Women who bobe low bone density or osteoporosis Vegan fat burning supplement Vitamin K and bone health taking an osteoporosis medicine, such as a bisphosphonate, when starting treatment with an healtg inhibitor. Bkne 2 Subgroup analysis to investigate the effect ehalth the type gone vitamin K on Qnd effect size of vitamin K combined with calcium on lumbar spines BMD Full size table. Some of them exist in the skeleton and cartilage such as osteocalcin, matrix Gla protein, Gla-rich protein, protein S, and gas 6 [ 30 ]. If you are currently being treated with any of the following medications, you should not take vitamin K without first talking to your health care provider. People who use over the counter or even prescription doses once in a while should not be concerned.

Vitamin K and bone health -

Studies on vitamin K and the bone Osteoporosis is a metabolic bone disease of reduced bone density, fragile bone, and elevated susceptibility to fracture [ 41 ].

Conclusion Studies suggest that vitamin K has a role in bone metabolism and it may contribute in maintaining BMD and diagnosing osteoporosis. References 1. Ferland G. The discovery of vitamin K and its clinical applications.

Booth SL. Roles for vitamin K beyond coagulation. Annual Review of Nutrition. Heiss C, Hoesel LM, Wehr U, Wenisch S, Drosse I, Alt V, et al. Diagnosis of osteoporosis with vitamin k as a new biochemical marker. Vitamins and Hormones. Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, et al.

Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam study. The Journal of Nutrition. Manna P, Kalita J.

Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and the reduced risk of type 2 diabetes: A review. Fan XV, Chen J, Duan L, Li S. Research progress on the anticancer effects of vitamin K2. Oncology Letters. Stafford DW. The vitamin K cycle.

Journal of Thrombosis and Haemostasis. Price PA, Otsuka AA, Poser JW, Kristaponis J, Raman N. Characterization of a gamma-carboxyglutamic acid-containing protein from bone.

Proceedings of the National Academy of Sciences of the United States of America. Sakamoto N, Nishiike T, Iguchi H, Sakamoto K.

The effect of diet on blood vitamin K status and urinary mineral excretion assessed by a food questionnaire. Nutrition and Health.

Masterjohn C. Vitamin D toxicity redefined: Vitamin K and the molecular mechanism. Medical Hypotheses. Novotny JA, Kurilich AC, Britz SJ, Baer DJ, Clevidence BA. Vitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kale.

The British Journal of Nutrition. Hara K, Akiyama Y, Tajima T, Shiraki M. Menatetrenone inhibits bone resorption partly through inhibition of PGE2 synthesis in vitro.

Journal of Bone and Mineral Research. Czeczuk A, Huk-Wieliczuk E, Michalska A, Bylina D, Sołtan J, Zofia D. The effect of menopause on bone tissue in former swimmers and innon-athletes. Advances in Clinical and Experimental Medicine. Azuma K, Inoue S.

Multiple Modes of Vitamin K Actions in Aging-Related Musculoskeletal Disorders. International Journal of Molecular Sciences. Vermeer C. Vitamin K: The effect on health beyond coagulation—an overview. Shearer MJ, McBurney A, Barkhan P. Studies on the absorption and metabolism of phylloquinone vitamin K1 in man.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin a, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Molybdenum, Nickel, Silicon, Vanadium and Zinc.

Chapter 5. Washington, DC: National Academy Press; Braam LA, Knapen MH, Geusens P, Brouns F, Vermeer C. Factors affecting bone loss in female endurance athletes: A two-year follow-up study. The American Journal of Sports Medicine. Fang Y, Hu C, Tao X, Wan Y, Tao F.

Effect of vitamin K on bone mineral density: A meta-analysis of randomized controlled trials. Journal of Bone and Mineral Metabolism. Kohlmeier M, Salomon A, Saupe J, Shearer MJ. Transport of vitamin K to bone in humans. Erkkila AT, Lichtenstein AH, Dolnikowski GG, Grusak MA, Jalbert SM, Aquino KA, et al.

Plasma transport of vitamin K in men using deuterium-labeled collard greens. Sadowski JA, Hood SJ, Dallal GE, Garry PJ.

Phylloquinone in plasma from elderly and young adults: Factors influencing its concentration. The American Journal of Clinical Nutrition. Shea MK, Booth SL. Concepts and controversies in evaluating vitamin K status in population-based studies.

Shearer MJ, Fu X, Booth SL. Vitamin K nutrition, metabolism, and requirements: Current concepts and future research. Advances in Nutrition. Kidd PM, Vitamins D. K as pleiotropic nutrients: Clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy.

Alternative Medicine Review. Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: Protector of bone health and beyond? Hamidi MS, Cheung AM. Vitamin K and musculoskeletal health in postmenopausal women.

Misra D, Booth SL, Tolstykh I, Felson DT, Nevitt MC, Lewis CE, et al. Vitamin K deficiency is associated with incident knee osteoarthritis. The American Journal of Medicine. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan ESC, et al.

Increased bone formation in osteocalcin-deficient mice. Azuma K, Ouchi Y, Inoue S. Vitamin K: Novel molecular mechanisms of action and its roles in osteoporosis. Kidd PM. Vitamins D and K as pleiotropic nutrients: Clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy.

Szulc P, Chapuy MC, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: A three year follow-up study. Gundberg CM, Nieman SD, Abrams S, Rosen H. Vitamin K status and bone health: An analysis of methods for determination of undercarboxylated osteocalcin.

The Journal of Clinical Endocrinology and Metabolism. Binkley NC, Krueger DC, Kawahara TN, Engelke JA, Chappell RJ, Suttie JW. A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. Bügel S. Vitamin K and bone health in adult humans.

Vergnaud P, Garnero P. Meunier P J, Breart G, Kamihagi K, and Delmas P D, Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: The EPIDOS study. Price PA. Gla-containing proteins of bone.

Connective Tissue Research. Shea MK, Holden RM. Vitamin K status and vascular calcification: Evidence from observational and clinical studies. Vitamin K-dependent formation of bone Gla protein osteocalcin and its function. Falcone TD, Kim SS, Cortazzo MH.

Vitamin K: Fracture prevention and beyond. Lorentzon M, Cummings SR. Osteoporosis: The evolution of a diagnosis. Journal of Internal Medicine. Tuck SP, Francis RM. Postgraduate Medical Journal.

Vermeer C, Jie KS, Knapen MH. Role of vitamin K in bone metabolism. Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 menatetrenone effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.

Kim MS, Kim ES, Sohn CM. Dietary intake of vitamin K in relation to bone mineral density in Korea adults: The Korea National Health and nutrition examination survey Journal of Clinical Biochemistry and Nutrition. Fujita Y, Iki M, Tamaki J, et al.

Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men FORMEN study. Osteoporosis International. Ikeda Y, Iki M, Morita A, et al. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese population-based osteoporosis JPOS study.

Macdonald HM, McGuigan FE, Lanham-New SA, Fraser WD, Ralston SH, Reid DM. Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: No evidence of gene-nutrient interaction with apolipoprotein E polymorphisms.

Kanai T, Takagi T, Masuhiro K, Nakamura M, Iwata M, Saji F. Serum vitamin K level and bone mineral density in post-menopausal women.

International Journal of Gynaecology and Obstetrics. Jaghsi S, Hammoud T, Haddad S. Relation between circulating vitamin K1 and osteoporosis in the lumbar spine in Syrian post-menopausal women.

Open Rheumatology Journal. Heiss C, Hoesel LM, Wehr U, et al. Vitamin K in combination with other biochemical markers to diagnose osteoporosis. Booth SL, Broe KE, Peterson JW, et al. Associations between vitamin K biochemical measures and bone mineral density in men and women.

Tsugawa N, Shiraki M, Suhara Y, et al. Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women. Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture.

Vitamin K and osteoporosis: Myth or reality? Written By Sawsan Jaghsi. Continue reading from the same book View All. IntechOpen Clinical Implementation of Bone Regener Chapter 9 Metabolic Disorders in Patients with Chronic Osteo By Archil Tsiskarashvili, Nikolay Zagorodny, Svetlana Chapter 10 Immunological Monitoring of Osteogenesis Disorder By Olga Viktorovna Berdyugina and Kirill Alexandrovic Chapter 11 Application of Adipose-Derived Stem Cells in Treat Most of these studies employed vitamin K 2 at rather high doses, a fact that has been criticized as a shortcoming of these studies.

However, there is emerging evidence in human intervention studies that vitamin K 1 at a much lower dose may also benefit bone health, in particular when coadministered with vitamin D.

Several mechanisms are suggested by which vitamin K can modulate bone metabolism. Besides the gamma-carboxylation of osteocalcin, a protein believed to be involved in bone mineralization, there is increasing evidence that vitamin K also positively affects calcium balance, a key mineral in bone metabolism.

Abstract In the past decade it has become evident that vitamin K has a significant role to play in human health that is beyond its well-established function in blood clotting.

Open heaalth peer-reviewed xnd. Submitted: 07 February Vitamin K and bone health 10 September Published: 21 November Edited by Mike Barbeck, Nahum Rosenberg, Patrick Rider, Željka Perić Kačarević and Ole Jung. com customercare cbspd. Vitamin K is an essential fat-soluble vitamin. Vitamin K, a cofactor for bbone γ-glutamyl carboxylase enzyme, is required Mental clarity practices the Viramin activation of hhealth and matrix Gla Vitmin, which Vitamin K and bone health a key role Vitamin K and bone health bone Healthy mindset muscle homeostasis. In vivo and heealth vitro models for osteoporosis and sarcopenia suggest the vitamin K could exert a positive effect in both conditions. In bone, it increases osteoblastogenesis, whilst decreases osteoclast formation and function. In muscle, it is associated with increased satellite cell proliferation and migration and might play a role in energy metabolism. Observational trials suggest that high levels of vitamin K are associated with increased bone mineral density and reduced fracture risk. However, interventional studies for vitamin K supplementation yielded conflicting results.