Flavonoids and hair health -
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Lee Y, Berryman CE, West SG, et al. Journal of the American Heart Association. Use limited data to select advertising. Create profiles for personalised advertising. Use profiles to select personalised advertising. Create profiles to personalise content. Use profiles to select personalised content.
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Kristin Granero. Real Simple's Editorial Guidelines. Medically reviewed by Jessica Levinson, MS, RDN, CDN. Jessica Levinson, MS, RDN, CDN is a nationally recognized nutrition expert with over 16 years of experience in culinary nutrition and communications. Learn More. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia.
Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles HF diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption.
We started from a query for "alopecia" OR "hair loss" AND " Panax ginseng C. The activities of seven common botanicals introduced with diet Panax ginseng C. Pavlou P, Antoniadou I, Peraki A, Vitsos A, Dallas P, Mostratos D, Deliconstantinos G, Papaioannou G, Grando SA and Rallis M: Protective effects of Pinus halepensis bark extract and nicotine on cigarette smoke-induced oxidative stress in keratinocytes.
In Vivo. Yoon CJ, Choi WS, Kang HS, Kim HJ, Lee WT, Lee JS, Lee S, Son SY, Lee CH, Sohn UD and Lee JY: Pinus thunbergii parl. Extracts reduce acute inflammation by targeting oxidative stress.
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Trüeb RM: Molecular mechanisms of androgenetic alopecia. Exp Gerontol. Arck PC, Handjiski B, Peters EM, Peter AS, Hagen E, Fischer A, Klapp BF and Paus R: Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways.
Am J Pathol. Malkud S: A hospital-based study to determine causes of diffuse hair loss in women. J Clin Diagn Res. El-Domyati M, Attia S, Saleh F and Abdel-Wahab H: Androgenetic alopecia in males: A histopathological and ultrastructural study.
Aslani FA, Esfahani MH and Sepaskhah M: Non-scarring alopecias in Iranian patients: A histopathological study with hair counts. Iran J Pathol. Clin Exp Dermatol. Zhang JM and An J: Cytokines, inflammation, and pain. Int Anesthesiol Clin. Opal SM and DePalo VA: Anti-inflammatory cytokines.
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Robertson NU, Schoonees A, Brand A and Visser J: Pine bark Pinus spp. extract for treating chronic disorders. Cochrane Database Syst Rev. Ma X, Wang R, Yu S, Lu G, Yu Y and Jiang C: Anti-inflammatory activity of oligomeric proanthocyanidins via inhibition of NF-κB and MAPK in LPS-stimulated MAC-T Cells.
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J Nat Med. Toda K, Tsukayama I, Nagasaki Y, Konoike Y, Tamenobu A, Ganeko N, Ito H, Kawakami Y, Takahashi Y, Miki Y, et al: Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation.
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Front Pharmacol. Gnann LA, Castro RF, Azzalis LA, Feder D, Perazzo FF, Pereira EC, Rosa PCP, Junqueira VBC, Rocha KC, Machado CA, et al: Hematological and hepatic effects of vascular epidermal growth factor VEGF used to stimulate hair growth in an animal model.
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Introduction Although hair loss does not generally represent a serious health issue, it is a matter of interest as it may reduce confidence and lead to social anxiety, particularly in patients with alopecia, who manifest psychiatric symptoms, including depression, social phobia and anxiety, compared with normal individuals 1 , 2.
Materials and methods Preparation of PBE Pinus thunbergii growing next to the seashore of Gangneung Republic of Korea was gathered and its outer bark was harvested specimen no. Qualitative analysis of PBE Total phenol content The total phenol contents were determined by Folin-Ciocalteu's colorimetric method 22 using gallic acid as a standard for the calibration curve.
Total flavonoid content The total flavonoid contents were determined by the aluminum nitrate method 23 using quercetin as a standard for the calibration curve. Topical application of PBE and hair growth-promoting score HGPS In accordance with precedent studies by our group 3 , 25 , topical application with PBE was performed.
Tissue preparation for histological analysis The histological sections of the dorsal skin were prepared according to a previously described method Immunohistochemical staining To examine alterations in inflammatory cytokines and growth factors in the dorsal skin tissues between the groups, immunohistochemical staining was performed in accordance with certain previous studies with minor modifications 3 , Table I.
Primary and secondary antibodies for immunohistochemical staining. A, Primary antibodies Antibody Dilution Supplier cat. Rabbit anti-TNF-α , Abcam ab Rabbit anti-IL-1β Santa Cruz Biotechnology, Inc.
sc Rabbit anti-IL-4 Santa Cruz Biotechnology, Inc. sc Mouse anti-IL Santa Cruz Biotechnology, Inc. sc Rabbit anti-IGF-I Santa Cruz Biotechnology, Inc.
sc Mouse anti-VEGF Abcam ab B, Secondary antibodies Antibody Dilution Supplier cat. Biotinylated horse anti-mouse IgG Vector Laboratories, Inc. BA Biotinylated goat anti-rabbit IgG Vector Laboratories, Inc. BA IGF, insulin-like growth factor. Figure 1.
Figure 2. Figure 3. Figure 4. Figure 5. Related Articles. This site uses cookies. About Contact Help Cookie Policy Privacy Policy. Spandidos Publications style. Mol Med Rep , Her, Y. Kim, S. Molecular Medicine Reports, 25, Molecular Medicine Reports Molecular Medicine Reports 25, no.
Rabbit anti-TNF-α. Abcam ab Rabbit anti-IL-1β. Santa Cruz Biotechnology, Inc. Rabbit anti-IL Mouse anti-IL Rabbit anti-IGF-I. Mouse anti-VEGF. B, Secondary antibodies. Supplier cat. Biotinylated horse anti-mouse IgG. Vector Laboratories, Inc. Biotinylated goat anti-rabbit IgG. IGF, insulin-like growth factor.
androgenetic alopecia. distilled water. hair growth-promoting score.
Increases mental concentration flavonoid ehalth is Eating disorder helpline major component of Flabonoids, a mixture of flavonoids that comprise a subset hralth the secondary Organic sustainable fashion derived from Hajr marianum Flavonoids and hair health 1 ]. A number of recent in vivo studies have indicated that silibinin is a haie antioxidant Flavonoids and hair health effective pharma- cological and chemopreventive properties that can lower the risk of various cancers Increases mental concentration those of the skin, prostate, and lungs [ 2 - 4 ]. Silibinin has also been shown to neutralize the dermatological toxicity induced by various chemicals and ultraviolet-B radiation [ 1 ]. Silymarin and silibinin have been found to inhibit TPA O-tetradecanoyl- 13 phorbol acetate and okadaic acid-induced carcinogenesis in skin [ 56 ]. Studies in mouse models have revealed that silymarin decreases TPA-induced skin edema and epidermal hyperplasia [ 5 ]. Additionally, silibinin has been shown to function as an anti-inflammatory agent, specifically, by preventing both the activation of oxidant-induced cyclooxygenase and production of TPA-induced cytokines, including tumor necrosis factor alpha TNF- α and interleukin 1 alpha IL-1 α in mouse skin [ 5 ].Flavonoids and hair health -
Cancer Inst. Lahiri-Chatterjee M, Katiyar SK, Mohan RR, Agarwal R. A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model.
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Mouse models for human hair loss disorders. Topouzi H, Logan NJ, Williams G, Higgins CA. Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles. Higgins CA, Chen JC, Cerise JE, Jahoda CAB, Christiano AM.
Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth. Higgins CA, Richardson GD, Ferdinando D, Westgate GE, Jahoda CAB.
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Activating β-catenin signaling in CDpositive dermal papilla cells increases hair inductivity. FEBS J. Choi YM, An S, Lee J, Lee JH, Lee JN, Kim YS, et al. Titrated extract of Centella asiatica increases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells.
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Upton JH, Hannen RF, Bahta AW, Farjo N, Farjo B, Philpott MP. Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. Rastegar H, Ashtiani HA, Aghaei M, Barikbin B, Ehsani A. Herbal extracts induce dermal papilla cell proliferation of human hair follicles.
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Woo H, Lee S, Kim S, Park D, Jung E. Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation. Kang BM, Kwack MH, Kim MK, Kim JC, Sung YK. Sphere formation increases the ability of cultured human dermal papilla cells to induce hair follicles from mouse epidermal cells in a reconstitution assay.
de Lacharriere O, Deloche C, Misciali C, Piraccini BM, Vincenzi C, Bastien P, et al. Hair diameter diversity: a clinical sign reflecting the follicle miniaturization. Whiting DA. Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss. Kishimoto J, Burgeson RE, Morgan BA.
Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev. Zhou D, Tan RJ, Fu H, Liu Y. Lu W, Lin C, King TD, Chen H, Reynolds RC, Li Y.
Kim T, Oh S. Korean J. Meidan VM, Touitou E. Treatments for androgenetic alopecia and alopecia areata: current options and future prospects. Drugs 61 : Dinh QQ, Sinclair R. Female pattern hair loss: current treatment concepts. Jain R, Monthakantirat O, Tengamnuay P, De-Eknamkul W. Identification of a new plant extract for androgenic alopecia treatment using a non-radioactive human hair dermal papilla cell-based assay.
BMC Complement. Harel S, Higgins CA, Cerise JE, Dai Z, Chen JC, Clynes R, et al. Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.
Murkute A, Sahu M, Mali P, Rangari V. Development and evaluation of formulations of microbial biotransformed extract of tobacco leaves for hair growth potential. Pharmacognosy Res. Bureau JP, Ginouves P, Guilbaud J, Roux ME.
Essential oils and low-intensity electromagnetic pulses in the treatment of androgen-dependent alopecia. Article Tools. Endnote Style Full Text PDF. Hong, Sungwon , Byoung-Ho Moon , Yeonjoong Yong , Soon Young Shin , Young Han Lee and Yoongho Lim. PDF Standard view Export citation Share Twitter Linkedin E-mail Line.
Contents Figure Table References. Research article J. kr Received : October 26, ; Accepted : December 14, Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. Abstract Introduction Materials and Methods Results Discussion Acknowledgment Conflict of Interest.
Identification of an anti-inflammatory potential of Eriodictyon angustifolium compounds in human gingival fibroblasts. Food Funct. Redox Biol. Growth of melanocytic cells is associated with down-regulation of protein kinase C alpha, delta, and epsilon isoforms.
Possible role of diacylglycerol. Pigmented hair regeneration after wounding has recently been reported in a geriatric patient with a large wound on the scalp. Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient.
Tissue Viability , 27 , — In conclusion, flavonoids with two OH groups in the B-ring effectively regenerate pigmented hairs after skin wounding, whereas those with one OH group in the B-ring do not.
Our finding may guide further exploration of novel agents that induce pigmented hair regeneration. Nobuhiko Taguchi is an employee of Hoyu Co. The other authors declare no conflict of interest. Already have an account? Sign in here. Biological and Pharmaceutical Bulletin.
Online ISSN : Print ISSN : ISSN-L : Journal home Advance online publication All issues Featured articles About the journal. Flavonoids with Two OH Groups in the B-Ring Promote Pigmented Hair Regeneration.
Minoru Yuriguchi Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine Takuya Ando Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine Ryosuke Kitai Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine Hitomi Aoki Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine Takahiro Kunisada Corresponding author Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine.
Corresponding author. Keywords: flavonoid , wound healing , pigmentation , hair regeneration. JOURNAL FREE ACCESS FULL-TEXT HTML. The total polyphenol and flavonoid content contained in PBE was determined to be total polyphenol was 0. First, hair growth in each group was evaluated by qualitative observation and scoring Fig.
In the control group, pink-colored dorsal skin was apparent until 10 days of topical application of DW Fig. In this group, gray- and black-colored dorsal skin with short hairs was sparsely present at 17 days of DW application Fig.
At day 17, in this group, gray-colored dorsal skin was apparent and a significant progression of hair growth was observed compared with that in the control group Fig.
In addition, at day 17, fully grown fur was detected in these two groups Fig. D Hair growth-promoting scores. PBE, Pinus thunbergii bark extract. As presented in Fig. In the control group, a typical morphology of the hair follicles was observed Fig. No significant difference was detected in their hair follicles arrows between the two groups.
C Mean numbers of hair follicles and D mean thickness of epidermis. Ep, epidermis; D, dermis; HF, hair follicle; PBE, Pinus thunbergii bark extract. In the control group, the numbers of hair follicles and epithermal thickness 8.
In addition, no infiltration of inflammatory cells was observed in the dorsal skin following topical application of DW of PBE in any of the groups Fig.
The effect of PBE on inflammatory cytokines was then assessed Fig. At 17 days of treatment, TNF-α immunoreactivity in the skin of the control group was principally detected in the hair follicles Fig.
In the PBE group, significantly weakened TNF-α immunoreactivity control group was observed as compared with that in the control group Fig. A-D Immunohistochemical analysis of TNF-α and IL-1β in the dorsal skin at 17 days after the application. RODs of E TNF-α and F IL-1β in the dorsal skin at 17 days after the application.
control group. PBE, Pinus thunbergii bark extract; ROD, relative optical density. In addition, strong IL-1β immunoreactivity was obtained in the hair follicles of the control group at 17 days of the treatment Fig. In the PBE group, IL-1β immunoreactivity was significantly lower control group compared with that in the control group Fig.
The effect of PBE on anti-inflammatory cytokines was then assessed Fig. In the control group, immunoreactivity of IL-4 was fundamentally observed in the hair follicles at 17 days of treatment Fig. In the PBE group, the immunoreactivity of IL-4 was significantly increased control group when compared with that in the control group Fig.
A-D Immunohistochemical analysis of IL-4 and IL in the dorsal skin at 17 days after the application. RODs of E IL-4 and F IL in the dorsal skin at 17 days after the application. In addition, the immunoreactivity of IL in the control group was predominantly present in the hair follicles Fig.
In the PBE group, the immunoreactivity of IL was significantly enhanced The effect of PBE on growth factors was then assessed Fig. At 17 days of treatment, immunoreactivity of insulin-like growth factor IGF -I in the control group was weakly present in the hair follicles Fig.
In the PBE group, the immunoreactivity of IGF-I was significantly enhanced A-D Immunohistochemical analysis of IGF-I and VEGF in the dorsal skin at 17 days after the application. RODs of E IGF-I and F VEGF in the dorsal skin at 17 days after the application.
PBE, Pinus thunbergii bark extract; ROD, relative optical density; IGF, insulin-like growth factor. In addition, the immunoreactivity of VEGF in the control group was fundamentally detected in the hair follicles Fig. In the PBE group, a significantly elevated immunoreactivity of VEGF The results of the present study indicated that PBE contained polyphenols Plant-derived phenolic compounds, including flavonoids and phenolic acids, have recently attracted a great deal of interest due to their diverse beneficial effects For instance, Aronia melanocarpa Rosaceae family extract contains an abundance of chlorogenic acid an ester of L-quinic acid and caffeic acid and rutin 3-rhamnosyl-glucosylquercetin , which was able to prevent ultraviolet UV B-induced skin damage by regulating collagen fibers and metalloproteinases in mouse dorsal skin In addition, Rhodomyrtus tomentosa Myrtaceae family fruit extract contains numerous phenolic compounds, such as flavonols, anthocyanins and stilbenes 30 , and the extract ameliorates bacteria-induced acnes in human skin by reducing inflammatory lesions Furthermore, it is well known that phenolic compounds occur as major ingredients in the commercialized products extracted from Korean and French pine bark PineXol ® and Pycnogenol ® , respectively 12 , 32 , Pine bark extract has been widely used due to its beneficial attributes.
For instance, a previous study demonstrated that oral ingestion of Pycnogenol ® protected against skin damage induced by UV irradiation, modulated skin pigmentation and enhanced skin barrier function and extracellular matrix homeostasis In addition, in , Pavlou et al 34 reported that the bark extract of Aleppo pine Pinus halepensis protected keratinocytes against cigarette smoke-induced oxidative stress.
Of note, a recent study reported that Pinus thunbergii extract ameliorated lipopolysaccharide-induced acute inflammatory responses by regulating oxidative stress The mouse model of spontaneous alopecia is expensive to develop, in addition to the low success rate Therefore, pilot experiments involving androgenetic and chemotherapy-induced alopecia models were performed by our group and no significant differences in the hair growth rate following shaving of their dorsal hair were noted.
The physiological attributes of the hair growth cycle in mice differ from those in humans. In addition, alopecia is not naturally induced in mice.
Based on previous studies, although mice do not undergo a vellus-to-terminal hair type switch, or suffer from AGA, they are used as an excellent model system for studying the hair cycle for several reasons 39 , 40 : i The first two cycles of mouse hair follicles are synchronized, while in humans, neighboring follicles cycle independently of each other when biopsy is taken; ii the hair cycle of mice is short ~3 weeks ; by contrast, human scalp hairs have a cycle time of several years and even that of vellus hairs takes months.
Therefore, the short-synchronized hair cycle allows hair follicles to be harvested and examined at specific time-points in the cycle; and iii the stages of the hair cycle have been well characterized in the mouse. Anagen is subdivided morphologically into six and catagen into eight different stages 39 , In this regard, the current model does not completely reflect the pathophysiology of human alopecia.
Of note, the hair growth-promoting effects of various treatments have been assessed and for this, the telogen phase was induced by shaving dorsal hair in mice 3 , 41 — Based on these experimental data, shaving dorsal hair is regarded as acceptable to assess the hair growth-promoting effect.
However, no differences in cellular distribution and morphology of the dorsal skin tissue were detected following saline or PBE treatment. Inflammatory phenomena are increasingly being recognized as an integral part of the progress of AGA 44 , In AGA, the inflammatory response associated with connective tissue remodeling leads to permanent hair loss In addition, TE, which is another cause of diffuse hair loss, is triggered by stress, shock or traumatic events 46 , In AGA, scalp biopsies from both male and female patients exhibited follicular micro-inflammation and lymphocytic folliculitis following exposure to immunological stress 44 , A previous study by our group demonstrated the hair growth-promoting effect of Angelica gigas Nakai Umbelliferae family root extract mediated via regulating inflammatory cytokines 3.
In that study, the regulated pro- and anti-inflammatory cytokines, which were controlled by topical application with root extract of Angelica gigas Nakai, were attributed to upregulation of high-mobility group box 1 HMGB1 protein, which is an inflammatory modulator of the peri-follicular regions.
Furthermore, in , Hwang et al 11 reported that HMGB1 modulated prostaglandin E2 PGE 2 metabolism, which was closely associated with inflammatory response, and represented a potential therapeutic target in alopecia.
Furthermore, the previous study by our group indicated that the enhancement of both IL-4 and IL contributed to the hair growth-promoting effect 3.
Based on these studies, the effects may be related to the upregulation of IL-4 and IL, which may have a hair growth-promoting effect.
Pro-inflammatory cytokines, which are produced by activated immune cells, induce advanced inflammatory response By contrast, anti-inflammatory cytokines act as antagonists of pro-inflammatory cytokines by suppressing their expression and inhibiting their receptors The present study did not investigate the potential active ingredient s of PBE.
However, accumulating data indicate that maritime pine bark extract contains high levels of procyanidins and proanthocyanidins 18 , 53 , Based on previous studies, the bark extract of Pinus thunbergii , which is a Korean maritime pine, may also contain procyanidins and proanthocyanidins.
In addition, it has been reported that these two components exert anti-inflammatory activity 55 , Taken together, the phenolic compounds including flavonoids contained in the PBE contribute to excellent anti-inflammatory effects 57 , In addition, the results of the present study suggested that the immunoreactivity of IGF-I and VEGF was significantly increased in the hair follicles at 17 days of PBE treatment.
Accumulating experimental evidence demonstrated that growth factors, such as IGF-I, VEGF, fibroblast growth factor and epidermal growth factor, stimulate hair growth in vitro and in vivo 10 , 59 — Among these growth factors, IGF-I, a potent mitogen assisting cell growth in diverse types of tissues and cells, potently stimulates hair growth.
For instance, exogenous IGF-I promotes hair shaft elongation in human hair follicle cells by increasing platelet-derived growth factor, which induces anagen phase in the hair growth cycle VEGF, a growth factor stimulating vasculogenesis and angiogenesis, also facilitates hair growth by providing nutrients to the hair follicles In , Yano et al 10 reported that hair follicle-derived VEGF enhanced perifollicular angiogenesis and increased the number and size of hair follicles in mouse dorsal skin.
Furthermore, in , Ahn et al 8 reported that topical application with a mixture of Platycladus orientalis L. Franco Cupressaceae family leaf extract and α-terpineol promoted hair growth in mouse dorsal skin by elevating both IGF-I and VEGF levels in the hair follicles.
Taken together, the phenolic compounds including flavonoids present in the PBE were indicated to contribute to hair growth promotion by increasing IGF and VEGF. In the present study, no in vitro experiments were performed due to technical limitations and no western blot analysis was performed.
Therefore, in the future, the mechanisms of the hair growth-promoting effect of PBE will be investigated using in vitro approaches and western blot analysis and identify a dissolvent that is harmless to the skin and may enhance the hair growth-promoting effect of PBE.
In addition, the results of the present study revealed elevated VEGF following topical application of PBE. However, the degrees of vasodilation and angiogenesis were not assessed; therefore, it is suggested that PBE application-induced changes in vasodilation and angiogenesis require to be examined in the future.
In conclusion, the experimental results of the present study suggested that PBE contained polyphenols Furthermore, certain growth factors IGF-I and VEGF were significantly increased in the hair follicles.
The authors would like to express their appreciation to Mr. Seung Uk Lee Department of Neurobiology, School of Medicine, Kangwon National University and Ms. Hyun Sook Kim Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University for their technical help with this work.
This work was supported by the Basic Science Research Program through the National Research Foundation NRF of Korea funded by the Ministry of Education grant no. NRFR1A6A1A and by the Agriculture, Food and Rural Affairs Convergence Technologies Program for Educating Creative Global Leader grant no.
All data produced and analyzed in the current study are available from the corresponding author on reasonable request. YH and TKL wrote the draft of the manuscript.
JCL, DWK, SYC, MHW and SSK were responsible for experimental conceptualization, data curation and data analysis. YH, TKL, HS, JKH, JWL and JDK performed experiments and data collection and data analysis.
TKL and MHW confirm the authenticity of the raw data. SYC, MHW and SSK reviewed and edited the manuscript and acquired funding. All authors read and approved the final manuscript. KW; approval date, Jan. Hunt N and McHale S: The psychological impact of alopecia.
Liu F, Miao Y, Li X, Qu Q, Liu Y, Li K, Feng C and Hu Z: The relationship between self-esteem and hair transplantation satisfaction in male androgenetic alopecia patients. J Cosmet Dermatol.
Copyright: © Her et Increases mental concentration. This gealth an open access article distributed under the Soothing sunburns Increases mental concentration Creative Commons Attribution License. Although hair Beat bloating for good does Increases mental concentration Flavonoidss represent a serious health issue, it Flavonoixs a matter of interest as healyh may reduce confidence and lead to social anxiety, particularly in patients with alopecia, who manifest psychiatric symptoms, including depression, social phobia and anxiety, compared with normal individuals 12. Hair loss in humans may be triggered by diverse factors, including mental stress, heredity and drug therapy i. Alopecia may be largely divided into the following categories: Androgenetic alopecia AGAalopecia areata and telogen effluvium TE 4. Therefore, the treatment and management of alopecia depends on the cause and type of alopecia 235. ehalth 발명은 플리보노이드를 Quick water weight reduction 발모 Flavonoics 육모 Flavnooids 관한 Cayenne pepper health tonic, 특히 천연 식물 adn Flavonoids and hair health 유효성분으로 포함하여 부작용이 없으면서도 우수한 발모력을 나타내는 것을 Flavlnoids 하는 Flavonoids and hair health 및 육모 조성물에 hfalth 것이다. Increases mental concentration present invention relates to a Flavonoids and hair health growth Flavoniids hair growth composition containing a flavonoid, and in particular to a hair growth and hair growth composition comprising a flavonoid derived from a natural plant as an active ingredient and exhibits excellent hair growth without side effects. 탈모는 유전적 요인이 가장 주요한 원인으로 작용하며 이외에도 스트레스가 탈모인구 증가의 주요 원인으로 작용하고 있다. 최근 사회적 스트레스의 증가와 더불어 환경오염 및 인스턴트식품 등 서구화된 식습관, 잦은 파마와 염색, 잘못된 두피관리들로 인하여 탈모 인구가 점차 증가하고 있다. Hair loss is a major cause of genetic factors, and stress is also a major cause of hair loss.
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