Aging, cell senescence, diseade chronic disease: Peach passionfruit recovery drink therapeutic strategies. Sharing lessons learnt across European cardiovascular research consortia. Fontana L, Partridge L. BMC Med.

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Fasting and its possible role in longevity

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and Mary Sue Shannon Family Director, Center for Regenerative Medicine, Marriott Family Director, Comprehensive Cardiac Regenerative Medicine, and Marriott Family Professor at Mayo Clinic. Authors are supported by the National Institutes of Health R01 HL , Marriott Family Foundation, Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic Center for Regenerative Medicine, Gerstner Family Foundation, Mayo Clinic Center for Individualized Medicine, and Medical Scientist Training Program at Mayo Clinic.

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Also, most are women. Because of their healthy habits, these older adults are less likely to develop age-related chronic diseases, such as high blood pressure, heart disease, cancer, and diabetes, than their same-age peers. The siblings and children collectively called first-degree relatives of long-lived individuals are more likely to remain healthy longer and to live to an older age than their peers.

People with centenarian parents are less likely at age 70 to have the age-related diseases that are common among older adults. The brothers and sisters of centenarians typically have long lives, and if they develop age-related diseases such as high blood pressure, heart disease, cancer, or type 2 diabetes , these diseases appear later than they do in the general population.

Longer life spans tend to run in families, which suggests that shared genetics, lifestyle, or both play an important role in determining longevity. The study of longevity genes is a developing science. It is estimated that about 25 percent of the variation in human life span is determined by genetics, but which genes, and how they contribute to longevity, are not well understood.

A few of the common variations called polymorphisms associated with long life spans are found in the APOE , FOXO3 , and CETP genes, but they are not found in all individuals with exceptional longevity. It is likely that variants in multiple genes, some of which are unidentified, act together to contribute to a long life.

Whole genome sequencing studies of supercentenarians have identified the same gene variants that increase disease risk in people who have average life spans.

The supercentenarians, however, also have many other newly identified gene variants that possibly promote longevity. Scientists speculate that for the first seven or eight decades, lifestyle is a stronger determinant of health and life span than genetics.

Eating well, not drinking too much alcohol, avoiding tobacco, and staying physically active enable some individuals to attain a healthy old age; genetics then appears to play a progressively important role in keeping individuals healthy as they age into their eighties and beyond.

Many nonagenarians and centenarians are able to live independently and avoid age-related diseases until the very last years of their lives. These cellular functions include DNA repair, maintenance of the ends of chromosomes regions called telomeres , and protection of cells from damage caused by unstable oxygen-containing molecules free radicals.

Other genes that are associated with blood fat lipid levels, inflammation, and the cardiovascular and immune systems contribute significantly to longevity because they reduce the risk of heart disease the main cause of death in older people , stroke, and insulin resistance.

In addition to studying the very old in the United States, scientists are also studying a handful of communities in other parts of the world where people often live into their nineties and older—Okinawa Japan , Ikaria Greece , and Sardinia Italy.

These three regions are similar in that they are relatively isolated from the broader population in their countries, are lower income, have little industrialization, and tend to follow a traditional non-Western lifestyle.

Unlike other populations of the very old, the centenarians on Sardinia include a significant proportion of men. Researchers are studying whether hormones, sex-specific genes, or other factors may contribute to longer lives among men as well as women on this island.

Home Metformin and insulin resistance Eat less, live longer? The science of fasting and longevity. A fasting-mimicking diet could spur cellular repair and improve health, preventkon USC Leonard Davis Peach passionfruit recovery drink Valter Longo. When prveention comes Peach passionfruit recovery drink what, when and how disexse eat, fasting — voluntarily abstaining from food for varying periods of time — is having a moment. Seemingly ageless celebrities like Halle Berry and Hugh Jackman praise the practice for helping them to look, feel and even sleep better. Yet fasting is far from a fad. It was a part of life in ancient civilizations, and many religions today retain some form of the rite, often as a way to achieve focus and clarity.