Resveratrol has been investigated Resverattol its potential use in preventing cancer and as Homemade pre-game meals adjuvant additional Homemade pre-game meals Resveatrol cancer treatments. Most Eco-friendly furniture designs supplements available in the US contain extracts of the root of Polygonum cuspidatumalso known as Fallopia japonicaJapanese knotweed, or Hu Zhang RSV vaccine errors in babies, pregnant people: Should you be worried? Copyright © Oregon State University Disclaimer.

Resveratrol side effects -

Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production. J Cardiovasc Pharmacol. Haider UG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM.

Resveratrol increases serinephosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells. Mnjoyan ZH, Fujise K.

Khandelwal AR, Hebert VY, Dugas TR. Essential role of ER-alpha-dependent NO production in resveratrol-mediated inhibition of restenosis. Duffy SJ, Vita JA. Effects of phenolics on vascular endothelial function. Curr Opin Lipidol. Klinge CM, Blankenship KA, Risinger KE, et al. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.

J Biol Chem. Klinge CM, Wickramasinghe NS, Ivanova MM, Dougherty SM. Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells.

FASEB J. Takahashi S, Nakashima Y. Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells. Br J Nutr. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease.

Clin Chim Acta. Shen MY, Hsiao G, Liu CL, et al. Br J Haematol. Yang YM, Chen JZ, Wang XX, Wang SJ, Hu H, Wang HQ. Resveratrol attenuates thromboxane A2 receptor agonist-induced platelet activation by reducing phospholipase C activity.

Eur J Pharmacol. Kodali M, Parihar VK, Hattiangady B, Mishra V, Shuai B, Shetty AK. Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation.

Sci Rep. Ma T, Tan MS, Yu JT, Tan L. Resveratrol as a therapeutic agent for Alzheimer's disease. Biomed Res Int. Chen J, Zhou Y, Mueller-Steiner S, et al.

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

Vingtdeux V, Giliberto L, Zhao H, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.

Neurochem Int. Capiralla H, Vingtdeux V, Zhao H, et al. J Neurochem. Ruszkiewicz J, Albrecht J. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders.

Albani D, Polito L, Batelli S, et al. The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta peptide.

Zhuang H, Kim YS, Koehler RC, Dore S. Potential mechanism by which resveratrol, a red wine constituent, protects neurons. Sakata Y, Zhuang H, Kwansa H, Koehler RC, Dore S. Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1. Exp Neurol.

Kumar A, Naidu PS, Seghal N, Padi SS. Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats.

Bishayee A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Bishayee A, Darvesh AS, Politis T, McGory R. Resveratrol and liver disease: from bench to bedside and community. Liver Int. Hecht SS, Kenney PM, Wang M, et al.

Berge G, Ovrebo S, Eilertsen E, Haugen A, Mollerup S. Br J Cancer. Schneider Y, Duranton B, Gosse F, Schleiffer R, Seiler N, Raul F.

Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr Cancer. Sengottuvelan M, Nalini N. Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development.

Ziegler CC, Rainwater L, Whelan J, McEntee MF. J Nutr. Patel KR, Brown VA, Jones DJ, et al. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

Howells LM, Berry DP, Elliott PJ, et al. Phase I randomized, double-blind pilot study of micronized resveratrol SRT in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics.

Popat R, Plesner T, Davies F, et al. A phase 2 study of SRT resveratrol with bortezomib for patients with relapsed and or refractory multiple myeloma. Smoliga JM, Blanchard O. Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution?

Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. Lippi G, Franchini M, Favaloro EJ, Targher G. Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox".

Semin Thromb Hemost. Salvamani S, Gunasekaran B, Shaharuddin NA, Ahmad SA, Shukor MY. Antiartherosclerotic effects of plant flavonoids. Gronbaek M, Becker U, Johansen D, et al.

Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Ann Intern Med. Klatsky AL, Friedman GD, Armstrong MA, Kipp H. Wine, liquor, beer, and mortality. Am J Epidemiol.

Renaud SC, Gueguen R, Siest G, Salamon R. Wine, beer, and mortality in middle-aged men from eastern France. Arch Intern Med. Mukamal KJ, Conigrave KM, Mittleman MA, et al.

Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ. Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits.

Wannamethee SG, Shaper AG. Type of alcoholic drink and risk of major coronary heart disease events and all-cause mortality. Am J Public Health. Barefoot JC, Gronbaek M, Feaganes JR, McPherson RS, Williams RB, Siegler IC.

Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart Study. McCann SE, Sempos C, Freudenheim JL, et al. Alcoholic beverage preference and characteristics of drinkers and nondrinkers in western New York United States. Nutr Metab Cardiovasc Dis. Mortensen EL, Jensen HH, Sanders SA, Reinisch JM.

Better psychological functioning and higher social status may largely explain the apparent health benefits of wine: a study of wine and beer drinking in young Danish adults. Johansen D, Friis K, Skovenborg E, Gronbaek M. Food buying habits of people who buy wine or beer: cross sectional study.

Ruidavets JB, Bataille V, Dallongeville J, et al. Alcohol intake and diet in France, the prominent role of lifestyle. Eur Heart J. Stocker R, O'Halloran RA. Dealcoholized red wine decreases atherosclerosis in apolipoprotein E gene-deficient mice independently of inhibition of lipid peroxidation in the artery wall.

De Curtis A, Murzilli S, Di Castelnuovo A, et al. Alcohol-free red wine prevents arterial thrombosis in dietary-induced hypercholesterolemic rats: experimental support for the 'French paradox'. J Thromb Haemost. Lekakis J, Rallidis LS, Andreadou I, et al.

Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil. Karatzi K, Karatzis E, Papamichael C, Lekakis J, Zampelas A.

Effects of red wine on endothelial function: postprandial studies vs clinical trials. Grover-Paez F, Zavalza-Gomez AB. Endothelial dysfunction and cardiovascular risk factors. Diabetes Res Clin Pract. Wang Z, Huang Y, Zou J, Cao K, Xu Y, Wu JM.

Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med. Kirk RI, Deitch JA, Wu JM, Lerea KM. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole blood.

Blood Cells Mol Dis. Szewczuk LM, Forti L, Stivala LA, Penning TM. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX a mechanistic approach to the design of COX-1 selective agents. Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol.

Br J Pharmacol. Fukao H, Ijiri Y, Miura M, et al. Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice.

Blood Coagul Fibrinolysis. Wang Z, Zou J, Huang Y, Cao K, Xu Y, Wu JM. Effect of resveratrol on platelet aggregation in vivo and in vitro. Chin Med J Engl. Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL. Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci. Fujitaka K, Otani H, Jo F, et al.

Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment. Nutr Res. Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Wong RH, Berry NM, Coates AM, et al. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults.

J Hypertens. Agarwal B, Campen MJ, Channell MM, et al. Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium.

Int J Cardiol. Tome-Carneiro J, Gonzalvez M, Larrosa M, et al. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease.

Am J Cardiol. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial.

Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease.

Cardiovasc Drugs Ther. Tome-Carneiro J, Larrosa M, Yanez-Gascon MJ, et al. One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease.

Pharmacol Res. Liu Y, Ma W, Zhang P, He S, Huang D. Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials. Clin Nutr. Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective.

Heilbronn LK, Ravussin E. Calorie restriction and aging: review of the literature and implications for studies in humans. Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Howitz KT, Bitterman KJ, Cohen HY, et al.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Wood JG, Rogina B, Lavu S, et al.

Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.

Curr Biol. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Semba RD, Ferrucci L, Bartali B, et al. Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Intern Med. Brown K, Rufini A, Gescher A.

Do not throw out the resveratrol with the bath water. Glaser JH. Effect of wine consumption on mortality. Wang J, Ho L, Qin W, et al. Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease.

Aguirre L, Fernandez-Quintela A, Arias N, Portillo MP. Resveratrol: anti-obesity mechanisms of action. Kennedy DO, Wightman EL, Reay JL, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.

Witte AV, Kerti L, Margulies DS, Floel A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci. Pasinetti GM, Wang J, Ho L, Zhao W, Dubner L. Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment.

Biochim Biophys Acta. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, Atlanta, GA: US Department of Health and Human Services. Szkudelski T, Szkudelska K.

Resveratrol and diabetes: from animal to human studies. Movahed A, Nabipour I, Lieben Louis X, et al. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Alternat Med. Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus.

Brasnyo P, Molnar GA, Mohas M, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Poulsen MM, Vestergaard PF, Clasen BF, et al. High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition.

Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.

Cell Metab. Yoshino J, Conte C, Fontana L, et al. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Carpene C, Gomez-Zorita S, Deleruyelle S, Carpene MA. Novel strategies for preventing diabetes and obesity complications with natural polyphenols.

Curr Med Chem. Hausenblas HA, Schoulda JA, Smoliga JM. Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis.

Liu K, Zhou R, Wang B, Mi MT. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. Burns J, Yokota T, Ashihara H, Lean ME, Crozier A. Plant foods and herbal sources of resveratrol. Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR.

Resveratrol, pterostilbene, and piceatannol in vaccinium berries. Sanders TH, McMichael RW, Jr. Occurrence of resveratrol in edible peanuts. Hurst WJ, Glinski JA, Miller KB, Apgar J, Davey MH, Stuart DA. Survey of the trans-resveratrol and trans-piceid content of cocoa-containing and chocolate products.

Creasey LL, Coffee M. Phytoalexin production potential of grape berries. J Am Soc Hortic Sci. Fremont L. Biological effects of resveratrol. Goldberg DM, Karumanchiri A, Ng E, Yan J, Eleftherios P, Soleas G. Direct gas chromatographic-mass spectrometric method to assay cis-resveratrol in wines: preliminary survey of its concentration in commercial wines.

Guerrero RF, Garcia-Parrilla MC, Puertas B, Cantos-Villar E. Wine, resveratrol and health: a review. Nat Prod Commun. Stervbo U, Vang O, Bonnesen C. A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine.

Food Chemistry. Sobolev VS, Cole RJ. trans-resveratrol content in commercial peanuts and peanut products. Hendler SS, Rorvik DR, eds, eds. PDR for Nutritional Supplements. Williams LD, Burdock GA, Edwards JA, Beck M, Bausch J.

Safety studies conducted on high-purity trans-resveratrol in experimental animals. Food Chem Toxicol. Johnson WD, Morrissey RL, Usborne AL, et al. Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity.

Gescher A, Steward WP, Brown K. Resveratrol in the management of human cancer: how strong is the clinical evidence? American Academy of Pediatrics. Committee on Substance Abuse and Committee on Children With Disabilities. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders.

Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React. Koe XF, Tengku Muhammad TS, Chong AS, Wahab HA, Tan ML. Cytochrome P induction properties of food and herbal-derived compounds using a novel multiplex RT-qPCR in vitro assay, a drug-food interaction prediction tool.

Food Sci Nutr. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components.

Toxicol Lett. Regev-Shoshani G, Shoseyov O, Kerem Z. Influence of lipophilicity on the interactions of hydroxy stilbenes with cytochrome P 3A4. Detampel P, Beck M, Krahenbuhl S, Huwyler J. Drug interaction potential of resveratrol.

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Toggle menu Go to search page. Search Field. You are here Dietary Factors » Phytochemicals » Resveratrol. Contents Summary Introduction Metabolism and Bioavailability Biological Activities Direct antioxidant activity Estrogenic and anti-estrogenic Cancer prevention Cardiovascular disease prevention Neurodegenerative disease prevention Disease Prevention Cancer Cardiovascular disease Longevity Cognitive decline Disease Treatment Impaired glucose tolerance and type 2 diabetes Sources Food Supplements Safety Adverse effects Pregnancy and lactation Estrogen-sensitive conditions Drug interactions Authors and Reviewers References.

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Disclaimer The Linus Pauling Institute's Micronutrient Information Center provides scientific information on the health aspects of dietary factors and supplements, food, and beverages for the general public. Like resveratrol, each of these supplements has antioxidant and anti-inflammatory properties that may benefit cardiovascular health, joint health, and cognitive function.

Many of these compounds are being studied for their potential anti-cancer effects. Taking these supplements alongside resveratrol is generally safe, but it is important to be mindful of possible interactions or side effects. Resveratrol is found in several dietary sources, including red wine, grapes, berries, and peanuts.

The amounts of resveratrol in these sources vary, and research shows that it is not possible to absorb the recommended therapeutic doses of resveratrol through diet alone. Therefore, supplements may be a more reliable way to ensure you get the therapeutic benefits of resveratrol.

Resveratrol is a natural compound found in various plant-based foods, particularly in the skins of red grapes and berries. Common food sources of resveratrol include:.

Resveratrol is available in capsule, tablet, powder, liquid, and gummy forms. Capsules and tablets are the most commonly used and can be taken with water. Liquids may be a good option if you have difficulty swallowing pills or prefer to add resveratrol to your food or drinks.

There is no evidence to suggest that one form of resveratrol is superior to others in terms of efficacy. The supplement's potency can vary, depending on the amount of resveratrol in the supplement and manufacturer. When shopping for resveratrol supplements, look for a high-quality product from a reputable brand.

Resveratrol is a naturally occurring polyphenol compound in grape skins, berries, and peanuts. It is also available as a dietary supplement.

Packed with antioxidant, anti-inflammatory, and anticancer compounds, resveratrol may benefit cardiovascular, joint, and metabolic health and improve cognitive function.

If you are considering using resveratrol to support your health, talk to a healthcare provider to determine if it is safe for you, especially if you have any health conditions or are taking medications.

When shopping for resveratrol supplements, choose a reputable brand, and follow the recommended dosage guidelines. Koushki M, Amiri-Dashatan N, Ahmadi N, Abbaszadeh HA, Rezaei-Tavirani M. Resveratrol: A miraculous natural compound for diseases treatment.

Food Sci Nutr. Oregon State University. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: a double-edged sword in health benefits. Cheng CK, Luo JY, Lau CW, Chen ZY, Tian XY, Huang Y.

Pharmacological basis and new insights of resveratrol action in the cardiovascular system. Br J Pharmacol. Li H, Xia N, Hasselwander S, Daiber A. Resveratrol and vascular function. Int J Mol Sci. Singh A, Kukreti R, Saso L, Kukreti S.

Oxidative stress: a key modulator in neurodegenerative diseases. Dias GP, Cocks G, do Nascimento Bevilaqua MC, Nardi AE, Thuret S. Resveratrol: A potential hippocampal plasticity enhancer. Oxid Med Cell Longev. Gu J, Li Z, Chen H, Xu X, Li Y, Gui Y. Neuroprotective effect of trans-resveratrol in mild to moderate Alzheimer's disease: A randomized, double-blind trial.

Neurol Ther. Zhou Q, Wang Y, Han X, Fu S, Zhu C, Chen Q. Efficacy of resveratrol supplementation on glucose and lipid metabolism: a meta-analysis and systematic review. Front Physiol.

Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res.

Mahjabeen W, Khan DA, Mirza SA. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.

Complement Ther Med. Hou CY, Tain YL, Yu HR, Huang LT. The effects of resveratrol in the treatment of metabolic syndrome. Marouf BH, Hussain SA, Ali ZS, Ahmmad RS. Resveratrol supplementation reduces pain and inflammation in knee osteoarthritis patients treated with Meloxicam: A randomized placebo-controlled study.

J Med Food. Sheng S, Wang X, Liu X, et al. The role of resveratrol on rheumatoid arthritis: From bench to bedside. Front Pharmacol. Ko JH, Sethi G, Um JY, et al. The role of resveratrol in cancer therapy.

Arabzadeh A, Mortezazadeh T, Aryafar T, Gharepapagh E, Majdaeen M, Farhood B. Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review.

Cancer Cell International. Xiao Q, Zhu W, Feng W, et al. A review of resveratrol as a potent chemoprotective and synergistic agent in cancer chemotherapy.

doi: Zhou DD, Luo M, Huang SY, et al. Effects and mechanisms of resveratrol on aging and age-related diseases. Lv C, Zhang Y, Shen L. Preliminary clinical effect evaluation of resveratrol in adults with allergic rhinitis.

Ratz-Łyko A, Arct J. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. J Cosmet Laser Ther. Abu-Amero KK, Kondkar AA, Chalam KV. Resveratrol and ophthalmic diseases. Malaguarnera L. Influence of resveratrol on the immune response. Published Apr Susan G.

Komen Foundation. Ramírez-Garza SL, Laveriano-Santos EP, Marhuenda-Muñoz M, et al. Health effects of resveratrol: results from human intervention trials. Mukherjee S, Dudley JI, Das DK. Dose-dependency of resveratrol in providing health benefits.

Dose Response. Shaito A, Posadino AM, Younes N, et al. Potential adverse effects of resveratrol: A literature review. Inchingolo AD, Inchingolo AM, Malcangi G, et al. Effects of resveratrol, curcumin and quercetin supplementation on bone metabolism-a systematic review.

Chan EWC, Wong CW, Tan YH, Foo JPY, Wong SK, Chan HT. R esveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties. J App Pharm Sci. Amin ARMR, Wang D, Nannapaneni S, Lamichhane R, Chen ZG, Shin DM. Combination of resveratrol and green tea epigallocatechin gallate induces synergistic apoptosis and inhibits tumor growth in vivo in head and neck cancer models.

Oncol Rep. McCubrey JA, Lertpiriyapong K, Steelman LS, et al. Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs.

Aging Albany NY. Weiskirchen S, Weiskirchen R. Resveratrol: How much wine do you have to drink to stay healthy? Adv Nutr. Use limited data to select advertising. Create profiles for personalised advertising. Use profiles to select personalised advertising.

Resveratrol offers Ressveratrol, anti-aging, Resveratrol side effects heart healthy benefits. Rebecca Jaspan is a registered Homemade pre-game meals specializing in anorexia, binge eating disorder, and bulimia, siide well as disordered eating and orthorexia. Anisha Shah, MD, is a board-certified internist, interventional cardiologist, and fellow of the American College of Cardiology. Shereen Lehman, MS, is a former writer for Verywell Fit and Reuters Health. She's a healthcare journalist who writes about healthy eating and offers evidence-based advice for regular people.

Resveratrol side effects -

Many of these compounds are being studied for their potential anti-cancer effects. Taking these supplements alongside resveratrol is generally safe, but it is important to be mindful of possible interactions or side effects.

Resveratrol is found in several dietary sources, including red wine, grapes, berries, and peanuts. The amounts of resveratrol in these sources vary, and research shows that it is not possible to absorb the recommended therapeutic doses of resveratrol through diet alone.

Therefore, supplements may be a more reliable way to ensure you get the therapeutic benefits of resveratrol. Resveratrol is a natural compound found in various plant-based foods, particularly in the skins of red grapes and berries. Common food sources of resveratrol include:.

Resveratrol is available in capsule, tablet, powder, liquid, and gummy forms. Capsules and tablets are the most commonly used and can be taken with water. Liquids may be a good option if you have difficulty swallowing pills or prefer to add resveratrol to your food or drinks.

There is no evidence to suggest that one form of resveratrol is superior to others in terms of efficacy. The supplement's potency can vary, depending on the amount of resveratrol in the supplement and manufacturer. When shopping for resveratrol supplements, look for a high-quality product from a reputable brand.

Resveratrol is a naturally occurring polyphenol compound in grape skins, berries, and peanuts. It is also available as a dietary supplement. Packed with antioxidant, anti-inflammatory, and anticancer compounds, resveratrol may benefit cardiovascular, joint, and metabolic health and improve cognitive function.

If you are considering using resveratrol to support your health, talk to a healthcare provider to determine if it is safe for you, especially if you have any health conditions or are taking medications. When shopping for resveratrol supplements, choose a reputable brand, and follow the recommended dosage guidelines.

Koushki M, Amiri-Dashatan N, Ahmadi N, Abbaszadeh HA, Rezaei-Tavirani M. Resveratrol: A miraculous natural compound for diseases treatment.

Food Sci Nutr. Oregon State University. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: a double-edged sword in health benefits. Cheng CK, Luo JY, Lau CW, Chen ZY, Tian XY, Huang Y. Pharmacological basis and new insights of resveratrol action in the cardiovascular system.

Br J Pharmacol. Li H, Xia N, Hasselwander S, Daiber A. Resveratrol and vascular function. Int J Mol Sci. Singh A, Kukreti R, Saso L, Kukreti S. Oxidative stress: a key modulator in neurodegenerative diseases.

Dias GP, Cocks G, do Nascimento Bevilaqua MC, Nardi AE, Thuret S. Resveratrol: A potential hippocampal plasticity enhancer. Oxid Med Cell Longev. Gu J, Li Z, Chen H, Xu X, Li Y, Gui Y. Neuroprotective effect of trans-resveratrol in mild to moderate Alzheimer's disease: A randomized, double-blind trial.

Neurol Ther. Zhou Q, Wang Y, Han X, Fu S, Zhu C, Chen Q. Efficacy of resveratrol supplementation on glucose and lipid metabolism: a meta-analysis and systematic review. Front Physiol. Bhatt JK, Thomas S, Nanjan MJ.

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res. Mahjabeen W, Khan DA, Mirza SA. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.

Complement Ther Med. Hou CY, Tain YL, Yu HR, Huang LT. The effects of resveratrol in the treatment of metabolic syndrome. Marouf BH, Hussain SA, Ali ZS, Ahmmad RS. Resveratrol supplementation reduces pain and inflammation in knee osteoarthritis patients treated with Meloxicam: A randomized placebo-controlled study.

J Med Food. Sheng S, Wang X, Liu X, et al. The role of resveratrol on rheumatoid arthritis: From bench to bedside. Front Pharmacol. Ko JH, Sethi G, Um JY, et al. The role of resveratrol in cancer therapy. Arabzadeh A, Mortezazadeh T, Aryafar T, Gharepapagh E, Majdaeen M, Farhood B.

Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review.

Cancer Cell International. Xiao Q, Zhu W, Feng W, et al. A review of resveratrol as a potent chemoprotective and synergistic agent in cancer chemotherapy.

doi: Zhou DD, Luo M, Huang SY, et al. Effects and mechanisms of resveratrol on aging and age-related diseases. Lv C, Zhang Y, Shen L. Preliminary clinical effect evaluation of resveratrol in adults with allergic rhinitis.

Ratz-Łyko A, Arct J. Department of Agriculture. Scientific Report of the Dietary Guidelines Advisory Committee. Alcoholic beverages. Is drinking alcohol part of a healthy lifestyle?

American Heart Association. Drinking red wine for heart health? Read this before you toast. Krittanawong C, et al. Alcohol consumption and cardiovascular health. The American Journal of Medicine. Lopez-Jimenez F expert opinion.

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About Mayo Clinic. About this Site. Contact Us. Health Information Policy. Media Requests. News Network. Systolic blood pressure typically goes up with age, as arteries stiffen.

Resveratrol may accomplish this blood-pressure-lowering effect by helping to produce more nitric oxide, which causes blood vessels to relax 10 , However, the authors of that study say more research is needed before specific recommendations can be made about the best dose of resveratrol to maximize blood pressure benefits.

Resveratrol supplements may help lower blood pressure by increasing the production of nitric oxide.

Several studies in animals have suggested that resveratrol supplements may change blood fats in a healthy way 12 , A study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements. Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production LDL oxidation contributes to plaque buildup in artery walls 9 , In one study, participants were given grape extract that had been boosted with extra resveratrol.

After six months of treatment, their LDL had gone down by 4. Resveratrol supplements may benefit blood fats in animals. As an antioxidant, they may also decrease LDL cholesterol odixation. It works to achieve this in the same way as calorie restriction, which has shown promise in lengthening lifespans by changing how genes express themselves 18 , Resveratrol supplements have lengthened lifespan in animal studies.

Several studies have suggested that drinking red wine can help slow down age-related cognitive decline 21 , 22 , 23 , Additionally, the compound may set off a chain of events that protects brain cells from damage While this research is intriguing, scientists still have questions about how well the human body is able to make use of supplemental resveratrol, which limits its immediate use as a supplement to protect the brain 1 , 2.

A potent antioxidant and anti-inflammatory compound, resveratrol shows promise in protecting brain cells from damage. These benefits include increasing insulin sensitivity and preventing complications from diabetes 26 , 27 , 28 , One explanation for how resveratrol works is that it may stop a certain enzyme from turning glucose into sorbitol, a sugar alcohol.

When too much sorbitol builds up in people with diabetes, it can create cell-damaging oxidative stress 30 , Here are a few more benefits resveratrol may have for people with diabetes 28 :. Researchers say the compound could be used to treat diabetes and its complications in the future, but more research is needed.

Resveratrol has helped mice develop better insulin sensitivity and fight complications of diabetes. In the future, humans with diabetes might also benefit from resveratrol therapy. Arthritis is a common affliction that leads to joint pain and loss of mobility Plant-based supplements are being studied as a way to treat and prevent joint pain.

When taken as a supplement, resveratrol may help protect cartilage from deteriorating 33 , Cartilage breakdown can cause joint pain and is one of the main symptoms of arthritis One study injected resveratrol into the knee joints of rabbits with arthritis and found that these rabbits suffered less damage to their cartilage Other research in test tubes and animals has suggested that the compound has potential to reduce inflammation and prevent damage to joints 33 , 35 , 36 , Resveratrol has been studied, especially in test tubes, for its ability to prevent and treat cancer.

However, results have been mixed 30 , 38 , In animal and test-tube studies, it has been shown to fight several kinds of cancer cells, including gastric, colon, skin, breast and prostate 40 , 41 , 42 , 43 , However, since the studies so far have been carried out in test tubes and animals, much more research is needed to see if and how this compound might be used for human cancer therapy.

No major risks have been revealed in studies that have used resveratrol supplements.

New Resveratrol side effects Ressveratrol little risk of infection from prostate biopsies. Discrimination at work is Homemade pre-game meals to high sidee pressure. Icy Resveratrol side effects and toes: Poor circulation or Raynaud's phenomenon? Rffects CONTENT: As a service to Beauty-enhancing nutrients readers, Harvard Health Publishing provides access to our library of archived content. Please note the date each article was posted or last reviewed. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Oh, the giddy abandon that overtakes some headline writers when crowning a story about resveratrol, a chemical found in red wine. Resveratroo is a Thermogenic fat-burning secrets polyphenol compound in certain plants and fruits, including grapes, berries, siide, and peanuts. In supplement form, most resveratrol Resveratrol side effects are Reveratrol from Effcts root of Polygonum cuspidatumalso known as the Japanese knotweed plant. Resveratrol is rich in antioxidantanti-inflammatory, and anticancer properties that may help relieve joint pain and benefit cardiovascular, brain, and metabolic health. This article discusses resveratrol's potential uses, benefits, and side effects. Unlike drugs, dietary supplements are not regulated in the United States, meaning the Food and Drug Administration FDA does not approve them for safety and effectiveness before products are marketed.