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Gut health and allergies

Gut health and allergies

Your email address will not be Heatlh. Our Post-competition meal plans Contact Us Feedback Frequently Asked Questions FAQ Events Medical Content Reviewers. The strengths of the current study lie in the novelty of assessing gut microbiome composition in an adult population with clinically well-characterised allergic disease. Parkway East WhatsApp Call.

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Gut health and allergies -

The composition of our intestinal flora has been affected not only by the rise in hygiene standards, but also by changed dietary habits.

Ready meals and industrially processed foods often contain preservatives that kill the microorganisms in the food — our immune system is less exposed to germs and can thus become more susceptible to allergies. A healthy immune system starts in the intestine. Gut remediation can therefore prove a sensible approach for tackling allergic diseases.

Following detailed laboratory diagnostics, they are able to tackle the individual intestinal situation in a targeted manner.

If you want to get your intestinal flora back on track yourself, you can follow a simple 2-stage programme:. create a clear environment in your bowel by starting the remediation process with an intestinal cleanse.

Radical laxatives such as castor oil, bitter or glaze salt are often used for this purpose - but prior consultation with healthcare professionals is absolutely recommended. A gentler course of treatment features a plant-based and natural diet that helps the bowel to regenerate.

It is possible to start rehabilitating the intestines during this cleansing process. In this case, the focus is on strengthening the intestinal mucosa as well as colonising the bowel with beneficial organisms.

Special nutrients e. L-glutamine , vitamin C , vitamin D , selenium and zinc benefit our intestinal mucosa, while probiotics and prebiotics e. dextrin, inulin, acacia fibres, citrus pectin help to build up a "good" intestinal flora.

Want to know more about gut remediation? Then continue reading here:. From bowel cleansing to bowel reconstruction. Our bowel and its tiny inhabitants play a central role in our health. According to a large scientific review meta-analysis , taking probiotics in children at an especially early stage has a positive effect on the development of childhood allergies.

Nowadays, people are increasingly aware of the importance of a healthy gut flora for a well-functioning immune system. A large-scale review meta-analysis examined 25 scientifically high-quality studies, which dealt with the intake of probiotics by mothers during pregnancy and with the administration of probiotics to newborns.

In addition, the risk of developing an atopic disease e. hay fever, atopic dermatitis, allergic asthma in childhood was reduced. While timing did not seem to play a role in reducing IgE levels, this was certainly the case with regard to the risk of atopy. Here, a preventive effect could only be observed if the probiotic intake was already started during pregnancy.

Reference: Nancy Elazab, MDa, et al. Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials. e -e The bowel is the headquarters of our immune defence. If the bowel is impaired, this can alter our immune response and promote the occurrence of allergies.

Studies show that healthy intestinal flora, which has a large bacterial variety, is associated with a lower risk of allergic diseases. Our immune system is always involved in an allergy. Studies indicate that lactobacilli, especially the strain Lactobacillus paracasei, can be beneficial for allergy sufferers.

Steiner, N. et al. Probiotic Potential of Lactobacillus Species in Allergic Rhinitis. Int Arch Allergy Immunol. doi: Epub Apr Noda, M. Plant-Derived Lactobacillus paracasei IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Peroni, D. Hufnagl, K. Lack of iron, zinc and vitamins as a contributor to the etiology of atopic diseases. Front Nutr. eCollection Li, Q. Zhou, Q. Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis; Nutrients. Wang, S. Serum level and clinical significance of vitamin E in children with allergic rhinitis; BMC Pediatrics volume 20, Article number: Seo, J.

Association of antioxidants with allergic rhinitis in children from seoul; Allergy Asthma Immunol Res Mar;5 2 Dysbiosis of the gut and lung microbiome has a role in asthma. Semin Immunopathol. So Nagler and several other researchers are working to find ways to treat food allergies more easily and durably.

Producing a microbiome-based treatment will be challenging , with many details to hash out, such as which microbes to provide and how best to deliver them. But the approach is gaining momentum.

And in March, scientists reported finding large amounts of antibodies against peanut allergens in the stomach and gut of allergic patients, further supporting the idea that the gastrointestinal tract is a hotspot for food allergy regulation and treatment. Already, companies are testing several strategies.

It has long been a puzzle why one person tolerates a food while another is allergic but, as outlined in an article she coauthored in the Annual Review of Immunology , Nagler is convinced that the microbiome is key.

Four years after finishing her graduate work, Nagler started running a lab at Harvard Medical School. She was studying inflammatory bowel disease, not food allergies, back then. But as research in the s showed that inflammatory bowel disease was primarily caused by immune reactions against gut bacteria, she shifted her attention to the microbiome.

Then, in , she came across an intriguing publication. It described a mouse model for peanut allergy that mimics key symptoms experienced by people. The mice scratch relentlessly.

Their eyes and mouths get puffy. Some struggle to breathe—a life-threatening allergic response called anaphylaxis. All of this happens after researchers feed the mice peanut powder. It ran counter to her earlier findings with the arthritic mice, where feeding collagen calmed the immune reaction.

Why the difference? The peanut-allergy mice, another report showed, had a genetic glitch that damages a receptor called TLR4 that sits in the membranes of immune cells and recognizes microbes. It looked as though the peanut-allergy mice lacked the normal cross talk that takes place between gut microbes and immune cells.

Perhaps the trillions of microbes that live in us suppress immune responses to food by stimulating the TLR4 receptor. And perhaps perturbations in that teeming microbiome alter the suppression and cause a rise in allergies.

The idea meshes with historical trends. As societies modernized, people moved to urban areas, had more babies by cesarean section, took more antibiotics and ate more processed, low-fiber foods—all of which shake up microbiomes. The timing of these lifestyle shifts parallels the observed increase in food and other types of allergies, whose steep rise over a generation points to some environmental cause.

In , Nagler and her coworkers published a report showing that peanuts provoked anaphylaxis only in mice with a mutated TLR4 receptor , not in genetically related strains with a normal TLR4. The difference disappeared when the scientists wiped out populations of gut bacteria with antibiotics.

Then, even normal mice became susceptible to food allergies, implying that bacteria are at the heart of the protection. Working with mice bred in a germ-free environment and thus without any microbiome at all, the team found that Clostridia , but not Bacteroides , prevented food-allergic responses when introduced into the guts of the squeaky-clean mice.

The Clostridia mice also produced more of a molecule called IL that strengthens the intestinal lining. A new theory began to emerge: If protective microbes are missing, the gut barrier weakens, allowing food proteins to seep into the bloodstream and potentially trigger allergic responses.

This reasoning jibes well with the curious observation that top food allergens certain proteins found in milk, eggs, peanuts, tree nuts, soy, wheat, fish and shellfish bear little biochemical resemblance to each other.

What they do have in common is the ability to remain intact in the digestive tract, which normally breaks food into small pieces that the body absorbs as nutrients. Analyzing feces of healthy babies and those with egg or milk allergies, researchers showed that allergic and nonallergic infants had different communities of gut bacteria.

Another study tracked children with milk allergy from infancy to age 8. The scientists found that certain bacteria, including Clostridia , were enriched in stool samples from 3- to 6-month-old infants who eventually outgrew their allergy , compared to those who remained allergic.

From birth, our immune systems get schooled in life-or-death choices. They learn to kill germs, tumors and dying cells. Much else in their surroundings they must learn to leave alone—nerve fibers, bone tissue, proteins from milk and cookies consumed at snack time. In one of the studies, Nagler and coworkers collected gut bacteria from the feces of healthy and milk-allergic babies and put those collections of microbes into the digestive tracts of germ-free mice.

Using mathematical and computer science techniques to analyze the results, the team identified bacterial strains that were present in healthy but not allergic babies. They also examined gene activity in cells lining the intestines—certain gene patterns are characteristic of a healthy gut barrier—and looked for microbes whose presence correlated with a healthy barrier.

One Clostridia species, Anaerostipes caccae , popped out of both analyses. When the scientists transferred A. caccae alone into germ-free mice, it seemed to mimic the protection imparted by a full, healthy microbiome.

Regulatory T cells were key to the response and were spurred into action by the microbes.

More and Organic wine and beer studies suggest that there Xnd a link between the excessive immune response that Aand with allergies and an imbalance in the intestine. This ane not all that uGt, as the gut and immune system are closely linked. Containing almost 80 percent of all immune cells, the intestines are home to the vast majority of our immune system. Together with an intact intestinal mucosa, which represents the mechanical boundary, the intestinal flora and the intestinal immune system form a 3-phase defence against undesirable germs and substances. If the intestinal balance is impaired e. The intestinal flora interact with our immune system. Gut health and allergies

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