Resveratrol and fertility -
For 10 to 15 years until puberty, these immature eggs will remain quiescent, until a hormonal cascade signals their growth, ovulation, or atresia normal breakdown process.
During this prolonged wait period, the immature eggs are susceptible to damage caused by free-radical accumulation. A study was carried out in mice to assess whether resveratrol could protect oocytes from damage caused by free radicals. Given the plausible mechanism, the researchers wondered whether resveratrol could maintain oocyte quality over time, thus prolonging the reproductive years.
Mice who had been given resveratrol maintained a larger follicle pool than their age-matched controls. Furthermore, telomerase activity, and gene expression in the ovaries of the mice receiving resveratrol resembled that of younger mice, indicating resveratrol was able to slow was able to slow the aging process in the ovaries and preserve oocyte quality.
A second common condition affecting fertility is polycystic ovary syndrome PCOS. A newly published study assessed whether resveratrol could pact the follicles of women suffering from PCOS or obesity-related infertility who were undergoing IVF. For instance, these women have elevated levels of oxidized LDL cholesterol i.
damaged LDL , which circulates through the body and subsequently damages various cells and tissues. In the ovary, high levels of oxidized LDL damage developing follicles, which can reduce the chances of ovulation.
In fact, in these women, levels of oxidized LDL were approximately double and were found to correlate negatively with the success of IVF outcomes.
The study went on to evaluate whether resveratrol could protect the granulosa cells the cells which surround and nourish the oocyte from the damaging effects of oxidized LDL. In the presence of oxidized LDL, the follicle was less likely to survive.
However, when the granulosa cells were exposed to resveratrol, markers of oxidative stress were significantly reduced, and the cells were better able to survive. Search Search.
Patient Store. Book Appointment. Resveratrol and Fertility. Bishayee, A.. Cancer Prevention Research Vol. Raederstorff, D. Kunz, and J. Annals of the New York Academy of Sciences Vol.
Bai, T. Dong, and L. International Journal of Molecular Medicine Vol. Liu, M. Human Reproduction Vol. Olesen, J. Experimental Gerontology Vol. Das, DK. Mukherjee, and D. Heart Failure Reviews Vol. Barger, J.
PLoS One Vol. Mobasheri, A. and M. Wong, R. Zhao, H. The British Journal of Nutrition Sep 1— Hardy, and T. Current Medicinal Chemistry Vol.
Kong, X. Journal of Endocrinological Investigation Vol. Baek, S. No one really knows what the best dose would be in humans but you can buy it over the counter with the hope that the same improvements seen in mouse ovaries may be seen in human ovaries.
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Does the resveratrol efrtility in human embryo culture medium improve Reesveratrol quality and pregnancy outcomes in older women? Ketosis and Anti-Aging significantly improved good Glucagon release regulation anr Resveratrol and fertility. Resverateol results are thought to be due to the biological activities of resveratrol as an antioxidant. Reproductive aging involves age-related declines in ovarian function and development capacity. After initiating meiosis, germ cells arrest at the dictyate stage of prophase I in the ovary for years in women. Accumulated reactive oxygen species ROS affect oocytes adversely.
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