We have prospectively examined the association between serum CLA and incident coronary heart disease and heart failure HF in older men. Methods and results: Prospective study of men, aged 60 to 79 years, without prevalent HF followed up for an average of 13 years, during which there were incident HF cases.

The reduced risk of HF was partially explained by NT-proBNP. High dairy fat intake was not associated with incident coronary heart disease but was associated with reduced risk of HF, largely because of the inverse effect of CLA.

Keywords: epidemiology; fatty acid; heart failure. A study found that high intakes of both cis-9,trans and trans,cis CLA raised the level of HDL cholesterol in healthy women.

HDL cholesterol promotes low cholesterol levels and healthy heart function [ 4 ]. High levels of glucose result in major heart damage and heart disease. A study in rat cells found that cells pre-treated with CLA and then exposed to high glucose levels had reduced heart damage and a decreased risk of heart disease than cells not pre-treated in the same conditions [ 5 ].

In another study, mice with heart disease who were treated with a combination of nitrate and CLA prior to a heart attack had improved heart function post-heart attack [ 6 ]. Hardening of the arteries is a heart disease that is caused by the buildup of fat in arteries. This eventually leads to hypertension and strokes.

In a cell study, cis-9,trans conjugated linoleic acid prevented fat from building up in the arteries [ 7 ]. A study done in overweight Chinese subjects found that CLA supplementation twice daily dissolved in milk helped with weight loss over a week period [ 8 ].

The supplementation was found to reduce body weight, reduce BMI, reduce total fat mass, and reduce fat percentage [ 8 ]. The treatment also reduced waist to hip ratio and reduced subcutaneous fat mass [ 8 ]. Studies have shown that CLAs decrease lipid storage by increasing the rate of fat breakdown in fat tissue [ 9 ].

The fatty acids also increase fatty acid oxidation and reduce glucose uptake in cultured fat cells [ 9 ]. It should be noted, though, that in a similar study, CLA supplementation did not prevent weight or fat regain in obese peoples after initial weight loss [ 10 , 11 ].

It should also be noted that some studies have found no association between CLA and weight loss [ 11 , 12 , 13 ]. The following purported benefits are only supported by limited, low-quality clinical studies.

There is insufficient evidence to support the use of CLA for any of the below-listed uses. Remember to speak with a doctor before taking CLA supplements, and never use them in place of something your doctor recommends or prescribes.

Fatty liver disease is often an issue in overweight subjects. The disease causes high levels of oxidative stress in the liver, which eventually leads to liver failure. An eight-week study of 38 obese patients with fatty liver disease found that CLA supplementation helped reduce oxidative stress in the liver [ 14 ].

CLA also helped decrease cholesterol levels and improve the fats profile in the liver [ 14 ]. A study done in 55 obese, postmenopausal women with type 2 diabetes found that CLA supplementation reduced BMI and improved diabetic symptoms in the subjects [ 15 ].

Decreased insulin sensitivity is a major symptom of type 2 diabetes. In mice, it was found that CLA supplementation led to a decreased fat gain. It was also found that while CLA supplementation decreased fat gain, the fatty acids also maintained fat tissue function and maintained insulin sensitivity [ 16 ].

CLA increased AMPK levels in mice [ 17 ]. No clinical evidence supports the use of CLA for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts.

However, the studies listed below should not be interpreted as supportive of any health benefit. A combination of CLA and omega-3 has been found to increase mitochondrial efficiency in muscle cells [ 18 ]. This causes an increased amount of energy production from glucose and fat in muscles [ 18 ].

A study done in aged mice found that CLA and fish oil work to reduce fat deposits in the bone marrow and increase bone mass [ 19 ]. Not enough evidence is available in humans to know if CLA is useful in any kind of cancer.

However, there are some preliminary studies that warrant further investigation. Breast cancer is a devastating disease that affects many lives. One of the reasons that breast cancer is so devastating is that it spreads to other parts of the body both easily and quickly.

One study performed in women with lipogenic phenotype breast cancer found that treatment with CLA over the course of 12 days reduced breast cancer tissue production [ 20 ].

Additionally, studies in rat breast cancer tumor cells have found that Gemcitabine a drug designed to prevent the spreading of tumors was more effective when used in combination with CLA [ 21 ]. A study in patients with rectal cancer who were currently undergoing chemoradiotherapy was conducted.

In the study, CLA supplementation was found to reduce tumor angiogenesis and decrease tumor resistance [ 22 ]. CLA was shown to improve the efficacy of chemoradiotherapy treatment [ 22 ]. In human colorectal cancer cells, CLA has been shown to promote growth arrest by inhibiting energy production in cancer cells [ 23 ].