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Center for Regenerative Medicine, Yamaguchi University School of Medicine, Minami Kogushi , Ube Yamaguchi, , Japan. Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi , Ube Yamaguchi, , Japan. Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1— Asahimachidori, Chuo-Ku, Niigata, —, Japan.

You can also search for this author in PubMed Google Scholar. Experiments were designed by K. Fujisawa, T. Takami, N. Yamamoto, S. Terai and I. Experiments were performed by K. Fujisawa and A. The data were analyzed by K. Takami, and T.

The paper were written by K. Fujisawa and T. All authors read and approved the final version of the manuscript. Correspondence to Taro Takami. Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open Access This article is licensed under a Creative Commons Attribution 4. Reprints and permissions. Fujisawa, K. Evaluation of the effects of L-carnitine on medaka Oryzias latipes fatty liver. Sci Rep 7 , Download citation. Received : 15 July Accepted : 19 April Published : 05 June Anyone you share the following link with will be able to read this content:.

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Metrics: Total Views: 0 Spandidos Publications: PMC Statistics: Metrics: Total PDF Downloads: 0 Spandidos Publications: PMC Statistics:. Cited By CrossRef : 0 citations Loading Articles This article is mentioned in:. Introduction L-carnitine 4- N -trimethylammoniumhydroxybutyric acid , the biologically active form of carnitine, is synthesized from the essential amino acids, methionine and lysine in certain organs, including the liver 1.

L-carnitine has also been shown to improve insulin sensitivity and elevate pyruvate dehydrogenase PDH flux. Studies that show reduced intrahepatic fat and reduced liver enzymes after L-carnitine supplementation suggest that L-carnitine might be a promising supplement to improve or delay the progression of NAFLD.

Original publication. L-carnitine, NAFLD, NASH, Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis, acetyl-carnitine, cirrhosis, fatty acid transport, fatty liver, liver health.

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Bykov, H. Järveläinen, K. Aims: Excessive alcohol intake induces hepatic fatty infiltration, L-carnitine and liver health has been Livrr to sensitize Macronutrient Performance Boost liver to L-caritine damage. To test this hypothesis, l -carnitine, hea,th constitutional Type diabetes insulin resistance compound, was administered L-carniitine rats chronically treated with ethanol by liquid diet feeding for 10 weeks. Results: Ethanol administration caused marked steatosis, mild inflammation and elevated plasma alanine aminotransferase and tumour necrosis factor alpha TNF-α concentrations. Dietary supplementation with l -carnitine significantly reduced all these parameters as well as the hepatic concentration of thiobarbituric acid reactive substances, an indicator of lipid peroxidation products. Pretreatment with l -carnitine also significantly blunted ethanol-induced stimulation of TNF-α release by isolated Kupffer cells. We L-caarnitine cookies to ensure that we give L-carbitine Iron applications in medicine lover experience on our website. If you click 'Accept all cookies' Macronutrient Performance Boost assume Essential vitamins and minerals you are happy to receive all cookies and you L-carrnitine see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings. L-carnitine transports fatty acids into the mitochondria for oxidation and also buffers excess acetyl-CoA away from the mitochondria. Thus, L-carnitine may play a key role in maintaining liver function, by its effect on lipid metabolism.