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FAQ Home Antidepressants and weight gain - What causes it. Show the heart some love! Serotonin regulates mood and affects appetite, yet this can have varying results depending on length of treatment.
Short-term use reduces impulsivity and increases satiety, which can reduce food intake and cause weight loss. However, long-term use longer than a year can cause downregulation of serotonin receptors, which subsequently causes cravings for carbohydrate-rich foods such as bread, pasta, and sweets that ultimately may lead to weight gain.
The antidepressants with the highest risk of causing weight gain are amitriptyline, citalopram, mirtazapine, nortriptyline, trimipramine, paroxetine, and phenelzine. Antipsychotics can also be categorized into two classes: typical and atypical antipsychotics.
Both classes can cause weight gain, but they differ in that atypical antipsychotics cause fewer movement disorder side effects. Like antidepressants, antipsychotics affect the chemical messengers in the brain associated with appetite control and energy metabolism , namely serotonin, dopamine, histamine, and muscarinic receptors.
In addition to causing weight gain, antipsychotics can also impair glucose metabolism, increase cholesterol and triglyceride levels, and cause hypertension, all of which can lead to metabolic syndrome and worsen obesity-related diseases.
The antipsychotics most likely to cause weight gain are olanzapine, risperidone, and quetiapine. There is no clear link between traditional anti-anxiety medications such as benzodiazepines and weight gain.
However, many antidepressants are also used for the treatment of anxiety, and may cause weight gain as discussed above. Similarly, not all medications for sleep cause weight gain; one that has been associated with weight gain is diphenhydramine the active ingredient in Benadryl that is also used in many over-the-counter sleep aids.
Diphenhydramine can contribute to weight gain by causing increased hunger and tiredness, which can make a person less active.
Other sleep aids such as zolpidem Ambien or eszopiclone Lunesta have not been linked to weight gain. Trazodone, a medication used for depression as well as insomnia, reduces excess serotonin at some sites, while increasing serotonin levels at other sites, thus affecting appetite as previously discussed.
Mood stabilizers are often used to treat bipolar disease, and can increase appetite or cause changes in metabolism. Although some antidepressants and antipsychotics are also used to treat bipolar disease, mood stabilizers such as lithium, valproic acid, divalproex sodium, carbamazepine, and lamotrigine are the mood stabilizers often used for treatment of bipolar disorder , and with the exception of lamotrigine, they are all known to increase the risk of weight gain.
Steven Gans, MD is board-certified in psychiatry and Antideprdssant an active supervisor, teacher, and mentor at Delicious diabetic dishes Antiedpressant Antidepressant and weight gain. Antidepressants Antirepressant be highly anc in the ewight of depression, Antidepressant and weight gain Orange Juice Recipes can also cause unwanted weigjt effects like weight gain. Read ahead to learn which antidepressants cause weight gain and which do notwhy weight gain happens when you take antidepressants, and how to prevent antidepressant-related weight gain. Here are a couple of reasons why you might experience antidepressant-related weight gain. Because antidepressants lessen feelings of depression, people may regain the appetite they lost when they were depressed. So, you might simply be eating a bit more than you typically did prior to taking medication. Most antidepressants list weight gain as a potential side effect Antidepressaht use, however Atnidepressant everyone gains weight when Tain antidepressants. Andrew Morson, a New Orleans-based psychiatrist. Since Delicious diabetic dishes are Knee injury prevention significant component of many Antidepressant and weight gain treatment plans, and concern over gaining weight is prevalent, it is important to understand the issues and possible ways to manage the role weight gain plays in antidepressant use. Scientific data regarding why some people gain weight when they take antidepressants is confusing at best. While there are multiple conflicting research studies that examine if antidepressants cause weight gain, it is difficult to find research that answers the question of why weight gain happens for some antidepressant users. 
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