Video
What is a Free Radical ScavengerFree radical scavengers -
Please enable JavaScript to access the full features of the site or access our non-JavaScript page. Issue 18, From the journal: Biomaterials Science. Polydopamine free radical scavengers. cn b Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing , China c National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou , China.
This article is part of the themed collection: Biomaterials Science Emerging Investigators You have access to this article. Please wait while we load your content Something went wrong.
Try again? Cited by. Download options Please wait Article type Review Article. Submitted 30 Jun Accepted 30 Jul First published 31 Jul Download Citation. Request permissions. Acta Haematol 37— Packer L, Tritschler HJ, Wessel K Neuroprotection by the metabolic antioxidant α-lipoic acid.
Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V α-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats.
Pentikainen MO, Lindstedt KA, Kovanen PT Inhibition of the oxidative modification of LDL by nitecapone. Arterioscler Thromb Vasc Biol — Riederer P, Sofic E, Rausch WD, Schmidt D, Reynolds GP, Jellinger K, Youdim MBH Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains.
Article Google Scholar. Sam EE, Verbeke N Free radical scavenging properties of apomorphine enantiomers and dopamine: Possible implication in their mechanism of action in parkinsonism.
J Neural Transm PD Sect — Sgaragli GP, Valoti M, Gorelli B, Fusi F, Palmi M, Mantovani P Calcium antagonist and antiperoxidant properties of some hindered phenols. Br J Pharmacol — Smith CD, Carney JM, Starke-Reed PE, Oliver CN, Stadtman ER, Floyd RA, Markesbery WR Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.
Proc Natl Acad Sci USA — Spear N, Aust SD Effects of glutathione on Fenton reagent-dependent radical production and DNA oxidation. Stadtman ER Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions.
Annu Rev Biochem — Terland O, Flatmark T, Tangeras A, Gronberg M Dopamine oxidation generates an oxidative stress mediated by dopamine semiquinone and unrelated to reactive oxygen species.
J Mol Cell Cardiol — Trenam CW, Winyard PG, Morris CJ, Blake DR Iron promotes oxidative damage in rheumatic diseases. In: Lauffer RB ed Iron and human disease. CRC Press, Boca Raton, pp — Vatessery GT Vitamin E: Neurochemical aspects and relevance to nervous system disorders.
Vimard F, Nouvelot A, Duval D Cytotoxic effects of an oxidative stress on neuronal-like pheochromocytoma cells PC Wolz P, Krieglstein J Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia. Neuropharmacology — Xiao G, van der Helm D, Hider RC, Rai BL Molecular modeling studies of a ferric hexadentate 3-hydroxy-2 lH -pyridone complex and an analog by molecular mechanics, molecular dynamics, and free energy pertubation simulations.
J Phys Chem — Yamasaki Y, Itoyama Y, Kogure K Involvement of cytokine production in pathogenesis of transient cerebral ischemic damage.
Keio J Med — Ann N Y Acad Sci 64— Zhao Q, Pahlmark K, Smith ML, Siesjö BK Delayed treatment with the spin trap a-phenyl-N-tert-butyl nitrone PBN reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand — Download references.
Biomedical Research CNS, Merck KGaA, Frankfurter Strasse , D, Darmstadt, Federal Republic of Germany. You can also search for this author in PubMed Google Scholar. Department of Neurology, St. Josef Hospital Ruhr University Bochum, Federal Republic of Germany.
Reprints and permissions. Gassen, M. Free radical scavengers: chemical concepts and clinical relevance. In: Przuntek, H. Journal of Neural Transmission. Supplementa, vol Springer, Vienna. Publisher Name : Springer, Vienna.
Print ISBN : Online ISBN : eBook Packages : Springer Book Archive. Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics.
Skip to main content. Keywords PC12 Cell Free Radical Scavenger Iron Chelator Semiquinone Radical Protect PC12 Cell These keywords were added by machine and not by the authors.
Buying options Chapter EUR eBook EUR Softcover Book EUR Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions. Preview Unable to display preview. References Anghileri LJ, Maincent P, Cordova MA, Thouvenot P The role of ATP as a mediator in the action of iron complexes on cellular calcium homeostasis.
J Neurochem — Article PubMed CAS Google Scholar Ben-Shachar D, Livne E, Spanier I, Zuk R, Youdim MBH Iron modulates neuroleptic-induced effects related to the dopaminergic system.
Isr J Med Sci — PubMed CAS Google Scholar Ben-Shachar D, Livne E, Spanier I, Leenders KL, Youdim MBH Typical and atypical neuroleptics induce alteration in blood-brain barrier and brain 59FeCl 3 uptake. J Neurochem — Article PubMed CAS Google Scholar Benov LC, Benchev IC, Monovich OH Thiol antidotes effect on lipid peroxidation in mercury-poisoned rats.
Chem Biol Interact — Article PubMed CAS Google Scholar Cadet JL, Ali S, Epstein C Involvement of oxygen-based radicals in metham-phetamine-induced neurotoxicity: evidence from the use of CuZnSOD transgenic mice. Ann N Y Acad Sci — Article PubMed CAS Google Scholar Cao X, Phillis JW The free radical scavenger, α-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils.
Free Radic Res — Article PubMed CAS Google Scholar Carney JM, Kindy MS, Smith CD, Wood K, Tatsuno T, Wu JF, Landrum WR, Floyd RA Gene expression and functional changes after acute ischemia: age-related differences in outcome and mechanisms.
Springer, Berlin Heidelberg New York Tokyo, pp — Chapter Google Scholar Cerruti C, Sheng P, Ladenheim B, Epstein CJ, Cadet JL Involvement of oxidative and L-arginine-NO pathways in the neurotoxicity of drugs of abuse in vitro. Clin Exp Pharmacol Physiol — Article PubMed CAS Google Scholar Cheng HY, Liu T, Feuerstein G, Barone FC Distribution of spin-trapping compounds in rat blood and brain: in vivo microdialysis determination.
Free Radic Biol Med — Article PubMed CAS Google Scholar Ciuffi M, Gentilini G, Franchi Micheli S, Zilletti L D-penicillamine affects lipid peroxidation and iron content in the rat brain cortex. Neurochem Res — Article PubMed CAS Google Scholar Colton CA, Pagan F, Snell J, Colton JS, Cummins A, Gilbert DL Protection from oxidation enhances the survival of cultured mesencephalic neurons.
Free Radic Biol Med — Article PubMed CAS Google Scholar Esterbauer H Aldehydes of lipid peroxidation. Ann Neurol — Article PubMed CAS Google Scholar Ferrari G, Yan CY, Greene LA N-acetylcysteine D-and L-stereoisomers prevents apoptotic death of neuronal cells.
J Neurosci — PubMed CAS Google Scholar Folbergrova J, Zhao Q, Katsura K, Siesjö BK N-tert-butyl-α-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci U S A — Article PubMed CAS Google Scholar Froissard P, Monrocq H, Duval D Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells.
Mov Disord 37—43 Article PubMed CAS Google Scholar Gassen M, Glinka Y, Pinchasi B, Youdim MBH Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction. Eur J Pharmacol — Article PubMed CAS Google Scholar Gassen M, Gross A, Pinchasi B, Youdim MBH Apomorphine enantiomers protect cultured pheochromocytoma PC12 cells from oxidative stress induced by H 2 O 2 and 6-hydroxydopamine.
Eur J Pharmacol — Article PubMed CAS Google Scholar Gerlach M, Ben-Shachar D, Riederer P, Youdim MBH Altered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem — Article PubMed CAS Google Scholar Gerlach M, Riederer P, Youdim MBH Molecular mechanisms for neurodegeneration.
Adv Neurol — PubMed CAS Google Scholar Giovanni A, Liang LP, Hastings TG, Zigmond MJ Estimating hydroxyl radical content in rat brain using systematic and intraventricular salicylate: impact of methamphetamine.
J Neurochem — Article PubMed CAS Google Scholar Götz ME, Kunig G, Riederer P, Youdim MBH Oxidative stress: free radical production in neural degeneration. Pharmacol Ther 37— Article PubMed Google Scholar Greene LA, Aletta JM, Rukenstein A, Green SH PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation.
Methods Enzymol — Article PubMed CAS Google Scholar Haenen GR, Paquay JB, Korthouwer RE, Bast A Peroxynitrite scavenging by flavonoids. Biochem Biophys Res Commun — Article PubMed CAS Google Scholar Hall ED Antioxidant Therapeutic Strategies in CNS Disorders.
Plenum Press, New York, pp — Google Scholar Hall ED, McCall JM Lazaroids: potent inhibitors of iron-dependent lipid peroxidation for neurodegenerative disorders. Springer, Wien New York, pp — Chapter Google Scholar Hall ED, Andrus PK, Yonkers PA Brain hydroxyl radical generation in acute experimental head injury.
J Neurochem — Article PubMed CAS Google Scholar Hallenbeck JM Significance of the inflammatory response in brain ischemia.
Acta Neurochir [Suppl] Wien 27—31 CAS Google Scholar Halliwell B, Gutteridge JMC Oxygen radicals and the nervous system.
and Pennock, J. The biochemistry of vitamin E in plants. Kagan, V. Tocopherol stabilizes membrane against phospholipase A, free fatty acids, and lysophospholipids.
In: Vitamin E: Biochemistry and Health Implications. Langebartels, C. Biochemical Plant Responses to Ozone. Lewis, N. Lignin: Occurrence, biogenesis, and degradation. Mascio, P. Carotenoids, tocopherols, and thiols as bioloical singlet molecular oxgen quenchers. McCay, P. Evidence that alpha. Machlin, L.
Melhorn, H. Induction of ascorbate peroxidase and glutathione reductase activities by interactions of mixtures of air pollutants. Free Rad. Niki, E. Oxidation of lipids. Synergistic inhibition of oxidation of phosphatidylcholine liposome in dispersion by vitamin E and vitamin C.
Inhibition of oxidation of methyl linoleate in solution between vitamin E and vitamin C. Regeneration of vitamin E from alphachromanoxyl radical by glutathione and vitamin C. Packer, J. Direct observation of a free radical interaction between vitamin E and vitamin C.
Nature , , — Polle, A. Composition and properties of hydrogen peroxide decomposing systems in extracellular and total extracts from needles of Norway spruce Picea abies L. Price, A. Free Radical Res. Stress and the role of activated oxygen scavengers and protective enzymes in plants subjected to drought.
Siedow, J. Plant lipoxygenase: structure and function. Skinner, W. Antioxidant properties of alphatocopherol derivatives and relationship of antioxidant ativity to biological activity. Lipids , 5 , — Swauger, J.
Role of benzooxyl radical in DNA damage mediated by benzoyl peroxide. Treshow, M. Plant Stress From Air Pollution. Wiley and Sons, New York, pp. Van Hasselt, P.
Effect of alpha-tocopherol, carotene, monogalactosyldiglyceride and phosphatidylcholine on light-induced degradation of chlorophyll in acetone.
Wang, Z. Reactive intermediates generated by aerobic and anaerobic reactions of glutathione with sodium selenite.
Wardman, P. Conjugation and oxidation of glutathione via thiyl free radicals. in: Glutathione Conjugation: Mechanisms and Biological Significance , eds.
Sies, H. and Ketterer, B. Academic Press, New York, pp. Wise, R. and Naylor, A. Evidence for the role of singlet oxygen and Superoxide in the breakdown of pigments and endogenous antioxidants. Download references.
You can also search for this author in PubMed Google Scholar. Division of Biological Sciences, Institute of Environmental and Biological Sciences, University of Lancaster, Lancaster, UK.
Reprints and permissions. Hess, J. Free radical scavenging. In: Alscher, R. eds Plant Responses to the Gaseous Environment. Springer, Dordrecht. Publisher Name : Springer, Dordrecht. Print ISBN : Online ISBN : eBook Packages : Springer Book Archive.
We use cookies and Free radical scavengers rdaical technologies to improve your browsing experience Fdee our website, to show you personalized Free radical scavengers and targeted ads, to analyze our website traffic, and to understand where our visitors are coming from. See the Privacy Policy for more information. Home Tools. Browse history. Products Inhibitors Libraries Recombinant Proteins Kits Services Contact Us. The Shopping Cart is Empty!Free radical scavengers -
b Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing , China.
c National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou , China. Polydopamine PDA is the most typical kind of synthetic melanin, which possesses interesting properties such as antioxidation, photoprotection, metal chelation, and energy dissipation.
Over the past few years, PDA has been successfully synthesized via polymerization methods and has demonstrated excellent free radical scavenging ability.
The related applications have been rapidly expanded to include sunscreens, anti-inflammatory treatment, and composite material fabrication. Despite great progress, the comprehensive mechanisms of its free radical scavenging behaviors are not fully understood.
This article strives to summarize the possible mechanisms, established antioxidant regulation methods and the related biomedical applications of PDA free radical scavengers.
We believe this paper can provide insight into the current PDA scavenging systems and offer inspiration towards the design of new melanin-inspired scavengers with a broad range of biomedical applications.
Hu, L. Yang, P. Yang, S. Jiang, X. Liu and Y. Li, Biomater. To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. Read more about how to correctly acknowledge RSC content.
Fetching data from CrossRef. This may take some time to load. Loading related content. Jump to main content. Jump to site search. You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.
Issue 18, From the journal: Biomaterials Science. Free radicals have the potential to serve as either effective oxidants or reductants. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution. Unable to display preview. Download preview PDF. Alscher, R. Biosynthesis and antioxidant function of glutathione in plants. Plant , 77 , — Article CAS Google Scholar.
Anderson, J. Chevone, B. Seasonal variation in the antioxidant system of eastern white pine needles. Plant Physiol. Purification characterization, and immunological properties for two isoforms of glutathione reductase from eastern white pine needles.
Asada, K. Production and scavenging of active oxygen in photosynthesis. In Photoinhibition , eds. Kyle, C. Elsevier Science, Amsterdam, pp. Google Scholar. Baszynski, T.
Effect of alphatocopherol on reconstitution of PSI in heptane extracted spinach chloroplasts. Acta , , 31— Bowler, C. Superoxide dismutase and stress tolerance. Plant Mol. Burton, G. Vitamin E as an antioxidant in vitro and in vivo.
In: Biology of vitamin E. Ciba Foundation Symposium , chairperson, Diplock, A. London, England. Vitamin E as an in vitro and in vivo antioxidant. in: Vitamin E: Biochemistry and Health Implications , eds.
Diplock, A. Ann N. CAS Google Scholar. Cadenas, E. Biochemistry of oxygen toxicity. Article Google Scholar. Castillo, F. Extracellular ascorbic acid and enzyme activities related to ascorbic acid metabolism in Sedum album L.
leaves after ozone exposure. Doba, T. Antioxidant and coantioxidant effect of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a watersoluble vitamin E analog, upon the peroxidation of aqueous multilamellar phospholipid liposomes.
Acta , , — Erin, A. Formation of alpha-tocopherol complexes with fatty acids. Nature of complexes. Gomez-Fernandes, J. Localization of alphatocopherol in membranes. Goin, J. Glutathionyl-and hydroxyl radical formation coupled to the redox transitions of 1,4-naphthoquinone bioreductive alkylating agents during two-electron reductive addition.
Gorbunov, N. Role of the isoprenoid chain of lateral mobility of alphatocopherol in the lipid bilayer. Grill, D. Halliwell, B. Oxidative damage, lipid peroxidation and antioxidant protection in chloroplasts. Lipids , 44 , — Free Radicals in Biology and Medicine , 2nd ed. Clarendon Press, Oxford. Hossain, M.
Monodehydroascorbate reductase from cucumber is a flavin adenine dinucleotide enzyme. Monodehydroascorbate reductase in spinach chloroplasts and its participation in regeneration of ascorbate for scavenging hydrogen peroxide. Plant and Cell Physiol. Jahnke, L. Chilling stress and oxygen metabolizing enzymes in Zea mays and Zea diploperennis.
Plant Cell and Environ. Janiszowska, W. and Pennock, J. The biochemistry of vitamin E in plants. Kagan, V. Tocopherol stabilizes membrane against phospholipase A, free fatty acids, and lysophospholipids. In: Vitamin E: Biochemistry and Health Implications. Langebartels, C.
Biochemical Plant Responses to Ozone. Lewis, N. Lignin: Occurrence, biogenesis, and degradation. Mascio, P. Carotenoids, tocopherols, and thiols as bioloical singlet molecular oxgen quenchers. McCay, P.
Evidence that alpha. Machlin, L. Melhorn, H. Induction of ascorbate peroxidase and glutathione reductase activities by interactions of mixtures of air pollutants. Free Rad. Niki, E. Oxidation of lipids. Synergistic inhibition of oxidation of phosphatidylcholine liposome in dispersion by vitamin E and vitamin C.
Inhibition of oxidation of methyl linoleate in solution between vitamin E and vitamin C. Regeneration of vitamin E from alphachromanoxyl radical by glutathione and vitamin C. Packer, J. Direct observation of a free radical interaction between vitamin E and vitamin C.
Nature , , — Polle, A. Composition and properties of hydrogen peroxide decomposing systems in extracellular and total extracts from needles of Norway spruce Picea abies L. Price, A. Free Radical Res.
Simply Healthy eating for older sports performers, a free radical is any molecule with ravical single, unpaired electron. Sfavengers radicals are naturally produced in radjcal body through Frfe normal functioning of body systems or through exposure to external sources such as pollutants, chemicals, and other environmental agents. They are a part of everyday life no matter where you live. So why are free radicals bad? Molecules with an unpaired electron are highly unstable and reactive. Free radical scavengers radical Frre is Free radical scavengers by an Boost Vitality Levels chain scaevngers of sequential oxidations and reductions Free radical scavengers can rapidly rwdical the concentration of reactive radicals. This potentially unstable electronic configuration can react either to acquire or to lose an electron and form a more stable product. Free radicals have the potential to serve as either effective oxidants or reductants. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Ich meine, dass Sie den Fehler zulassen. Schreiben Sie mir in PM, wir werden reden.