Arthritis is relentless, but so are we. Unleash your generosity! Nearly 60 million adults and children in America are diagnosed with arthritis, and most have pain that interferes with their daily lives. Every dollar you give helps provide research, support and services.

Please give now to help conquer arthritis pain. Get involved with the arthritis community. The Ultimate Arthritis Diet Learn which foods from the Mediterranean diet can help fight inflammation caused by arthritis. Fish How much: Health authorities like the American Heart Association and the Academy of Nutrition and Dietetics recommend three to four ounces of fish, twice a week.

Arthritis experts claim more is better. Why: Some types of fish are good sources of inflammation-fighting omega-3 fatty acids.

One study found those who had the highest consumption of omega-3s had lower levels of two inflammatory proteins: C-reactive protein CRP and interleukin More recently, researchers have shown that taking fish oil supplements helps reduce joint swelling and pain, duration of morning stiffness and disease activity among people who have rheumatoid arthritis RA.

Best sources: Salmon, tuna, sardines, herring, anchovies, scallops and other cold-water fish. Hate fish? Take a supplement.

Studies show that taking to 1, mg of fish oil daily eases joint stiffness, tenderness, pain and swelling. Ordovás, PhD, director of nutrition and genomics at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston.

Another study found that subjects with lower levels of vitamin B6 — found in most nuts — had higher levels of inflammatory markers. More good news: Nuts are jam-packed with inflammation-fighting monounsaturated fat.

Best sources: Walnuts, pine nuts, pistachios and almonds. Together, we are conquering arthritis. Why: Fruits and vegetables are loaded with antioxidants. Research has shown that anthocyanins found in cherries and other red and purple fruits like strawberries, raspberries, blueberries and blackberries have an anti-inflammatory effect.

More good news: Citrus fruits — like oranges, grapefruits and limes — are rich in vitamin C. Research shows getting the right amount of that vitamin aids in preventing inflammatory arthritis and maintaining healthy joints. Other research suggests eating vitamin K-rich veggies like broccoli, spinach, lettuce, kale and cabbage dramatically reduces inflammatory markers in the blood.

Best sources: Colorful fruits and veggies — the darker or more brilliant the color, the more antioxidants it has. Good ones include blueberries, cherries, spinach, kale and broccoli.

Olive Oil How much: Two to three tablespoons daily. Why: Olive oil is loaded with heart-healthy fats, as well as oleocanthal, which has properties similar to nonsteroidal anti-inflammatory drugs NSAIDs. Best sources: Extra virgin olive oil goes through less refining and processing, so it retains more nutrients than standard varieties.

Avocado and safflower oils have shown cholesterol-lowering properties, while walnut oil has 10 times the omega-3s that olive oil has.

High-glycemic index carbohydrate increases nuclear factor-kappaB activation in mononuclear cells of young, lean healthy subjects. Am J Clin Nutr.

Gomes JMG, Fabrini SP, Alfenas RCG. Low glycemic index diet reduces body fat and attenuates inflammatory and metabolic responses in patients with type 2 diabetes. Arch Endocrinol Metab. Gögebakan O, Kohl A, Osterhoff MA, van Baak MA, Jebb SA, Papadaki A, Martinez JA, Handjieva-Darlenska T, Hlavaty P, Weickert MO, Holst C, Saris WH, Astrup A, Pfeiffer AF, DiOGenes.

Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes DiOGenes study: a randomized, controlled trial.

Anderson JW, Baird P, Davis RH Jr, Ferreri S, Knudtson M, Koraym A, Waters V, Williams CL. Health benefits of dietary fiber. Nutr Rev. Influence of dietary fat and carbohydrates proportions on plasma lipids, glucose control and low-grade inflammation in patients with type 2 diabetes-The TOSCA.

IT Study. Eur J Nutr. King DE, Egan BM, Woolson RF, Mainous AG 3rd, Al-Solaiman Y, Jesri A. Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level.

Arch Intern Med. Ning H, Van Horn L, Shay CM, Lloyd-Jones DM. Associations of dietary fiber intake with long-term predicted cardiovascular disease risk and C-reactive protein levels from the National Health and Nutrition Examination Survey Data [].

Am J Cardiol. Lichtenstein AH, Kennedy E, Barrier P, Danford D, Ernst ND, Grundy SM, Leveille GA, Van Horn L, Williams CL, Booth SL. Dietary fat consumption and health.

Tan BL, Norhaizan ME. Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function. Davis NJ, Crandall JP, Gajavelli S, Berman JW, Tomuta N, Wylie-Rosett J, Katz SD.

Differential effects of low-carbohydrate and low-fat diets on inflammation and endothelial function in diabetes. J Diabetes Complications. Zhou H, Urso CJ, Jadeja V. Saturated fatty acids in obesity-associated inflammation. J Inflamm Res. Arya S, Isharwal S, Misra A, Pandey RM, Rastogi K, Vikram NK, Dhingra V, Chatterjee A, Sharma R, Luthra K.

C-reactive protein and dietary nutrients in urban Asian Indian adolescents and young adults. González F, Considine RV, Abdelhadi OA, Acton AJ. Inflammation triggered by saturated fat ingestion is linked to insulin resistance and hyperandrogenism in polycystic ovary syndrome.

J Clin Endocrinol Metab. Schwingshackl L, Hoffmann G. Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies. Lipids Health Dis. Yoneyama S, Miura K, Sasaki S, Yoshita K, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakagawa H.

Dietary intake of fatty acids and serum C-reactive protein in Japanese. J Epidemiol. Shahidi F, Ambigaipalan P. Omega-3 polyunsaturated fatty acids and their health benefits.

Annu Rev Food Sci Technol. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women.

Lopez-Garcia E, Schulze MB, Manson JE, Meigs JB, Albert CM, Rifai N, Willett WC, Hu FB. Consumption of n-3 fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J Nutr.

Yang B, Ren XL, Li ZH, Shi MQ, Ding F, Su KP, Guo XJ, Li D. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.

Food Funct. Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial.

Brain Behav Immun. Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser R. Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial. Allison DB, Egan SK, Barraj LM, Caughman C, Infante M, Heimbach JT.

Estimated intakes of trans fatty and other fatty acids in the US population. J Am Diet Assoc. Lopez-Garcia E, Schulze MB, Meigs JB, Manson JE, Rifai N, Stampfer MJ, Willett WC, Hu FB. Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.

Mozaffarian D, Pischon T, Hankinson SE, Rifai N, Joshipura K, Willett WC, Rimm EB. Dietary intake of trans fatty acids and systemic inflammation in women. Baer DJ, Judd JT, Clevidence BA, Tracy RP.

Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. Andersen CJ. Impact of dietary cholesterol on the pathophysiology of infectious and autoimmune disease.

Mazidi M, Heidari-Bakavoli A, Khayyatzadeh SS, Azarpazhooh MR, Nematy M, Safarian M, Esmaeili H, Parizadeh SM, Ghayour-Mobarhan M, Kengne AP, Ferns GA. Serum hs-CRP varies with dietary cholesterol, but not dietary fatty acid intake in individuals free of any history of cardiovascular disease.

Eur J Clin Nutr. Khayyatzadeh SS, Kazemi-Bajestani SMR, Bagherniya M, Mehramiz M, Tayefi M, Ebrahimi M, Ferns GA, Safarian M, Ghayour-Mobarhan M. Serum high C reactive protein concentrations are related to the intake of dietary macronutrients and fiber: findings from a large representative Persian population sample.

Clin Biochem. Dietary protein intake and human health. Hruby A, Jacques PF. Dietary protein and changes in biomarkers of inflammation and oxidative stress in the Framingham Heart Study Offspring Cohort. Curr Dev Nutr. Koelman L, Markova M, Seebeck N, Hornemann S, Rosenthal A, Lange V, Pivovarova-Ramich O, Aleksandrova K.

Effects of high and low protein diets on inflammatory profiles in people with morbid obesity: a 3-week intervention study. Yeh KL, Kautz A, Lohse B, Groth SW.

Associations between dietary patterns and inflammatory markers during pregnancy: a systematic review. Lopez-Legarrea P, de la Iglesia R, Abete I, Navas-Carretero S, Martinez JA, Zulet MA.

The protein type within a hypocaloric diet affects obesity-related inflammation: the RESMENA project. Floegel A, Chung SJ, von Ruesten A, Yang M, Chung CE, Song WO, Koo SI, Pischon T, Chun OK.

Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study.

Public Health Nutr. Schwab S, Zierer A, Schneider A, Heier M, Koenig W, Kastenmüller G, Waldenberger M, Peters A, Thorand B. Vitamin E supplementation is associated with lower levels of C-reactive protein only in higher dosages and combined with other antioxidants: The Cooperative Health Research in the Region of Augsburg KORA F4 study.

Br J Nutr. Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W. Juanola-Falgarona M, Salas-Salvadó J, Estruch R, Portillo MP, Casas R, Miranda J, Martínez-González MA, Bulló M. Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk.

Cardiovasc Diabetol. Jung S, Kim MK, Choi BY. The long-term relationship between dietary pantothenic acid vitamin B5 intake and C-reactive protein concentration in adults aged 40 years and older.

Nutr Metab Cardiovasc Dis. Detopoulou P, Panagiotakos DB, Antonopoulou S, Pitsavos C, Stefanadis C. Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study.

Cox SE, Arthur P, Kirkwood BR, Yeboah-Antwi K, Riley EM. Vitamin A supplementation increases ratios of proinflammatory to anti-inflammatory cytokine responses in pregnancy and lactation. Clin Exp Immunol. Bitarafan S, Mohammadpour Z, Jafarirad S, Harirchian MH, Yekaninejad MS, Saboor-Yaraghi AA.

The effect of retinyl-palmitate on the level of pro and anti-inflammatory cytokines in multiple sclerosis patients: a randomized double blind clinical trial. Clin Neurol Neurosurg. Jafarirad S, Siassi F, Harirchian MH, Amani R, Bitarafan S, Saboor-Yaraghi A.

The effect of vitamin a supplementation on biochemical parameters in multiple sclerosis patients. Iran Red Crescent Med J. Alaei-Shahmiri F, Soares MJ, Zhao Y, Sherriff J.

The impact of thiamine supplementation on blood pressure, serum lipids and C-reactive protein in individuals with hyperglycemia: a randomised, double-blind cross-over trial. Diabetes Metab Syndr. von Martels JZH, Bourgonje AR, Klaassen MAY, Alkhalifah HAA, Sadaghian Sadabad M, Vich Vila A, Gacesa R, Gabriëls RY, Steinert RE, Jansen BH, Bulthuis MLC, van Dullemen HM, Visschedijk MC, Festen EAM, Weersma RK, de Vos P, van Goor H, Faber KN, Harmsen HJM, Dijkstra G.

J Crohns Colitis. Drug Des Devel Ther. Fumeron C, Nguyen-Khoa T, Saltiel C, Kebede M, Buisson C, Drüeke TB, Lacour B, Massy ZA. Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients.

Nephrol Dial Transplant. Zhang K, Li Y, Cheng X, Liu L, Bai W, Guo W, Wu L, Zuo L. Cross-over study of influence of oral vitamin C supplementation on inflammatory status in maintenance hemodialysis patients. BMC Nephrol. Block G, Jensen CD, Dalvi TB, Norkus EP, Hudes M, Crawford PB, Holland N, Fung EB, Schumacher L, Harmatz P.

Vitamin C treatment reduces elevated C-reactive protein. Free Radic Biol Med. Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, Luo G, Meng Z, De Backer D, Xiang H, Peng Z. Pilot trial of high-dose vitamin C in critically ill COVID patients.

Ann Intensive Care. DiBella M, Thomas MS, Alyousef H, Millar C, Blesso C, Malysheva O, Caudill MA, Fernandez ML. Choline intake as supplement or as a component of eggs increases plasma choline and reduces interleukin-6 without modifying plasma cholesterol in participants with metabolic syndrome.

Sharifi A, Hosseinzadeh-Attar MJ, Vahedi H, Nedjat S. A randomized controlled trial on the effect of vitamin D3 on inflammation and cathelicidin gene expression in ulcerative colitis patients. Saudi J Gastroenterol.

Mousa A, Naderpoor N, Johnson J, Sourris K, de Courten MPJ, Wilson K, Scragg R, Plebanski M, de Courten B. Sci Rep. Cheshmazar E, Hosseini AF, Yazdani B, Razmpoosh E, Zarrati M. Effects of vitamin D supplementation on omentin-1 and spexin levels, inflammatory parameters, lipid profile, and anthropometric indices in obese and overweight adults with vitamin D deficiency under low-calorie diet: a randomized placebo controlled trial.

Evid Based Complement Alternat Med. Lotfi-Dizaji L, Mahboob S, Aliashrafi S, Vaghef-Mehrabany E, Ebrahimi-Mameghani M, Morovati A. Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial.

Clin Endocrinol Oxf. Wamberg L, Kampmann U, Stødkilde-Jørgensen H, Rejnmark L, Pedersen SB, Richelsen B.

Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels - results from a randomized trial. Eur J Intern Med. Chandler PD, Scott JB, Drake BF, Ng K, Manson JE, Rifai N, Chan AT, Bennett GG, Hollis BW, Giovannucci EL, Emmons KM, Fuchs CS.

Impact of vitamin D supplementation on inflammatory markers in African Americans: results of a four-arm, randomized, placebo-controlled trial. Cancer Prev Res Phila. Pessoa Mamede LCG, de Lima RLFC, Silva AS, Rodrigues Pita JCL, Galdino Gomes NI, de Sena EA, Moraes Nobrega RP, Scarano Alcântara JO, Fontes de Souza JH, Cardoso GA, de Brito Alves JL, Rodrigues Gonçalves MDC.

Effects of a single oral megadose of vitamin D3 on inflammation and oxidative stress markers in overweight and obese women: a randomized, double-blind, placebo-controlled clinical trial. Diabetes Metab Syndr Obes. de Medeiros Cavalcante IG, Silva AS, Costa MJ, Persuhn DC, Issa CT, de Lunafreire TL, da Conceição Rodrigues Gonçalves M.

Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: vitamin D3 megadose reduces inflammatory markers.

Exp Gerontol. Waterhouse M, Tran B, Ebeling PR, English DR, Lucas RM, Venn AJ, Webb PM, Whiteman DC, Neale RE. Effect of vitamin D supplementation on selected inflammatory biomarkers in older adults: a secondary analysis of data from a randomised, placebo-controlled trial.

Khatami PG, Soleimani A, Sharifi N, Aghadavod E, Asemi Z. The effects of high-dose vitamin E supplementation on biomarkers of kidney injury, inflammation, and oxidative stress in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial.

J Clin Lipidol. Pirhadi-Tavandashti N, Imani H, Ebrahimpour-Koujan S, Samavat S, Hakemi MS. The effect of vitamin E supplementation on biomarkers of endothelial function and inflammation among hemodialysis patients: a double-blinded randomized clinical trial.

Complement Ther Med. Mangoni AA, Arya R, Ford E, Asonganyi B, Sherwood RA, Ouldred E, Swift CG, Jackson SH. Effects of folic acid supplementation on inflammatory and thrombogenic markers in chronic smokers.

A randomised controlled trial. Thromb Res. Solini A, Santini E, Ferrannini E. Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects.

Int J Obes Lond. Durga J, van Tits LJ, Schouten EG, Kok FJ, Verhoef P. Effect of lowering of homocysteine levels on inflammatory markers: a randomized controlled trial. Chen H, Liu S, Ji L, Wu T, Ji Y, Zhou Y, Zheng M, Zhang M, Xu W, Huang G. Mediators Inflamm. Ma F, Wu T, Zhao J, Song A, Liu H, Xu W, Huang G.

Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI. Chen H, Liu S, Ge B, Zhou D, Li M, Li W, Ma F, Liu Z, Ji Y, Huang G.

J Prev Alzheimers Dis. Ma F, Zhou X, Li Q, Zhao J, Song A, An P, Du Y, Xu W, Huang G. Effects of Folic Acid and Vitamin B12, Alone and in combination on cognitive function and inflammatory factors in the elderly with mild cognitive impairment: a single-blind experimental design.

Curr Alzheimer Res. van Dijk SC, Enneman AW, Swart KM, van Wijngaarden JP, Ham AC, de Jonge R, Blom HJ, Feskens EJ, Geleijnse JM, van Schoor NM, Dhonukshe-Rutten RA, de Jongh RT, Lips P, de Groot LC, Uitterlinden AG, van den Meiracker TH, Mattace-Raso FU, van der Velde N, Smulders YM.

Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia. Vasc Med. Christen WG, Cook NR, Van Denburgh M, Zaharris E, Albert CM, Manson JE. Effect of combined treatment with folic acid, vitamin B6, and vitamin B12 on plasma biomarkers of inflammation and endothelial dysfunction in women.

J Am Heart Assoc. Bleie Ø, Semb AG, Grundt H, Nordrehaug JE, Vollset SE, Ueland PM, Nilsen DW, Bakken AM, Refsum H, Nygård OK. Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease. J Intern Med. Shishavan NG, Gargari BP, Jafarabadi MA, Kolahi S, Haggifar S, Noroozi S.

Vitamin K1 supplementation did not alter inflammatory markers and clinical status in patients with rheumatoid arthritis. Int J Vitam Nutr Res. Kristensen M, Kudsk J, Bügel S. Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women.

Mehri A. Trace elements in human nutrition II - an update. Int J Prev Med. Chacko SA, Song Y, Nathan L, Tinker L, de Boer IH, Tylavsky F, Wallace R, Liu S.

Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women.

Diabetes Care. Song Y, Li TY, van Dam RM, Manson JE, Hu FB. Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women. Gong JH, Lo K, Liu Q, Li J, Lai S, Shadyab AH, Arcan C, Snetselaar L, Liu S. Pinna K, Kelley DS, Taylor PC, King JC.

Immune functions are maintained in healthy men with low zinc intake. Bo S, Durazzo M, Gambino R, Berutti C, Milanesio N, Caropreso A, Gentile L, Cassader M, Cavallo-Perin P, Pagano G. Associations of dietary and serum copper with inflammation, oxidative stress, and metabolic variables in adults.

Cepeda-Lopez AC, Osendarp SJ, Melse-Boonstra A, Aeberli I, Gonzalez-Salazar F, Feskens E, Villalpando S, Zimmermann MB. Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity-related inflammation rather than by differences in dietary iron intake.

Jamilian M, Bahmani F, Siavashani MA, Mazloomi M, Asemi Z, Esmaillzadeh A. The effects of chromium supplementation on endocrine profiles, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.

Biol Trace Elem Res. Amiri Siavashani M, Zadeh Modarres S, Mirhosseini N, Aghadavod E, Salehpour S, Asemi Z. The effects of chromium supplementation on gene expression of insulin, lipid, and inflammatory markers in infertile women with polycystic ovary syndrome candidate for in vitro fertilization: a randomized, double-blinded, placebo-controlled trial.

Front Endocrinol Lausanne. Moradi F, Kooshki F, Nokhostin F, Khoshbaten M, Bazyar H, Pourghassem GB. A pilot study of the effects of chromium picolinate supplementation on serum fetuin-A, metabolic and inflammatory factors in patients with nonalcoholic fatty liver disease: a double-blind, placebo-controlled trial.

J Trace Elem Med Biol. Saiyed ZM, Lugo JP. Impact of chromium dinicocysteinate supplementation on inflammation, oxidative stress, and insulin resistance in type 2 diabetic subjects: an exploratory analysis of a randomized, double-blind, placebo-controlled study.

Food Nutr Res. Iqbal N, Cardillo S, Volger S, Bloedon LT, Anderson RA, Boston R, Szapary PO. Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults. Metab Syndr Relat Disord.

Jain SK, Kahlon G, Morehead L, Dhawan R, Lieblong B, Stapleton T, Caldito G, Hoeldtke R, Levine SN, Bass PF 3rd. Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-α, oxidative stress, and insulin resistance in type 2 diabetic subjects: randomized, double-blind, placebo-controlled study.

Mol Nutr Food Res. Kim HN, Kim SH, Eun YM, Song SW. Effects of zinc, magnesium, and chromium supplementation on cardiometabolic risk in adults with metabolic syndrome: a double-blind, placebo-controlled randomised trial.

DiSilvestro RA, Joseph EL, Zhang W, Raimo AE, Kim YM. A randomized trial of copper supplementation effects on blood copper enzyme activities and parameters related to cardiovascular health.

Ma J, Sun Q, Liu J, Hu Y, Liu S, Zhang J, Sheng X, Hambidge KM. The effect of iron fortification on iron Fe status and inflammation: a randomized controlled trial.

PLoS ONE. Dostal A, Baumgartner J, Riesen N, Chassard C, Smuts CM, Zimmermann MB, Lacroix C. Effects of iron supplementation on dominant bacterial groups in the gut, faecal SCFA and gut inflammation: a randomised, placebo-controlled intervention trial in South African children.

Tang M, Frank DN, Sherlock L, Ir D, Robertson CE, Krebs NF. Effect of vitamin E with therapeutic iron supplementation on iron repletion and gut microbiome in US iron deficient infants and toddlers.

J Pediatr Gastroenterol Nutr. Chacko SA, Sul J, Song Y, Li X, LeBlanc J, You Y, Butch A, Liu S. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals.

Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B. Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women.

J Res Med Sci. Nielsen FH, Johnson LK, Zeng H. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep.

Magnes Res. Zanforlini BM, Ceolin C, Trevisan C, Alessi A, Seccia DM, Noale M, Maggi S, Guarnieri G, Vianello A, Sergi G. Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients. Aging Clin Exp Res. Simental-Mendía LE, Rodríguez-Morán M, Reyes-Romero MA, Guerrero-Romero F.

No positive effect of oral magnesium supplementation in the decreases of inflammation in subjects with prediabetes: a pilot study. Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F.

Oral magnesium supplementation decreases C-reactive protein levels in subjects with prediabetes and hypomagnesemia: a clinical randomized double-blind placebo-controlled trial.

Arch Med Res. Afshar Ebrahimi F, Foroozanfard F, Aghadavod E, Bahmani F, Asemi Z. The effects of magnesium and zinc co-supplementation on biomarkers of inflammation and oxidative stress, and gene expression related to inflammation in polycystic ovary syndrome: a randomized controlled clinical trial.

Gijsbers L, Dower JI, Schalkwijk CG, Kusters YH, Bakker SJ, Hollman PC, Geleijnse JM. Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study.

Bahmani F, Kia M, Soleimani A, Mohammadi AA, Asemi Z. The effects of selenium supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy: a randomised, double-blind, placebo-controlled trial.

Raygan F, Behnejad M, Ostadmohammadi V, Bahmani F, Mansournia MA, Karamali F, Asemi Z. Selenium supplementation lowers insulin resistance and markers of cardio-metabolic risk in patients with congestive heart failure: a randomised, double-blind, placebo-controlled trial.

Salehi M, Sohrabi Z, Ekramzadeh M, Fallahzadeh MK, Ayatollahi M, Geramizadeh B, Hassanzadeh J, Sagheb MM. Selenium supplementation improves the nutritional status of hemodialysis patients: a randomized, double-blind, placebo-controlled trial.

Asemi Z, Jamilian M, Mesdaghinia E, Esmaillzadeh A. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: randomized, double-blind, placebo-controlled trial. Razavi M, Jamilian M, Kashan ZF, Heidar Z, Mohseni M, Ghandi Y, Bagherian T, Asemi Z.

Selenium supplementation and the effects on reproductive outcomes, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome. Horm Metab Res.

Kamali A, Amirani E, Asemi Z. Effects of selenium supplementation on metabolic status in patients undergoing for coronary artery bypass grafting CABG surgery: a randomized, double-blind, placebo-controlled trial.

Farrokhian A, Bahmani F, Taghizadeh M, Mirhashemi SM, Aarabi MH, Raygan F, Aghadavod E, Asemi Z. Selenium supplementation affects insulin resistance and serum hs-CRP in patients with type 2 diabetes and coronary heart disease.

Daeian N, Radfar M, Jahangard-Rafsanjani Z, Hadjibabaie M, Ghavamzadeh A. Selenium supplementation in patients undergoing hematopoietic stem cell transplantation: effects on pro-inflammatory cytokines levels.

Jafari F, Amani R, Tarrahi MJ. Effect of zinc supplementation on physical and psychological symptoms, biomarkers of inflammation, oxidative stress, and brain-derived neurotrophic factor in young women with premenstrual syndrome: a randomized, double-blind, placebo-controlled trial.

Bao B, Prasad AS, Beck FW, Fitzgerald JT, Snell D, Bao GW, Singh T, Cardozo LJ. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the effect of zinc supplementation on the frequency of migraine attack, duration, severity, lipid profile and hs-CRP in adult women.

Clin Nutr Res. Bao B, Prasad AS, Beck FW, Snell D, Suneja A, Sarkar FH, Doshi N, Fitzgerald JT, Swerdlow P. Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients. Ranjbar E, Shams J, Sabetkasaei M, M-Shirazi M, Rashidkhani B, Mostafavi A, Bornak E, Nasrollahzadeh J.

Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression.

Nutr Neurosci. Kim J, Ahn J. Effect of zinc supplementation on inflammatory markers and adipokines in young obese women.

Khorsandi H, Nikpayam O, Yousefi R, Parandoosh M, Hosseinzadeh N, Saidpour A, Ghorbani A. Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial.

Diabetol Metab Syndr. Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Effects of zinc supplementation on endocrine outcomes in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.

Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian-Attar A, Shapouri J, Poursafa P, Rouzbahani A. Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Landete JM.

Updated knowledge about polyphenols: functions, bioavailability, metabolism, and health. Crit Rev Food Sci Nutr. Chun OK, Chung SJ, Claycombe KJ, Song WO. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.

Rohrmann S, Shvetsov YB, Morimoto Y, Wilkens LR, Monroe KR, Le Marchand L, Franke AA, Kolonel LN, Maskarinec G. Self-reported dietary flavonoid intake and serum markers of inflammation: the multiethnic cohort.

Cancer Causes Control. Filiberto AC, Mumford SL, Pollack AZ, Zhang C, Yeung EH, Perkins NJ, Wactawski-Wende J, Schisterman EF. Habitual dietary isoflavone intake is associated with decreased C-reactive protein concentrations among healthy premenopausal women. Landberg R, Sun Q, Rimm EB, Cassidy A, Scalbert A, Mantzoros CS, Hu FB, van Dam RM.

Selected dietary flavonoids are associated with markers of inflammation and endothelial dysfunction in U.

Hsieh CT, Wang J, Chien KL. Association between dietary flavonoid intakes and C-reactive protein levels: a cross-sectional study in Taiwan.

J Nutr Sci. Zhang H, Xu Z, Zhao H, Wang X, Pang J, Li Q, Yang Y, Ling W. Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia. Redox Biol. Nikbakht E, Singh I, Vider J, Williams LT, Vugic L, Gaiz A, Kundur AR, Colson N.

Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults. Inflamm Res. Guo Y, Zhang P, Liu Y, Zha L, Ling W, Guo H. A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: a randomized controlled trial.

Hassellund SS, Flaa A, Kjeldsen SE, Seljeflot I, Karlsen A, Erlund I, Rostrup M. Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: a double-blind randomized placebo-controlled crossover study.

J Hum Hypertens. Thompson K, Hosking H, Pederick W, Singh I, Santhakumar AB. The effect of anthocyanin supplementation in modulating platelet function in sedentary population: a randomised, double-blind, placebo-controlled, cross-over trial.

Bazyar H, Hosseini SA, Saradar S, Mombaini D, Allivand M, Labibzadeh M, Alipour M. Effects of epigallocatechingallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial.

J Complement Integr Med. Mielgo-Ayuso J, Barrenechea L, Alcorta P, Larrarte E, Margareto J, Labayen I. Effects of dietary supplementation with epigallocatechingallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial.

Yari Z, Movahedian M, Imani H, Alavian SM, Hedayati M, Hekmatdoost A. The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial.

Haidari F, Heybar H, Jalali MT, Ahmadi Engali K, Helli B, Shirbeigi E. Hesperidin supplementation modulates inflammatory responses following myocardial infarction. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial.

Phytother Res. Yari Z, Cheraghpour M, Alavian SM, Hedayati M, Eini-Zinab H, Hekmatdoost A. The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial.

Cheraghpour M, Imani H, Ommi S, Alavian SM, Karimi-Shahrbabak E, Hedayati M, Yari Z, Hekmatdoost A. Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: a randomized, placebo-controlled, double-blind clinical trial.

Dehghani F, Sezavar Seyedi Jandaghi SH, Janani L, Sarebanhassanabadi M, Emamat H, Vafa M. Effects of quercetin supplementation on inflammatory factors and quality of life in post-myocardial infarction patients: a double blind, placebo-controlled, randomized clinical trial. Askari G, Ghiasvand R, Feizi A, Ghanadian SM, Karimian J.

The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. Dower JI, Geleijnse JM, Gijsbers L, Schalkwijk C, Kromhout D, Hollman PC. Supplementation of the pure flavonoids epicatechin and quercetin affects some biomarkers of endothelial dysfunction and inflammation in pre hypertensive adults: a randomized double-blind, placebo-controlled, crossover trial.

Javadi F, Ahmadzadeh A, Eghtesadi S, Aryaeian N, Zabihiyeganeh M, Rahimi Foroushani A, Jazayeri S. The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: a double-blind, randomized controlled trial. Heinz SA, Henson DA, Nieman DC, Austin MD, Jin F.

A week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects.

Egert S, Wolffram S, Bosy-Westphal A, Boesch-Saadatmandi C, Wagner AE, Frank J, Rimbach G, Mueller MJ. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans.

Javadi F, Eghtesadi S, Ahmadzadeh A, Aryaeian N, Zabihiyeganeh M, Foroushani AR, Jazayeri S. The effect of quercetin on plasma oxidative status, C-reactive protein and blood pressure in women with rheumatoid arthritis.

Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, Langguth P, Alteheld B, Fimmers R, Stehle P, Egert S. No effects of quercetin from onion skin extract on serum leptin and adiponectin concentrations in overweight-to-obese patients with pre- hypertension: a randomized double-blinded, placebo-controlled crossover trial.

Javid AZ, Hormoznejad R, Yousefimanesh HA, Haghighi-Zadeh MH, Zakerkish M. Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis.

Faghihzadeh F, Adibi P, Rafiei R, Hekmatdoost A. Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease.

Nutr Res. Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Anti-inflammatory effects of resveratrol in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study.

Bo S, Ciccone G, Castiglione A, Gambino R, De Michieli F, Villois P, Durazzo M, Cavallo-Perin P, Cassader M. Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial. Curr Med Chem.

Khodabandehloo H, Seyyedebrahimi S, Esfahani EN, Razi F, Meshkani R. Saldanha JF, Leal VO, Rizzetto F, Grimmer GH, Ribeiro-Alves M, Daleprane JB, Carraro-Eduardo JC, Mafra D.

Effects of resveratrol supplementation in Nrf2 and NF-κB expressions in nondialyzed chronic kidney disease patients: a randomized, double-blind, placebo-controlled, crossover clinical trial.

J Ren Nutr. Ley SH, Sun Q, Willett WC, Eliassen AH, Wu K, Pan A, Grodstein F, Hu FB. Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women.

Chai W, Morimoto Y, Cooney RV, Franke AA, Shvetsov YB, Le Marchand L, Haiman CA, Kolonel LN, Goodman MT, Maskarinec G. Dietary red and processed meat intake and markers of adiposity and inflammation: the multiethnic cohort study.

Papier K, Hartman L, Tong TYN, Key TJ, Knuppel A. Higher meat intake is associated with higher inflammatory markers, mostly due to adiposity: results from UK Biobank.

Mazidi M, Kengne AP, George ES, Siervo M. The association of red meat intake with inflammation and circulating intermediate biomarkers of type 2 diabetes is mediated by central adiposity. Gadotti TN, Norde MM, Rogero MM, Fisberg M, Fisberg RM, Oki E, Martini LA.

Dairy consumption and inflammatory profile: a cross-sectional population-based study, São Paulo, Brazil. Abreu S, Agostinis-Sobrinho C, Santos R, Moreira C, Lopes L, Gonçalves C, Oliveira-Santos J, Sousa-Sá E, Rodrigues B, Mota J, Rosário R. Association of dairy product consumption with metabolic and inflammatory biomarkers in adolescents: a cross-sectional analysis from the LabMed study.

Panagiotakos DB, Pitsavos CH, Zampelas AD, Chrysohoou CA, Stefanadis CI. Dairy products consumption is associated with decreased levels of inflammatory markers related to cardiovascular disease in apparently healthy adults: the ATTICA study.

Zampelas A, Panagiotakos DB, Pitsavos C, Das UN, Chrysohoou C, Skoumas Y, Stefanadis C. Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study.

J Am Coll Cardiol. van Bussel BC, Henry RM, Schalkwijk CG, Ferreira I, Feskens EJ, Streppel MT, Smulders YM, Twisk JW, Stehouwer CD. Fish consumption in healthy adults is associated with decreased circulating biomarkers of endothelial dysfunction and inflammation during a 6-year follow-up.

Tani S, Kawauchi K, Atsumi W, Matsuo R, Ashida T, Imatake K, Suzuki Y, Yagi T, Takahashi A, Matsumoto N, Okumura Y. Association among daily fish intake, white blood cell count, and healthy lifestyle behaviors in an apparently healthy Japanese population: implication for the anti-atherosclerotic effect of fish consumption.

Heart Vessels. Tani S, Matsuo R, Atsumi W, Kawauchi K, Ashida T, Yagi T, Imatake K, Suzuki Y, Takahashi A, Matsumoto N, Okumura Y. Ann Nutr Metab. Acosta-Estrada BA, Reyes A, Rosell CM, Rodrigo D, Ibarra-Herrera CC.

Benefits and challenges in the incorporation of insects in food products. Front Nutr. Stull VJ, Finer E, Bergmans RS, Febvre HP, Longhurst C, Manter DK, Patz JA, Weir TL. Impact of edible cricket consumption on gut microbiota in healthy adults, a double-blind, randomized crossover trial. Khatibi N, Shahvazi S, Nadjarzadeh A, Samadi M, Zare F, Salehi-Abargouei A.

Empirically derived dietary patterns and serum inflammatory markers in Iranian female teachers: a cross-sectional study. Nutr Diet. Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.

Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women. J Acad Nutr Diet. Navarro SL, Schwarz Y, Song X, Wang CY, Chen C, Trudo SP, Kristal AR, Kratz M, Eaton DL, Lampe JW.

Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults. Jiang R, Jacobs DR Jr, Mayer-Davis E, Szklo M, Herrington D, Jenny NS, Kronmal R, Barr RG.

Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis. Am J Epidemiol. Yu Z, Malik VS, Keum N, Hu FB, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS, Bao Y.

Associations between nut consumption and inflammatory biomarkers. Ren GY, Chen CY, Chen GC, Chen WG, Pan A, Pan CW, Zhang YH, Qin LQ, Chen LH. Effect of flaxseed intervention on inflammatory marker C-reactive protein: a systematic review and meta-analysis of randomized controlled trials.

Moreira Alves RD, Boroni Moreira AP, Macedo VS, Bressan J, de Cássia Gonçalves Alfenas R, Mattes R, Brunoro Costa NM. High-oleic peanuts: new perspective to attenuate glucose homeostasis disruption and inflammation related obesity.

Obesity Silver Spring. Liu JF, Liu YH, Chen CM, Chang WH, Chen CY. The effect of almonds on inflammation and oxidative stress in Chinese patients with type 2 diabetes mellitus: a randomized crossover controlled feeding trial.

Rajaram S, Connell KM, Sabaté J. Effect of almond-enriched high-monounsaturated fat diet on selected markers of inflammation: a randomised, controlled, crossover study. Madan J, Desai S, Moitra P, Salis S, Agashe S, Battalwar R, Mehta A, Kamble R, Kalita S, Phatak AG, Udipi SA, Vaidya RA, Vaidya AB.

Effect of almond consumption on metabolic risk factors-glucose metabolism, hyperinsulinemia, selected markers of inflammation: a randomized controlled trial in adolescents and young adults. Fitó M, Cladellas M, de la Torre R, Martí J, Muñoz D, Schröder H, Alcántara M, Pujadas-Bastardes M, Marrugat J, López-Sabater MC, Bruguera J, Covas MI, SOLOS Investigators.

Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial. Bogani P, Galli C, Villa M, Visioli F. Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil.

Qi L, van Dam RM, Liu S, Franz M, Mantzoros C, Hu FB. Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women. Vitaglione P, Mennella I, Ferracane R, Rivellese AA, Giacco R, Ercolini D, Gibbons SM, La Storia A, Gilbert JA, Jonnalagadda S, Thielecke F, Gallo MA, Scalfi L, Fogliano V.

Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber. Hoevenaars FPM, Esser D, Schutte S, Priebe MG, Vonk RJ, van den Brink WJ, van der Kamp JW, Stroeve JHM, Afman LA, Wopereis S.

Whole grain wheat consumption affects postprandial inflammatory response in a randomized controlled trial in overweight and obese adults with mild hypercholesterolemia in the Graandioos Study.

Wu SH, Shu XO, Chow WH, Xiang YB, Zhang X, Li HL, Cai Q, Ji BT, Cai H, Rothman N, Gao YT, Zheng W, Yang G. Soy food intake and circulating levels of inflammatory markers in Chinese women. Saraf-Bank S, Esmaillzadeh A, Faghihimani E, Azadbakht L.

Effect of non-soy legume consumption on inflammation and serum adiponectin levels among first-degree relatives of patients with diabetes: a randomized, crossover study.

Hermsdorff HH, Zulet MÁ, Abete I, Martínez JA. Noronha NY, Pinhel MAS, Nicoletti CF, Quinhoneiro DCG, Pinhanelli VC, Oliveira BAP, Cortes-Oliveira C, Delfino HBP, Wolf LS, Frantz FG, Marchini JS, Nonino CB. Green tea supplementation improves oxidative stress biomarkers and modulates IL-6 circulating levels in obese women.

Nutr Hosp. Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.

Kempf K, Herder C, Erlund I, Kolb H, Martin S, Carstensen M, Koenig W, Sundvall J, Bidel S, Kuha S, Tuomilehto J. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Lopez-Garcia E, van Dam RM, Qi L, Hu FB.

Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Loftfield E, Shiels MS, Graubard BI, Katki HA, Chaturvedi AK, Trabert B, Pinto LA, Kemp TJ, Shebl FM, Mayne ST, Wentzensen N, Purdue MP, Hildesheim A, Sinha R, Freedman ND.

Associations of coffee drinking with systemic immune and inflammatory markers. Cancer Epidemiol Biomarkers Prev. Zampelas A, Panagiotakos DB, Pitsavos C, Chrysohoou C, Stefanadis C. Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study.

di Giuseppe R, Di Castelnuovo A, Centritto F, Zito F, De Curtis A, Costanzo S, Vohnout B, Sieri S, Krogh V, Donati MB, de Gaetano G, Iacoviello L. Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population.

Jafarirad S, Ayoobi N, Karandish M, Jalali MT, Haghighizadeh MH, Jahanshahi A. Dark chocolate effect on serum adiponectin, biochemical and inflammatory parameters in diabetic patients: a randomized clinical trial. Kuebler U, Arpagaus A, Meister RE, von Känel R, Huber S, Ehlert U, Wirtz PH.

Dark chocolate attenuates intracellular pro-inflammatory reactivity to acute psychosocial stress in men: a randomized controlled trial. Hamed MS, Gambert S, Bliden KP, Bailon O, Singla A, Antonino MJ, Hamed F, Tantry US, Gurbel PA. Dark chocolate effect on platelet activity, C-reactive protein and lipid profile: a pilot study.

South Med J. Kunnumakkara AB, Sailo BL, Banik K, Harsha C, Prasad S, Gupta SC, Bharti AC, Aggarwal BB. Chronic diseases, inflammation, and spices: how are they linked? J Transl Med. Jiang TA. Health benefits of culinary herbs and spices. J AOAC Int. Hadi V, Kheirouri S, Alizadeh M, Khabbazi A, Hosseini H.

Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Avicenna J Phytomed. CAS Google Scholar.

Amizadeh S, Rashtchizadeh N, Khabbazi A, Ghorbanihaghjo A, Ebrahimi AA, Vatankhah AM, Malek Mahdavi A, Taghizadeh M. Mahdavi R, Namazi N, Alizadeh M, Farajnia S. Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: a randomized double-blind, placebo-controlled clinical trial.

Kazemi S, Yaghooblou F, Siassi F, Rahimi Foroushani A, Ghavipour M, Koohdani F, Sotoudeh G. Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre-diabetic women: a randomized double-blind clinical trial. J Sci Food Agric.

Davari M, Hashemi R, Mirmiran P, Hedayati M, Sahranavard S, Bahreini S, Tavakoly R, Talaei B. Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 SIRT1 in type 2 diabetes: a randomized, double blind, and controlled clinical trial.

Nutr J. Azimi P, Ghiasvand R, Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes patients.

Rev Diabet Stud. Mashhadi NS, Ghiasvand R, Askari G, Feizi A, Hariri M, Darvishi L, Barani A, Taghiyar M, Shiranian A, Hajishafiee M.

Influence of ginger and cinnamon intake on inflammation and muscle soreness endued by exercise in Iranian female athletes.

Askari F, Rashidkhani B, Hekmatdoost A. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients.

Shishehbor F, Rezaeyan Safar M, Rajaei E, Haghighizadeh MH. Cinnamon consumption improves clinical symptoms and inflammatory markers in women with rheumatoid arthritis.

Zareie A, Sahebkar A, Khorvash F, Bagherniya M, Hasanzadeh A, Askari G. Effect of cinnamon on migraine attacks and inflammatory markers: a randomized double-blind placebo-controlled trial. Mammen RR, Natinga Mulakal J, Mohanan R, Maliakel B, Illathu MK. Clove bud polyphenols alleviate alterations in inflammation and oxidative stress markers associated with binge drinking: a randomized double-blinded placebo-controlled crossover study.

J Med Food. Morovati A, Pourghassem Gargari B, Sarbakhsh P, Azari H, Lotfi-Dizaji L. The effect of cumin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, triple blind, placebo-controlled clinical trial. Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: a randomized, double-blind, placebo-controlled clinical trial.

Clin Nutr ESPEN. Zare E, Alirezaei A, Bakhtiyari M, Mansouri A. Evaluating the effect of garlic extract on serum inflammatory markers of peritoneal dialysis patients: a randomized double-blind clinical trial study.

van Doorn MB, Espirito Santo SM, Meijer P, Kamerling IM, Schoemaker RC, Dirsch V, Vollmar A, Haffner T, Gebhardt R, Cohen AF, Princen HM, Burggraaf J. Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects.

Asgharpour M, Khavandegar A, Balaei P, Enayati N, Mardi P, Alirezaei A, Bakhtiyari M.

For example, both the Mediterranean diet and the Dietary Approaches to Stop Hypertension DASH diet include fresh fruits and vegetables, fish, whole grains, and fats that are good for the heart. For example, research suggests that the Mediterranean diet, focusing on plant-based foods and healthful oils, can reduce the effects of inflammation on the cardiovascular system.

Research also shows that the DASH diet can have a positive impact on reducing inflammation markers compared to regular diets. The DASH diet may also have additional benefits in inflammatory arthritis conditions, such as lowering uric acid levels, which are a risk factor for gout.

An anti-inflammatory diet may serve as a complementary therapy for many conditions that become worse with chronic inflammation.

Eating a diet that is rich in antioxidants may also help reduce the risk of certain cancers. Foods that may help manage inflammation include :.

The authors of a article also recommended the following:. It is important to include a variety of healthful ingredients in the diet. Some people may also have intolerances to specific foods, meaning that eating them can cause inflammation and other adverse effects.

Common intolerances include:. A vegetarian or vegan diet may be one option for people looking to reduce inflammation as these diets typically priortize natural, whole foods while reducing saturated fat intake.

For exmaple, a analysis found that people who follow a vegan or vegetarian diet for 2 years or more typically have lower inflammatory biomarkers than those that eat meat.

However, large, controlled studies into the anti-inflammatory mechanisms of vegan and vegetarian diets are lacking , and further research is neccesary to fully explore their positive effects. Get some tips on switching to a plant-based diet here. Anti-inflammatory diets typically prioritize, whole fruits, vegetables, and grains, while limiting processed food, alcohol, and red meat.

No food will immediately reduce inflammation in the body when someone eats it. However, eating a balanced, broad diet of whole foods and grains is proven to reduce inflammatory markers as part of a balanced lifestyle.

However, highly processed foods items high in sugar, saturated fats, and salt, and alcohol are common causes of inflammation via diet. An anti-inflammatory diet may help reduce inflammation and improve symptoms of some common health conditions, such as rheumatoid arthritis.

There is no single anti-inflammatory diet, but a diet that includes plenty of fresh fruits and vegetables, whole grains, and healthy fats may help manage inflammation. Anyone who has a chronic health condition that involves inflammation should ask a healthcare professional about the best dietary options for them.

People with the endomorph body type can gain weight quickly. They may wish to avoid processed foods and those with a high fat content. Learn more here. However, it should be a gradual process. Learn more about no-sugar diets…. Leaky gut syndrome causes uncomfortable digestive symptoms.

Making certain dietary changes may help people manage these symptoms. Find out which foods…. Recent research suggests that following the Atlantic diet, which is similar to the Mediterranean diet, may help prevent metabolic syndrome and other…. A new study showed that a Mediterranean or MIND diet improved women's cognitive health during midlife.

The study of twins found that those…. My podcast changed me Can 'biological race' explain disparities in health? Why Parkinson's research is zooming in on the gut Tools General Health Drugs A-Z Health Hubs Health Tools Find a Doctor BMI Calculators and Charts Blood Pressure Chart: Ranges and Guide Breast Cancer: Self-Examination Guide Sleep Calculator Quizzes RA Myths vs Facts Type 2 Diabetes: Managing Blood Sugar Ankylosing Spondylitis Pain: Fact or Fiction Connect About Medical News Today Who We Are Our Editorial Process Content Integrity Conscious Language Newsletters Sign Up Follow Us.

Medical News Today. Health Conditions Health Products Discover Tools Connect. Anti-inflammatory diet: What to know. Medically reviewed by Katherine Marengo LDN, R. What is the diet? This inflammation does not go through the entire wall of the intestines and therefore does not result in fistulas.

However, extensive inflammation may eventually require surgery for removal of the affected area. FAQ: Dietary Management of IBD Information regarding dietary treatments for IBD is often confusing. Can diet control IBD? How can I identify problem foods? Continue reading What are dietary strategies for managing symptoms and when are they appropriate?

Diet Recommendations for Ulcerative Colitis Flare Follow a low residue diet to relieve abdominal pain and diarrhea. Avoid foods that may increase stool output such as fresh fruits and vegetables, prunes and caffeinated beverages.

Decrease concentrated sweets in your diet, such as juices, candy and soda, to help decrease amounts of water pulled into your intestine, which may contribute to watery stools. Decrease alcohol consumption. Try incorporating more omega-3 fatty acids in your diet.

These fats may have an anti-inflammatory effect. They are found in fish, including salmon, mackerel, herring and sardines. Patients often find that smaller, more frequent meals are better tolerated.

This eating pattern can help increase the amount of nutrition you receive in a day. Consider taking nutritional supplements if appetite is poor and solid foods are not tolerated well see section on recommended liquid supplements. Diet Recommendations for Crohn's Disease Flare Follow a low residue diet to relieve abdominal pain and diarrhea.

If you have strictures, it is especially important to avoid nuts, seeds, beans and kernels. Cold foods may help reduce diarrhea. If you have lactose intolerance , follow a lactose-free diet. Lactose intolerance causes gas, bloating, cramping and diarrhea 30 to 90 minutes after eating milk, ice cream or large amounts of dairy.

A breath hydrogen test may confirm suspicions of lactose intolerance. If you have oily and foul-smelling stools, you may have fat malabsorption. Treat fat malabsorption by following a low-fat diet. Discuss these symptoms with your doctor or nutritionist. Smaller, more frequent meals are better tolerated and can maximize nutritional intake.

If your appetite is decreased and solid foods not tolerated well, consider taking nutritional supplements see section on recommended liquid supplements. Diet Progression Following Flares for Ulcerative Colitis and Crohn's Disease Continue to follow a low residue diet and slowly add back a variety of foods.

Begin with well-tolerated liquids and advance to soft solids, then solids see below for liquid and solid food suggestions. Introduce one or two items every few days and avoid any foods that cause symptoms. Add fiber to diet as tolerated.

Well-tolerated fiber sources include tender cooked vegetables, canned or cooked fruits, and starches like cooked cereals and whole wheat noodles and tortillas.

Between flares, eat a wide variety of foods as tolerated. This includes fruits, vegetables, whole grains, lean protein, and low-fat and nonfat dairy products. Increase your calorie and protein intake following a flare. Abdominal pain, diarrhea and decreased appetite may have caused poor food intake.

Steroids used to treat flares also can increase protein needs. Suggestions for first foods after a flare include: Diluted juices Applesauce Canned fruit Oatmeal Plain chicken, turkey or fish Cooked eggs or egg substitutes Mashed potatoes, rice or noodles Bread — sourdough or white FAQ: Treatments and Nutritional Side Effects Do any medications have nutritional side effects?

Prednisone causes decreased absorption of calcium and phosphorus from the small intestine. It also causes increased losses of calcium, zinc, potassium and vitamin C.

With continual use of high doses of prednisone, the result may be bone loss and development of bone disease. People on prednisone may need up to milligrams a day. Protein needs also are increased for people taking prednisone because it increases protein breakdown in the body.

Cholestyramine decreases absorption of fat-soluble vitamins A,D, E and K , as well as folate, vitamin B, calcium and iron. Sulfasalazine interferes with folate absorption.

People taking this drug also should take a 1 milligram folate supplement each day. Can surgery affect nutritional status? What side effects of IBD can cause malnutrition? What are the specific nutritional needs for people with Crohn's disease and ulcerative colitis?

Calories Calorie needs are only slightly increased, unless weight gain is desired. Weight loss can occur due to episodes of inflammation, poor appetite and decreased intake. Protein Protein needs for patients between flares are the number of grams protein equal to your weight in kilograms 1 kilogram equals 2.

For example, a lb. female is and should therefore eat approximately 55 grams of protein each day. For weight gain and to restore losses after an acute flare, needs may be increased by 50 percent.

Needs also are increased if you are taking corticosteroids prednisone. Fluids and Electrolytes It is important to drink adequate amounts of fluid. A good guideline for hydration is to drink half of your body weight in ounces of water e.

a lb. person should drink 60 ounces of water. Fluid requirements increase during or after episodes of diarrhea and with exercise. Make sure you replenish losses of electrolytes from diarrhea. Sodium, chloride and potassium can be replenished by drinking sports drinks, such as Gatorade and Powerade.

Vitamins and Minerals A standard multivitamin with minerals can be taken each day. Increased risk for deficiencies of specific nutrients should be treated with an additional amount of those nutrients.

Discuss vitamin and mineral needs with your nutritionist or doctor. People with Crohn's disease are at greater risk for deficiencies of several vitamins and minerals due to extensive inflammation or removal of large portions of the digestive tract.

What can I do for periods of poor appetite and weight loss to prevent malnutrition? Liquid Supplements for Crohn's Disease Peptamen or Peptamen Junior for kids Contains protein that has been partially broken down, making it easier to absorb.

This may be useful if portions of the digestive tract are inflamed or have been removed. This formula also contains MCT oils that are absorbed more easily, decreasing the undesirable effects of fat malabsorption diarrhea, gas and bloating.

This formula is not highly concentrated, which also may help decrease diarrhea. An 8 ounce ready-to drink can provides calories, 10 grams protein; made by Nestle.

Recommend adding flavor packets to improve palatability. Peptamen 1. An 8 ounce ready-to-drink can provides calories, 16 grams protein; made by Nestle. Modulen IBD A mild formulation, which may help control diarrhea.

It also contains a growth factor which may decrease inflammation. It contains MCT oil for better absorption of fat. An 8 ounce serving made from powder provides calories, 9 grams protein; made by Nestle. Useful for nutrition before surgery, fat malabsorption, lactose intolerance and gluten sensitivity.

This is a clear liquid supplement that is a good source of protein and calories. An 8 ounce. ready-to drink box provides calories, 10 grams protein; made by Ross. Lipisorb High in MCT oil, which is an easily absorbed form of fat -- useful for fat malabsorption.

An 8 ounce ready-to drink can provides calories, 14 grams protein; made by Mead Johnson.