Time-restricted eating for better insulin control of Vetter Disclosures: Ms Ready Time-restricted eating for better insulin control being a Time-restrcted of the Certified Diabetes Care and Etaing Specialist for the Academy of Nutrition and Dietetics etaing being employed as a clinician at Green building materials Medical Group Weight Loss Solutions and Diabetes Education outside the submitted work. Conclusions and relevance This randomized clinical trial found that a TRE diet strategy without calorie counting was effective for weight loss and lowering of HbA 1c levels compared with daily calorie counting in a sample of adults with T2D. Andriessen, C. Sleep—wake patterns were similar in both interventions, with a mean sleep duration of 8. Flipping the switch from a fed to fasting state does more than help us burn calories and lose weight. A limitation of our approach is that we did not measure hepatic glycogen dynamics during the night.

Time-restricted eating for better insulin control -

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Download references. The authors would like to thank the staff and participants of Chu Hsien-I Memorial Hospital. We also thank American Journal Experts AJE for English language editing.

This work was supported by the National Natural Science Foundation of China No. RC and ZC Department of Neurology, Chu Hsien-I Memorial Hospital, Tianjin Medical University, Tianjin, , China.

You can also search for this author in PubMed Google Scholar. Conception and design: ZW, XL, TC; Data collection and interpretation: TC, CY, DT; Data analyses: XZ; Manuscript draft and critical review: all authors.

Final approval of the study content and manuscript and accountability for data integrity: all authors. All authors read and approved the final manuscript.

Correspondence to Xuejun Liu or Zhongming Wu. This study was approved by the Ethics Committee of Tianjin Medical University. Written informed consent was obtained from all of the participants.

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Reprints and permissions. Che, T. et al. Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 diabetes: a randomised controlled trial. Nutr Metab Lond 18 , 88 Download citation. Received : 23 April Accepted : 19 August Published : 07 October Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Download ePub. Abstract Background Time-restricted feeding is an emerging dietary intervention that is becoming increasingly popular.

Conclusion These results suggest that h restricted feeding improves blood glucose and insulin sensitivity, results in weight loss, reduces the necessary dosage of hypoglycaemic drugs and enhances quality of life.

Methods Patients Researchers recruited subjects from diabetes clinics by placing advertisements around the Zhu Xianyi Hospital of Tianjin Medical University.

Full size image. Results Participants As shown in Fig. Table 1 General characteristics of the study participants Full size table.

Table 2 Dietary intake at study baseline and after the week intervention Full size table. Table 3 Glucoregulatory factors, body composition and CVD risk markers Full size table. Discussion This study is the first to test the effects of TRF on weight, blood sugar, and CVD risk factors in overweight patients with type 2 diabetes.

Limitations This study has several limitations. Conclusion Our research is the first randomised controlled trial to explore the effects of TRF in humans with type 2 diabetes. Availability of data and materials The datasets used during the present study are available from the corresponding author upon reasonable request.

Abbreviations BMI: Body mass index FPG: Fasting plasma glucose HbA1c: Haemoglobin A1c HOMA-β: Homeostasis model of assessment-estimated β function HOMA-IR: Homeostasis model of assessment-estimated insulin resistance HDL: High-density lipoprotein LDL: Low-density lipoprotein MES: Medication effects score OHA: Oral hypoglycaemic agents TG: Triglyceride TC: Total cholesterol.

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Time-restricted eating for better insulin control -

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Procedures for numerical analysis of circadian rhythms. Rhythm Res. Download references. This work was supported by grants from the CAMS Innovation Fund for Medical Sciences CIFMS No. and H. The study sponsors played no role in study design, conduct, data acquisition, analysis, manuscript preparation or the decision to submit the manuscript for publication.

We thank Mark Cleasby, PhD from Liwen Bianji Edanz www. cn for editing the language of a draft of this manuscript. Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. You can also search for this author in PubMed Google Scholar.

oversaw the design, regulatory compliance, execution, and data analyses in this study. designed the study. Zhang, Z. Zhao, and H. recruited participants, collected data, and monitored participants compliance. All the authors contributed to data analyses.

wrote the manuscript. All the authors contributed to the composition and revision of the manuscript and gave final approval to its content.

Correspondence to Huayu Yang or Yilei Mao. Nature Communications thanks Heather Allore, Marta Garaulet and the other anonymous reviewer s for their contribution to the peer review this work.

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Subjects Feeding behaviour Nutrition Obesity Pre-diabetes. Abstract Time-restricted feeding TRF improves metabolic health. Introduction Long-term dietary habits are determinants of metabolic health 1. Results Participants Ninety volunteers who met the eligibility criteria participated in the trial and were randomized at a ratio of to eTRF, mTRF, and control groups Fig.

Full size image. Table 1 Baseline Characteristics. Full size table. Discussion The present study has shown that 5 weeks of eTRF, but not mTRF, improves insulin sensitivity, reduces fasting plasma glucose, reduces body mass and adiposity, ameliorates inflammation, and increases gut microbial diversity.

Randomization procedure For the pilot RCT, participants were randomly assigned to either the eTRF, mTRF, or control group in a ratio, using a computer-based random-number generator by designated researchers. Inclusion and exclusion criteria The inclusion criteria were: 1 18—64 years old; 2 ability to attend the hospital at regular intervals; 3 ability to independently provide informed consent; 4 BMI between Anthropometric measurements Body mass and percentage body fat were measured using an HBF Bioelectrical impedance analyzer Omron Healthcare Co.

Blood sampling and storage Blood sampling was performed at the beginning and the end of the trial. Flow cytometric analysis PBMCs were separated from blood samples using Ficoll GE Healthcare, Chicago, IL and centrifugation.

Fecal sample collection and storage Fecal samples were collected during the 3 days before the start of the trial and during the same period of time before the end of the trial. Biochemical measurements The plasma activities of AST, ALT, ALP, GGT, and lactate dehydrogenase; and the concentrations of LDL-C, HDL-C, total cholesterol, triglyceride, and glucose were measured using an automated analyzer Beckmann-Coulter AU , Brea, CA.

Real-time quantitative PCR RNA was pooled from PBMCs and used for cDNA synthesis. Subjective sleep quality and eating habits The participants were required to maintain their normal sleeping habits throughout the trial and to avoid undergoing testing after a night shift. Statistical analysis For the sample size calculation, we estimated that the eTRF group would show a Data availability The individual de-identified participant microbiota metagenomic sequencing data can be accessed from the BioProject Database of National Centre for Biotechnology Information with the dataset accession number PRJNA Code availability No code was involved in this manuscript.

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This is notable as diabetes is particularly prevalent among those groups, so having studies that document the success of time-restricted eating for them is particularly useful, the researchers said. The study was small and should be followed up by larger ones, said Varady, who is also a member of the University of Illinois Cancer Center.

While it acts as a proof of concept to show that time-restricted eating is safe for those with Type 2 diabetes, Varady said people with diabetes should consult their doctors before starting this sort of diet. The other current and former UIC authors on the paper are Vasiliki Pavlou, Sofia Cienfuegos , Shuhao Lin, Mark Ezpeleta, Kathleen Ready, Sarah Corapi, Jackie Wu, Jason Lopez, Kelsey Gabel , Lisa Tussing-Humphreys , Vanessa Oddo , Julienne Sanchez and Dr.

Terry Unterman. Other authors are from Northwestern University, the University of Minnesota, Minneapolis, and the University of Southern California.

Contact Emily Stone emilysto uic. Research , UIC today. diabetes , intermittent fasting , weight loss. Intermittent fasting is safe, effective for those with Type 2 diabetes October 27, Time-restricted eating, also known as intermittent fasting, can help people with Type 2 diabetes lose weight and control their blood sugar levels, according to a new study published in JAMA Network Open from researchers at the University of Illinois Chicago.

Krista Varady. Categories Research , UIC today Topics diabetes , intermittent fasting , weight loss.

Weight loss is an important target for individuals diagnosed with type 2 insupincontroo condition Time-restricted eating for better insulin control linked to insupin weight Timd-restricted obesity ; however, the most Orange Marinade Recipes dietary approach remains btter. In a new study, participants who eatimg their eating to eatin Time-restricted eating for better insulin control window from noon to 8 p. experienced greater weight loss compared to those who simply reduced their overall calorie intake through calorie counting. Time-restricted eating has gained popularity, but prior to this study, no research had specifically explored an eight-hour eating window in individuals with type 2 diabetes. The study involved 75 individuals, ages 18—80 years, who had both obesity and type 2 diabetes and who were divided into three groups: one followed time-restricted eating, another practiced calorie restriction and the third served as the control group. Those in the time-restricted eating group consumed their meals only from noon to 8 p.

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Can Time-Restricted Eating Help Control Blood Sugar? - with Dr. Satchin Panda - The Proof EP 221