Eating enough healtb Anti-bacterial cleaning products to a stronger immune system, reduced risk Metabolic health updates chronic and preventable diseases, meeting macronutrient and micronutrient needs and overall better metabolic health. Related Nealth. Researchers at Closed-loop system Institutet have developed Metabllic method to study liver function and disease without requiring invasive procedures. Behemoth lab test company Quest Diagnostics is partnering with Google's Fitbit to study how wearable technologies can improve metabolic health. Share on Mastodon Enter your Mastodon instance URL optional Share. Each participant was given a diet that was low in fat and high in carbohydrates for two weeks and one that was low in carbohydrates and high in fat for two weeks.

Metabolic health updates -

Date 6 hours 12 hours 1 day 3 days all. Last day 1 week 1 month all. Biomedical technology. Feb 1, 0 Jan 29, 0 0. Jan 19, 0 Jan 19, 0 0. Jan 12, 0 Jan 10, 0 0. Dec 29, 0 0. Dec 10, 0 9. Dec 4, 0 0. The rates of metabolic conditions are already very high in the general population.

In fact, research from Stanford Medicine colleagues suggests that developing a metabolic disorder such as insulin resistance can double your risk for depression, even if you have no prior history of mental illness.

Research shows that those with treatment-resistant bipolar disorder fared better when insulin resistance was addressed. For a long time, doctors have thought of nutrition as mostly a secondary therapy, an add-on to medications that might lower blood pressure or improve diabetes.

But we have realized that nutritional metabolic therapy can serve as a significant medical intervention for mental illness, one that can change the structure and function of the brain.

We take lessons from our neurology colleagues who recognized over a century ago the links between metabolism in the brain and body, which led to successfully treating pediatric epilepsy with ketogenic diets before the advent of the first anti-seizure drug. How does that work?

This results in a buildup of toxic substances and increased inflammation. We see significantly more inflammation in the brains of people with mental illness, especially in treatment-resistant patients, than in healthy people. There has also been a lot of research over the last century regarding metabolism and mitochondrial dysfunction, and how that affects brain activity in mental illness.

Mitochondria are the site for energy production and consumption in the cell. Working alongside a neuroscientist colleague from UC San Francisco, Judith Ford, we are recruiting patients who have been diagnosed with either bipolar disorder or schizophrenia in a randomized control trial that explores the effects of a ketogenic diet on insulin resistance and neural network stability, as measured through functional MRI.

Can you tell us more about the ketogenic diet and why it might be beneficial for some patients with severe mental illness? I want to stress that a ketogenic diet is not for everyone. That said, a ketogenic diet is a very low-carbohydrate, high-fat diet with moderate protein intake.

Patients on this diet avoid bread, rice, pasta and cereals, while consuming whole foods like eggs, avocado, nuts, fish and chicken.

Studies in animals have found that repeated cycles of fasting, even without reducing total calories, can improve a range of metabolic and immune functions. Examples include lower cholesterol levels, blood pressure, and inflammation.

Small clinical studies have also found that periodic fasting can have health benefits in people. Some of the benefits seen include lower inflammation and blood pressure, and better control of blood sugar.

Researchers are now studying whether such approaches might be safely used to improve human health over the long term, and whom they might benefit. The human body contains two main kinds.

Most is white fat. This stores excess energy in the form of molecules called triglycerides. White fat is found throughout the body, usually in a layer under the skin and around internal organs. Having too much white fat is what makes someone have obesity. Its job is to help maintain body temperature by burning triglycerides to generate heat.

Until about 15 years ago, humans were believed to lose most of their brown fat after infancy. Since then, researchers have learned that nearly every adult human has some functioning brown fat.

Brown fat may have a big impact on our metabolic health. In mice, activating brown fat reduces levels of triglycerides and cholesterol in the blood. It also prevents atherosclerosis, a sticky buildup along the artery walls that contributes to heart disease.

In people, more brown fat is associated with lower rates of type 2 diabetes, cardiovascular disease, high blood pressure, and heart failure. So, having more brown fat, or more active brown fat, may be good for metabolic health. This suggests that increasing brown fat activity might protect against metabolic syndrome.

The simplest way to activate brown fat is long exposure to cold temperatures. But people might not be willing to spend hours a day sitting in the cold. It would be more practical if we could take a drug to activate our brown fat.

Cypess and his team are studying one potential drug, mirabegron, that is currently approved by the Food and Drug Administration for treating overactive bladder. It works by binding to and activating a protein found on the surface of certain cells, including brown fat cells.

In a small trial, Cypess and his team showed that mirabegron could activate brown fat at least as well as cold exposure. In a follow-up study, mirabegron increased the amount and activity of brown fat over the course of the study. The amount of energy used increased, and some measures of metabolism improved, although there were no changes in body weight or the percentage of body fat.

These changes were comparable to those caused by mild exercise, bariatric surgery, or anti-diabetic drugs. The only side effect was a small increase in resting heart rate. We thankfully have some seemingly effective ways to deal with people who have severe obesity, or complications of obesity.

But there's still a lot of work to do. References: Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake. Hall KD, Guo J, Courville AB, Boring J, Brychta R, Chen KY, Darcey V, Forde CG, Gharib AM, Gallagher I, Howard R, Joseph PV, Milley L, Ouwerkerk R, Raisinger K, Rozga I, Schick A, Stagliano M, Torres S, Walter M, Walter P, Yang S, Chung ST.

Nat Med. doi: PMID: Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake. Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, Chung ST, Costa E, Courville A, Darcey V, Fletcher LA, Forde CG, Gharib AM, Guo J, Howard R, Joseph PV, McGehee S, Ouwerkerk R, Raisinger K, Rozga I, Stagliano M, Walter M, Walter PJ, Yang S, Zhou M.

Cell Metabolism. pii: S 19 Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep. Depner CM, Melanson EL, Eckel RH, Snell-Bergeon JK, Perreault L, Bergman BC, Higgins JA, Guerin MK, Stothard ER, Morton SJ, Wright KP Jr.

Curr Biol. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity.

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