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Seven Ways to Improve Bone HealthForskolin and bone health -
Permissions Icon Permissions. Close Navbar Search Filter Journal of Bone and Mineral Research This issue Clinical Medicine Endocrinology and Diabetes Medicine and Health Neuroscience Books Journals Oxford Academic Enter search term Search. Google Scholar Crossref. Search ADS. Bone resorption in tissue culture: factors influencing the response to parathyroid hormone.
Stimulation of bone resorption by various prostaglandins in organ culture. Activation of skeletal adenyl cyclase by parathyroid hormone in vitro. In: Conn. Google Scholar Google Preview OpenURL Placeholder Text.
Cyclic nucleotides in bone and mineral metabolism. Google Scholar PubMed. OpenURL Placeholder Text. Evidence for preferential effects of parathyroid hormone, calcitonin and adenosine on bone and periosteum.
Response to hormones of cells cultured from human giant cell tumors of bone. Delayed stimulatory effect of cyclic AMP on bone resorption in vitro. Transient inhibition on calcium mobilization from cultured mouse calvaria bones by the adenylate cyclase stimulator forskolin.
Google Scholar OpenURL Placeholder Text. Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. DNA synthesis is not necessary for osteoclastic responses to parathyroid hormone in cultured fetal rat long bone. Effects of osteoclast activating factor from human lymphocytes on cyclic AMP concentrations in isolated mouse bone and bone cells.
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Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model. Cancer 11, Krett, N. Cancer Res. CAS PubMed Google Scholar. Cancer Lett. Klein, B. Interleukin-6 is the central tumor growth factor in vitro and in vivo in multiple myeloma.
Cytokine Netw. Interleukin-6 in human multiple myeloma. Blood 85, — Rickles, R. Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multi-target mechanism discovered through systematic combination screening in B-cell malignancies.
Blood , — Seamon, K. Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. USA 78, — Article CAS ADS Google Scholar. Valdés, L.
Coleus barbatus C. forskohlii Lamiaceae and the Potential New Drug Forskolin Coleonol. Economic Botany 41, — Laurenza, A.
Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? Trends Pharmacol. Ono, K. A direct effect of forskolin on sodium channel bursting. Pflugers Arch. Kikura, M. Pharmacokinetics and a simulation model of colforsin daropate, new forskolin derivative inotropic vasodilator, in patients undergoing coronary artery bypass grafting.
Baumann, G. Cardiovascular effects of forskolin HL in patients with idiopathic congestive cardiomyopathy—a comparative study with dobutamine and sodium nitroprusside. Godard, M. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.
Bersudsky, Y. A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients. Short communication. Neural Transm. Huerta, M. Forskolin compared with beclomethasone for prevention of asthma attacks: a single-blind clinical trial.
Henderson, S. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. Sports Nutr.
Misund, K. A Method for Measurement of Drug Sensitivity of Myeloma Cells Co-cultured with Bone Marrow Stromal Cells. Darzynkiewicz, Z. Features of apoptotic cells measured by flow cytometry. Cytometry 13, — Kroemer, G.
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death Cell Death. Chou, T. Theoretical basis, experimental design and computerized simulation of synergism and antagonism in drug combination studies.
Gentile, M. Emerging biological insights and novel treatment strategies in multiple myeloma. Drugs 17, — Hideshima, T. The proteasome inhibitor PS inhibits growth, induces apoptosis and overcomes drug resistance in human multiple myeloma cells. Kaufmann, M. In-vitro testing of cyclophosphamide on tumors.
Naturwissenschaften 62, — Haskell, C. Comparative survival in tissue culture of normal and neoplastic human cells exposed to adriamycin. Rowley, M. Heterogeneity in therapeutic response of genetically altered myeloma cell lines to interleukin 6, dexamethasone, doxorubicin and melphalan.
Blood 96, — Insel, P. Metab Res. Moujalled, D. Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim. EMBO Rep. Wang, Z. Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis.
Luciano, F. Oncogene 22, — Adenosine A2A and beta-2 adrenergic receptor agonists: novel selective and synergistic multiple myeloma targets discovered through systematic combination screening. Cancer Ther. Meads, M. The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance.
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The work was supported by grants from the Norwegian Cancer Society, the Jahre Foundation, the Blix Family Foundation, the Research Council of Norway, K. Jebsen Foundation for Medical Research and the University of Oslo.
The authors are grateful to Camilla Solberg and Jannicke Holmseth for excellent technical help. Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, PO Box Blindern, Oslo, N, Norway. KG Jebsen Center for Myeloma Research and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, N, Norway.
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Klin Monatsbl Augenheilkd ; [in German]. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung ; Bauer K, Dietersdorfer F, Sertl K, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma.
Clin Pharmacol Ther ; Bone K, Morgan M. Clinical Applications of Ayurvedic and Chinese Herbs: Monographs for the Western Herbal Practitioner. Queensland, Australia: Phytotherapy Press, Learn more about TraceGains, the company.
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Learn how we develop our content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Home Health Information Library Coleus. Uses Botanical names: Coleus forskohlii. What Are Star Ratings?
This supplement has been used in connection with the following health conditions: Used for Why 2 Stars. Studies have shown that intraocular pressure may be lowered by directly applying a sterile fluid extract of forskolin, a constituent of the Ayurvedic herb Coleus forskohlii.
Clinical trials suggest coleus may help regulate body weight and improve metabolic health. Coleus forskohlii is an Ayurvedic medicinal plant used historically to treat high blood pressure, heart failure, eczema, digestive colic, respiratory ailments, painful urination, insomnia, and seizures, as well as overweight and obesity.
Laboratory research suggests forskolin, an active compound from coleus, may reduce excessive inflammatory signaling by fat cells. In a week placebo-controlled trial that included 23 mildly overweight women, those receiving a standardized coleus extract, at a dose of mg twice daily, lost 0.
A similar trial that included 30 women with overweight and obesity being treated with a reduced-calorie diet found taking coleus resulted in the same weight loss as placebo; however, coleus had greater positive impacts on insulin levels and insulin resistance, suggesting it may improve metabolic health generally.
One trial found that a constituent of coleus, called forskolin, when inhaled, could decrease lung spasms in asthmatics. Coleus contains forskolin, a substance that may help dilate blood vessels and improve the forcefulness with which the heart pumps blood.
A small amount of preliminary evidence suggests Coleus forskohlii and its active ingredient forskohlin may have blood pressure-lowering effects. Coleus forskohlii and its active constituent forskolin have been found to relax blood vessel walls and lower blood pressure in laboratory and animal studies.
A pilot trial evaluated the effect of two preparations of in subjects with high blood pressure and found 31 of the 41 participants who completed the trial Forskolin was also found to lower blood pressure and increase cardiac output in an uncontrolled preliminary trial with 12 subjects suffering from cardiomyopathy.
Some herbalists use the herb coleus in treating people with psoriasis. Traditional Use May Not Be Supported by Scientific Studies As recorded in ancient Sanskrit texts, coleus was used in Ayurvedic medicine 1 to treat heart and lung diseases, intestinal spasms, insomnia , and convulsions.
How It Works Botanical names: Coleus forskohlii. How It Works Forskolin, a chemical found in coleus, activates the enzyme adenylate cyclase. Interactions Botanical names: Coleus forskohlii.
Interactions with Medicines Certain medicines interact with this supplement. What Are Drug Interactions. Types of interactions: Beneficial Adverse Check. Replenish Depleted Nutrients none. Reduce Side Effects none.
Support Medicine Albuterol A test tube study demonstrated that the bronchodilating effects of salbutamol albuterol were significantly increased by the addition of forskolin, the active component of the herb Coleus forskohlii. Learn More.
Heaoth Forskolin and bone health CF can stand for a Coping with anxiety in daily life different things in the medical and Flrskolin world. Chronic fatigue Antioxidant vitamins Forskolin and bone health fibrosis Forskolin and bone health two healrh spring to hdalth immediately. Coleus Foorskolin is Forsoklin perennial plant in the Lamiaceae family which also includes mint oregano marjoram basil rosemary and sage. The plant also goes by the name Plectranthus barbatus or Indian coleus and it grows primarily in the subtropical temperate climates of India Nepal Sri Lanka and Thailand. The root portion has a long tradition of use in Hindu and Ayurvedic medicine as well as folk medicine in Brazil China and tropical Africa. Forskolin is believed to be responsible for virtually all the pharmacological activities attributed to Coleus forskohlii. It is a lipid-soluble diterpene that penetrates cell membranes and activates the enzyme adenylyl cyclase also called adenylate cyclase which increases intracellular levels of cyclic AMP cAMP. Cissus quadrangularis is Fordkolin species of perennial plant that has been Beauty and skincare products Forskolin and bone health for centuries. Anr mainly grows in tropical climates and is Forwkolin of Forskolun Vitaceae family Forskolin and bone health family. Although many parts of the Cissus quadrangularis plant are known to contain phytonutrients, the stems are thought to be especially abundant in chemicals and substances that may have health benefits. Bioactive compounds found in Cissus quadrangularis include flavonoidsphenols, tannins, plant sterols including beta-sitosteroland resveratrol. Cissus quadrangularis is also a source of calciumphosphorus, vitamin Avitamin Cand other nutrients.Forskolin and bone health -
The letters CF can stand for a few different things in the medical and nutrition world. Chronic fatigue and cystic fibrosis are two that spring to mind immediately.
Coleus forskohlii is a perennial plant in the Lamiaceae family which also includes mint oregano marjoram basil rosemary and sage. The plant also goes by the name Plectranthus barbatus or Indian coleus and it grows primarily in the subtropical temperate climates of India Nepal Sri Lanka and Thailand.
The root portion has a long tradition of use in Hindu and Ayurvedic medicine as well as folk medicine in Brazil China and tropical Africa.
Forskolin is believed to be responsible for virtually all the pharmacological activities attributed to Coleus forskohlii. It is a lipid-soluble diterpene that penetrates cell membranes and activates the enzyme adenylyl cyclase also called adenylate cyclase which increases intracellular levels of cyclic AMP cAMP.
Activation of adenylate cyclase by forskolin is rapid and reversible which distinguishes forskolin from other compounds e. hormones pathogens that also activate this enzyme. cAMP is an important messenger compound for the proper biological response to hormones and other extracellular signals.
For this reason forskolin is sometimes included in supplements intended to support healthy thyroid function. The many diverse effects of elevating cAMP may be why coleus forskohlii has been used for intestinal and liver conditions respiratory disorders heart disease nervous system disorders and more.
There are few tissue systems not affected by cAMP. cAMP inhibits basophil and mast cell degranulation and histamine release lowers blood pressure and intraocular pressure inhibits platelet aggregation promotes vasodilation and bronchodilation stimulates lipolysis in adipose tissue and promotes thyroid hormone secretion.
Conditions associated with reduced levels of cAMP include asthma cardiovascular disease psoriasis hypertension and obesity. Regarding obesity adipocytes from obese women have lower adenylate cyclase activity than those of non-obese women.
Promoting enzyme activity and stimulating cAMP production may be helpful in the seemingly unwinnable battle of the bulge. Animal and in vitro studies also support a potential role for coleus forskohlii in enhancing lipolysis and reducing body weight and fat accumulation.
Fortunately human studies also support a modest effect of forskolin for fat loss. And considering how mightily some people struggle to reduce their body fat modest effects are better than nothing!
A separate study concluded that forskolin may not be a home run for fat loss but it could be helpful for preventing fat gain and it does so in the absence of any observed adverse effects on hematological profile. Studies in men are slightly more promising. Forskolin may also help boost thyroid function which could augment its fat loss effects for individuals whose stubborn fat loss is due to sluggish thyroid activity.
It may be especially helpful for asthma. May 24, Kim Krieger - UConn Communications. UConn Health scientists describe a new method that can promote regrowth of long bones more affordably and with fewer side effects than other techniques. Repairing severely damaged bones is a challenge—especially the long bones of the arms and legs.
Now, UConn Health scientists describe a new method in the 22 May issue of PNAS that can promote regrowth of long bones more affordably and with fewer side effects than other techniques.
Cleanly broken bones often heal without problems. But bones with smashed or missing sections are much more difficult to regenerate.
Grafting across the gaps using bone from elsewhere is one way to fix them, and about , bone grafts are done in the US every year.
Recently, orthopedic surgeons have begun treating difficult breaks with specific human proteins that encourage bone growth, both alone and paired with grafts or scaffolds.
They are used to encourage bone regrowth in spinal fusion surgeries, for example. But the proteins, known more specifically as recombinant human bone morphogenetic proteins rhBMPs , have limitations.
First is that large molecules such as rhBMPs can be expensive to manufacture and store. Another is that the immune system has a tendency to treat them as invaders to be neutralized, limiting their usefulness.
And rhBMP treatments have been known to induce bone growth in undesirable locations in addition to the site of the bone fracture. University Professor Dr.
Cato T. Laurencin and colleagues at UConn School of Medicine used a slightly different approach to encourage bone growth. They wanted to release a medicine directly where new bone needed to grow, and do it in a short period of time. So they built a scaffold out of a biodegradable polymer to guide the growth of the new bone.
They impregnated the scaffold with forskolin, a small molecule that encourages the same bone growth response as rhBMPs do. And guessing that some of the undesirable effects from rhBMPs were related to longterm use, they engineered the scaffold to release the forskolin almost entirely within a 24 hour period.
They then tested two forskolin-impregnated scaffolds one high dose, one low dose against a scaffold impregnated with rhBMP, and a control scaffold that had no bone growth factor added.
Our hewlth may use cookies to personalize and Forskolin and bone health your experience. By continuing bonf changing healtn Forskolin and bone health settings, you agree to this collection. For more information, please see our University Websites Privacy Notice. May 24, Kim Krieger - UConn Communications. UConn Health scientists describe a new method that can promote regrowth of long bones more affordably and with fewer side effects than other techniques.
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