Roche An, NE Nugent A: CLA and bone health linoleic acid: a healtn therapeutic nutrient?. Pregnancy detox diets PubMed Google Scholar Hsalth PAK, Liu W, Strkson JM, Bpne ME: Effect Cholesterol level impact on heart health conjugated linoleic acid on body composition in bome. The results of ELISA assay Figure 6C showed that CLA effectively inhibited the UVB-induced expression of inflammatory factors IL-6 and TNF-α in BMMCs, while promoting the production of anti-inflammatory factor IL We will examine how supplements developed in and indicate what trends can be expected in the future. Mice were given the respective diets for 14 weeks and at the end of which they were sacrificed.

CLA and bone health -

The purpose of this study was to determine how dietary calcium modulates the effects of conjugated linoleic acid CLA in preventing bone loss, using an ovariectomised mouse model. CLA supplementation significantly prevented ovariectomy-associated weight and fat mass gain, compared to non-supplemented controls.

CLA significantly increased bone markers without major changes in bone mineral composition in the femur compared to respective controls.

Meanwhile, CLA significantly reduced femur tartrate resistant acid phosphatase TRAP activity, suggesting potential reduction of osteoclastogenesis. The data suggest that CLA, along with dietary calcium, has great potential to be used to prevent bone loss and weight gain associated with menopause.

Lipids 32 , — Lipids 34 , — Tissue Int. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen. Terpstra AH : Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature.

Vieth R : Vitamin D supplementation, hydroxyvitamin D concentrations, and safety. Download references. This work was supported by funding made available by the Irish Government under the National Development Plan — Department of Food and Nutritional Sciences, University College, Cork, Ireland.

Department of Medicine, University College, Cork, Ireland. Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James' Hospital, Dublin, Ireland. You can also search for this author in PubMed Google Scholar.

Correspondence to K D Cashman. Contributors : LD contributed to design, execution, analysis and writing of the study. CJ, AM, and APN contributed to the execution and analysis of the study. KDC and HMR contributed to design, analysis and writing of the study.

Reprints and permissions. Doyle, L. et al. Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men.

Eur J Clin Nutr 59 , — Download citation. Received : 11 February Revised : 19 July Accepted : 14 October Published : 26 January Issue Date : 01 March Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Journal of Bone and Mineral Metabolism European Journal of Clinical Nutrition Skip to main content Thank you for visiting nature.

nature european journal of clinical nutrition original communication article. Abstract Introduction: Conjugated linoleic acid CLA has been shown to positively influence calcium and bone metabolism in experimental animals and cells in culture, but there are limited human data available.

Objective: To investigate the effect of CLA supplementation on biomarkers of calcium and bone metabolism in healthy adult males. Design: The study consisted of a double-blind, placebo-controlled trial in which 60 healthy adult males aged 39—64 y were randomly assigned to receive daily either 3.

Results: Supplementation with CLA or placebo for 8 weeks had no significant effects on markers of bone formation serum osteocalcin and bone-specific alkaline phosphatase or bone resorption serum C-telopeptide-related fraction of type 1 collagen degradation products, urinary N-telopeptide-related fraction of type 1 collagen degradation products, urinary pyridinoline and deoxypyridinoline , or on serum or urinary calcium levels.

Conclusion: Under the conditions tested in this double-blind, placebo-controlled trial in adult men, a CLA supplement of mixed isomers did not affect markers of calcium or bone metabolism. Sponsorship: Irish Government. Access through your institution. Buy or subscribe. Change institution.

Learn more. Article CAS Google Scholar Belury MA : Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Article Google Scholar Dallal GE : PC-Size consultant—A program for sample size determinations.

PubMed Google Scholar Kritchevsky D : Antimutagenic and some other effects of conjugated linoleic acid.

Thank healtn for visiting nature. You are using a Kettlebell workouts version with CA support for CSS. To obtain the annd experience, we recommend you use a CLA and bone health up to date browser or turn none compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Conjugated linoleic acid CLA has been shown to positively influence calcium and bone metabolism in experimental animals and cells in culture, but there are limited human data available. To investigate the effect of CLA supplementation on biomarkers of calcium and bone metabolism in healthy adult males.

Video

What to Eat to Reverse Osteoporosis Naturally!

CLA and bone health -

The purpose of this study was to determine how dietary calcium modulates the effects of conjugated linoleic acid CLA in preventing bone loss, using an ovariectomised mouse model. CLA supplementation significantly prevented ovariectomy-associated weight and fat mass gain, compared to non-supplemented controls.

CLA significantly increased bone markers without major changes in bone mineral composition in the femur compared to respective controls. Meanwhile, CLA significantly reduced femur tartrate resistant acid phosphatase TRAP activity, suggesting potential reduction of osteoclastogenesis.

The data suggest that CLA, along with dietary calcium, has great potential to be used to prevent bone loss and weight gain associated with menopause.

Nutritional interventions have gained more interest as the incidence of fractures has grown, and is predicted to grow even more with the ageing population. Conjugated linoleic acid CLA is a family of fatty acids that have received considerable attention due to the many biological effects of the different geo metric and positional isomers of this compound.

Considerable research exists in cell culture and animal based models in regards to the influence of CLA on bone metabolism. Generally, most cell culture and animal models suggest a beneficial influence of CLA on bone health and metabolism.

However, a gap exists in the literature with regards to the influence and efficacy of CLA on bone health in humans. This review summarizes the influence of CLA on cell culture models, animal models and human models of bone health and metabolism.

CLA and bone health bonne the Division of Clinical Immunology Nutrition and hydration for injury prevention Rheumatology at hexlth University of Texas Health Science Center at Bnoe Antonio have found boe conjugated helath acid Healh helps maintain bone mineral density in mice, possibly through anti-inflammatory actions. Electrolyte Balance Optimization exerts a significant influence on bone turnover, inducing the chronic form of osteoporosis. Dietary nutrition has the capacity to modulate inflammatory response. Therefore, nutritional strategies and lifestyle changes may prevent age-related osteoporosis, thereby improving the quality of life of the elderly population. In past studies, CLA—which is derived from milk, cheese and meat and has been well studied for its role in weight management—has positively influenced calcium and bone metabolism. After 10 weeks, CLA-fed mice maintained a higher BMD in different bone regions compared to corn-oil-fed mice.