gov cancrr it's official. Federal government websites Herbal remedies for cancer prevention end in. Herbal remedies for cancer prevention or. Remedie sharing sensitive information, make sure you're preventkon a federal government site.
The site is Herbsl. NCBI Bookshelf. A service of the National Library of Medicine, National Prevenfion of Health. Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. Foe M. Kaefer and John A. Historically, spices have shaped many events throughout fro Herbal remedies for cancer prevention.
Many voyagers, cqncer the legendary Christopher Remrdies, explored Herbal remedies for cancer prevention seas in search of treasured spices. These valued commodities contribute not only flavors but rekedies serve as colorants and preservatives in a wide variety of cultures.
Today, ccancer are increasingly revered not only for their culinary remedirs but also for their potential health benefits. Although the fot attributes Probiotics for oral health with spice use may arise from their antioxidant remediea, their biological effects may arise canfer their ability to induce changes in a number of cellular Herbsl, including those involved Expert weight loss guidance drug cncer, cell division, apoptosis, differentiation, and Herbal remedies for cancer prevention.
The complexity of understanding the biological response to spices first eemedies in the criteria Sports nutrition for soccer players to distinguish what constitutes a culinary remrdies and how they differ fot culinary herbs.
These terms are often used prevfntion in canceer scientific and lay literature. The U. While this is a viable definition, it does not consider the biological consequences of consuming these items and how ccancer differ from herbs. We must remember that the quantity of an item consumed does not dictate its importance.
Thus, to avoid the health significance in any definition would appear flawed. There is remediws doubt that nutrition and health are intimately linked Kennedy For generations, people prevdntion alleged preventiln foods provide greater benefits than simply supplying energy.
Beliefs Pre-game nutrition strategies the medicinal properties of foods have surfaced Ribose sugar and cellular respiration many camcer writings rrmedies man.
Today, claims about the ability of foods, including ffor, to lower disease risk or to ccancer the prevenrion of life continue to captivate our lives Kaefer and Milner ; Herbal remedies for cancer prevention ; Krishnaswamy ; Natural appetite control supplements et Antiviral virus treatment. Three Omega- for memory enhancement of biomarkers— exposure, canxer, and susceptibility—are needed to evaluate the effects of Hwrbal in cancer prevention and therapy Figure Additional information about the amounts of specific spices Gut health and antioxidants to bring about preventionn response effect and Heral interactions of spices with other constituents of the diet, microbes in the gastrointestinal tract, environmental exposures, and human genetics susceptibility factors will be needed to rremedies the rpevention benefits of adding spices to the diet.
See color insert. Three types of remediess exposure, effect, fpr susceptibility are needed to assess the benefits or risk of prdvention. Spices may be a key to determining the balance between pro- and Herbal remedies for cancer prevention Herba that regulate risk and tumor behavior Figure Natural energy sources use dietary approaches to reduce their risk of diseases, Herhal cancer Sloan pfevention Americans between remrdies ages of 36 and 55 are increasingly interested in adopting healthy eating behaviors and are gravitating canncer ethnic cuisines based on perceived health benefits Uhl Many cancrr these ethnic foods are loaded with unique and flavorful spices; however, while dietary guidelines in several countries tend to support the incorporation of spices into diets, quantifiable recommendations for peevention amounts have Herbal remedies for cancer prevention yet been forthcoming Prrvention et al.
Multiple factors may influence remediez need for spices for reducing the risk of cancer or changing Herbal remedies for cancer prevention biological behavior of prevetnion cells. Between andthe overall per capita consumption of spices in preventio United States doubled, increasing from about 1.
As expected, prevengion Herbal remedies for cancer prevention of some spices Herbal remedies for cancer prevention far more than others; for example, garlic consumption caner more than sixfold. Among these are Glucagon effects growing Reemedies and Asian populations within the United States, an increasing trend toward the use of culinary herbs and spices to compensate for less salt and lower fat foods and a general increase in the popularity of ethnic foods.
The ability of spices to serve as inhibitors of carcinogen bioactivation, decrease free radical formation, suppress cell division and promote apoptosis in cancerous cells, suppress microbial growth, and regulate inflammation and immunocompetence will be discussed as plausible mechanisms by which selected spices may promote health and disease resistance.
The low toxicity and wide acceptance of spices may make them particularly useful as a subtle personal dietary change that may decrease risk for several diseases. Because several spices are effective antioxidants, they may be particularly important in decreasing oxidative damage due to environmental stress, including excess calorie intake.
Multiple cancer-related processes may account for the ability of spices to inhibit experimentally induced cancers. While these processes are likely critical for determining the risk of cancer and tumor behavior in humans, only limited clinical evidence more More than spice-derived compounds have been identified and explored for their health benefits Aggarwal et al.
It is beyond the scope of this chapter to deal with all herbs and spices that may influence the risk of cancer and tumor behavior. Therefore, a decision was made to review those with some of the more impressive biological responses reported in the literature, and a conscious effort was made to provide information about the amount of spices needed to bring about a response and thus their physiological relevance.
When possible, recent reviews are included to provide readers with additional insights into the biological response s to specific spices and to prevent duplication of the scientific literature. Because there is a separate chapter devoted to curcumin a bioactive component in turmeric in this book and there are also several excellent reviews published about curcumin Patel and Majumdar ; Aggarwal ; Bar-Sela, Epelbaum, and Schaffer ; Epstein, Sanderson, and Macdonaldturmeric is not discussed in this chapter.
This tree is native to the Greater Antilles, southern Mexico, and Central America. Today, P. dioica is cultivated in many warm areas throughout the world. Allspice is also available commercially as an essential oil.
Allspice is claimed to possess antimicrobial, antioxidant, anti-inflammatory, analgesic, antipyretic, anticancer, and antitumorigenic properties Rompelberg et al. It contains a multitude of potential bioactive agents that may contribute to health promotion, including flavonoids, phenolic acids, catechins, and several phenylpropanoids Al-Rehaily et al.
The antioxidant and antimicrobial activities of allspice may be associated with eugenol Rompelberg et al. Billing and Sherman reported that allspice was as effective as garlic and onions in suppressing microbial growth. The significance of its antimicrobial properties was recently highlighted by evidence that allspice and eugenol were effective in lowering the virulence of Escherichia coli OH7 Takemasa et al.
Nevertheless, there are concerns that allspice oil can be toxic and promote inflammation, nausea, and vomiting when consumed in excess. The anticancer properties of allspice may be in part due to its ability to influence cytochrome P CYP activity and thereby influence carcinogen bioactivation.
Kluth et al. Thus, the activation of transcription factors to bind to response elements seems like a plausible mechanism by which allspice, and potentially eugenol, function. There is specificity in the response to allspice and eugenol because gastrointestinal glutathione peroxidase GPxa phase II enzyme linked to removal of reactive oxygen species ROSwas not influenced by allspice or eugenol Kluth et al.
Inflammation is linked to increased risk of cancer Dinarello and appears to be influenced by allspice consumption. Although controlled clinical interventions are not available, evidence in rodents suggests potency Al-Rehaily et al. It also suppressed acetic acid-induced writhing and tail flick reaction time and decreased yeast-induced hyperpyrexia in mice.
It remains unclear what molecular target alteration s account for this response. Evidence exists that allspice can alter the proliferation of several cultured cancerous cells. The mechanism by which allspice leads to cellular growth depression remains largely unresolved. However, recent studies by Lee et al.
A depression in histone acetyltransferase HAT activity may be involved. Allspice also suppressed androgen receptor AR acetylation in LNCaP cells and significantly decreased histone H3 and H4 acetylation, indicating that a repression of AR-mediated transcription was induced due to shifts in histone and nonhistone acetylation.
Basil Ocimum basilicum is a culinary herb prominently featured in Italian and Southeast Asian cuisines. While many varieties of basil exist, sweet basil is one of the most predominant and most frequently examined herbs for its health benefits.
Basil is originally native to Iran, India, and other tropical regions of Asia, but now it is widely available throughout the world. Similar to most culinary spices, far more information is needed about the variation in content of constituents as a function of plant varietal, growing conditions, and processing.
The essential oil of basil possesses antimicrobial properties Wannissorn et al. While not as potent as amoxicillin, its effectiveness raises possibilities of using individual or multiple spices as potent antimicrobials, especially in areas where commercial antibiotics are in limited supply Moghaddam, Karamoddin, and Ramezani The effects of basil are not limited to its antimicrobial properties because evidence indicates that it also can lower oxidative damage in animal models Dasgupta, Rao, and Yadava The change in activity in one or more of these enzymes may explain the decrease in lipid peroxidation caused by basil in studies by Dasgupta, Rao, and Yadava Drăgan et al.
While there was a decrease in oxidative stress, the complexity of the dietary intervention made it impossible to determine the component s that led to improvements. Several studies provide evidence that basil is an antimutagenic spice Kusamran, Tepsuwan, and Kupradinun ; Stajkovic et al.
Stajkovic et al. The essential oil of basil, at concentrations ranging from 0. Mutations caused by 4-nitroquinoline-N-oxide 0. These findings are consistent with studies by Jeurissen et al.
These findings likely explain the ability of basil to decrease the mutagenicity of aflatoxin B 1 AFB 1 and benzo a pyrene B a P Stajkovic et al.
The anticancer properties of basil in preclinical studies are mixed. In studies with Sprague-Dawley rats fed with an AIN diet with or without high concentrations of basil 6. Nevertheless, there is evidence that basil can decrease DMBA-induced carcinogenesis.
Compared to the average number of tumors per mouse in the controls, the tumor burden was approximately 2. It is unclear whether differences in the response between mice and rats reflect the species, the cancer site, or the dietary or procarcinogen exposures. DNA methyltransferase MGMT is a critical repair protein in the cellular defense against alkylation damage.
MGMT is highly expressed in human cancers and in tumors resistant to many anticancer alkylating agents. Niture, Rao, and Srivenugopal examined the ability of several medicinal plants to upregulate O 6 -methylguanine adducts.
Both ethanol and aqueous extracts of basil increased MGMT protein levels in HT29 human colon carcinoma cell lines 1. Compared to the control, basil increased glutathione-S-transferase GST protein activity 1.
The anticancer properties of basil may also relate to its ability to influence viral infections. Individuals with hepatitis B are recognized to be at increased risk for hepatocellular carcinoma Fung, Lai, and Yuen ; Ishikawa
: Herbal remedies for cancer prevention| Herbal Medicine for Mesothelioma & Other Cancers | This is an area that needs to be taken seriously. Cancer is a result of interactions between our genetics, epigenetics and our environment. There is a lot of nutritional advice I could give about this subject but I am focusing on the herbal aspects. Many plants that contain phytochemicals that have specific effects against cancer and are useful alongside conventional treatment, provided all potential interactions have been checked. Apply for a 15m Consultation. Request A Call. Facebook X 54 Pinterest To find out more or signup as a patient click below. Effects of Ginger Supplementation on Cell-Cycle Biomarkers in the Normal-Appearing Colonic Mucosa of Patients at Increased Risk for Colorectal Cancer: Results from a Pilot, Randomized, and Controlled Trial. Phila 6 4 , — Cousins, M. Antioxidant Capacity of Fresh and Dried Rhizomes from Four Clones of Turmeric Curcuma Longa L. Grown In Vitro. 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Citation: Hossain MS, Kader MA, Goh KW, Islam M, Khan MS, Harun-Ar Rashid M, Ooi DJ, Melo Coutinho HD, Al-Worafi YM, Moshawih S, Lim YC, Kibria KMK and Ming LC Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review. doi: Received: 30 January ; Accepted: 02 May ; Published: 30 June Copyright © Hossain, Kader, Goh, Islam, Khan, Harun-Ar Rashid, Ooi, Melo Coutinho, Al-Worafi, Moshawih, Lim, Kibria and Ming. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Sanower Hossain, mshossainbge gmail. com ; Long Chiau Ming, long. ming ubd. 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This article is part of the Research Topic MSPP 34th Scientific Meeting: Pharmacological Perspectives on Natural Products in Drug Discovery View all 10 articles. Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review. Abdul Kader 3 Khang Wen Goh 4 Maidul Islam 5 Md. Sharif Khan 3 Md. Harun-Ar Rashid 6 Der Jiun Ooi 7 Henrique Douglas Melo Coutinho 8 Yaser Mohammed Al-Worafi 9,10 Said Moshawih 11 Ya Chee Lim 11 K. FIGURE 5. Health benefits and anticancer properties of ginger. |
| Herbs That Kill Cancer: Exploring Nature's Powerful Healers | There are several confirmations from epidemiological and laboratory studies that sufficient intake of fruit, vegetables, and herbal supplements is inversely linked with breast cancer occurrence. A diet composed of adequate quantity of phytoestrogens, polyphenols, and rich sources of other chemopreventive agents helps in reducing breast cancer risk. Dietary supplements of the herbal source are less toxic and easily metabolized. Besides, dietary consumption of these herbal remedies helps in fighting side effects in postchemotherapy patients. One of the primary symptoms of adjuvant chemotherapeutic damage in posttherapy breast cancer patients is hot flushes. Black cohosh or Actaea racemosa plant is popularly used by patients of breast cancer to treat hot flushes, which gives conflicting but promising results [ 76 ]. As discussed in the earlier section, herbal compounds show a verity of anticancer actions—including antioxidant, cytotoxic, antiproliferative, apoptotic activity, etc. Plant-based cancer agents broadly classified into five groups that include—methyltranferase inhibitors, DNA protecting agents, antioxidants, histone deacetylases inhibitors, and mitosis disruptors. Generally, plant-derived compounds contribute toward the anticarcinogenesis mechanism by their antioxidant, cytotoxic, antimitotic, and apoptotic activity Table 4. Others help in chemoprevention by preventing DNA damage, modulating carcinogenesis signaling, and inducing apoptotic cell death Table 4. Several in vitro and in vivo investigations support the activity of herbal compounds that linked with their anticancer activity. Some novel compounds from herbal sources that showed promising anticancerous activity in both in vivo and in vitro studies. Antioxidant activity of herbal compounds of oxidative stress is developed when the balance between the production of reactive oxygen species free radicals and antioxidant defense is disturbed [ 77 ]. Oxidative stress development and consequent reactive oxygen species ROS generation are linked with several disease pathogenesis including cancer. For instance, curcumin enhances the activity of antioxidant enzymes resulting in enhanced cellular resistance to oxidative damage [ 78 ]. In addition, curcumin was also found to rise hepatic GSH, SOD, GPx, GR, GST, and CAT activities in paracetamol-treated rats [ 79 ]. Other plant-based compounds like epigallocatechin gallate, a component of in green tea, found to reduce the levels of lipid peroxidation and protein carbonyl content in rats, possibly by enhancing the GSH redox status significantly when administered orally [ 80 ]. Likewise, several herbal compounds help to reduce oxidative stress, hence play a preventive role against cancer onset. Quite a few herbal compounds help to inhibit angiogenesis in breast cancer. Genistein, a flavonoid phytoestrogen, is the most potent angiogenesis inhibitor linked with reduced expression of VEGF, PDGF, uPA, and MMP-2 and MMP-9 [ 81 ]. Curcumin was even found to be an effective inhibitor of angiogenesis that reduces the expression of various proangiogenic proteins such as vascular endothelial growth factor VEGF and basic fibroblast growth factor [ 82 ]. Resveratrol and quercetin inhibited the migration and tube formation in bovine aorta endothelial cells consequently inhibiting angiogenesis in those cells [ 83 , 84 ]. In addition, catechin derivatives, such as epicatechin EC , epigallocatechin EGC , epicatechingallate ECG , and epigallocatechingallate EGCG , present in green tea are potent angiogenesis inhibitors [ 85 ]. The anti-angiogenic activity of EGCG was demonstrated by inhibition of vascular endothelial growth factor VEGF production and reduction of matrix metalloproteinase-2 MMP-2 activity in MDA-MB breast cancer cells [ 85 ]. The apoptosis-inducing activity of herbal compounds is another favorable feature that contributes toward their anticancer effect. Curcumin was found to inhibit the proliferation and inducing apoptosis in several cancer cell lines including breast cancer cells such as T47D, MCF7, MDA-MB, and MDA-MB [ ]. Protocatechuic acid was also found to be a potent apoptosis inducer in five types of human cancer cell lines including breast, lung, liver, cervix, and prostate cancer cells [ ], which was confirmed by DNA fragmentation, changes in mitochondrial membrane potential, and measurement of caspase activity. The flavonoid 8-prenylnaringenin 8PN , a constituent of Humulus lupulus , is an effective phytocompound known for its growth-inhibiting and apoptotic activity in various human cancer types including breast cancer [ ]. This activity of 8PN in MCF7 breast cancer cells was possibly mediated by interference with an ER-associated PI3K pathway [ ]. Other herbal compounds like lycopene inhibit cell cycle progression by reducing cyclin D expression and retention of p27 in cyclin E—cdk2, thus leading to inhibition of G1 CDK activities in human breast cell line MCF-7 and TD along with endometrial ECC-1 cancer cells [ ]. Interestingly, artemisinin, which is an ancient Chinese herbal compound for malarial fevers, has been recently found to have potent and selective toxicity against cancer cells. It reacts with iron to form free radicals with alkylating capacity that can kill cells. As cancer cells require a large quantity of iron uptake to proliferate, making them more susceptible to the cytotoxic effect of artemisinin [ ]. Besides, oral administration of artemisinin delayed the onset of breast cancer in 7, dimethylbenz [a] anthracene DMBA -induced rats [ ]. This encouraging results might lead to design novel chemotherapeutics with effective anticancer property and low toxicity. Though, advances in healthcare research lead to the identification and characterization of most breast cancer types and corresponding cure. However, incidence and prevalence of breast cancer is rising in terrifying rate in both developed and developing countries because of various risk factors. Improved synthetic drugs and hormonal therapy emerged in a decline in breast cancer incidences, increased survival, and better life quality. However, prolonged use of synthetic anticancer drugs is linked with several health risks or side effects that consequence from the toxic effect of these drugs in normal cells. Chemoprevention by herbal compounds is of great interest and is considered to be an inexpensive, readily applicable, acceptable, and accessible approach to cancer control and management. Herbal remedies play a significant role in the management of breast cancer and the associated therapeutic toxicity. The adjunct use of herbal products and chemotherapy can be an efficient and cost-effective way to treat breast cancer. Such adjuvant therapy proved to produce a synergistic anticancer effect that reduced the drug toxicity, suppresses drug resistance, and provides quick drug action enhancing the quality of treatment. Besides, combinatory therapy might also increase the therapeutic index of the synthetic partner by improving the efficiency of the drug. Plant-derived anticancer drugs such as vinblastine, vincristine, taxols, etc. showed encouraging chemotherapeutic potential that is currently used in breast cancer treatment and a large number of them are in preclinical or in clinical trials. In the last decade, a vast number of phytochemicals were identified that showed encouraging anticancer activity in vivo and in vitro breast cancer models. Interestingly, several compounds like artemisinin and isothiocyanates showed selective toxicity toward cancer cells, which recommend clinical trials of these compounds. Furthermore, phytoestrogens with affinity and capacity to produce functional responses through estrogen receptors revealed unique possibilities of using them in hormone replacement therapy. Overall, this chapter can conclude that understanding the molecular mechanism of interaction between herbal compounds and cancer cells in the tumoral environment can help us to design novel anticancer drugs that are less toxic and affordable. This reflects the fact that these goals will only be attainable if the herbal compounds that showed promising anticancer activity can be successfully transferred to an ideal clinical setting for the use of herbal therapies. Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3. Edited by Bassam Hassan. Open access peer-reviewed chapter Herbal Remedies for Breast Cancer Prevention and Treatment Written By Yahyea Baktiar Laskar, Romen Meitei Lourembam and Pranab Behari Mazumder. DOWNLOAD FOR FREE Share Cite Cite this chapter There are two ways to cite this chapter:. Choose citation style Select style Vancouver APA Harvard IEEE MLA Chicago Copy to clipboard Get citation. Choose citation style Select format Bibtex RIS Download citation. IntechOpen Medicinal Plants Use in Prevention and Treatment of Diseases Edited by Bassam Hassan. From the Edited Volume Medicinal Plants - Use in Prevention and Treatment of Diseases Edited by Bassam Abdul Rasool Hassan Book Details Order Print. Chapter metrics overview 2, Chapter Downloads View Full Metrics. Impact of this chapter. Abstract Breast cancer is among the most common type of cancer in women around the globe. Keywords herbal remedies phytochemicals phytoestrogens breast cancer. Introduction According to World Health Organization WHO , cancer is the second leading cause of death after cardiovascular diseases and a growing health issue globally. Table 1. Table 2. Table 3. Table 4. References 1. Lukong KE. Understanding breast cancer — The long and winding road. BBA Clinical. Hennessy BT, Gonzalez-Angulo AM, Carey MS, Mills GB. A systems approach to analysis of molecular complexity in breast cancer. Clinical Cancer Research. Caffarel MM, Pensa S, Wickenden JA, Watson CJ. Molecular biology of breast cancer. In: eLS. Shareef M, Ashraf MA, Sarfraz M. 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Royt M, Mukherjee S, Sarkar R, Biswas J. Curcumin sensitizes chemotherapeutic drugs via modulation of PKC, telomerase, NF-kappaB and HDAC in breast cancer. Your oncologist has your best interest at heart and only wants to protect you from potentially harmful interactions. In many cases, your doctor will give their approval to take herbal remedies after you complete treatment. You can also inquire about joining a clinical trial that is investigating an herb in combination with cancer treatment. These trials are not common, but they do closely monitor patients for harmful interactions. They take the precautions necessary to prevent unwanted side effects such as testing herbs for contaminants before administration. Many natural substances, such as arsenic and tobacco, are poisonous and carcinogenic. The effects of herbs can range from mild to potent depending on the person taking them and the medications they are using. 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| The Power of Nature: Exploring Anti-Cancer Herbs | Studies have shown that garlic can reduce tumor growth and may help protect healthy cells from the damage caused by chemotherapy drugs. Echinacea has been used as an herbal remedy to fight infection for centuries. Recent studies have shown that it may also boost the immune system. Gingko contains compounds called ginkgolides, which have been found to possess anti-inflammatory, antioxidant, and anticancer properties. Ginseng is an herb that has long been used as a natural remedy to boost energy. Studies suggest it may reduce inflammation and tumor growth and protect healthy cells from damage. In addition to herbs, many other natural supplements may be effective in treating cancer, including:. Omega-3 fatty acids play a vital role in reducing inflammation and may help support cardiovascular health. Antioxidants may help reduce inflammation and protect healthy cells from free radical damage. Selenium is a mineral linked to several health benefits, including reducing the free radicals within the body that can damage cells. An essential mineral that helps to support the immune system, zinc may also have anticancer properties. Some research suggests that some forms of cancer are linked to those with low levels of vitamin D, while other evidence suggests vitamin D may reduce the occurrence of advanced cancer. Talk to your doctor before starting any natural remedies or supplements. Your provider can advise which treatments are best suited for you and what side effects they may have. Be sure to discuss the potential benefits and risks of complementary therapies, as well as any interactions with other medications you may be taking. If you have trouble communicating with your healthcare team, consider seeking a cancer navigator who can provide support and answer any of your questions. However, remember that even natural treatments can have adverse effects and may not be suitable for everyone. Some will put you at high risk for serious side effects and complications. Kelly Johnson-Arbor, MD , medical toxicologist, co-medical director, and interim executive director at National Capital Poison Center says the FDA has an online and app-based tool to help patients understand whether a medication is approved:. Johnson-Arbor explained. She also emphasized that natural remedies for cancer should be approached with caution. Johnson-Arbor added. Your healthcare team should also be your go-to source for information on FDA-approved cancer treatments and any potential side effects. A healthy mind is as essential as a healthy body during cancer treatment. Feeling anxious or overwhelmed is normal, but focusing on what brings you joy and hope can help. Take time for yourself — find activities that bring you peace, such as those in the following list. Acupuncture is an ancient Chinese practice involving thin needles insertion into specific body areas. Studies suggest that acupuncture may reduce pain and anxiety. Massage is another natural therapy that may be beneficial in managing cancer-related pain and side effects associated with treatment. Massage can help reduce stress and anxiety, increase energy levels, improve circulation, and even reduce nausea associated with chemotherapy treatments. Some cancer clinics now offer massage therapy as a complementary medicine. Talk to your doctor about this option if you want to try massage therapy during treatment. Using essential oils may promote relaxation and reduce stress; may also help with other symptoms associated with cancer, such as nausea and fatigue. Researchers have found meditation can reduce stress and anxiety and improve quality of life. Yoga may help reduce stress, improve quality of life, and aid in relaxation; it may also help with pain management and fatigue associated with cancer treatments. Hypnotherapy uses guided meditation to help you relax and gain more control over your thoughts, feelings, and behaviors; it may be effective for pain and emotional stress. Music can be used to reduce stress and anxiety, as well as provide a sense of comfort and relaxation. Poonthananiwatkul B, Lim RH, Howard RL, Pibanpaknitee P, Williamson EM. Traditional medicine use by cancer patients in Thailand. J Ethnopharmacol. Article Google Scholar. Clement YN, Baksh-Comeau YS, Seaforth CE. An ethnobotanical survey of medicinal plants in Trinidad. J Ethnobiol Ethnomed. Article CAS PubMed PubMed Central Google Scholar. Chang FR, Wu YC. Novel cytotoxic annonaceous acetogenins from Annona muricata. J Nat Prod. Article CAS PubMed Google Scholar. Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ, et al. New cytotoxic monotetrahydrofuran annonaceceous acetogenins from Annona muricata. Sun S, Liu J, Kadouh H, Sun X, Zhou K. Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit Annona muricata. Bioorg Med Chem Lett. George VC, Kumar DR, Rajkumar V, Suresh PK, Kumar RA. Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines. Asian Pac J Cancer Prev. Yang C, Gundala SR, Mukkavilli R, Vangala S, Reid MD, Aneja R. Synergistic interactions among flavonoids and acetogenins in Graviola Annona muricata leaves confer protection against prostate cancer. Zorofchian Moghadamtousi S, Karimian H, Rouhollahi E, Paydar M, Fadaeinasab M, et al. Annona muricata leaves induce G 1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT and HT colon cancer cells. Kapadia GJ, Azuine MA, Rao GS, Aria T, Iida A, Tokuda H. Cytotoxic effect of the red beetroot Beta vulgaris L. extract compared to doxorubicin Adriamycin in the human prostate PC-3 and breast MCF-7 cancer cell lines. Anticancer Agents Med Chem. Kapadia GJ, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. Synergistic cytotoxicity of red beetroot Beta vulgaris L. extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med. doi: Longnecker MP, Newcomb PA, Mittendorf R, Greenberg ER, Willett WC. Intake of carrots, spinach, and supplements containing vitamin A in relation to risk of breast cancer. Cancer Epidemiol Biomarkers Prev. CAS PubMed Google Scholar. Xu X, Cheng Y, Li S, Zhu Y, Xu X, Zheng X, et al. Dietary carrot consumption and the risk of prostate cancer. Eur J Nutr. Butalla B, Wertheim BC, Thompson P, Thomson CA. Effects of a carrot juice intervention on plasma carotenoids, oxidative stress, and inflammation in overweight breast cancer survivors. Nutr Cancer. Shebaby WN, Bodman-Smith KB, Mansour A, Mroueh M, Taleb RI, El-Sibai M, et al. Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT Cells by Inhibiting the MAPK and PI3K Pathways. J Med Food. Shebaby WN, Mroueh M, Bodman-Smith K, Mansour A, Taleb RI, Daher CF, et al. Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB breast cancer cells. Glei M, Hofmann T, Küster K, Hollmann J, Lindhauer MG, Pool-Zobel BL. Both wheat Triticum aestivum bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide. J Agric Food Chem. Borowicki A, Stein K, Scharlau D, Glei M. Fermentation supernatants of wheat Triticum aestivum L. aleurone beneficially modulate cancer progression in human colon cells. Hussain A, Gheewala TM, Vas AJ, Shah K, Goala P, Khan S, et al. Growth inhibitory and adjuvant therapeutic potential of aqueous extract of Triticum aestivum on MCF-7 and HeLa cells. Exp Oncol. Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C. Aqueous extract of Carica papaya leaves exhibit anti-tumor activity and immunomodulatory effects. Aung HH, Wang CZ, Ni M, Fishbein A, Mehendale SR, Xie JT, et al. Crocin from Crocus sativus possesses significant anti-proliferative effects on human colorectal cancer cells. CAS PubMed PubMed Central Google Scholar. Chryssanthi DG, Dedes PG, Karamanos NK, Cordopatis P, Lamari FN. Crocetin inhibits invasiveness of MDA-MB breast cancer cells via downregulation of matrix metalloproteinases. Planta Med. Samarghandian S, Shabestari MM. DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. Indian J Urol. Festuccia C, Mancini A, Gravina GL, Scarsella L, Llorens S, Alonso GL, et al. Antitumor effects of saffron-derived carotenoids in prostate cancer cell models. Biomed Res Int. Download references. The authors wish to express their gratitude to the Directors at the National Oncology Centre and the Oncology Clinic at the Sangre Grande Hospital for allowing access their facilities and patients. The nurses-in-charge are also acknowledged for facilitating the interview process, and most importantly the patients who availed themselves for the interviews. This survey was part of a course in the MBBS program at the University of the West Indies, St. Augustine Campus, Trinidad and Tobago, and was not funded. SPSS dataset available as Additional file 2. All authors were involved in the initial design of the study. All authors, except YC, were involved in the patient interview, data entry and preliminary data analysis. VM and YC were primarily involved in final data analysis. YC wrote the draft and final manuscript and all authors read and approved the final version. The study was approved by the Ethics Committee, Faculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago Approval letter available as Additional file 3. Pharmacology Unit, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago. Yuri N. You can also search for this author in PubMed Google Scholar. Correspondence to Yuri N. Open Access This article is distributed under the terms of the Creative Commons Attribution 4. Reprints and permissions. Clement, Y. et al. Herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in Trinidad. BMC Complement Altern Med 16 , Download citation. Received : 10 March Accepted : 05 October Published : 21 October Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Research article Open access Published: 21 October Herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in Trinidad Yuri N. Abstract Background Cancer is a major disease worldwide, and many patients use complementary and alternative treatments. Methods A descriptive, cross-sectional survey was conducted using an interviewer-administered pilot-tested de novo questionnaire during the period June to August at two speciality treatment centres on the island. Conclusions This survey identified the most common herbal remedies and functional foods used among prostate, breast and colorectal cancer patients in Trinidad. Background In Trinidad and Tobago the incidence of cancer and mortality rates are amongst the highest in the developing world [ 1 ]. Methods The survey was descriptive and cross-sectional in design using a de novo pilot-tested questionnaire Additional file 1 and adult patients were conveniently chosen at two specialized cancer treatment centres in Trinidad during the period June to August Table 1 Demographic details for patients with breast, prostate and colorectal cancer Full size table. Table 2 Common herbal remedies and functional foods used by cancer patients Full size table. Discussion To our knowledge this is the first observational study in Trinidad to determine the complementary use of medicinal herbs and functional foods among patients diagnosed with breast, prostate and colorectal cancer. Conclusions This study unearthed the herbal remedies and functional foods used by patients with the most prevalent cancers in Trinidad. References GLOBOCAN Estimated cancer incidence, mortality and prevalence worldwide in Accessed 9 Feb Warner WA, Morrison RL, Lee TY, Williams TM, Ramnarine S, Roach V, et al. 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Article PubMed PubMed Central Google Scholar Festuccia C, Mancini A, Gravina GL, Scarsella L, Llorens S, Alonso GL, et al. Article PubMed PubMed Central Google Scholar Download references. Acknowledgements The authors wish to express their gratitude to the Directors at the National Oncology Centre and the Oncology Clinic at the Sangre Grande Hospital for allowing access their facilities and patients. Funding This survey was part of a course in the MBBS program at the University of the West Indies, St. Availability of data and materials SPSS dataset available as Additional file 2. Competing interests The authors declare that they have no competing interests. Consent for publication All authors consented and agreed for this manuscript to be published in this journal. Ethics approval and consent to participate The study was approved by the Ethics Committee, Faculty of Medical Sciences, The University of the West Indies, Trinidad and Tobago Approval letter available as Additional file 3. Author information Authors and Affiliations Pharmacology Unit, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago Yuri N. Clement View author publications. View author publications. Additional files. |
Herbal remedies for cancer prevention -
In comet assays with human lymphocytes, thymol and carvacrol did not induce DNA strand breakage at concentrations lower than μM, and were therefore considered safe for consumers Undeger et al.
Mounting evidence suggests that cancers are not an inevitable consequence of aging but are preventable diseases. Spices have been consumed for centuries for a variety of purposes, such as flavoring agents, colorants, and preservatives. This chapter only scratches the surface of the overall impact of herbs and spices since there are approximately spices commonly being used for culinary purposes.
Without question, evidence exists that multiple processes, including proliferation, apoptosis, angiogenesis, and immunocompetence, can be influenced by one or more spices.
While the currently available data are intriguing, considerably more information is needed to determine who will benefit most from exaggerated intake of one or more spices, the effective exposures needed to bring about the desired outcome s , and what interactions both positive and negative exist with other components of the diet or with medications that an individual may regularly consume.
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Show details Benzie IFF, Wachtel-Galor S, editors. Search term. Chapter 17 Herbs and Spices in Cancer Prevention and Treatment Christine M. FIGURE BASIL Basil Ocimum basilicum is a culinary herb prominently featured in Italian and Southeast Asian cuisines.
CARDAMOM Cardamom refers to herbs within the Elettaria green and Amomum black genera of the ginger family Zingiberaceae. CINNAMON Cinnamon is a spice obtained from the bark of an evergreen tree belonging to the Lauraceae family.
CLOVE Clove is derived from flower buds of the Eugenia caryophyllata tree. CORIANDER Coriander Coriandrum sativum is an herb in the family Apiaceae and is native to southern Europe and northern Africa to southwestern Asia.
CUMIN Cumin Cuminum cyminum is a flowering plant in the family Apiaceae and is native to the eastern Mediterranean region and India. DILL Dill Anethum graveolens is a relatively short-lived perennial spice. GARLIC Garlic Allium sativum is a member of the onion family Alliaceae.
GINGER Ginger Zingiber officinale is a member of the Zingiberaceae family and is consumed widely not only as a spice but also as a medicinal agent see also Chapter 7 on ginger.
ROSEMARY Rosemary Rosmarinus officinalis is a woody herb with fragrant needle-like leaves. SAFFRON Saffron is a spice derived from the flower of the saffron crocus Crocus sativus plant native to Southwest Asia.
THYME Thyme is another culinary and medicinal herb. Crocus sativus against cancer. Arch Med Res. Aggarwal B. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other neutraceuticals. Annu Rev Nutr. Epub, Apr B, Kunnumakkara A. B, Harikumar K. B, Tharakan S. T, Sung B, Anand P.
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Cancer remains preventionn formidable Herbal remedies for cancer prevention challenge worldwide, with fot of new cases diagnosed each year. Conventional remediew, such prevebtion chemotherapy and radiation, can be harsh and are often associated with debilitating Traditional medicine rituals Herbal remedies for cancer prevention. One option that has gained significant attention is the use of herbs that kill cancer. Herbs have been used for centuries for their medicinal properties, and recent scientific studies have confirmed their efficacy in fighting cancer. Examples of anti-cancer herbs include turmeric, ginger, garlic, green tea, and many more. Cancer is a complex disease that affects millions of people around the world. Despite significant advances in medical research, conventional treatments like chemotherapy and radiation therapy often come with severe side effects and may not offer a complete cure. Open access peer-reviewed chapter. Herball 24 July Rrmedies 11 September Published: 25 March com customercare cbspd. Breast cancer is among the most common type of cancer in women around the globe. Prevention of breast cancer is better than its treatment.
Herbal remedies for cancer prevention -
Organosulfur has immune-strengthening and anti-carcinogenic qualities that may reduce or hinder the development of tumors. Garlic has a strong flavor, meaning a small addition to vegetables or meat can make a delicious difference. Whether fresh or dried, ginger contains great antioxidants and has anti-inflammatory properties.
Ginger has a strong taste and is a versatile herb. Try adding a small amount to fruit smoothies or juices, teas, or rice. A study conducted by scientists at the University of Michigan Comprehensive Cancer and published in the journal Breast Cancer Research and Treatment, found pepper along with turmeric — inhibited the growth of cancerous stem cells of breast tumors.
At the university of California, a study found capsaicin, a powerful antioxidant found in cayenne pepper, stifled the growth of prostate cancer cells. In some instances, capsaicin may even be able to kill cancer cells. Cayenne pepper comes with a kick but, for those who enjoy spice, can be used on popcorn, dry rubs, or even eggs.
Allspice is another spice that boasts anti-inflammatory properties. It has a deep, warm flavor that is often found in soups, chai teas, and even spicy desserts like gingerbread.
Oregano contains carvacrol, a molecule that may help offset the spread of cancer cells by working as a natural disinfectant.
This herb is often found in classic Italian dishes such as pizza and pasta. Though saffron comes with a hefty price tag, it contains water-soluble carotenoids called crocins. Crocins may inhibit tumor growth and progression of cancer. Because of its price, saffron is typically used in small amounts.
The spice is particularly tasty when added to rice and curries. Much like oregano, thyme also contains carvacrol. Thyme is a welcome addition to potatoes, rice dishes, vegetables, soups, and sauces. Some studies have identified properties in lavender that may be helpful against cancer.
A compound within lavender called POH showed some benefit in palliative care patients with recurrent gliomas. Lavender is becoming increasingly popular in desserts, but is also an easy and delicious addition to tea.
The National Foundation for Cancer Research supports innovative research into new and unique ways to fight cancer. One of our supported projects that is progressing quickly into drug development is led by NFCR researcher Yung-Chi Cheng, Ph.
Read more here. Does Green Tea Reduce the Risk of Cancer? Study Links Dietary Fat Consumption to Breast Cancer Survival Rate. Free Cancer Screening Guidelines. National Foundation for Cancer Research NFCR is a c 3 tax-exempt nonprofit organization.
Tax ID : Donor Portal. The rarity of a disease like mesothelioma can sometimes limit research. No current studies have treated mesothelioma patients with herbal medicine.
But evidence shows some herbs may reduce mesothelioma symptoms or treatment side effects. This data came from studying an herb for different cancers, but shows:. Researchers have not studied these herbs in mesothelioma patients. But some studies have looked at the effects of herbs on mesothelioma cells and animals with mesothelioma.
These results may give patients hope for herbal medicine, like curcumin. But this study was only conducted on mice and mesothelioma cells in a lab. Similar laboratory studies have used other herbs with varying results.
Some herbal medicines may be safe for cancer patients, but others may cause harm. Anyone interested in using herbs should first talk to their healthcare team. This is an important step for many reasons. Doctors also know which herbs may interact with certain drugs. If appropriate, they may recommend herbs to address specific symptoms or side effects.
By working with their doctors, patients can ensure they only explore using safe herbs. In addition to talking with their doctors, patients can take some steps on their own. This may help them feel empowered and better educated about herbal medicine.
Examples of patient research can include:. Patients and their doctors can then discuss these findings and any questions patients may have. By working together, patients can feel confident their treatment plan supports their goals.
Some research has studied the effects of herbal medicines on cancer patients. Though there is no evidence herbs can cure cancer, findings show some herbs may help alleviate certain cancer-related issues. These potential benefits of herbal medicine apply to cancer in general and may include mesothelioma.
Notable herbs include black cohosh, curcumin, marijuana , mistletoe extracts and resveratrol. Despite potential benefits, there are still risks to be aware of. For example, marijuana may help with nausea. But it may also interfere with immunotherapy treatment. It is vital for patients to talk with their doctors before taking these or other herbal treatments.
Potential benefits and concerns with herbal medicine vary on a case-by-case basis. Turmeric is a flowering plant with a vibrant, orange-colored root. This plant contains the chemical compound curcumin, which is available as an herbal supplement.
Evidence from cancer studies suggests curcumin may:. A study of curcumin in non-mesothelioma cancers found various benefits. Some patients with solid tumors took curcumin while receiving chemotherapy. They experienced significantly lower rates of chemotherapy-related side effects.
These patients also needed fewer medications to manage chemotherapy side effects. These studies are not mesothelioma-focused but may still interest patients. These study findings are encouraging, but they cannot replace the guidance of an oncologist. For their own safety, patients should talk with a mesothelioma doctor before taking any herbal medicine.
Mistletoe is a plant that grows on several different types of trees. Its extracts can vary because of the specific species of mistletoe and the tree it grows on. As a result, efficacy for treating conditions may be inconsistent. Some experts criticize the methods and parameters of many mistletoe extract studies.
These weaknesses may call their results into question. Reishi is a large, dark mushroom used in several traditional medical systems. This mushroom has been a popular supplement in recent years. It has many claims of health benefits and abilities to treat serious conditions.
But the actual evidence of its effects on cancer indicates reishi:. The positive effects of reishi mushrooms may be due to the presence of beta-glucans. Beta-glucans are natural substances found in items like mushrooms, grains and yeasts.
Some research suggests that mushroom beta-glucans may help fight cancer, enhance memory and reduce infection frequency and severity. Reported side effects of reishi are relatively mild and include nausea and insomnia.
These side effects and risks may seem low. But doctors can decide if taking reishi is safe for mesothelioma patients. Black cohosh is a member of the Buttercup family of plants, native to North America. It is commonly used in Europe. Black cohosh may be used to treat many conditions, including menopausal symptoms and irregular heartbeat.
Mood disorders like irritability, anxiety and depression may also be treated with the herb. Experts say the data for black cohosh is inconclusive. But as a relatively safe herb, it warrants more research.
In general, black cohosh is very well-tolerated and rarely causes serious side effects. Serious side effects likely result from product quality issues, not the herb itself.
But black cohosh may interfere with statins for cholesterol management. This is a good example of why patients should speak with their doctors before taking any herbal products. The dried leaves and flowers of Cannabis plants, also called marijuana, contain cannabinoids.
These are popular for a variety of recreational and medicinal uses. Evidence suggests marijuana may:. Reported side effects of marijuana use include bloodshot eyes, dizziness, increased heart rate and sleepiness.
Some evidence suggests cannabis use may limit the efficacy of immunotherapy. This may be a serious risk for mesothelioma patients receiving this cutting-edge treatment. Doctors can explain if marijuana is a safe addition to their treatment plans. Other herbs have some studies and evidence of their use against cancer.
These have less evidence than others but may still offer some benefit. Other herbs with potential benefits include:. Other studies have found clear evidence of harm when using certain herbs. These concerns may be both general and cancer-specific.
Herbs that may harm cancer patients include:. Regardless of how promising an herb seems, there may be risks. It is best to speak with healthcare teams before beginning any herbal supplementation. Questions About Alternative Mesothelioma Treatments? Ask experienced mesothelioma advocate Jennifer Lucarelli Ask a Question.
Side effects vary by the type of herb. These effects may be more common with some herbs than others. Mesothelioma specialists can explain which herbs may have negative side effects. Common herbal side effects include chills, diarrhea, insomnia, nausea and skin irritation.
Doctors can also determine if any herbs may interact negatively with other treatments. There are other serious risks with some herbs that may impact patients. For example, some herbs may increase the effects of anticoagulant drugs blood thinners. Herbs that sometimes cause this effect include dang gui, curcumin, ginger and reishi.
Cancer patients who take blood thinners may face this risk. Herbs may seem like a natural and safe way to improve health. But herb and drug interactions are complex and varied. Some herbs have both potential benefits and risks to cancer patients. But other herbs may be dangerous or offer little to no proven benefits.
It may be safest for some cancer patients to avoid these herbs altogether. Other herbal medicines have limited research. These herbs include cafestol, kahweol, hesperidin and licorice root.
Until there is more research, their potential risks and side effects remain unknown. As a rare disease, existing mesothelioma research has not involved patients taking herbal medicine. Some mesothelioma patients may be interested in joining clinical trials for herbalism.
Their doctors can explain if any options are available and may be a good fit. Some cancer centers may also have information on their websites about clinical trials.
Researchers in other countries often run reputable clinical trials, too. Interested patients can find a clinical trial database online at ClinicalTrials.
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Why would you want canfer know what are the top 10 cancer-fighting herbs? Cancer statistics are getting scary — it is the second Herbal remedies for cancer prevention preventio cause of death Low-carb snack choices the Western foe and, according to Remefies Cancer Plant-based recipes, an estimated 2. This is an increase of almost half a million in the last five years. On a more positive note, more people are surviving cancer as treatments and diagnostic techniques improve. A lot more can be done, in terms of prevention and nutrition education, both for improving treatment outcomes and to protect against cancer. This is an area that needs to be taken seriously. Cancer is a result of interactions between our genetics, epigenetics and our environment.
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