Erratum Erratum antioxidaant U. Sci Rep13 127 Dec A subscription may be required.

L-carnitine and antioxidant activity -

Based on the degree of lipid peroxidation, the hippocampus, striatum, and cortex are likely to be highly sensitive to ROS stress. Some age-related increases in lipid peroxidation may be correlated with decreased antioxidant enzyme activities.

l -Carnitine supplementation causes a dramatic reduction in malondialdehyde formation in each of the three brain regions. Carnitine supplementation increased overall antioxidant enzyme status as a function of the duration of treatment, thus decreasing the levels of free radicals available for lipid peroxidation.

Carnitine can also act as a chelator by decreasing the concentration of cytosolic iron, which plays a very important role in free radical chemistry Koudelova and colleagues 25 showed that the production of lipoperoxides were decreased by carnitine, thereby protecting various tissues from damage.

Carnitine and its esters protect cells from ROS damage both by inhibiting free radical propagation and by contributing to the repair of oxidized membrane phospholipid Differential activities of these enzymatic antioxidants in diverse regions may be responsible for different rates of aging in various brain regions.

In summary, the regional variation seen in the action of carnitine on antioxidant status in different brain regions of young and old rats may be caused by regional differences in the uptake and transport of l -carnitine. Our results show that l -carnitine has a capacity to prevent free radical-induced damage, partly because of its antioxidant property.

Effect of l -Carnitine on Lipid Peroxidation of Various Brain Regions. Values are expressed as the means ± SD for six animals in each group. Comparison of the 7-d, d, and d groups with the 0-d group young and the 7-d, d, and d groups with the 0-d group old :.

Effect of l -Carnitine on Superoxide Dismutase Activity of Various Brain Regions. Effect of l -Carnitine on Glutathione Proxidase Activity of Various Brain Regions. Effect of l -Carnitine on Catalase Activity of Various Brain Regions.

This work was supported in part by a research grant from Lady Tata Memorial Trust Mumbai, India and the University Grant Commission Delhi, India. Reiter RJ, Oxidative process and oxidative defense mechanism in the aging brain. FASEB J. Zs-Nagy I. The Membrane Hypothesis of Aging CRC Press Inc.

Scaglia F, Longo N, Primary and secondary alterations of neonatal carnitine metabolism. Semin Perinatol. Hagen TM, Ingersoll RT, Wehr CM, et al. Acetyl-L-carnitine fed old rats partially restores mitochondrial function and ambulatory activity.

Proc Natl Acad Sci USA. Aureli T, Di Cocco ME, Capuani G, et al. Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by 31 PNMR spectroscopy. Neurochem Res. Matsouka M, Igisu H, Kohriyama K, Inove N, Suppression of neurotoxicity of ammonia by L-carnitine.

Brain Res. Costell MQ, Connor JE, Grisolia S, Age-associated decrease of carnitine content in muscle of mice and humans. Biochem Biophys Res Commun. Famularo G, DeSimone C, Carnitine stands on its own in HIV infection treatment. Arch Intern Med.

Glowinski K, Iverson LL, Regional studies of catecholamines in the rat brain. The disposition of [ 3 H]dopamine and [ 3 H]DOPA in various regions of rat brain. J Neurochem. Marklund S, Marklund G, Involvement of the superoxide anion radical in autoxidation of pyrogallol and a convenient assay for superoxide dismutase.

Eur J Biochem. Sinha AK, Colorimetric assay of catalase. Anal Biochem. Rotruck JT, Pope A, Ganther HE, Selenium: biochemical role as a component of glutathione peroxidase, purification and assay.

Science : Ohkawa H, Ohishi N, Yagi K, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Oxidative process and antioxidative defense mechanism in the aging brain.

Jayachandran M, Jayanthi B, Sundaravadivel B, Panneerselvam C, Status of lipids, lipid peroxidation and antioxidant systems with vitamin C supplementation during aging in rats. J Nutr Biochem. Kalaiselvi T, Panneerselvam C, Effect of L-carnitine on the status of lipid peroxidation and antioxidants in aging rats.

Chia LS, Thompson TE, Mescarello MA, Disorder in human myelin induced by superoxide radical: an in vitro investigation. Gardner PR, Nguyen DD, White CW, Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs.

Proc Natl Acad Sci USA 91 : Jain A, Martensson J, Stole E, Auld PAM, Meistar A, Glutathione deficiency leads to mitochondrial damage in brain. Matsuoka M, Igisu H, Protection of the brain by carnitine.

Igisu H, Matsuoka M, Iryo Y, J Occup Health. Yu BP, Yang R, Critical evaluation of the free radical theory of aging. NY Acad Sci. Backer GT, Martin GR, Biological aging and longevity. Underlying mechanism and potential intervention strategies.

J Aging Activity 2 : Resnik AZ, Kagan VE, Ramsey R, et al. Antiradical effects of L-propionyl carnitine protection of the heart against ischemia reperfusion injury: the possible role of iron chelation. Arch Biochem Biophys. Koudelova J, Mourek J, Drahota Z, Rauchova H, Protective effect of carnitine on lipid peroxide formation in rat brain.

Physiol Res. Arduini A, Carnitine and its acyl esters as secondary antioxidants?. Am Heart J. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.

Sign In or Create an Account. Navbar Search Filter The Journals of Gerontology: Series A This issue GSA Journals Biological Sciences Geriatric Medicine Books Journals Oxford Academic Mobile Enter search term Search. Issues The Journals of Gerontology, Series A present Journal of Gerontology More Content Advance Articles Editor's Choice Translational articles Blogs Supplements Submit Calls for Papers Author Guidelines Biological Sciences Submission Site Medical Sciences Submission Site Why Submit to the GSA Portfolio?

Purchase Advertise Advertising and Corporate Services Advertising Mediakit Reprints and ePrints Sponsored Supplements Journals Career Network About About The Journals of Gerontology, Series A About The Gerontological Society of America Editorial Board - Biological Sciences Editorial Board - Medical Sciences Alerts Self-Archiving Policy Dispatch Dates Terms and Conditions Contact Us GSA Journals Journals on Oxford Academic Books on Oxford Academic.

GSA Journals. Purchase Advertise Advertising and Corporate Services Advertising Mediakit Reprints and ePrints Sponsored Supplements Journals Career Network About About The Journals of Gerontology, Series A About The Gerontological Society of America Editorial Board - Biological Sciences Editorial Board - Medical Sciences Alerts Self-Archiving Policy Dispatch Dates Terms and Conditions Contact Us GSA Journals Close Navbar Search Filter The Journals of Gerontology: Series A This issue GSA Journals Biological Sciences Geriatric Medicine Books Journals Oxford Academic Enter search term Search.

Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. Effect of l -Carnitine on Brain Lipid Peroxidation and Antioxidant Enzymes in Old Rats. Juliet Arockia Rani , P.

Juliet Arockia Rani. Panneerselvam, Department of Medical Biochemistry, Dr. Alagappa Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, India E-mail: julietibms yahoo. Oxford Academic. Google Scholar. PDF Split View Views.

Cite Cite P. Select Format Select format. ris Mendeley, Papers, Zotero. enw EndNote. scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, total reducing power and metal chelating on ferrous ions activities.

Also, those various antioxidant activities were compared to alpha-tocopherol and trolox as references antioxidants.

References Articles referenced by this article 66 The effect of L-carnitine on the prevention of experimentally induced myringosclerosis in rats. Akbas Y , Pata YS , Gorur K , Polat G , Polat A , Ozcan C , Unal M Hear Res, MED: Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats.

Ando S , Tadenuma T , Tanaka Y , Fukui F , Kobayashi S , Ohashi Y , Kawabata T J Neurosci Res, 2 MED: Carnitine and its acyl esters as secondary antioxidants? Arduini A Am Heart J, 6 MED: Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity.

Binienda ZK , Ali SF Toxicol Lett, MED: Antioxidant determinations by the use of a stable free radical Blois Nature Leukocyte-mediated inactivation of alpha 1-proteinase inhibitor is inhibited by amino analogues of alpha-tocopherol. Bolkenius FN Biochim Biophys Acta, 1 MED: Carnitine-metabolism and functions Bremer Physiology Review Metabolic and clinical effects of l-carnitine in peripheral vascular disease Brevetti Nitric oxide and mitochondrial respiration.

Brown GC Biochim Biophys Acta, MED: In vitro antioxidant properties of dantrolene sodium. Buyukokuroglu ME , GulcIn I , Oktay M , Kufrevioglu OI Pharmacol Res, 6 MED: Show 10 more references 10 of Investigation of the effect of carnitine on cerebral vasospasm in experimental subarachnoid hemorrhage model.

Resitoglu G , Akgun MY , Ates O , Oztanir MN Sci Rep , 13 1 , 27 Dec Cited by: 0 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license. The hepatotoxicity of γ-radiation synthesized 5-fluorouracil nanogel versus 5-fluorouracil in rats model.

Barakat WE , Moawed FS , Ahmed ES , Abo-Zaid OA Int J Immunopathol Pharmacol , , 01 Jan Cited by: 0 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license. Marine versus Non-Marine Bacterial Exopolysaccharides and Their Skincare Applications.

Benhadda F , Zykwinska A , Colliec-Jouault S , Sinquin C , Thollas B , Courtois A , Fuzzati N , Toribio A , Delbarre-Ladrat C Mar Drugs , 21 11 , 07 Nov Cited by: 0 articles PMID: PMCID: PMC Review Articles in the Open Access Subset are available under a Creative Commons license.

Chemical Composition, Antioxidant, and Antitumor Activity of Fucoidan from the Brown Alga Dictyota dichotoma. El-Sheekh MM , Ward F , Deyab MA , Al-Zahrani M , Touliabah HE Molecules , 28 20 , 19 Oct Cited by: 0 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

Anti-Hyperalgesic Efficacy of Acetyl L-Carnitine ALCAR Against Visceral Pain Induced by Colitis: Involvement of Glia in the Enteric and Central Nervous System. Lucarini E , Micheli L , Toti A , Ciampi C , Margiotta F , Di Cesare Mannelli L , Ghelardini C Int J Mol Sci , 24 19 , 02 Oct Cited by: 0 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Screening of antiradical and antioxidant activity of monodesmosides and crude extract from Leontice smirnowii tuber.

Gülçin I , Mshvildadze V , Gepdiremen A , Elias R Phytomedicine , 13 5 , 16 Sep Cited by: 55 articles PMID: Spectroscopic studies on the antioxidant activity of ellagic acid. Kilic I , Yeşiloğlu Y , Bayrak Y Spectrochim Acta A Mol Biomol Spectrosc , , 02 May Cited by: 49 articles PMID: Antioxidant and radical scavenging properties of curcumin.

Ak T , Gülçin I Chem Biol Interact , 1 , 07 May Cited by: articles PMID: The chemistry behind antioxidant capacity assays. Huang D , Ou B , Prior RL J Agric Food Chem , 53 6 , 01 Mar Cited by: articles PMID: Review.

Dependence of DPPH radical scavenging activity of dietary flavonoid quercetin on reaction environment. Sak K Mini Rev Med Chem , 14 6 , 01 Jan Cited by: 8 articles PMID: Review.

Follow us News blog Technical blog Twitter YouTube. About About Europe PMC. Become a funder. Tools Tools overview. ORCID article claiming. Journal list. Grant finder. External links service. Annotations submission service. Developers Developer resources. Articles RESTful API.

Grants RESTful API. API case studies. SOAP web service. Annotations API. OAI service. Bulk downloads. Developers Forum. Help Help using Europe PMC. Search syntax reference.

Contact us Helpdesk. Tech blog. Developer forum. Let us know how we are doing. How are we doing. Europe PMC is a GBC global core biodata resource.

Europe PMC is a service of the Europe PMC Funders' Group , in partnership with the European Bioinformatics Institute ; and in cooperation with the National Center for Biotechnology Information at the U. It includes content provided to the PMC International archive by participating publishers.

Either your web browser L-cxrnitine support Javascript or it is xnd turned off. In the latter case, please turn Digestive health chia seeds Javascript Managing diabetes during pregnancy Digestive health chia seeds ane web browser and reload this page. Akbas YPata YSGorur KPolat GPolat AOzcan CUnal M. Hear Res, Ando STadenuma TTanaka YFukui FKobayashi SOhashi YKawabata T. J Neurosci Res, 2

Video

Does L-Carnitine Have Benefits For Fat Loss? Discover The Answer Here L-carnitine and antioxidant activity of Pharmacy, the Affiliated Hospital of Medical Atcivity, Qingdao University. Department of Pharmacology, Activitt L-carnitine and antioxidant activity, Qingdao University. School of Biomedical Sciences, Charles Sturt University. L-carnitine has been used as a supplement to treat cardiovascular or liver disease. However, there has been little information about the effect of L-carnitine on anti-oxidation capability in healthy human subjects. This study was designed to investigate the correlation between plasma L-carnitine concentration and antioxidant activity.

L-carnitine and antioxidant activity -

Although carnitine can be synthesized in the body, adults normally obtain carnitine from the diet. The decrease in carnitine concentration in old age is attributed mainly to malnourishment 7. This compound is also used as a therapeutic agent in several conditions such as atherosclerosis, kidney failure, mitochondrial myopathy, and AIDS 8.

The current study analyzes the free radical scavenging action of l -carnitine in various brain regions of young and old rats. l -Carnitine inner salt was obtained from Sigma St. Louis, MO. All other chemicals were of reagent grade. Male Wistar albino rats were segregated into two different age groups: young 4 months of age and old 24 months of age , respectively.

Each age group was subdivided into four groups: a control group Ia and three treated groups. Treated groups were based on the days of carnitine administration: 7 days, 14 days, and 21 days.

Each group consisted of six rats. The rats had access to food and water ad libitum. Twenty-four hours after the last injection in the respective groups, all the animals were decapitated; their brains were quickly, but carefully, removed and dissected into the hypothalamus, hippocampus, cortex, cerebellum, and striatum according to the method of Glowinski and Iverson 9 and immersed in saline.

Tissue homogenates were used to measure superoxide dismutase SOD 10 , catalase 11 , glutathione peroxidase 12 , and lipid peroxidation The difference in values of control and experimental groups were analyzed by Student's t test. Table 1 shows the status of lipid peroxidation in various brain regions of young and old rats before and after l -carnitine supplementation.

For old rats, compared with young control rats, a greater level of lipid peroxidation was observed in the cortex, hippocampus, striatum, and cerebellum, but not the hypothalamus.

l -Carnitine supplementation did not induce any alteration in the brains of young rats, whereas in the brains of old rats, lipid peroxidation was reduced in all areas except the hypothalamus.

Table 2 presents the effect of l -carnitine on the activity of SOD in the brains of young and old rats. Our observation revealed that the activity of SOD was lower in old control rats when compared with young control rats.

After 21 days of treatment, l -carnitine supplementation restored the enzyme activity to near-normal levels in the brains of old rats. Table 3 shows the activities of glutathione peroxidase in the brains of young and old rats before and after l -carnitine treatment.

Apparently, both l -carnitine supplementations enhanced the activity of glutathione peroxidase in the brains of both young and old rats. The activity of glutathione peroxidase was near normal in the cortex, hippocampus, and striatum of day treated old rats, compared with that of old control rats.

Table 4 shows the efficacy of l -carnitine supplementation on the activity of catalase in the brains of young and old rats. Age-dependent decrements in the activity of catalase were observed in specific brain regions of rats.

Supplementation of carnitine to the old rats partially reversed the age-associated decrements. Aging induces several structural and functional changes in the brain. An imbalance of changes caused by increased generation of free radicals and decreased functional efficiency of the antioxidant system has been suggested to be one of the primary factors that contributes to the aging process Antioxidant enzymes, such as SOD, catalase, and glutathione peroxidase, constitute a natural defense system against the activity of oxidants.

The survival of an organism may depend on the ability of the organism to overcome the toxic effects of ROS. SOD catalyzes the dismutation of the superoxide radical into hydrogen peroxide H 2 O 2.

Age-related decline in SOD activity, as documented in this study, was also observed in earlier investigations 15 Superoxide radicals affect the lipid phase of the myelin by changing its structure into a more disordered state The superoxide radical also inhibits aconitase activity and thereby affects the tricarboxylic acid cycle Earlier studies 16 showed that carnitine supplementation enhances the dismutation of superoxide radicals by increasing the levels of SOD activities.

Susceptibility to oxidative stress may differ among various regions of the brain. A form of glutathione peroxidase is the major antioxidative enzyme present in the brain. Glutathione peroxidase decomposes H 2 O 2 at the expense of the glutathione molecule The activity of this enzyme was low in the brains of old rats.

The lowering of glutathione peroxidase activity with aging may be attributed to a decline in glutathione concentration. The enzyme monoamine oxidase oxidizes dopamine with the production of H 2 O 2 , leading to an accumulation of H 2 O 2 and dopamine metabolites. During aging, the activity of monoamine oxidase is particularly high in the cortex and striatum, which may be responsible for the higher susceptibilities of these regions to ROS stress.

l -Carnitine enhanced glutathione peroxidase activity significantly in both of these regions. Apparently l -carnitine promotes energy production particularly in the brains of old rats. The energy-promoting action of l -carnitine was confirmed in the condition of hyperammonemia 20 An increase in the activity of catalase after supplementation was observed, confirming that carnitine provides reducing equivalents necessary for converting catalase from the inactive form to the active form.

The greater the degree of unsaturation in fatty acid, the higher the rate of lipid peroxidation. Neuronal membranes, that are rich in unsaturated fatty acids, are highly susceptible to lipid peroxidative damage, an index of ROS stress Increased arachidonic acid turnover may play a vital role in increased ROS stress.

Iron is a potent pro-oxidant and a necessary catalyst for in vitro lipid peroxidation The hippocampus contains a large amount of nonheme iron that makes this area of the brain particularly susceptible to free radica l- induced lipid peroxidation.

Based on the degree of lipid peroxidation, the hippocampus, striatum, and cortex are likely to be highly sensitive to ROS stress. Some age-related increases in lipid peroxidation may be correlated with decreased antioxidant enzyme activities.

l -Carnitine supplementation causes a dramatic reduction in malondialdehyde formation in each of the three brain regions. Carnitine supplementation increased overall antioxidant enzyme status as a function of the duration of treatment, thus decreasing the levels of free radicals available for lipid peroxidation.

Carnitine can also act as a chelator by decreasing the concentration of cytosolic iron, which plays a very important role in free radical chemistry Koudelova and colleagues 25 showed that the production of lipoperoxides were decreased by carnitine, thereby protecting various tissues from damage.

Carnitine and its esters protect cells from ROS damage both by inhibiting free radical propagation and by contributing to the repair of oxidized membrane phospholipid Differential activities of these enzymatic antioxidants in diverse regions may be responsible for different rates of aging in various brain regions.

In summary, the regional variation seen in the action of carnitine on antioxidant status in different brain regions of young and old rats may be caused by regional differences in the uptake and transport of l -carnitine.

Our results show that l -carnitine has a capacity to prevent free radical-induced damage, partly because of its antioxidant property. Effect of l -Carnitine on Lipid Peroxidation of Various Brain Regions.

Values are expressed as the means ± SD for six animals in each group. Comparison of the 7-d, d, and d groups with the 0-d group young and the 7-d, d, and d groups with the 0-d group old :.

Effect of l -Carnitine on Superoxide Dismutase Activity of Various Brain Regions. Effect of l -Carnitine on Glutathione Proxidase Activity of Various Brain Regions. Effect of l -Carnitine on Catalase Activity of Various Brain Regions. This work was supported in part by a research grant from Lady Tata Memorial Trust Mumbai, India and the University Grant Commission Delhi, India.

Reiter RJ, Oxidative process and oxidative defense mechanism in the aging brain. FASEB J. Zs-Nagy I. The Membrane Hypothesis of Aging CRC Press Inc. Scaglia F, Longo N, Primary and secondary alterations of neonatal carnitine metabolism.

Semin Perinatol. Hagen TM, Ingersoll RT, Wehr CM, et al. Acetyl-L-carnitine fed old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci USA.

Aureli T, Di Cocco ME, Capuani G, et al. Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by 31 PNMR spectroscopy. Neurochem Res. Matsouka M, Igisu H, Kohriyama K, Inove N, Suppression of neurotoxicity of ammonia by L-carnitine.

Brain Res. Costell MQ, Connor JE, Grisolia S, Age-associated decrease of carnitine content in muscle of mice and humans. Biochem Biophys Res Commun. Famularo G, DeSimone C, Carnitine stands on its own in HIV infection treatment.

Arch Intern Med. Glowinski K, Iverson LL, Regional studies of catecholamines in the rat brain. The disposition of [ 3 H]dopamine and [ 3 H]DOPA in various regions of rat brain.

J Neurochem. Marklund S, Marklund G, Involvement of the superoxide anion radical in autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. Sinha AK, Colorimetric assay of catalase. Anal Biochem.

Rotruck JT, Pope A, Ganther HE, Selenium: biochemical role as a component of glutathione peroxidase, purification and assay. Science : Ohkawa H, Ohishi N, Yagi K, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Oxidative process and antioxidative defense mechanism in the aging brain.

Jayachandran M, Jayanthi B, Sundaravadivel B, Panneerselvam C, Status of lipids, lipid peroxidation and antioxidant systems with vitamin C supplementation during aging in rats.

J Nutr Biochem. Kalaiselvi T, Panneerselvam C, Effect of L-carnitine on the status of lipid peroxidation and antioxidants in aging rats.

Chia LS, Thompson TE, Mescarello MA, Disorder in human myelin induced by superoxide radical: an in vitro investigation. Binienda ZK , Ali SF. Toxicol Lett, Nature Bolkenius FN. Biochim Biophys Acta, 1 Physiology Review Brown GC. Biochim Biophys Acta, Buyukokuroglu ME , GulcIn I , Oktay M , Kufrevioglu OI.

Pharmacol Res, 6 Resitoglu G , Akgun MY , Ates O , Oztanir MN. Sci Rep , 13 1 , 27 Dec Cited by: 0 articles PMID: PMCID: PMC Articles in the Open Access Subset are available under a Creative Commons license.

This means they are free to read, and that reuse is permitted under certain circumstances. There are six different Creative Commons licenses available , see the copyright license for this article to understand what type of reuse is permitted.

Free full text in Europe PMC. Barakat WE , Moawed FS , Ahmed ES , Abo-Zaid OA. Int J Immunopathol Pharmacol , , 01 Jan Benhadda F , Zykwinska A , Colliec-Jouault S , Sinquin C , Thollas B , Courtois A , Fuzzati N , Toribio A , Delbarre-Ladrat C.

Mar Drugs , 21 11 , 07 Nov Review Articles in the Open Access Subset are available under a Creative Commons license. El-Sheekh MM , Ward F , Deyab MA , Al-Zahrani M , Touliabah HE. Molecules , 28 20 , 19 Oct Lucarini E , Micheli L , Toti A , Ciampi C , Margiotta F , Di Cesare Mannelli L , Ghelardini C.

Int J Mol Sci , 24 19 , 02 Oct To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Gülçin I , Mshvildadze V , Gepdiremen A , Elias R. Phytomedicine , 13 5 , 16 Sep Cited by: 55 articles PMID: Kilic I , Yeşiloğlu Y , Bayrak Y.

Spectrochim Acta A Mol Biomol Spectrosc , , 02 May Cited by: 49 articles PMID: Ak T , Gülçin I. Chem Biol Interact , 1 , 07 May Cited by: articles PMID: Huang D , Ou B , Prior RL. J Agric Food Chem , 53 6 , 01 Mar Sak K. Mini Rev Med Chem , 14 6 , 01 Jan Cited by: 8 articles PMID: Contact us.

Europe PMC requires Javascript to function effectively. Recent Activity. Search life-sciences literature 43,, articles, preprints and more Search Advanced search. This website requires cookies, and the limited processing of your personal data in order to function.

By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. Abstract Available from publisher site using DOI.

A subscription may be required. Gülçin I 1. Affiliations 1. Atatürk University, Faculty of Arts and Sciences, Department of Chemistry, TRErzurum-Turkey. Authors Gülçin I 1.

Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract L-carnitine plays an important regulatory role in the mitochondrial transport of long-chain free fatty acids. In this study, the antioxidant activity of L-carnitine was investigated as in vitro.

The antioxidant properties of the L-carnitine were evaluated by using different antioxidant assays such as 1, 1-diphenylpicryl-hydrazyl free radical DPPH. scavenging, total antioxidant activity, reducing power, superoxide anion radical scavenging, hydrogen peroxide scavenging and metal chelating activities.

Total antioxidant activity was measured according to ferric thiocyanate method. alpha-tocopherol and trolox, a water-soluble analogue of tocopherol, were used as the reference antioxidant compounds.

In addition, L-carnitine had an effective DPPH. scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, total reducing power and metal chelating on ferrous ions activities.

Also, those various antioxidant activities were compared to alpha-tocopherol and trolox as references antioxidants. References Articles referenced by this article 66 The effect of L-carnitine on the prevention of experimentally induced myringosclerosis in rats.

Akbas Y , Pata YS , Gorur K , Polat G , Polat A , Ozcan C , Unal M Hear Res, MED: Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. Ando S , Tadenuma T , Tanaka Y , Fukui F , Kobayashi S , Ohashi Y , Kawabata T J Neurosci Res, 2 MED: Carnitine and its acyl esters as secondary antioxidants?

Arduini A Am Heart J, 6 MED:

Digestive health chia seeds you antiioxidant visiting nature. You L-caenitine using a ativity version with limited support for Vegan meal planner. To obtain L-carnitnie best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Pemphigus vulgaris PVas an autoimmune disease including mucosa and the skin, is associated with several complications and comorbidities.