Study design. Alpha Alpha-liipoic Acid for Alpha-lipoic acid and cognitive function Function by Vorst Canada April 21, Bio-Enhanced® is a registered trademark of GeroNova Research, Inc.

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Monograph sections include interactions with herbs, drugs, foods and labs, contraindications, depletions, dosing, toxicology, adverse effects, pregnancy and lactation data, synonyms, safety and effectiveness. Login Subscribe. Print Feedback. November ALA May Impact Cognitive Function in People With Alzheimer's and Diabetes Alpha-lipoic acid ALA may have a positive impact on cognitive function, according to a study.

References Fava A, Pirritano D, Plastino M, et al. The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Journal of Neurodegenerative Diseases. Â www. com The information in this brief report is intended for informational purposes only, and is meant to help users better understand health concerns.

Prior to January , he was the director of the Center of Excellence for Research on Neurodegenerative Diseases at the University of Pennsylvania and served on data safety monitoring committees for Elan Pharmaceuticals and Myriad and the diagnostic adjudication committee for a Bristol-Myers Squibb treatment trial.

Dr Quinn is on the speakers bureau for Pfizer, Forest, and Novartis. He is an investigator in clinical trials sponsored by Elan, Bristol-Meyers Squibb, Pfizer, and Danone.

He is a coinventor on a patent for the use of docosahexaenoic acid for the treatment of AD Martek Biosciences. He also receives research support from the Department of Veterans Affairs merit review funding and NIH grants P50 AGO PI and U01 AG project director.

Dr Ringman currently receives research support from National Institute on Aging NIA grants P50 AG PI and U01 AG site PI. He has served on an advisory board for Takeda Pharmaceuticals.

Dr Jicha is an investigator on clinical trials sponsored by Janssen, Baxter, Pfizer, Medivation, and Danone. He has consulted for Medivation, Martek, and Avanir in clinical trial development.

He receives research support from NIH grants P30 AG coinvestigator , R01 AG coinvestigator , U01 AG coinvestigator , R01 HD coinvestigator , and L30 AG PI and from Alzheimer's Association grant NIRG PI.

Dr Cotman receives research support from NIH grants AR, AG, AG, and AG Dr Montine serves as senior editor for Brain Pathology and on the editorial board of the American Journal of Pathology and receives research support from NIH grants P50 NS PI , R01 ES PI , T32 ES PI , R01 AG PI , U01 AG coinvestigator , and P50 AGO coinvestigator.

Dr Thomas has served as a consultant for Medivation and Bristol-Myers Squibb. He has also served on the data safety monitoring board for a trial sponsored by Myriad.

Role of the Sponsors: The funding agency had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.

Additional Contributions: The ADCS Data Coordinating Center provided oversight for the conduct and monitoring of the clinical trial. full text icon Full Text. Download PDF Top of Article Abstract Methods Results Comment Article Information References. View Large Download. Table 1. Demographic and Clinical Features of 78 Study Participants a.

Table 2. CSF Biomarker Data. Lovell MA, Markesbery WR. Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res. Montine TJ, Neely MD, Quinn JF, et al. Lipid peroxidation in aging brain and Alzheimer's disease.

Free Radic Biol Med. Morris MC. The role of nutrition in Alzheimer's disease: epidemiological evidence. Eur J Neurol. Yaffe K, Clemons TE, McBee WL, Lindblad AS. Age-Related Eye Disease Study Research Group. Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial.

Heart Protection Study Collaborative Group. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease: the Alzheimer's Disease Cooperative Study.

N Engl J Med. Petersen RC, Thomas RG, Grundman M, et al; Alzheimer's Disease Cooperative Study Group. Vitamin E and donepezil for the treatment of mild cognitive impairment. Floyd RA, Hensley K.

Oxidative stress in brain aging: implications for therapeutics of neurodegenerative diseases. Neurobiol Aging. Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.

Curr Med Chem. Sung S, Yao Y, Uryu K, et al. Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease.

FASEB J. Harrison FE, Allard J, Bixler R, et al. Nutr Neurosci. Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol. Cotman CW, Head E.

The canine dog model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis.

Quinn JF, Bussiere JR, Hammond RS, et al. Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg mice.

Siedlak SL, Casadesus G, Webber KM, et al. Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease. Free Radic Res. Hager K, Kenklies M, McAfoose J, Engel J, Münch G. Alpha-lipoic acid as a new treatment option for Alzheimer's disease: a 48 months follow-up analysis.

J Neural Transm Suppl. Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment.

J Bioenerg Biomembr. Yang X, Yang Y, Li G, Wang J, Yang ES. Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation.

J Mol Neurosci. Wadsworth TL, Bishop JA, Pappu AS, Woltjer RL, Quinn JF. Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease.

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Folstein MF, Folstein SE, McHugh PR. J Psychiatr Res.

Galasko D, Kershaw PR, Schneider L, Zhu Y, Tariot PN. Galantamine maintains ability to perform activities of daily living in patients with Alzheimer's disease. J Am Geriatr Soc. Thal LJ, Kantarci K, Reiman EM, et al.

The role of biomarkers in clinical trials for Alzheimer disease. Alzheimer Dis Assoc Disord. Blennow K, Hampel H, Weiner M, Zetterberg H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease.

Nat Rev Neurol. Galasko D, Montine TJ. Biomarkers of oxidative damage and inflammation in Alzheimer's disease. Biomark Med. Montine TJ, Beal MF, Cudkowicz ME, et al. Increased CSF F2-isoprostane concentration in probable AD.

Alpha lipoic acid can potentially improve memory in both healthy people, and people with cognitive impairments. This impact is a result of its ability to lessen inflammation and oxidative stress in the brain, both of which contribute to cognitive impairment.

The incapacitating disorder known as a stroke occurs when the blood flow to the brain is cut off, causing damage and cell death. According to studies, alpha lipoic acid may improve blood flow to the brain and shield brain cells from harm, which can lessen the risk of a stroke.

Common mental health conditions like depression and anxiety have a serious negative effect on cognitive performance. It has been shown that alpha lipoic acid reduces the signs of depression and anxiety by reducing inflammation and oxidative stress in the brain.

Alpha Lipoic Acid is a potent antioxidant and neuroprotective agent with a variety of potential health benefits. In addition to its well-documented cognitive benefits, this compound may also hold promise in the treatment of peripheral neuropathy, skin health improvement, and regulation of blood sugar levels.

One potential benefit of Alpha Lipoic Acid is its ability to treat peripheral neuropathy, a condition characterized by numbness, tingling, and pain in the hands and feet. By reducing inflammation and safeguarding nerve cells, Alpha Lipoic Acid has been shown to effectively alleviate these symptoms.

Alpha Lipoic Acid may also have anti-aging effects on the skin, as it has been found to reduce oxidative stress and enhance collagen production.

This translates to younger-looking, healthier skin. Another benefit of Alpha Lipoic Acid is its ability to regulate blood sugar levels and improve insulin sensitivity, making it beneficial for individuals with diabetes.

ALA is made naturally fucntion the body andd Alpha-lipoic acid and cognitive function protect against cell xnd Alpha-lipoic acid and cognitive function a variety of conditions. Alpa-lipoic sources rich in alpha-lipoic acid functioj spinach, broccoli, and yeast. ALA, known as the "universal oxidant," has been used for decades in Europe to treat nerve conditions, including nerve damage resulting from poorly controlled diabetes. There is strong evidence that ALA may help treat type 2 diabetes and neuropathy. In the current study, researchers looked at the potential impact of ALA in a group of people with Alzheimer's disease, both with and without diabetes. David also Alpha-lpioic the cognjtive Nootropics Expert YouTube channel. Natural detox for preventing chronic diseases Acai berry superfood ALA is a sulfur-containing fatty acid naturally acidd in your body. Lipoic acid is Alpha-lipoic acid and cognitive function among other antioxidants because it is both water- and fat-soluble. You get small amounts of lipoic acid in your diet from spinach and collard greens, broccoli, beef and organ meats. But lipoic acid declines in your body as you age. So you need to supplement with Alpha-Lipoic Acid to achieve the levels your body needs to run optimally.