations may experience insufficient activation of the MC4 receptor in the brain, which could contribute to obesity.
Setmelanotide works by increasing the activation of this receptor, leading to reduced hunger, decreased calorie intake, and increased metabolismall of which could promote weight loss.
Participants also experienced a significant reduction in hunger with no serious treatment-related adverse events reported. Another small study in children, adolescents, and adults found that setmelanotide significantly improved quality of life as early as 5 weeks after starting treatment, which could be related to reduced hunger and body weight.
Side effects: Some of the most common side effects of setmelanotide include injection site reactions, hyperpigmentationnausea, headache, diarrhea, and stomach or back pain.
Fatigue, vomiting, and depression have also been reported. Contraindications: This medication is not recommended for people with renal impairment, and those who are pregnant or breastfeeding.
There are several anorectics, or appetite suppressantsavailable. However, phentermine Adipex-P or Lomaira is the most commonly prescribed.
Phentermine is taken orally and requires a prescription from a doctor or other healthcare professional. How it works: These medications reduce appetite by altering levels of certain neurotransmitters in the brain, which can lead to weight loss. Effectiveness: One study in 3, people compared the effectiveness of several medications for obesity and found that people taking phentermine lost the highest percentage of body weight over 12 weeks.
Those taking phentermine lost an average of 8. However, keep in mind that these medications are only recommended for short-term use, as you can build up a tolerance after several weeks, resulting in decreased effectiveness.
Side effects: Potential side effects may include nausea, vomiting, diarrhea, and stomach cramps. Other severe side effects have been reported and require immediate medical attention, including shortness of breath, chest pain, and swelling of the lower extremities.
Contraindications: This medication is not recommended for people with a history of heart disease, hypertension, hyperthyroidism, glaucoma, diabetes, pregnancy, and certain prescription medications.
Most weight loss medications are approved for adults with obesity or overweight and at least one weight-related condition, such as:. Similarly, setmelanotide Imcivreeis intended to treat obesity caused by certain genetic disorders. Keep in mind that weight loss medications are not suitable for everyone, including people who are pregnant, those with certain health conditions, or individuals taking specific medications.
A healthcare professional can provide guidance on whether you might be a candidate for a prescription, depending on your personal goals, medical history, and health status. Contact a trusted healthcare professional, like your OB-GYN, before taking any weight loss medications or supplements.
Some digital weight loss platforms, including Ro and Calibrate, include GLP-1 medications in their treatment plans for people who meet certain eligibility criteria. You can read our comprehensive reviews of Calibrate and Ro Health to learn more. Studies also suggest that people with higher body weights are disproportionately more likely to experience disordered eating and eating disorder symptoms.
These behaviors may indicate a disordered relationship with food or an ED. Disordered eating and EDs can affect anyone, regardless of gender identity, race, age, body size, socioeconomic status, or other identities. They can be caused by any combination of biological, social, cultural, and environmental factors — not just by exposure to diet culture.
GLP-1 agonists are currently the most effective anti-obesity medications and are considered safe for long-term use. Currently, only liraglutide Saxendasemaglutide Wegovyand tirzepatide Zepbound are approved for weight loss, though some other GLP-1 drugs may be prescribed off-label.
Still, keep in mind that individual results can vary based on many factors, including your diet, health status, and activity level. In addition to maximizing your potential results, it can increase the likelihood of maintaining weight loss in the long term.
If considered medically necessary, insurance companies may cover certain prescription weight loss medications. Some manufacturers also offer savings cards, which can help lower your copay.
Ozempic and Wegovy are two different brands of the same drug, semaglutide. However, there are differences in the recommended dosage and how each is administered. Additionally, Wegovy is FDA approved for weight management.
Saxenda liraglutideWegovy semaglutideand tirzepatide Zepbound are three GLP-1 medications recently approved for weight loss. Other GLP-1 medications, such as Ozempic semaglutideare also sometimes prescribed off-label for weight management.
Prescription medications have strong evidence to support their effectiveness for meaningful weight loss. Additionally, though they can promote weight loss and may even offer other health benefits, note that these medications are not suitable for everyone and can lead to weight regain once you stop taking them.
A doctor or other trusted healthcare professional can help you determine which is right for you and how to incorporate it into a healthy weight management plan. Obesity is a chronic condition, and medications are just one part of a treatment plan to help achieve and maintain weight loss.
Instead, they should be used only as directed and paired with a balanced diet, healthy lifestyle, and regular physical activity for best results.
Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. VIEW ALL HISTORY. This article tells you all you need to know about GLP-1 agonists like Wegovy, including whether they are safe and effective for weight loss.
Alli diet pills are the over-the-counter version of a weight loss drug called orlistat. This article looks at whether they are actually worth taking…. Plenity, a new hydrogel capsule that expands in the stomach to make a person feel full with less food, has been approved for use by the FDA to help….
: Effective weight loss pills| Top Weight Loss Medications | That information will help prevent serious problems. Journal of Clinical Endocrinology and Metabolism. naltrexone-bupropion Contrave. LeWine, MD , Chief Medical Editor, Harvard Health Publishing Dr. news Alerts There are no new alerts at this time. |
| Best Weight Loss Supplements 2024: Top 7 Products That Actually Work | Like Saxenda, Wegovy is a GLP-1 receptor agonist. If prescribed Imcivree, your dose may depend on your kidney health. Wegovy is given under the skin once weekly, at the same time every week, with or without meals. Check Price See TrimTone Reviews. That belief — in addition to older anti-obesity medications not being very effective — has made insurers reluctant to cover many of the new therapies, he said. Coronary Artery Disease: Should I Have Bypass Surgery? |
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You should spread your daily fat intake over the three main meals. The manufacturer recommends a fat intake of about 15 grams a meal. If you eat a meal that has no fat, then you don't need a dose of Alli.
If you take Alli with a high-fat meal, you'll likely experience more-severe digestive side effects. Alli can reduce the absorption of fat-soluble nutrients, including beta carotene and vitamins A, D, E and K. Take a multivitamin at least two hours after your last dose of Alli.
For some people, this timing works out best to be at bedtime. The active ingredient in Alli, orlistat, causes digestive side effects related to undigested fats passing through your digestive system. They generally lessen over time and with proper use of the drug.
These side effects include:. Before taking Alli, talk with your health care provider about possible interactions with other drugs, particularly if you take drugs for any of the following conditions:. A weight-loss plan with diet, exercise and drug therapy is generally considered successful if you lose about 1 pound 0.
If the treatment is successful, you are more likely to keep weight off or lose more weight if you continue with the diet, exercise and drug treatment plan. Most weight loss with the drug occurs within the first few months. The risks, side effects and cost related to taking the drug likely override any potential benefit.
Alli isn't an easy answer to weight loss. Losing weight and keeping it off require a commitment to eat a healthy, calorie-controlled diet and get regular physical activity. Work with your health care provider to evaluate the potential benefits and risks of Alli or any other weight-loss drugs.
As a team, you and your provider can create the right weight-loss plan for you. There is a problem with information submitted for this request.
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Mayo Clinic; Obesity adult. Pilitsi E, et al. Pharmacotherapy of obesity: Available medications and drugs under investigation. Perreault L. Obesity in adults: Drug therapy. Accessed Oct. Prescription medications to treat overweight and obesity. National Institute of Diabetes and Digestive and Kidney Diseases.
Accessed Aug. Melmed S, et al. In: Williams Textbook of Endocrinology. Elsevier; Patel K. Obesity treatment: A focus on pharmacotherapy of weight management. Papadakis MA, et al. McGraw Hill; Shah M expert opinion. Mayo Clinic. Apovian CM, et al. Pharmacological management of obesity: An Endocrine Society clinical practice guideline.
Journal of Clinical Endocrinology and Metabolism. Food and Drug Administration. Wegovy prescribing information. Novo Nordisk; Imcivree prescribing information. Rhythm Pharmaceuticals; Products and Services The Mayo Clinic Diet Online A Book: The Mayo Clinic Diet Bundle.
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