A analysis of existing research studies found that SAM-e improved symptoms of depression in eight studies. However, each of these studies had methodological flaws.

In a separate analysis , SAM-e worked better than a placebo in six placebo-controlled trials. According to the NCCIH, SAM-e may not be safe for people with bipolar disorder because it may increase mania symptoms.

People living with HIV should also avoid SAM-e because it may encourage the growth of Pneumocystis jirovecii , which could lead to pneumonia. Some studies show that St.

Researchers do not know if St. Some research suggests that St. In some studies, St. A review of previous research studies found that St. However, little data suggested that it works well to treat severe depression, or that it can be a long-term depression treatment.

Some types of fatty fish, such as tuna and albacore, contain omega-3 fatty acids. People who do not eat fish and want to boost their omega-3 levels can take them as supplements. According to a analysis of 20 clinical trials, large doses of omega-3 fatty acids may improve mood and treat depression.

More findings from a report show that omega-3s may help with depression in both adults and children. Researchers do not know how or why omega-3s work. They may reduce inflammation or reduce the effects of the stress-related hormone cortisol.

At high doses, omega-3s may cause a fishy aftertaste or an upset stomach. According to a clinical trial , they may also thin the blood. People with clotting disorders and blood thinners should carefully regulate how much omega-3 they consume.

As many people with depression also experience anxiety and sleep issues, lavender could help them sleep without the side effects of sleeping pills. According to a systematic review inhaling lavender aromas before sleeping, did help people get to sleep.

However, the studies were small, and most had methodological issues, so researchers need to do more studies to support the findings. However, a randomized controlled trial does provide more evidence that lavender may help with sleep. In that study, two groups practiced healthy sleep hygiene, with one group wearing a lavender aromatherapy patch.

Both groups were sleeping better, but the results were stronger in the lavender group. Parents of pre-pubescent children should use lavender oils or extracts with caution.

A case report suggests that lavender may increase estrogen and cause premature breast enlargement. More studies are needed to confirm this. Some suggest it may ease symptoms of depression. A study on mice suggests it might be a viable alternative for treatment-resistant depression.

However, there is not enough research on 5-HTP to conclude if it is an effective treatment for depression.

A very small number of studies suggest it may ease some mental health symptoms, including PTSD , depression, and anxiety. However, DHEA causes many side effects. It may interact with a wide range of drugs, increase the risk of certain types of cancer , change blood sugar, affect menstruation and fertility, and cause bleeding.

Other treatments are safer. Researchers have not studied all antidepressants, including some herbal medicines. If you have health insurance, you are encouraged to contact your insurer for a list of participating health care providers and facilities. The service is confidential.

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What Is Substance Abuse Treatment? A Booklet for Families Created for family members of people with alcohol abuse or drug abuse problems.

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Neeraj Gandotra, M. Plus, the NAC supplements were safe and well tolerated This supplement from Pure Encapsulations is a great NAC supplement because it contains just one active ingredient and is tested multiple times throughout manufacturing.

Vitamin D is a critical nutrient that plays numerous essential roles in your body. Research shows that people with depression are more likely to be low or deficient in vitamin D. Those with the condition tend to have lower vitamin D levels than the general population, and people with the lowest levels tend to have the most significant depressive symptoms Vitamin D may reduce the risk of depression through several mechanisms, including by reducing inflammation, regulating mood, and protecting against neurocognitive dysfunction Several studies in people with depression suggest that taking vitamin D supplements may lead to significant improvements in depressive symptoms, quality of life, and illness severity 19 , Keep in mind that more research is needed before vitamin D can be recommended as a universal treatment for depression.

Thorne is certified by NSF International, an organization that inspects manufacturing facilities and tests supplements for quality and potency. B vitamins play important roles in brain function and mood regulation. B vitamins, including folate, B12, and B6, are necessary for the production and regulation of neurotransmitters such as serotonin, gamma-aminobutyric acid GABA , and dopamine Older research suggests that deficiencies in vitamin B12 and folate may increase the risk of depression and that supplementing with these nutrients may help reduce depressive symptoms in certain populations 23 , 24 , 25 , An older study also found B12 injections to be beneficial in people with MDD when used alongside antidepressant medication Additionally, a review suggested that taking vitamin B12 supplements earlier in life may delay the onset of depression and improve the effects of antidepressant medications Vitamin B6 has also been found to improve depressive symptoms when used in combination with other nutrients, including tryptophan and a form of vitamin B3 called nicotinamide Because several B vitamins may benefit people with depression, a B-complex supplement that contains all eight B vitamins may be the best choice.

Klaire Labs B-Complex Plus contains all eight B vitamins, including active forms of folate and B12 for better absorption. It also boasts antioxidant and anti-inflammatory properties Zinc deficiency is strongly linked to an increased risk of depression and depression symptom severity A analysis found that zinc supplementation significantly lowered symptom scores in people with depression Additionally, a analysis of 5 studies suggested that zinc supplementation may be useful for reducing depressive symptoms in people with clinical depression who are taking antidepressant medications.

The studies used zinc doses of about 10—25 mg S -Adenosylmethionine SAMe is a sulfur-containing compound that has shown promise in the treatment of depression. A review of 8 studies found that SAMe, when used alone or with antidepressant medications, improved depressive symptoms in people with MDD.

The studies used doses of —3, mg and treatment times of 2—12 weeks While this is promising, keep in mind that more research is needed before strong conclusions can be made.

Jarrow Formulas products are third-party tested by U. Department of Agriculture USDA accredited laboratories. Magnesium deficiency is common among people with depression, and research shows that supplementing with it may reduce depressive symptoms A randomized study in people with mild to moderate depression found that taking mg of magnesium per day for 6 weeks significantly improved depressive symptoms compared with a placebo Bluebonnet Magnesium Glycinate provides mg of magnesium per capsule.

You can adjust your dose depending on how much magnesium you need. Creatine is an organic acid that plays an important role in maintaining brain energy, among other functions.

Altered brain energy levels are thought to be involved in the development of depression Some studies suggest that supplementing with 2—10 grams of creatine per day may reduce symptoms in people with MDD This protective effect seemed to be strongest in females, people ages 20—39, and those not taking antidepressant or anti-anxiety medication Thorne Creatine is a great creatine supplement because it contains just one ingredient and is NSF Certified for Sport — a third-party certification ensuring that the product is free of more than substances banned by major athletics organizations.

Everyone feels low from time to time. However, depression is completely different from a low mood. Depression causes a persistent feeling of sadness and causes you to lose interest in things you once enjoyed. While you wait for help to arrive, stay with someone and remove any weapons or substances that can cause harm.

You are not alone. Studies show that certain dietary supplements, including omega-3s, vitamin D, rhodiola, B12, and saffron, may be helpful for reducing depressive symptoms in some people. Be sure to clear any new dietary supplement with a healthcare professional before taking it.

A healthcare professional can help you decide which supplements may be the most appropriate based on factors like your medical history, medications, and laboratory values. There is no one best supplement for people with depression.

Although some supplements have been shown to benefit certain populations with depression, not everyone will benefit from the same supplements. Every person with depression has different needs and should work with a healthcare professional to create an individualized care plan, which may or may not involve dietary supplements.

While some herbs, such as rhodiola and chamomile, may be helpful for reducing or managing symptoms in some individuals, there is no best herb for treating anxiety or depression Depression is a mental health condition that affects millions of people worldwide.

Although depression is typically treated with medication and therapy, some people may want to try other safe methods, such as dietary modifications or supplements, to reduce their symptoms. The supplements in this article have been studied for their potential to reduce depressive symptoms and may be appropriate for some people with depression.

Read this article in Spanish. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. VIEW ALL HISTORY.

Want to supplement your seasonal depression treatment?

Optum Store, Optum Perks, and Healthline Media are owned by RVO Health. Healthline only shows you brands and products that we stand behind. Depression is a mental health condition that affects more than 17 million adults in the United States alone.

Below are the five classifications of depressive disorders, which share features such as sadness, irritability, a feeling of emptiness, and changes in the body and brain that affect daily functioning 2 :.

Depressive disorders are treated with medication and psychotherapy. In addition, lifestyle modifications , such as making dietary changes and taking certain supplements, may help people recover and reduce the chance of relapse.

For example, some research shows that specific vitamins, minerals, herbs, and other compounds may provide added benefits in improving depressive symptoms. While supplements may be helpful in managing depression, they are not a cure for the condition.

Therefore, when selecting supplements, be wary of products that claim to treat or cure depression. There are a ton of dietary supplements on the market, but not all of them are safe and effective.

One dollar sign means the product is rather affordable, whereas four dollar signs indicate a higher cost. Therefore, a product that you need to take fewer times per day may end up being comparatively cheaper, despite having a higher price per count than a product that you need to take multiple times per day.

Rhodiola is an herb that, when taken in supplement form, has been linked to a variety of potential health benefits, including reduced depressive symptoms and an improved stress response 3.

Specifically, the herb is thought to benefit people with depression by reducing overactivity of the hypothalamic-pituitary-adrenocortical HPA axis and affecting neurotransmitter receptors and molecular networks 3 , 4 , 5. For example, studies focusing on adults with depression have found that taking rhodiola daily for 6 or 12 weeks led to clinically meaningful reductions in depressive symptoms 6 , 7.

The company exceeds standards set by United States Pharmacopeia USP , an organization that sets strict product-specific standards for supplements. Pure Encapsulations products are also third-party tested by independent laboratories such as Eurofins, Silliker, and Intertek. Interestingly, saffron has shown promise as a natural remedy for depression 8 , 9.

Studies have observed that saffron increases levels of the mood-boosting neurotransmitter serotonin in the brain.

Two reviews from found that saffron significantly improved depression severity and was significantly more effective than placebo 8 , NOW Saffron 50 mg provides a dose that has been shown to be effective for reducing symptoms of depression 11 , The CGMPs are regulations set by the Food and Drug Administration FDA to ensure safe supplement manufacturing and processing.

Omega-3 fats are essential fats, meaning you need to get them from your diet. Some studies show that omega-3 supplements may help reduce depressive symptoms in some people For example, one review of 10 studies including people with MDD found that omega-3 supplements were superior to placebo treatments in reducing depressive symptoms and that higher dose omega-3 supplements were more effective than lower dose supplements Another review found that supplements with a higher ratio of eicosapentaenoic acid EPA to docosahexaenoic acid DHA were particularly effective.

EPA and DHA are two types of omega-3 fatty acids, both of which are concentrated in seafood While these findings are promising, more research is needed to investigate the effects of omega-3 supplements on depressive symptoms.

Research suggests that supplements with a greater amount of EPA are most effective for people with depression. Therefore, choosing an omega-3 supplement that delivers at least 1, mg of EPA may be best Nordic Naturals EPA Xtra meets this criteria, providing 1, mg of EPA and mg of DHA per 2-softgel serving.

Nordic Naturals fish oil products are third-party tested to ensure the product meets strict standards for purity, potency, and freshness. Plus, the company makes it easy to view the certificate of analysis COA for every batch of its supplements online for ultimate transparency.

NAC is a precursor to the amino acids L-cysteine and glutathione. Glutathione is considered one of the most important antioxidants in your body and is critical for regulating inflammation and protecting cells from oxidative damage Research shows that people with depression are more likely to have higher levels of inflammatory cytokines such as C-reactive protein, interleukin-6, and tumor necrosis factor-alpha.

Taking NAC may help reduce inflammation and ease depressive symptoms The dysregulation of neurotransmitters such as dopamine and glutamate may be associated with mood disorders and schizophrenia, among other conditions Finally, a review of five studies concluded that treatment with NAC significantly reduced depressive symptoms and improved functioning in people with depression compared with placebo treatments.

Plus, the NAC supplements were safe and well tolerated This supplement from Pure Encapsulations is a great NAC supplement because it contains just one active ingredient and is tested multiple times throughout manufacturing. Vitamin D is a critical nutrient that plays numerous essential roles in your body.

Research shows that people with depression are more likely to be low or deficient in vitamin D. Those with the condition tend to have lower vitamin D levels than the general population, and people with the lowest levels tend to have the most significant depressive symptoms Vitamin D may reduce the risk of depression through several mechanisms, including by reducing inflammation, regulating mood, and protecting against neurocognitive dysfunction Several studies in people with depression suggest that taking vitamin D supplements may lead to significant improvements in depressive symptoms, quality of life, and illness severity 19 , Keep in mind that more research is needed before vitamin D can be recommended as a universal treatment for depression.

Thorne is certified by NSF International, an organization that inspects manufacturing facilities and tests supplements for quality and potency. B vitamins play important roles in brain function and mood regulation. B vitamins, including folate, B12, and B6, are necessary for the production and regulation of neurotransmitters such as serotonin, gamma-aminobutyric acid GABA , and dopamine Older research suggests that deficiencies in vitamin B12 and folate may increase the risk of depression and that supplementing with these nutrients may help reduce depressive symptoms in certain populations 23 , 24 , 25 , An older study also found B12 injections to be beneficial in people with MDD when used alongside antidepressant medication Additionally, a review suggested that taking vitamin B12 supplements earlier in life may delay the onset of depression and improve the effects of antidepressant medications Vitamin B6 has also been found to improve depressive symptoms when used in combination with other nutrients, including tryptophan and a form of vitamin B3 called nicotinamide Because several B vitamins may benefit people with depression, a B-complex supplement that contains all eight B vitamins may be the best choice.

Klaire Labs B-Complex Plus contains all eight B vitamins, including active forms of folate and B12 for better absorption. It also boasts antioxidant and anti-inflammatory properties Zinc deficiency is strongly linked to an increased risk of depression and depression symptom severity A analysis found that zinc supplementation significantly lowered symptom scores in people with depression Additionally, a analysis of 5 studies suggested that zinc supplementation may be useful for reducing depressive symptoms in people with clinical depression who are taking antidepressant medications.

The studies used zinc doses of about 10—25 mg S -Adenosylmethionine SAMe is a sulfur-containing compound that has shown promise in the treatment of depression. A review of 8 studies found that SAMe, when used alone or with antidepressant medications, improved depressive symptoms in people with MDD.

The studies used doses of —3, mg and treatment times of 2—12 weeks While this is promising, keep in mind that more research is needed before strong conclusions can be made.

Jarrow Formulas products are third-party tested by U. Department of Agriculture USDA accredited laboratories. Magnesium deficiency is common among people with depression, and research shows that supplementing with it may reduce depressive symptoms A randomized study in people with mild to moderate depression found that taking mg of magnesium per day for 6 weeks significantly improved depressive symptoms compared with a placebo Bluebonnet Magnesium Glycinate provides mg of magnesium per capsule.

You can adjust your dose depending on how much magnesium you need. Creatine is an organic acid that plays an important role in maintaining brain energy, among other functions.

Altered brain energy levels are thought to be involved in the development of depression Some studies suggest that supplementing with 2—10 grams of creatine per day may reduce symptoms in people with MDD This protective effect seemed to be strongest in females, people ages 20—39, and those not taking antidepressant or anti-anxiety medication Thorne Creatine is a great creatine supplement because it contains just one ingredient and is NSF Certified for Sport — a third-party certification ensuring that the product is free of more than substances banned by major athletics organizations.

Everyone feels low from time to time. However, depression is completely different from a low mood. Depression causes a persistent feeling of sadness and causes you to lose interest in things you once enjoyed.

While you wait for help to arrive, stay with someone and remove any weapons or substances that can cause harm. You are not alone. Studies show that certain dietary supplements, including omega-3s, vitamin D, rhodiola, B12, and saffron, may be helpful for reducing depressive symptoms in some people.

Be sure to clear any new dietary supplement with a healthcare professional before taking it. A healthcare professional can help you decide which supplements may be the most appropriate based on factors like your medical history, medications, and laboratory values.

There is no one best supplement for people with depression. The good news is that, there are a number of natural remedies for depression that can support mood, lift spirits and alleviate symptoms. In this article we will look at some of the best antidepressant herbs and natural supplements for depression that are used by people with depression to improve their mental well-being.

According to Chinese medicine, depression is when Shen, or our spirit that resides in the heart, is disturbed. This disturbance is a result of vital energy deficiency, it caused by imbalance in the body, such as Qi deficiency , inflammation and phlegm and dampness and so on. It can manifest in the following:.

In addition, Qi energy can get stuck in the body and not flow freely. Stagnant Qi can lead to emotional problems such as fear, anger, or grief, among others. Studies have shown Acupuncture can be effective for helping manage and overcome both low-grade depression and major depression.

In fact, research has also shown that Acupuncture therapy can be used as an antidepressant drug substitute that is equally as effective or as a supplement to lessen some of the unfavourable side effects. This study also showed that acupuncture patients saw an increase in their mood and quality of life after only a few weeks of therapy, but antidepressant-using individuals waited longer to notice the benefits.

If you are looking for natural antidepressant herbs , there are a number of herbal remedies for depression that may benefit you and make you feel better. The following 4 herbs are commonly used in Chinese medicine for depression:.

Ginkgo Biloba is a herb that has also been used in Traditional Chinese Medicine for thousands of years. It is one of the most commonly prescribed herbs in the world.

Ginkgo Biloba comes from the Ginkgo tree, which is native to China and other parts of East Asia. The leaves are harvested from this tree and dried out before they can be used as medicine.

The leaf extract of Ginkgo Biloba has been shown to have a positive effect on depression. Study showed Ginkgo can reduce levels of SB, a marker of brain injury, when paired with an antidepressant. Buy here. Dong Quai, also known as Angelica Sinensis, is a Chinese herb that has been used to treat a wide range of health problems.

In Traditional Chinese Medicine TCM , Dong Quai is considered to be warming and drying in nature. It may increase serotonin levels in your brain. People with depression tend to have lower levels of serotonin than people without depression do, so increasing it might help relieve symptoms. St Johns Wort is a natural herb that has been used for thousands of years to treat depression and other mental illnesses.

These brain chemical messengers play an important role in controlling moods and feelings of happiness or sadness.

The active ingredients in St. The following top formulas from traditional Chinese medicine may help relieve symptoms of depression:. Xiao Yao San is comprised of 8 different herbs and is said to be effective in treating depression and reducing psychological stress.

This review included clinical trials that tested Xiao Yao San against placebo, antidepressants, or in combination with antidepressants. Jia Wei Xiao Yao is a widely used Chinese herb for depression. The herb is thought to strengthen the kidney Qi, which helps stabilise and regulate emotional responses, especially when they are excessive or extreme in nature.

Chai Hu Shu Gan San is an ancient formula that has been used for over years to help depression. It contains four herbs that are commonly used to manage depression and anxiety.

Each herb in this formula has its own unique benefits and functions. A systematic review and meta-analysis of 42 randomised controlled trials involving patients with depression in 15 different types of diseases, report that Chai Hu Shu Gan San is effective for 3 types of depressions: for pure depression, for post-stroke depression, and for postpartum depression.

The researchers did not see any reports of severe adverse events from taking Chai Hu Shu Gan San orally. The Chinese herbs in this formula are used to nourish the liver and balance the emotions.

They work to calm anger and irritability, reduce restlessness and anxiety, relieve insomnia, help you sleep better at night, and increase your energy level during the day. According to the most recent review, Shu Gan Jie Yu capsules SGJYC have been shown to be effective in addressing depression, specifically, in post-stroke depression patients.

In addition, a comprehensive meta-analysis of 63 RCTs Randomised Controlled Trials involving adults, which was published in August , also found that SGJYC are powerful in treating adults with depression. Natural antidepressant supplements and antidepressant herbs are popular among people who want to improve their mood.

The most effective natural remedy will depend on your symptoms and the underlying cause of your depression. We highly recommend consulting with a practitioner near you alternatively, we also offer free online consultation if you want to find out more about natural remedies that may be right for you or someone close to you who suffers from depression.

We will take into account your unique symptoms and needs when creating a personalised treatment plan tailored just for you. For more information about how Chinese Medicine can help you with depression, book your free consultation with our Chinese Medicine experts today. This information is not intended to diagnose, treat, cure, or prevent any disease.

The treatment length and recovery time also varies for individual. Please visit our clinics website: GinSen where a specialists will discuss your care and provide a consultation, and the treatment will be designed to meet your individual needs.

Depression is a multi genetic or multifactorial syndrome. If you are struggling with depression and are not receiving treatment, there are some warning signs that we recommend taking seriously:. Save my name, email, and website in this browser for the next time I comment.

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Ginkgo Biloba. Dong Quai. Ginkgo Biloba Ginkgo Biloba is a herb that has also been used in Traditional Chinese Medicine for thousands of years. Dong Quai Dong Quai, also known as Angelica Sinensis, is a Chinese herb that has been used to treat a wide range of health problems.

The following top formulas from traditional Chinese medicine may help relieve symptoms of depression: 1. Xiao Yao San Xiao Yao San is comprised of 8 different herbs and is said to be effective in treating depression and reducing psychological stress.

Buy here 2. Jia Wei Xiao Yao Jia Wei Xiao Yao is a widely used Chinese herb for depression. Buy here 3. Chai Hu Shu Gan San Chai Hu Shu Gan San is an ancient formula that has been used for over years to help depression. Shu Gan Jie Yu The Chinese herbs in this formula are used to nourish the liver and balance the emotions.

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If a person believes they are experiencing symptoms of depression, they should speak with a healthcare or mental health professional before trying any natural antidepressants. In this article, we focus on six natural antidepressants, their effectiveness in treating depression, and other alternatives.

If a person thinks they have symptoms of depression , they should speak to a healthcare professional as soon as possible so that they can begin treatment. Natural antidepressants may offer some relief. However, as with prescription antidepressants, results vary from person to person.

S-adenosylmethionine SAM-e naturally occurs in the body. According to the National Center for Complementary and Integrative Health NCCIH , several studies suggest that SAM-e may help treat depression.

However, no conclusive scientific research has shown it works. A analysis of existing research studies found that SAM-e improved symptoms of depression in eight studies.

However, each of these studies had methodological flaws. In a separate analysis , SAM-e worked better than a placebo in six placebo-controlled trials. According to the NCCIH, SAM-e may not be safe for people with bipolar disorder because it may increase mania symptoms.

People living with HIV should also avoid SAM-e because it may encourage the growth of Pneumocystis jirovecii , which could lead to pneumonia. Some studies show that St. Researchers do not know if St. Some research suggests that St. In some studies, St. A review of previous research studies found that St.

However, little data suggested that it works well to treat severe depression, or that it can be a long-term depression treatment. Some types of fatty fish, such as tuna and albacore, contain omega-3 fatty acids.

People who do not eat fish and want to boost their omega-3 levels can take them as supplements. According to a analysis of 20 clinical trials, large doses of omega-3 fatty acids may improve mood and treat depression.

More findings from a report show that omega-3s may help with depression in both adults and children. Researchers do not know how or why omega-3s work. They may reduce inflammation or reduce the effects of the stress-related hormone cortisol. At high doses, omega-3s may cause a fishy aftertaste or an upset stomach.

According to a clinical trial , they may also thin the blood. People with clotting disorders and blood thinners should carefully regulate how much omega-3 they consume. As many people with depression also experience anxiety and sleep issues, lavender could help them sleep without the side effects of sleeping pills.

According to a systematic review inhaling lavender aromas before sleeping, did help people get to sleep. However, the studies were small, and most had methodological issues, so researchers need to do more studies to support the findings. However, a randomized controlled trial does provide more evidence that lavender may help with sleep.

In that study, two groups practiced healthy sleep hygiene, with one group wearing a lavender aromatherapy patch. Both groups were sleeping better, but the results were stronger in the lavender group. Parents of pre-pubescent children should use lavender oils or extracts with caution.

A case report suggests that lavender may increase estrogen and cause premature breast enlargement. More studies are needed to confirm this.