How long does it take to bring the results? In acute conditions, the results can be felt within a few hours of taking Herbal Daily. One needs to take Herbal Daily for 6 months to bring about a complete cure.

Should I stop my medicine while taking Herbal Daily? We do not recommend you to stop your medications. Frequently check your health status and reduce the dosages if recommended by your doctor. Keep a minimum gap of a ½ hour if you are taking any medicines. Always use Herbal Daily with water.

How effective is the Treatment? Though, results vary from person to person depending upon the severity of the problem. This formula can be prepared at home but lack of knowledge in terms of preparation, quantity, temperature and processing methodology makes it difficult, thereby making the combination ineffective.

The good news is, we have made the product readily available to you. What should I do if I have forgotten to take this medicine? Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances. I suffer the problem of ulcer from many years, I started using this pack I feel good results. Finding much relief in my Ulcer symptoms after taking Anti Ulcer pack.

My endoscopy also shows improvement. Home Products Anti Ulcer Supplements. Anti-Ulcer Supplements Product Code: Price Rs. Product Details. Body Balance Capsule: Ashwagandha Withania Somnifera , Ashwagandha Leaves Withania Somnifera , Kaunch Beej Mucuna Pruiens , Saunth Zingiber Officinale , Vijaysaar Pterocarpus Marsupium , Salab Mishri Orchis Mascula , Salab Panja Eulophia Campestris , Kutaki Picrorhiza Kurroa , Kala Namak Unaqua Sodium Chloride , Tulsi Ocimum Sanctum , Shankhpuspi Convolvulus Pluricaulis , Atibala Abutilon Indicum , Vidari kand Pueraria Tuberosa , Babul chall Acacia Arabica , Safed Musli Asparagus Adscenens , Bhumi Amla Phyllanthus Niruri , Punarnava Boerhavia Diffusa , Brahmi Bacopa Monnieri , Sudh Shilajit Asphaltum Punibium , Bargad Ficus Bengalensis , Bavchi Psoralea Corylifolia , Jatamasi Nardostachys Jatamansi , Vidhara mool Argyreia Nervosa Aloevera Rose: Aloevera Barbadensis , Rose Rosa , Garlic Allium Sativum , Lemon Citrus Medica , Honey Pushpras , Apple Cider Vinegar with Mother Malus Domestica.

Dosage: Haldi: 3 teaspoons 15ml of Herbal Daily Haldi in ml of water, on an empty stomach before breakfast in Morning, Daily. Expiry Date: Tonics: 1 years from the date of manufacturing.

If you are taking allopathy or any other medicines, keep an hour gap. At a time, only one product can be taken either liquid or capsule. Do not give it to children below 10 years of age. Always take the remedy at the prescribed time. Store in a cool dry place.

Keep out of reach of children. These foods, such as miso, sauerkraut, and kimchi , may prevent reinfection. Turmeric is currently being studied as a potential treatment for ulcers as well. Garlic , decaffeinated green tea, and licorice round out the list of things you might want to incorporate in your diet.

If your stomach ulcer is being treated with an antibiotic, consider taking a probiotic supplement as part of your diet plan. This can help reduce antibiotic-associated symptoms.

It may also improve the effectiveness of the antibiotic. Ask your doctor what probiotics would be best to take with your antibiotic medication. Lactobacillus , Bifidobacterium , and Saccharomyces supplements have shown benefits in people with H.

pylori ulcers. Deglycyrrhizinated licorice taken one hour before meals and curcumin extracts have shown promise in some ulcer research due to their action against H. Some people who have an ulcer also have acid reflux. In some people, certain foods can relax the lower part of the esophagus , known as the lower esophageal sphincter LES.

A relaxed LES makes it easier for acid to back up into the esophagus and causes heartburn , indigestion , and pain. Ulcers caused by H. pylori will most likely need to be treated with antibiotics. Strict adherence to your treatment plan and close follow-up with your doctor are the best ways to make sure your treatments are effective and your ulcers are healing.

You will also be prescribed a medication that temporarily keeps your stomach from making or secreting as much acid as it normally would. This medication may be a proton pump inhibitor or H2 blocker. Learn more about treatment for a peptic ulcer. You can try beverages that contain probiotics, such as kombucha.

In addition, research has found that drinking cranberry juice may help fight an H. You can get fast relief by taking acid blockers like famotidine Pepcid. A stomach ulcer could go away on its own , but this is less common.

More often, the symptoms of a stomach ulcer continue for weeks or even months until a person seeks treatment. Most ulcers caused by H. pylori are completely treatable. But untreated stomach ulcers can lead to more serious problems, like internal bleeding and stomach cancer.

Speak to your healthcare professional, make a plan, and get treatment. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

VIEW ALL HISTORY. Stomach ulcers are open sores in the lining of the stomach. They are often extremely painful. Read on to learn about easy stomach ulcer home remedies….

Gastric and duodenal ulcers are both types of peptic ulcers. These ulcers can cause different symptoms, depending on where they are.

A peptic ulcer on…. A bleeding ulcer requires immediate treatment. Learn more about the warning signs and what to expect during treatment. Peptic ulcers are painful sores in the lining of the stomach, esophagus, or small intestine.

pylori is a common bacteria that may cause pain and increase the risk of ulcers or stomach cancer. Learn about symptoms, complications, and more. Gastric tissue biopsy is the examination of tissue removed from the stomach.

The tissue is placed in a special dish to see if bacteria or other…. A rectal ulcer happens when one or more of the mucous layers that line the rectum are injured or damaged, resulting in a painful sore.

Famotidine, sold under the brand name Pepcid and its generic form, is often the first-line treatment for stomach ulcers. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Stomach Ulcer Diet. Medically reviewed by Jerlyn Jones, MS MPA RDN LD CLT , Nutrition — By Kathryn Watson — Updated on June 12, Causes What to eat What to avoid Ulcer treatment FAQs Outlook.

How we vet brands and products Healthline only shows you brands and products that we stand behind. Our team thoroughly researches and evaluates the recommendations we make on our site.

To establish that the product manufacturers addressed safety and efficacy standards, we: Evaluate ingredients and composition: Do they have the potential to cause harm?

Fact-check all health claims: Do they align with the current body of scientific evidence?

Furthermore, angiogenesis and collagenization within gastric tissues are among the main molecular mechanisms of curcumin, which is modulated via the up-regulation of VEGF, membrane type MT 1-MMP, MMP-2, and transforming growth factor TGF -β expression at both protein and mRNA levels[ 52 ].

This activity is mediated by suppressing the pro-inflammatory cytokine TNF-α, as well the intercellular adhesion molecule ICAM-1[ 53 ]. It has been reported that curcumin has a strong antibacterial effect against 65 clinical isolates of H. The antibacterial potential of curcumin on metronidazole-resistant H.

pylori strains revealed different mechanisms from the mode of action of current antibiotics for the prevention of H. pylori infection. Curcumin also demonstrated a therapeutic effect in an animal model of H. It was able to significantly eradicate H.

pylori from infected mice and improve H. pylori -associated gastric damage. Inhibiting shikimate dehydrogenase, an essential pathway for the synthesis of vital metabolites in bacteria, seems to be among the main biological mechanisms of curcumin in the eradication of H.

pylori [ 54 ]. Several clinical investigations have evaluated the therapeutic effect of curcumin in the management of peptic ulcer, as well as the eradication of H. pylori infection Table 1 [ 55 - 58 ]. In addition, curcumin mucoadhesive microspheres enhance the stomach residence time of curcumin, leading to an improvement in its ability to eradicate H.

pylori and its related gastropathy[ 59 ]. Gallic acid 3,4,5-trihydroxybenzoic acid is a polyhydroxy phenolic compound commonly used as a dietary herbal supplement. Gallic acid is naturally found in various vegetables and fruits, such as gallnuts, Tragopogon species, sumach, grapes, pineapple, Phyllanthus spp.

It is a strong antioxidant and possesses various therapeutic effects, including anti-cancer, anti-obesity, hepatoprotective, and anti-asthmatic effects[ 63 ]. Gallic acid is considered an essential active constituent of a wide range of herbal preparations used for the management of peptic ulcer[ 8 ].

The bioavailability of gallic acid in humans is low and its plasma concentration subsequent to 50 mg oral consumption of gallic acid is 1. This polyphenol is generally metabolized into 4-O-methylgallic acid, which is presumed to play an important role in its therapeutic action in peptic ulcer[ 8 , 61 , 62 ].

Gallic acid encompasses the ability to prevent and heal gastric mucosal damage induced by NSAIDs by its antihistaminic activity, as well as inhibiting up-regulation of pro-inflammatory cytokines and modulating inflammatory reactions[ 63 , 64 ].

Iron-chelating, free radicals scavenging, and preventing OH-mediated oxidative endothelial damage have been assumed to be its main mechanisms in preventing and healing peptic ulcers. In addition, gallic acid diminishes diclofenac- and indomethacin-associated mitochondrial oxidative stress by suppressing mitochondrial protein carbonyl generation, thiol depletion, and lipid peroxidation.

It is suggested that apoptosis is the main cause of cellular injury in gastropathy. Gallic acid significantly suppresses apoptosis induced by indomethacin in preclinical studies. In fact, this polyphenol prevents apoptosis via suppressing activation of caspase-3, a key mediator in the execution level of indomethacin-associated gastric mucosal cell apoptosis, and caspase-9, which is a mediator of the mitochondrial pathway of apoptosis[ 14 - 17 , 63 ].

In addition, gallic acid modulates oxidative damage-induced mitochondrial dysfunction by regulating mitochondrial transmembrane potential and mitochondrial dehydrogenase activity[ 63 ]. Seven days of pretreatment with gallic acid in an animal model of gastric ulcer induced by aspirin plus pylorus ligation reduced mucosal injury and gastric juice volume, which indicated the anti-secretory potential of this polyphenol.

It prevented the release of endogenous offensive factors, pepsin, and free and total acidity, along with the enhancement of pH and carbohydrate concentration in the stomach. Likewise, it inhibited protein and DNA leakage from gastric mucosa through reinforcement the mucosal barrier.

Enzymatic and non-enzymatic antioxidant proteins encompass an obvious role in the prevention of peptic ulcer. Phenolic acid elevated the level and activity of SOD, CAT, reduced GSH, GPx, glutathione reductase, and glucosephosphate dehydrogenase, while peroxidation of lipids was significantly lessened in mucosal tissue.

It suppresses MPO level in mucosal tissue, indicating diminishing neutrophil migration and infiltration within damaged tissue[ 8 ]. One week treatment with gallic acid enriched herbal extract Phyllanthus emblica significantly alleviated indomethacin-induced ulcer in animals.

The healing potential of gallic acid enriched extract was reversed by the nonspecific NOS inhibitor, N-nitro-L-arginine methyl ester L-NAME , while the i-NOS-specific inhibitor, L-N6- 1-iminoethyl lysine hydrochloride L-NIL did not prevent healing activity, indicating the important role of eNOS in its therapeutic action[ 65 ].

It is now well-recognized that gastric ulceration induced by indomethacin is associated with elevated expression and activity of mucosal iNOS, while eNOS activity is lessened.

Moreover, augmentation of tissue growth factors, including VEGF, which improves cell proliferation, as well as hepatocyte growth factor, which regulates cell migration and re-epithelialization, are key contributors in the gastric mucosal repairment of gallic acid.

These finding support the positive effect of dietary gallic acid in the vasodilation and angiogenesis pathways of ulcer healing[ 11 , 17 , 65 ]. The grape, a fruiting berry of the woody vines Vitis spp. from the family Vitaceae, is an essential source of nutritional phytochemicals such as flavonoids and anthocyanins.

A wide variety of anthocyanins containing glycosidic forms of cyanidin, delphinidin, peonidin, malvidin, pelargonidin, and petunidin have been identified in grapes.

Several experimental investigations reported that grape polyphenol encompass positive medicinal functions like antioxidant, anti-inflammatory, antimicrobial and anti-platelet activities[ 66 , 67 ].

Grape seed extract is rich in flavonoids generally proanthocyanidin and possesses preventive activity against numerous diseases, such as atherosclerosis, vascular injury, cardiovascular disease, and cancer, as well as combating the aging process.

It has been shown that proanthocyanidin of grape seeds has an adequate bioavailability in the vital organs. Its protective potential against biochemically-produced free radicals, ROS-induced peroxidation of tissue lipid, and oxidation of protein is significantly higher than vitamin E, vitamin C, β-carotene, and a combination of vitamins C and E[ 68 - 70 ].

Physical stress has been demonstrated to associate with oxidative tissue damage, resulting in severe gastrointestinal mucosal injury in animal models. Grape seed proanthocyanidin extract mitigates gastrointestinal mucosal injury induced by acute or chronic stress via the prevention of superoxide anion production, DNA fragmentation, lipid peroxidation, and membrane microviscosity[ 69 ].

Ten-day pretreatment with proanthocyanidin-enriched grape seed extract decreased gastric lesions and gastric MDA level induced by ethanol more effectively than vitamins E and C. Likewise, it diminishes aspirin-induced gastric injury and peroxidation of mucosal lipid in a similar manner to antioxidants agents and vitamins E and C[ 70 ].

Dietary supplementation of grape seed proanthocyanidin The protective effect of dietary grape proanthocyanidin is mediated by hormonal mechanisms, including anti-gastrin and anti-histaminic potential, as well as stimulation of PGE2 secretion.

Iwasaki et al [ 72 ] reported that inhibition of neutrophil infiltration to gastric mucosal tissue reduction of gastric MPO and enhancement of enzymatic antioxidant defense e. Grape extract seed and skin showed antibacterial effect on both cagA -negative and cagA -positive H.

pylori clinical strains, in vitro [ 73 ]. It also inhibits H. pylori attachment to gastric cells, which is considered to be a key step in the colonization and virulence of this bacterium. Moreover, dietary supplementation of grape polyphenols mitigated H. pylori infection associated gastritis via the reduction of lymphocyte, plasma cell, eosinophil, and neutrophil infiltration in the lamina propria, as well as alleviating inflammatory response in infected mice.

This therapeutic function of dietary grape polyphenols is mediated through the suppression of pro-inflammatory cytokines IL-1β, TNF-α, and IFN-γ, which are elevated by H.

Likewise, polyphenols promoted H. pylori eradication from the gastric tissue of infected mice[ 74 , 75 ]. Green tea Camellia sinensis is an evergreen shrub which has been used for approximately years.

Green tea is the most popular beverage in the world after water and encompasses a wide range of polyphenols, including catechin, epicatechin, epicatechin gallate, epigallocatechin, and epigallocatechin gallate[ 76 ].

Various studies indicated EGCG as the greatest antioxidant and anti-inflammatory substance of tea polyphenols, as well as having a higher antioxidant effect than vitamins C and E, and promising anti-inflammatory activity[ 77 ].

Numerous studies have shown that the positive anti-ulcer action of EGCG is based on its ability to alleviate the production of key inflammatory mediators within the pathological condition of ulceration.

Adhikary et al [ 78 ] evaluated the role of COX-independent pro-inflammatory pathway in the gastroprotective effects of EGCG and showed that this polyphenol significantly reduces neutrophil infiltration and MPO activity.

MPO is an enzyme produced by activated neutrophils which has strong pro-oxidative and pro-inflammatory activities. iNOS-derived NO is involved in oxidative epithelium damage and the exacerbation of ulceration. Moreover, EGCG inhibits neutrophil-endothelial cell interactions via the suppression of soluble E-selectin sE-selectin and P-selectin sP-selectin levels in damaged gastric tissue.

Consistent with this, indomethacin up-regulates soluble ICAM-1 sICAM-1 and VCAM-1 sVCAM-1 in gastric tissue, which is significantly modulated by EGCG. Thus, this polyphenol suppresses both the early rolling phase through the selectins down-regulation as well as the late firm adhesion phase through the CAMs down-regulation[ 78 , 79 ].

During the pathological process of ulceration, the pro-inflammatory Th1 cytokines are elevated and the anti-inflammatory Th2 cytokines are lessened.

This cytokine imbalance caused stimulation of oxidative stress and up-regulation of adhesion molecules. EGCG modulates the cytokine imbalance and reinforces anti-inflammatory cytokines, leading to the promotion of ulcer healing.

Such anti-inflammatory potential of EGCG in damaged gastric tissue via the modulating COX-independent pro-inflammatory pathway is significantly more potent than the standard drug omeprazole[ 78 , 80 ].

Given the importance of COX isoforms and PGs in the pathogenesis of ulceration, the effect of EGCG on these inflammatory mediators was evaluated by Adhikary et al [ 80 ]. It also improves mucin content in gastric tissue, causing enhancement of mucosal membrane protection.

Oxidative damage in gastric tissue, which possesses a strong effect in initializing and exacerbating peptic ulcers, is modulated by EGCG; it enhances thiol defense, suppresses lipid peroxidation, and protein oxidation in ulcerated gastric tissue. Inhibitory function on H. pylori infection is another pharmacological mechanism of tea polyphenol for the management of peptic ulcer[ 82 ].

EGCG alleviate H. pylori -associated gastropathy, which is mediated by the TLR4 signaling pathway. TLR-4 is activated by the lipopolysaccharide of H. pylori and plays a key role in initializing and adapting the immune reaction to this pathogen. Lee et al [ 83 ] showed EGCG inhibits glycosylation of TLR pylori induced host intracellular signaling and its subsequent pathways.

EGCG suppresses NF-κB-DNA binding, which is a major transcription mediator involved in inflammation and redox. In addition, tea polyphenols significantly diminish gastric mucosal cytotoxicity and DNA damage of epithelial cells induced by H.

They also have inhibitory effects against urease enzyme, a virulence factor of H. pylori which is vital for its colonization and establishment in gastric mucosa[ 84 ]. Crude catechin, as one of the main phenolics in green tea, possesses a remarkable preventive effect on stress-associated peptic ulcer.

Dietary supplementation of crude catechins [ Endocrine parameters are involved in the gastroprotective effect of dietary catechin due to the reduction of somatostatin, gastrin, and histamine levels[ 86 ]. In addition, dietary consumption of green tea reduced the incidence of H.

pylori infection in patients with peptic ulcer Table 1 [ 87 ]. Pomegranate Punica granatum L. Polyphenolic compounds are the main constituent of this fruit in which ellagitannins and anthocyanins are represented as the predominant polyphenols. Degradation of ellagitannins does not occur in the presence of hydrochloric acid and the gastric enzymes of the stomach, indicating its stability under stomach conditions.

In addition to ellagitannins, anthocyanins, as another main polyphenol group of pomegranates, are quite stable under gastric acidic conditions. Pomegranate anthocyanins contain 3,5-diglucosides and 3-glucosides of cyanidin, delphinidin, and pelargonidin[ 89 , 90 ].

A wide variety of polyphenol-enriched pomegranate products have commonly been introduced into the pharmaceutical market and consumed as a beneficial complementary health drug. Various investigations support the remarkable antioxidant and anti-inflammatory properties of pomegranate polyphenols[ 91 - 93 ].

Ajaikumar et al [ 94 ] showed polyphenol enriched fruit rind extract prevents gastric injury and necrosis induced by ethanol in animal models. Ethanol-associated gastric mucosal injury is mediated by ROS, in addition to decreasing endogenous antioxidants, leading to the endothelial layer becoming more prone to oxidative damage.

Pomegranate extract possess the ability to scavenge the ROS formation, as well as reinforce the performance of antioxidant enzymes and proteins, including SOD, CAT, GSH, and GPx. Ellagic acid, a phenolic lactone compound, is the main in vivo hydrolysis product of pomegranate polyphenols, and possesses anti-inflammatory, antioxidant, hepatoprotective, and anti-mutagenic effects.

In addition, intestinal microbiota metabolizes the most active pomegranate phenolics ellagitannins to urolithins, which are subsequently absorbed and reach different tissue. Urolithins have an anti-inflammatory function i. Beserra et al [ 96 ] reported the gastroprotective effect of ellagic acid on ethanol-induced ulcers was attributed to the enhancement of endogenous NO production, in addition to anti-oxidative damage potential, by restoring depleted non-protein sulfhydryls and suppressing the pro-inflammatory cytokine TNF-α.

Ellagic acid also reduces gastric ulcer and bleeding induced by indomethacin in which suppressing leukotriene LT -B4 expression is a key molecular factor.

It showed remarkable healing properties in chronic gastric ulcer associated with acetic acid as well, which is due to the mitigation of the pro-inflammatory cytokines INF-γ, IL-4, IL-6, and TNF-α. Pretreatment with ellagic acid prevents hemorrhagic lesions induced by stomach ischemia, followed by reperfusion, which is considered oxidative-associated mucosal damage.

The preventive potential of this oxidative mucosal injury was more effective than the antioxidant enzyme SOD. Iino et al [ 97 ] exhibited that free radical scavenging potential, as well as inhibiting lipid peroxidation, has a pivotal role in the protective effect of ellagic acid. Ellagic acid also protects gastric tissue against injury and damage of mucosal blood flow induced by stomach ischemia followed by ammonia NH 4 OH , which is mediated by replenishing anti-oxidative performance[ 97 , 98 ].

Murakami et al [ 99 ] demonstrated ip administration of ellagic acid mitigates stress-induced gastric lesions and suppresses acid secretion significantly.

Polyphenolic extract of peel and fruit rind has a strong growth inhibitory effect on H. pylori clinical strains in vitro , which was comparable with metronidazole. Investigations revealed that pomegranate extract possess both bacteriostatic and bactericidal effects, as well as possessing the potential to modulate H.

pylori cell surface hydrophobicity[ , ]. Quercetin is one of the most potent scavengers of free radicals e. This phenolic compound possesses a wide range of positive biological activities, such as: cardioprotective, anti-atherosclerotic, hypotensive, anti-diabetic, anti-tumor, anti-proliferative, and anti-metastasis effects[ ].

Bioavailability of quercetin depends on the type of glycosides present in various food sources. However, the dietary supplementation of quercetin can improve the plasma level i. It is worth mentioning that the absorption of quercetin glycosides is also influenced by gut microflora, which metabolizes to the locally active aglycone forms[ , ].

Various experimental investigations have studied the therapeutic benefits of quercetin and its derivatives on models of peptic ulcer disease. Its antioxidant and anti-inflammatory properties are contributing factors to therapeutic efficacy for peptic ulcers[ - ].

Accumulating evidence suggests that ethanol-associated ROS lead to disruption of cellular function and vital cell constituents, and produces toxic agents such as lipid hydroperoxides, lipid peroxyl radicals, and other lipid fragmentations.

These toxic agents disturb the mucosal and interstitial matrix, causing gastric injury, which is mitigated by pretreatment with oral administration of quercetin.

This phenolic substance lowers the tissue level of thiobarbituric acid reactive substances, indicating the inhibitory effect on lipid peroxidation. It also suppresses free radical-associated damaging of proteins and the production of protein carbonyl content significantly.

Its ability to lessen histamine levels as the final chemo-stimulant of gastric secretion reveals its anti-secretory potential in gastroprotective function. Quercetin also elevates non-enzymatic and enzymatic antioxidant agents protein sulfhydryl, SOD, and CAT.

It also inhibits neutrophil infiltration and the gastric tissue level of MPO[ 9 , ]. Min et al [ ] reported quercetinO-β-D-glucuronopyranoside prevents indomethacin-induced gastric ulcer dose-dependency.

It modulates gastric acid secretion via the reduction of gastric volumes and total acidity. It also lessens the level of end-product lipid peroxidation, indicating the protective role of this polyphenol against indomethacin-associated oxidative mucosal stress.

The gastroprotective, anti-secretory, and anti-oxidative effect of quercetinO-β-D- glucopyranoside was significantly higher than that of quercetin. Rutin is a quercetin glycoside with strong radical scavenging, anti-inflammatory, and vasoactive activity.

It has been reported to possess cytoprotective and gastroprotective effects in animal models of gastroduodenal ulcer, including restraint stress, ethanol, and reserpine[ ].

The protective potential of rutin against absolute ethanol-associated gastric mucosal ulceration and necrosis is due to its anti-lipoperoxidant effect, as well as an improvement in enzymatic antioxidant performance[ ].

Olaleye et al [ ] compared the healing potential of cimetidine and a low dose of rutin in animal experimental models of gastric ulcer induced by acetic acid, stress, or ethanol.

It is reported that an increase in the antioxidant activity of vitamin C and GPx and inhibiting peroxidation of cellular lipid reduction of MDA is a crucial contributor in the current therapeutic action of rutin.

Resveratrol is a natural dietary phenolic compound with various reported therapeutic benefits, including anti-carcinogenic, chemopreventive, and anti-aging effects, and is useful for the management of cardiovascular diseases, cancer, and neurodegenerative diseases[ ].

It has been reported that resveratrol has beneficial effects in various biological tissues, despite its rapid metabolism and elimination.

In addition, a wide range of investigations has been executed to enhance resveratrol bioavailability to overcome its normally poor bioavailability. The potential of resveratrol in the management of gastric and intestinal injury and inflammation, due to its strong antioxidant, anti-oxidative stress, free radical scavenging, and anti-inflammatory activities, is widely evaluated[ , ].

The protective effect of resveratrol in the models of peptic ulcer is reasonably well-reported, with most investigations being based on its potential to suppress the production of key inflammatory mediators.

In vitro studies demonstrated that resveratrol inhibits the expression and activation of nuclear factors NF-κB and intracellular transcriptional enzymes MAPKs [ ].

In an experimental study by Solmaz et al [ ], resveratrol exhibited both protective and therapeutic effects in an animal model of gastric ulcer induced by acetic acid, which was due to attenuating gastric MPO activity inhibition of leukocyte infiltration , MDA suppressing tissue lipid peroxidation , elevating collagen content, and restoring depleted GSH.

Suppressing the key pro-inflammatory agent TNF-α has an essential role in its therapeutic function in gastric tissue. This polyphenol also diminished the level of lucigenin- and luminol-enhanced chemiluminescence, indicating its significant suppression on intracellular and extracellular oxidative events in gastric mucosal tissue.

In another experimental study executed by Li et al [ ], this polyphenol protects against gastric injury induced by acidified ethanol, which is attributed to the enhancement of dimethylarginine dimethylaminohydrolase DDAH activity and the subsequent reduction of asymmetric dimethylarginine ADMA content, resulting in blocked methylarginines accumulation, the induction of NO synthesis, and vasodilation in mucosal tissue.

Thus, augmentation of gastric NO production is among the most important abilities of resveratrol in the protection of gastric mucosa. However, Dey et al [ ] reported that resveratrol has a biphasic protective effect.

This polyphenol, in low doses, showed preventive potential on indomethacin-induced gastric ulcer due to the enhancement of eNOS expression and, in higher doses, blocked PGE2 synthesis in gastric tissue, which is mediated by inhibiting COX-1 enzyme activity and expression. It is now well-recognized that resveratrol has an excellent antibacterial effect against H.

Resveratrol inhibits the virulence factor of H. pylori and urease enzyme activity significantly. The inhibitory property of resveratrol on this enzyme is non-competitive and dose-dependent[ , ]. pylori infection stimulates pro-inflammatory mediators, causing disturbance of surface epithelial cell integrity, irregularity of the luminal border, damage to the gastric microvilli, and inducing mucosal vacuolation.

Among the pro-inflammatory cytokines, IL-8 possesses an obvious effect in the pathogenesis of H. pylori diseases by activating neutrophils and inducing cellular chemoattraction.

Resveratrol prevents H. pylori -induced gastric mucosal damage and gastritis by suppressing the secretion of IL-8 from H.

pylori -infected cells. pylori infection associates with ROS generation, oxidative DNA damage, and epithelial proliferation. Pretreatment with this polyphenol mitigates intracellular ROS generation and oxidative DNA fragmentation induced by H.

pylori infection dose-dependently in gastric epithelial cell. The interaction of H. Cellular studies showed that H. pylori -initiated gastric morphological changes were noticeably suppressed by resveratrol[ 21 , , ].

Peptic ulcer disease has been a major threat to human health over the past two centuries. Despite medical advances, the management of peptic ulcer and its relevant complications remains a medical challenge, due to its high morbidity and mortality[ 1 , 4 , 93 ].

Therefore, there is a growing interest in dietary factors as supplements for the prevention or remission of gastritis and gastrointestinal ulcers. Polyphenols, secondary plant metabolites ubiquitously present in vegetables and fruits, are progressively viewed as natural dietary ingredients which must be present in a balanced diet, owing to their wide range of biological effects.

Natural polyphenols have been reported to possess numerous beneficial roles in the gastrointestinal tract, including antispasmodic, anti-colitis, anti-secretory, anti-diarrheal, anti-ulcer, and anti-oxidative stress properties[ 26 - 28 ].

Additionally, it is possible that the therapeutic benefits of various traditional and complementary medicines in the treatment of peptic ulcer are related to the presence of polyphenol constituents[ 10 , ].

An accumulating body of evidence suggests that, among a wide range of natural molecules, dietary polyphenols with multiple biological mechanisms of action can play a pivotal role in the management of gastric and intestinal ulcers. Figure 1 illustrates the chemical structure of the most relevant dietary polyphenols with a potential role for the management of peptic ulcer.

Recently, several distinct molecular mechanisms that possibly commensurate with peptic ulcer pathogenesis have been demonstrated.

A growing body of in vitro and preclinical studies suggests a beneficial role of dietary polyphenols in peptic ulcer, in terms of their well-established intracellular and molecular pharmacological mechanisms of action.

The ulcer healing process is a complex one that includes a combination of injury retraction and re-epithelization. The complex sequence of events in the ulcer healing process needs a high degree of coordination modulated by significant factors, of which the growth factors and PGs are considered a key contributors that are involved in the essential cell functions of tissue healing containing tissue restoration and angiogenesis[ 39 , ].

In addition, polyphenols suppress vascular permeability, leucocyte infiltration, and leukocyte-endothelium interaction mediated by the down-regulation of cellular and intercellular adhesion agents, including CAMs and selectins. Dietary polyphenols mitigate inflammatory reactions and down-regulate pro-inflammatory cytokines such as TNF-α and IL-1β within mucosal ulcers by inhibiting intracellular signaling pathways of the inflammatory process JNK, ERK, and MAPK , as well as modulating intracellular transcriptional factors.

Regarding the important role of oxidative stress in ulceration, the remarkable ability of polyphenols in the suppression of oxidative mucosal damage and the scavenging of gastric free radicals mediated by enzymatic and non-enzymatic antioxidant substances are among its main anti-ulcer mechanisms.

Additionally, modulating cellular events and functions leading to the enhancement of tissue eNOS-derived NO level possesses a crucial role in the management of peptic ulcer.

Figure 2 illustrates the potential cellular mechanisms of dietary polyphenols as preventive or therapeutic factors in the management of peptic ulcer. It is worthwhile mentioning that Figure 2 is elicited from the pharmacological mechanisms demonstrated in the scientific literature with different dietary polyphenols, and not all of these mechanisms apply to each dietary polyphenol.

Due to the increase in antibacterial resistance, a diet-based treatment against pathogens infection has an important role in the management of various diseases.

The accumulated data confirms that H. pylori infection can lead to severe gastritis and gastroduodenal ulceration, and its eradication is considered the therapeutic approach for peptic ulcer.

Hence, host nutritional factors are thought to play a significant role in the management of H. pylori colonization and subsequent diseases[ 19 , ].

A growing body of evidence shows the strong therapeutic potential of dietary polyphenols on H. pylori infection and its associated disease, which is mediated by inhibiting the activity of vital enzymes of this pathogen like urease and shikimate dehydrogenase, preventing its adhesion and vacuolation in gastric tissue, in addition to blocking H.

pylori -induced morphological changes of gastric epithelial cells, causing dysregulation of host cell functions. Polyphenols prevent H. pylori -initiated inflammatory response in gastric tissue via suppressing pro-inflammatory cytokines TNF-α, IFN-γ, and IL-8 and cellular and nuclear inflammatory signaling MAPK , as well as modulating intracellular transduction and transcription pathways TLR4.

In addition, dietary polyphenols protect against H. pylori associated oxidative mucosal damage and ROS generation. Figure 3 summarizes the possible biological mechanisms of dietary polyphenols in the management of H.

pylori -associated gastritis and gastroduodenal ulceration. The current paper calls attention to a group of dietary natural phytochemicals, polyphenols, with a growing body of evidence regarding their beneficial association in human health. The evidence suggests that polyphenols, as non-essential dietary supplements, probably possess a pivotal role in improving the inflammatory process, oxidative reactions, degenerative mucosal events, and recurrence gastroduodenal ulceration.

A wide range of preclinical investigations support the therapeutic benefits of dietary natural polyphenols in the management of peptic ulcer, although there are few clinical trials evaluating the efficacy of dietary polyphenols in peptic ulcer.

Table 1 shows the clinical evidence of dietary polyphenols in the treatment of peptic ulcers. Among the dietary polyphenols with therapeutic potential for managing peptic ulcer, curcumin has the higher level of evidence, and there are different clinical studies evaluating its beneficial effect in gastrointestinal ulcers and H.

Further well-designed clinical trials are necessary to evaluate the role of dietary polyphenols as promising preventive and therapeutic dietary factors in the management of peptic ulcer. In addition, our review exhibited that further in vitro and preclinical investigations are mandatory to understand the absorption, metabolism, bioavailability, bioefficacy, and cellular mechanisms of dietary polyphenols.

In conclusion, the administration of a significant content of dietary polyphenols in the human diet or as dietary supplementation along with conventional treatment can resulted in perfect prevention and treatment for peptic ulcer.

Regarding the role of NSAID intake in the pathogenesis of ulceration, dietary polyphenols can be considered as adjuvants with NSAID-therapy for the protection of peptic ulcer. It is suggested that, according to the hierarchy pyramid of evidence-based medicine, well-designed controlled clinical trials must be performed in order to recognize higher levels of evidence for the confirmation of dietary polyphenol efficacy and safety in the management of peptic ulcer.

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Copyright Assignment PDF. Citation of this article. Farzaei MH, Abdollahi M, Rahimi R. Role of dietary polyphenols in the management of peptic ulcer. World J Gastroenterol ; 21 21 : [PMID: DOI: Corresponding Author of This Article.

Roja Rahimi, PhD, Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Amir Abad, Keshavarz Boulevard, Tehran , Iran. rojarahimi gmail. Checklist of Responsibilities for the Scientific Editor of This Article.

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Publication Name. Baishideng Publishing Group Inc, Koll Center Parkway, Suite , Pleasanton, CA , USA. Review Open Access. Copyright ©The Author s Published by Baishideng Publishing Group Inc. All rights reserved. World J Gastroenterol. Jun 7, ; 21 21 : Published online Jun 7, doi: Mohammad Hosein Farzaei , Mohammad Abdollahi , Roja Rahimi.

Mohammad Hosein Farzaei, Mohammad Abdollahi, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran , Iran.

Mohammad Hosein Farzaei, Roja Rahimi, Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran , Iran.

Mohammad Hosein Farzaei, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah , Iran. Author contributions : Farzaei MH contributed to study design, data collection, and drafting the manuscript; Abdollahi M contributed to study design, editing the manuscript, and English language editing; Rahimi R reviewed data collection and supervised the entire study.

Open-Access : This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. Correspondence to : Roja Rahimi, PhD, Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Amir Abad, Keshavarz Boulevard, Tehran , Iran.

Received: November 26, Peer-review started : November 26, First decision : February 10, Revised: February 22, Accepted: April 3, Article in press : April 3, Published online: June 7, Key Words: Anti-inflammatory , Dietary supplement , Helicobacter pylori , Inflammatory cytokines , Natural medicine , Non-steroidal anti-inflammatory drugs , Peptic ulcer , Polyphenols , Ulcer healing.

Citation: Farzaei MH, Abdollahi M, Rahimi R. Table 1 Clinical evidence of dietary polyphenols in the management of peptic ulcer. Polyphenol Preparations Study design Disease No.

of patients Treatment duration Outcomes Level of evidence 1 Ref. Treatment group Control group Curcumin Turmeric mg, four times per day Liquid antacid: aluminum hydroxide g and magnesium hydroxide There was no significant alteration in hematological parameters, liver, or renal functions after treatment 4 Prucksunand et al [ 56 ] Curcumin Turmeric tablet 40 mg curcumin Omeprazole 20 mg , amoxicillin 1 g , metronidazole mg , twice a day for 1 wk Randomized controlled trial Chronic gastritis with H.

pylori infection 36 4 wk The eradication rate of H. pylori in curcumin group was 5. pylori infection was lower in patients consuming green tea Pomegranate polyphenols and ellagic acid.

Open in New Tab Full Size Figure Download Figure. Figure 1 Structure of the most relevant polyphenol with a potential role for the management of peptic ulcer.

A: Allylpyrocatechol; B: Catechin; C: Curcumin; D: Cyanidin; E: Chlorogenic acid; F: Ellagic acid; G: Epigallocatechin gallate; H: Gallic acid; I: Quercetin; J: Rutin; K: Resveratrol. Figure 2 Potential cellular mechanisms of dietary polyphenols as preventive or therapeutic factors in the management of peptic ulcer.

IL: Interleukin; NF: Nuclear factor; MAPK: Mitogen-activated protein kinases; ERK: Extracellular signal-regulated kinase; TNF: Tumor necrosis factor; SOD: Superoxide dismutase; GSH: Glutathione; GPx: Glutathione peroxidase; EGF: Epidermal growth factor; VEGF: Vascular endothelial growth factor; NO: Nitric oxide; vWF: Von Willebrand factor.

Figure 3 Summary of the possible biological mechanisms of dietary polyphenols in the management of Helicobacter pylori associated gastritis and gastroduodenal ulceration. TLR4: Toll like receptor; IL: Interleukin; ROS: Reactive oxygen species; TNF: Tumor necrosis factor; JNK: c-Jun N-terminal kinase; NF: Nuclear factor.

P- Reviewer: Baik GH, Guadagni S S- Editor: Qi Y L- Editor: Rutherford A E- Editor: Wang CH. Malfertheiner P , Chan FK, McColl KE. Peptic ulcer disease.

Sumbul S , Ahmad MA, Mohd A, Mohd A. Role of phenolic compounds in peptic ulcer: An overview. J Pharm Bioallied Sci. Clin Nurse Spec.

Borrelli F , Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. Repetto MG , Llesuy SF. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res. Cryer B. Mucosal defense and repair. Role of prostaglandins in the stomach and duodenum.

Gastroenterol Clin North Am. Bandyopadhyay D , Biswas K, Bhattacharyya M, Reiter RJ, Banerjee RK. Gastric toxicity and mucosal ulceration induced by oxygen-derived reactive species: protection by melatonin. Curr Mol Med. Sen S , Asokkumar K, Umamaheswari M, Sivashanmugam AT, Subhadradevi V.

Antiulcerogenic effect of gallic Acid in rats and its effect on oxidant and antioxidant parameters in stomach tissue. Indian J Pharm Sci.

Tandon R , Khanna HD, Dorababu M, Goel RK. Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma. Indian J Physiol Pharmacol. Farzaei MH , Rahimi R, Abbasabadi Z, Abdollahi M.

An evidence-based review on medicinal plants used for the treatment of peptic ulcer in traditional Iranian medicine. Int J Pharmacol. Arakawa T , Watanabe T, Tanigawa T, Tominaga K, Fujiwara Y, Morimoto K.

Quality of ulcer healing in gastrointestinal tract: its pathophysiology and clinical relevance. Halter F , Tarnawski AS, Schmassmann A, Peskar BM. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives.

Wallace JL. NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies. Br J Pharmacol. Souza MH , Mota JM, Oliveira RB, Cunha FQ.

Gastric damage induced by different doses of indomethacin in rats is variably affected by inhibiting iNOS or leukocyte infiltration. Inflamm Res. Yadav SK , Adhikary B, Chand S, Maity B, Bandyopadhyay SK, Chattopadhyay S. Molecular mechanism of indomethacin-induced gastropathy.

Free Radic Biol Med. Langenbach R , Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, Kluckman KD.

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Tarnawski AS , Jones MK. Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications. J Mol Med Berl. Bahramsoltani R , Farzaei MH, Rahimi R.

Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res. Wang YC. Medicinal plant activity on Helicobacter pylori related diseases.

Vítor JM , Vale FF. Alternative therapies for Helicobacter pylori: probiotics and phytomedicine. FEMS Immunol Med Microbiol. Zaidi SF , Ahmed K, Yamamoto T, Kondo T, Usmanghani K, Kadowaki M, Sugiyama T. Effect of resveratrol on Helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells.

Biol Pharm Bull. Crabtree JE , Xiang Z, Lindley IJ, Tompkins DS, Rappuoli R, Covacci A. Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori.

J Clin Pathol. Toracchio S , Cellini L, Di Campli E, Cappello G, Malatesta MG, Ferri A, Ciccaglione AF, Grossi L, Marzio L. Role of antimicrobial susceptibility testing on efficacy of triple therapy in Helicobacter pylori eradication. Aliment Pharmacol Ther. Miederer SE.

Fortschr Med. Gisbert JP , Calvet X. Review article: the effectiveness of standard triple therapy for Helicobacter pylori has not changed over the last decade, but it is not good enough. Daglia M. Polyphenols as antimicrobial agents. Curr Opin Biotechnol.

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Sample preparation in the determination of phenolic compounds in fruits. Farzaei MH , Khanavi M, Moghaddam G, Dolatshahi F, Rahimi R, Shams-Ardekani MR, Amin G, Hajimahmoodi M. Standardization of Tragopogon graminifolius DC.

extracts based on phenolic compounds and antioxidant activity. J Chem. Cardona F , Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health.

J Nutr Biochem. Ferguson LR , Shelling AN, Browning BL, Huebner C, Petermann I. Genes, diet and inflammatory bowel disease. Mutat Res. McCarty MF. Dietary nitrate and reductive polyphenols may potentiate the vascular benefit and alleviate the ulcerative risk of low-dose aspirin.

Med Hypotheses. Scalbert A , Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr. Romier B , Schneider YJ, Larondelle Y, During A. Dietary polyphenols can modulate the intestinal inflammatory response.

The mastic tree generally grows in the Mediterranean region, and its sap can be dried into pieces of brittle translucent resin.

More recently, animal studies report that it may act as a potent natural ulcer remedy In one recent study, intake of mg of mastic gum three times a day for 14 days eradicated H. Although this finding has not been universally observed in all studies, long-term mastic consumption is generally considered safe.

Thus, it might be worth testing it out for yourself Summary: Mastic is a traditional anti-ulcer remedy that may help reduce symptoms and speed up recovery. In fact, people suffering from ulcers are often advised to limit their consumption of chili peppers or to avoid them completely.

However, recent research shows that these peppers are unlikely to cause ulcers and may actually help get rid of them.

Both of these factors are thought to help prevent or heal ulcers The capsaicin found in chili peppers may also help increase mucus production, which can coat the stomach lining and protect it from injury Most, although not all, animal studies show beneficial effects.

However, few human studies could be found 42 , 43 , Also, note that the animal studies above used capsaicin supplements rather than whole chili peppers. In at least one study, such supplements led to more intense gastric pain in certain individuals Therefore, it may be best to stick to the whole food and adjust your intake based on your personal tolerance.

Summary: Contrary to popular belief, regular consumption of chili peppers may help protect against ulcers and perhaps even enhance their healing.

However, more studies are needed, especially in humans. Aloe vera is a plant widely used in the cosmetic, pharmaceutical and food industries. It is widely known for its antibacterial and skin-healing properties. Interestingly, aloe vera may also be an effective remedy against stomach ulcers 46 , 47 , 48 , In one study, aloe vera consumption significantly reduced the amount of stomach acid produced in rats suffering from ulcers In another study in rats, aloe vera had ulcer-healing effects comparable to omeprazole, a common anti-ulcer medication However, few studies have been done in humans.

In one, a concentrated aloe vera drink was used to successfully treat 12 patients with stomach ulcers In another study, taking antibiotics with 1. pylori levels Aloe vera intake is considered generally safe and the above studies show some promising results.

However, more studies in humans are needed. Summary: Aloe vera may be an easy, well-tolerated remedy against stomach ulcers. However, more research in humans is needed.

Probiotics are live microorganisms that offer an array of health effects. Their benefits range from improving the health of your mind to the health of your gut, including its ability to prevent and fight ulcers.

Although the way this works is still being investigated, probiotics seem to stimulate the production of mucus, which protects the stomach lining by coating it. They may also promote the formation of new blood vessels, which eases transport of healing compounds to the site of the ulcer and speeds up the healing process 2.

Interestingly, probiotics may play a direct role in preventing H. pylori infections The dose required for maximum benefits is still being researched. That said, most of the studies above report benefits after taking million to 2 billion colony-forming units CFU for 2—16 weeks Probiotic-rich foods tend to provide less colony-forming units per portion than supplements, but they are worth adding to your diet nonetheless.

Summary: Probiotics may help prevent and fight ulcers. They may also enhance the efficiency of anti-ulcer medications and reduce their side effects. Just like some foods can help prevent ulcers from forming or help them heal faster, some have the exact opposite effect.

Those trying to heal their stomach ulcers or avoid developing them should consider minimizing their intake of the following foods 56 :. In addition to avoiding the foods above, consuming small meals at regular times, snacking throughout the day, eating slowly and chewing your food well can help reduce pain and promote healing Summary: Certain foods may increase the likelihood of developing ulcers and delay their healing.

Their intake should be minimized by individuals prone to or suffering from stomach ulcers. The natural remedies listed above may help prevent the development of stomach ulcers and facilitate their healing. In some cases, they may even improve the effectiveness of conventional treatment and reduce the severity of its side effects.

Thus, those suffering from ulcers should seek advice from their healthcare professional before self-medicating. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Stomach ulcers are painful sores in the lining of the stomach. They are a type of peptic ulcer disease. Stomach ulcers occur when the thick layer of…. Gastric and duodenal ulcers are both types of peptic ulcers.

These ulcers can cause different symptoms, depending on where they are. A peptic ulcer on…. MindBodyGreen provides third-party-tested supplements made with high quality ingredients.

Our testers and dietitians discuss whether MindBodyGreen…. Vitamins are for athletes to stay healthy. You may get all you need from the food you eat.

Some athletes may benefits from vitamin supplements. Docosahexaenoic acid, or DHA, is a type of omega-3 fat that may improve many aspects of your health, from your brain to your heart. Here are 12…. Vitamins are what your body needs to function and stay healthy.

It's possible to get all the vitamins you need from the food you eat, but supplements…. Vitamin K is an essential nutrient that helps with blood clotting and healthy bones. It can be found in leafy greens, vegetable oils, and broccoli.

L-citrulline is an amino acid made naturally in your body. It may also be taken as a supplement to help boost exercise performance, lower blood….

A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based 9 Science-Backed Home Remedies for Ulcers. By Alina Petre, MS, RD NL — Updated on February 15, Cabbage Juice. Share on Pinterest.

In another study, the same quantity of fresh cabbage juice was given to participants with stomach ulcers, most of whom had previously received conventional treatment with no success. However, researchers have yet to identify its exact recovery-promoting compounds, and no recent studies could be identified.

Moreover, neither of these early studies had a proper placebo, which makes it difficult to know for certain that the cabbage juice is what produced the effect.

Summary: Cabbage juice contains compounds that may help prevent and heal stomach ulcers. Cabbage is also rich in vitamin C, which appears to have similar protective properties. It comes from the dried root of the Glycyrrhiza glabra plant and is a popular traditional herbal medicine used to treat many conditions.

For instance, licorice may stimulate the stomach and intestines to produce more mucus, which helps protect the stomach lining. The extra mucus may also help speed up the healing process and help reduce ulcer-related pain Researchers further report that certain compounds found in licorice may prevent the growth of H.

However, studies are generally based on the use of these compounds in supplement form 12 , Dried licorice root should not be confused with licorice-flavored sweets or candy.

Licorice candy is unlikely to produce the same effects and is generally very high in sugar. Additionally, some studies report no effect, so using licorice as an ulcer remedy may not work in all cases Licorice may also interfere with certain medications and cause side effects, such as muscle pain or numbness in the extremities.

Consider speaking to your healthcare practitioner before increasing the licorice content of your diet. Honey is an antioxidant-rich food linked to a variety of health benefits.

These include improved eye health and a reduced risk of heart disease, stroke and even certain types of cancer Honey also appears to prevent the formation and promote the healing of many wounds, including ulcers pylori , one of the most common causes of stomach ulcers 17 , However, human studies are needed 19 , 20 , 21 , Summary: Regular consumption of honey may help prevent ulcers, especially those caused by H.

Garlic is another food with antimicrobial and antibacterial properties. Animal studies observe that garlic extracts may speed up recovery from ulcers and even reduce the likelihood of them developing in the first place 6 , 23 , pylori growth — one of the most common causes of ulcers In a recent study, eating two cloves of raw garlic per day for three days helped significantly reduce bacterial activity in the stomach lining of patients suffering from H.

Pylori infection However, not all studies were able to reproduce these results and more are needed before strong conclusions can be made Summary: Garlic has antimicrobial and antibacterial properties that may help prevent ulcers and heal them quicker. However, more research is needed.

Turmeric is a South Asian spice used in many Indian dishes. These range from improved blood vessel function to reduced inflammation and heart disease risk 28 , 29 , It appears to have immense therapeutic potential, especially in preventing damage caused by H.

Limited studies have been done in humans. One study gave 25 participants mg of turmeric five times per day. In another, individuals who tested positive for H.

pylori were given mg of turmeric four times per day. Thus, more research is needed. However, more research is needed, especially in humans. Mastic is a resin obtained from the Pistacia lentiscus tree, more commonly known as the mastic tree.

The mastic tree generally grows in the Mediterranean region, and its sap can be dried into pieces of brittle translucent resin.

More recently, animal studies report that it may act as a potent natural ulcer remedy In one recent study, intake of mg of mastic gum three times a day for 14 days eradicated H. Although this finding has not been universally observed in all studies, long-term mastic consumption is generally considered safe.

Thus, it might be worth testing it out for yourself Summary: Mastic is a traditional anti-ulcer remedy that may help reduce symptoms and speed up recovery. In fact, people suffering from ulcers are often advised to limit their consumption of chili peppers or to avoid them completely.

However, recent research shows that these peppers are unlikely to cause ulcers and may actually help get rid of them. Both of these factors are thought to help prevent or heal ulcers The capsaicin found in chili peppers may also help increase mucus production, which can coat the stomach lining and protect it from injury Most, although not all, animal studies show beneficial effects.

However, few human studies could be found 42 , 43 , Beverages cannot get rid of stomach ulcers, but they may help relieve the discomfort. Some options include cabbage juice, kombucha, and honey water.

Learn more about drinks for stomach ulcers. Most peptic ulcers heal within about weeks. Eating foods that naturally contain probiotics such as fermented foods may help the ulcer heal. In addition, eating broccoli or berries may also help.

Learn more about the best foods to eat with a stomach ulcer. A person may be able to find relief with some home remedies. But, people should see their doctor to find out the cause and receive medical treatment. A doctor can create a treatment plan to help treat the ulcer.

At-home remedies may help prevent ulcers from developing in the future and naturally help ease symptoms. Ulcers usually occur due to bacteria or are a side effect of nonsteroidal anti-inflammatory drugs. Learn more about causes and how diet can help…. A look at throat ulcers, a condition that makes it hard to swallow and causes other problems.

Included is detail on diagnosis and home remedies. What are the symptoms of a bleeding ulcer and what causes them? Learn about diagnosis, treatment, outlook, and myths about bleeding ulcers. My podcast changed me Can 'biological race' explain disparities in health? Why Parkinson's research is zooming in on the gut Tools General Health Drugs A-Z Health Hubs Health Tools Find a Doctor BMI Calculators and Charts Blood Pressure Chart: Ranges and Guide Breast Cancer: Self-Examination Guide Sleep Calculator Quizzes RA Myths vs Facts Type 2 Diabetes: Managing Blood Sugar Ankylosing Spondylitis Pain: Fact or Fiction Connect About Medical News Today Who We Are Our Editorial Process Content Integrity Conscious Language Newsletters Sign Up Follow Us.

Medical News Today. Health Conditions Health Products Discover Tools Connect. Nine ways to relieve stomach ulcers at home. Medically reviewed by Angelica Balingit, MD — By Jenna Fletcher — Updated on September 5, Home remedies Medical treatments FAQ Outlook In April , the Food and Drug Administration FDA requested that all forms of prescription and over-the-counter OTC ranitidine Zantac be removed from the U.

Ten evidence-based remedies for stomach ulcers. Medical treatments for ulcers. Frequently asked questions. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations.

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Related Coverage. Everything you need to know about stomach ulcers. Medically reviewed by Saurabh Sethi, M.

Long-term use of proton pump inhibitors, particularly at high doses, may increase your risk of hip, wrist and spine fracture.

Ask your doctor whether a calcium supplement may reduce this risk. Medications to reduce acid production. Acid blockers — also called histamine H-2 blockers — reduce the amount of stomach acid released into your digestive tract, which relieves ulcer pain and encourages healing.

Available by prescription or over the counter, acid blockers include the medications famotidine Pepcid AC , cimetidine Tagamet HB and nizatidine Axid AR. Antacids that neutralize stomach acid. Your doctor may include an antacid in your drug regimen. Antacids neutralize existing stomach acid and can provide rapid pain relief.

Side effects can include constipation or diarrhea, depending on the main ingredients. Medications that protect the lining of your stomach and small intestine. In some cases, your doctor may prescribe medications called cytoprotective agents that help protect the tissues that line your stomach and small intestine.

Treatment for peptic ulcers is often successful, leading to ulcer healing. But if your symptoms are severe or if they continue despite treatment, your doctor may recommend endoscopy to rule out other possible causes for your symptoms.

If an ulcer is detected during endoscopy, your doctor may recommend another endoscopy after your treatment to make sure your ulcer has healed. Ask your doctor whether you should undergo follow-up tests after your treatment. Peptic ulcers that don't heal with treatment are called refractory ulcers.

There are many reasons why an ulcer may fail to heal, including:. Treatment for refractory ulcers generally involves eliminating factors that may interfere with healing, along with using different antibiotics.

If you have a serious complication from an ulcer, such as acute bleeding or a perforation, you may require surgery. However, surgery is needed far less often now than previously because of the many effective medications available. There is a problem with information submitted for this request.

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You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail. Your in-depth digestive health guide will be in your inbox shortly. You will also receive emails from Mayo Clinic on the latest health news, research, and care. Products containing bismuth may help with symptoms of a peptic ulcer.

There is also some evidence that zinc can help heal ulcers. Mastic powder, the product of a type of evergreen shrub, may also help improve symptoms and speed healing of peptic ulcers.

While certain over-the-counter and alternative medications may be helpful, evidence on effectiveness is lacking. Therefore they are not recommended as the primary treatment for peptic ulcers. Make an appointment with your regular doctor if you have signs or symptoms that worry you.

Your doctor may refer you to a specialist in the digestive system gastroenterologist. It's a good idea to be well prepared for your appointment. Here's some information to help you get ready, and what you can expect from your doctor.

In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask other questions during your appointment. Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over points you want to cover.

Your doctor may ask:. While you're waiting to see your doctor, avoiding tobacco, alcohol, spicy foods and stress may help lessen your discomfort. Peptic ulcer care at Mayo Clinic.

Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. This content does not have an English version.

This content does not have an Arabic version. Diagnosis Upper endoscopy Enlarge image Close. Upper endoscopy An upper endoscopy procedure involves inserting a long, flexible tube called an endoscope down your throat and into your esophagus.