Penn investigators Janos Tanyi, MD, PhD, and Sunil Singhal, MD, led its Phase 2 and 3 clinical trials leading to approval. And belzutifan marketed as Welirig , the first treatment of its kind to treat or intercept cancer in von Hippel-Lindau disease-associated tumors, such as those in renal cell carcinoma and central nervous system hemangioblastomas — a new cancer drug with Penn connections from basic science discovery about cancer hypoxia through to the definitive clinical trial leading to its approval.

On Jan. has dropped 33 percent. Every single drug you see advertised on TV — once upon a time, some patient somewhere was the first patient ever treated with it. This is why we do what we do.

Many therapies that start in oncology eventually have broader disease applications — like CAR T cell therapy, which is already showing promise with other diagnoses, like the autoimmune disease lupus.

Since , the FDA has approved more than two dozen new therapies with roots at Penn Medicine — almost half of which are first-in-class for their indications. The researchers said this showed that the enzyme — which only recently started being explored in cancer research — has the potential to be the basis of next-generation anti-cancer agents.

Using protein engineering, you need a separate mechanism for each component. We have achieved this and shown our strategy to be an interesting alternative to using the classical protein engineering approach. Click chemistry relies on two reaction partners click handles that can attach to each other very rapidly and selectively, without the production of any toxic by-products.

These click handles can be added to proteins, in this case using functionalised pyridazinediones PDs , allowing the proteins to click neatly together like LEGO.

The pioneers of click chemistry were awarded the Nobel Prize in Chemistry. Carolyn Bertozzi, the Anne T. By watching how the cells divide in response to certain chemical signals over time, the team is uncovering New Tumor Spatial Mapping Tool Will Help Clinicians Assess Aggressiveness of Cancer and Personalize Treatment.

Scientists Develop a Low-Cost Device to Make Cell Therapy Safer. The device can remove a large percentage of stem cells that have not yet fully become spinal cord Lung Cancer Hijacks Immune Cell Metabolism to Fuel Its Own Growth.

New Research Uncovers Biological Drivers of Heart Disease Risk. However, researchers lack efficient ways to explore how these genetic Using Cancer's Strength to Fight Against It. By studying mutations in malignant T cells that cause lymphoma, they zeroed A Study Finds a Molecular Mechanism Related to Neuronal Death.

This high energy demand for neuronal functions depends on the transport and precise distribution of New Approach for Fast and Cost-Effective Pathogen Detection.

A research team now develops intelligent, miniaturized The Unexpected Long-Term Consequences of Female Fertility. Scientists have now uncovered these New Cell Therapy Shows Promise With ARDS Patients.

The patients in Computer-Engineered DNA to Study Cell Identities. It will be used to screen for anti-cancer or viral infections drugs, or to Scientists Uncover a Crucial Link Between Cholesterol Synthesis and Cancer Progression. Specifically, the research reveals how the enzyme FAXDC2 influences cancer cell growth and Epigenetic Status Determines Metastasis.

Others leave the blood vessel and may then enter a Human Cells Building 'Molecular Highways' Captured for First Time. The findings lay the foundations for potential Diabetes and Liver Cancer: Study Suggests New Screening Guidelines. Highly Targeted CRISPR Delivery System Advances Gene Editing in Living Animals.