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Always Fast After a Surgery, Injury or Trauma Wound healing and chronic heaoing are serious healling health issues. While heqling heal, cellular stores Ribose in wound healing Iron and energy levels are depleted. d healnig l -cysteine DRLC is a Coconut Oil Recipes to the antioxidant glutathione. The effect of oral supplementation with DRLC on wound healing was studied in rats. A rodent model of calibrated wounding was used. Group A rats were given DLRC for 1 week before wounding and for 3, 7, or 14 days after wounding. Group B rats were given DRLC only after wounding.Ribose in wound healing -
Diabetes was induced in rats by streptozotocin injection followed by confirmation through measuring elevated blood glucose levels all over the period of the study. Full thickness skin wounds of 20 mm diameter showed slow healing and were still unhealed at 20th day in the control animals.
The most striking result was seen in the effect of sugar on angiogenesis in the wound beds where alginate alone did not improve the extent of CD34 identified blood vessels in the wound beds but the addition of sugar significantly increased these — this could be seen as early as seven days post addition of the sugar-loaded alginate dressing and was still evident at day Thus, these results suggest that the controlled use of 2-deoxy-d-ribose could be a novel and cost-effective therapy for the management of impaired wound healing in diabetic patients.
Skip to main content. Home Browse By Year By Subject By Department Search Help. Addition of 2-deoxy-d-ribose to clinically used alginate dressings stimulates angiogenesis and accelerates wound healing in diabetic rats.
Conclusions: DRLC supplementation appears to reduce wound inflammation early after wounding and enhance wound strength by 14 days. This suggests that increased intracellular glutathione levels may improve and enhance wound healing. Keywords: Glutathione; Inflammation; Nutritional supplementation; Wound healing; Wound strength.
Abstract Background: Wound healing and chronic wounds are serious public health issues. Publication types Research Support, Non-U. Substances Thiazolidines 2- 1',2',3',4'-tetrahydroxybutyl thiazolidinecarboxylic acid Cysteine. The second way is when an injury is unexpected and not caused by doctors, so ribose would not ordinarily be taken prior.
Once an injury or pathological condition has occurred, D-ribose can be used topically over the targeted site. This can be done using a solution of the D-ribose alone, or on the electrodes conveying a micro electric current, or as an ointment, gel, cream, or lotion with anti-microbial agents and even other agents as disclosed below, taking advantage of D-ribose's use as a carrier of such substances.
As part of a topical vehicle, ribose's soothing nature enhances quality of life. With respect to rectal hemorrhoids, D-ribose can be used with all techniques including using the rubber band technique or used in combination with a scalpel after tying off a severe hemorrhoid.
Also an infrared coagulator, preferably the Redfield IRC , can be used for less severe pathology. Both types of procedures are improved with parenteral or local D-ribose or both, with local D-ribose also being valuable when accompanying micro electric currents from an appropriate very low amperage therapeutic electromedical device or as it frequently would be called with old terminology, a very low amperage TENS device.
It promotes faster healing of open wounds whether surgical or traumatic. It produces greater pain relief from open wounds. It produces greater pain relief from closed injuries or painful pathological conditions by releasing more extracellular ATP and faster.
The transmitting device can be made so small that it can be worn comfortably on the body. In the event that the individual is squeamish about even a very low amperage unit that imparts no sensation, so does not want to insert electrodes or have a small electromedical unit attached, by giving ribose orally in advance before, during and after the surgery, potentiation of healing is still obtained.
The oral dose of D-ribose can be given dissolved in water so the daily dose of at least one gram but preferably 10 to 20 grams can be varied easily to suit the patient in need of healing. D-ribose can be provided with anti-infective agents to potentiate them. D-ribose can be used as a topical vehicle or carrier of medicaments across the skin, subcutaneous tissues and cell membranes.
D-ribose can be used internally or parentally to protect coronary stents from failing to heal fast enough to prevent re-stenosis. The features of the present invention which are believed to be novel are set forth with particularity in the appended claims.
The present invention, both as to its organization and the manner of operation, together with the further objects and advantages thereof, may be best understood by reference to the following exemplary and non-limiting detailed description of the invention, wherein; [].
The present invention comprises a method employing a series of steps to use D-ribose in the various ways its unique structure accomnodates, including as a carrier and as a topical vehicle of medicaments by itself, as a precursor for ATP, AMP and NAD, and finally in combination with a variety of therapeutic devices that employ non-living source energy such as obtained directly from an electric generator or batteries, by high temperature or refrigeration means or by various radiation devices, including X rays and radioactive material.
While the method of this disclosure is primarily planned to be used on human beings, it can be used on animals also because it is a treatment procedure involving living, or derived from living, tissue that has been injured or needs topical therapy.
The method comprises steps that involve employing or enduring said non-living source energy in combination with D-ribose, an essential precursor for nucleotides AMP, ATP and NADPH and nucleoside NAD and as a carrier and topical vehicle for medicaments across normal or injured skin.
D-ribose as a synthesized precursor is not ordinarily immediately available from food, because, its synthesis is by a tedious, lengthy process, however, made much shorter by supplying de novo D-ribose. On the other hand, as a carrier of medicaments it is immediately available for the action of transporting medicaments across a barrier such as the skin or mucous membranes and then with a delayed action, but much shorter than the full hexose monophosphate shunt, acting as a precursor, so its application can have a combined action, the first being as a vehicle.
With the infliction of energy-caused trauma resulting in injuries, with or without a surgical or therapeutic purpose, D-ribose can be given orally, mixed with other substances, including anti-microbials, cortical steroids, and certain anti-neoplastic drugs, by intravenous infusion, by placement into the rectum and even inside the abdomen during surgery.
It also can be applied topically to the skin with other medicaments, especially anti-microbials and topical anti-neoplastics, the ribose acting as a vehicle and carrier for these as well as its own precursor use.
It can be administered as a solid by mouth or as an aqueous solution and, of course, parentally in the form of an intravenous aqueous solution similar to the various kinds that employ glucose and water. Non-living-energy required for therapeutic units, including lasers, cauterization devices, infrared coagulators, skin penetrating scopes like arthroscopes, electrotherapeutic TENS devices, cryogenic devices, high-energy radiation devices and materials, ultrasonic devices, vibratory devices and simple heat and ice packs are well known and commercially available.
This disclosure is designed to be of use in part when such devices cause damage to the living tissue they are dealing with as part of their purpose. Thus a cryogenic device used to remove a shallow skin lesion actually freezes the pathological tissue and some surrounding tissue resulting in the same kind of damage as if a burn occurred.
A laser actually burns a tiny amount of tissue with each application to realize its objective. An infrared coagulator burns a larger amount of tissue with a single application than does the laser, because it cannot be so precisely focused as the laser, even though photons are the particles delivered in both cases, just with different wave lengths.
In surgery an electro-cauterization device imposes burns also. In addition toxic anti-neoplastic drugs irritate the skin when used to treat pre-cancerous skin lesions. This disclosure further seeks to offer means to enable faster healing, less irritation, with minimal scarring by using D-ribose in various ways in the therapeutic procedure.
When de novo D-ribose is given, a considerable amount of the pentose phosphate pathway is eliminated, saving as much as 88 hours of the up to 96 hours the entire pathway takes at its longest. Even if it takes only the minimum of time, 72 hours, 64 hours are saved. All the other precursors of ATP and NADPH are immediately available in food, but if de novo D-ribose is administered into body orifices, including the mouth, ears, nose, rectum, or vagina or placed on various locations on the skin by itself or preferably on the skin with anti-infective agents, besides its carrier use, the other precursors of ATP and NADPH, all available immediately from food, can be utilized by the body faster as long as the D-ribose is there already, to have all of the ingredients quickly available to increase the amount of these vital molecules.
Whereas, electricity in the hands of a surgeon can be destructive as in the case of the electro-cautery during the surgical procedure, special note in this disclosure is for the use of electric currents when they are not destructive but supportive.
This occurs after the surgery when such currents can be used at the wound site to effect faster healing. In order to be completely safe and work best, these currents must be less than one milliamp, and preferably less than 12 volts.
The electrodes can be of various numbered pairs, usually two or four electrodes, and can be the kind of electrodes used to monitor the heart such as those used for ECG's when only parenteral D-ribose is given. When D-ribose in solution is placed on electrodes for transcutaneous delivery, they can be of sponge material with liquids soaked in.
The cotton tip of an applicator stick can also be used. The liquids can be ordinary tap water or saline solution or have special electrically conducting material in them.
In this disclosure sponge-type electrodes, cotton applicator stick tips, or even bandages soaked in an aqueous solution can be used, but in addition to any other ingredient or without any other ingredient, D-ribose dissolved in the water in various strength solutions is of primary importance, and a major reason for this disclosure.
As long as D-ribose is in one sponge-type electrode, the other electrode can be an ECG or equivalent electrode or a hand held conductor of copper or other highly conductive material. When used as a topical preparation without the soothing and healing help of a TENS device, besides being active itself from the precursor point of view, as exemplified by the Carniglia, et al patents discussed in the Background, and as all the prior art involved with D-ribose been restricted to, its action as a physical carrier for other substances as part of a topical vehicle has never been disclosed.
This omission being addressed here includes using D-ribose as a carrier for anti-microbial agents, vaginal and rectal agents, corticosteroids, anti-neoplastic and other drugs that when water soluble can be in a solution with D-ribose but usually as a solid mixture containing D-ribose as part of the vehicle and with one or more medicaments, even toxic ones like 5-fluorouracil.
It can be used without an electric current in aqueous solutions alone for this purpose, but mostly it is used in ointments, gels, creams, and lotions as a vehicle or part of a vehicle.
The mechanism whereby DMSO penetrates the skin and carries therapeutic agents through it may differ from that of ribose, since DMSO is a solvent and ribose and sugars like it such as lactose are solids.
Nevertheless, D-ribose especially has the capacity to cross membranes, being a key ingredient in the molecule cells want most, ATP, and experience has taught us that when a wound or bum is encountered, ribose and antibiotics work faster than antibiotics alone, so ribose must make them more available.
This, of course, can extend to other medicaments, including 5-fluorouracil and certain refined herbs or herb-derived chemicals. When the electric current is used, the ingredients are also transported by iontophoresis, including the ribose, and then the ribose in turn may carry even higher concentrations of the other ingredients with it across the skin and then across target cell membranes.
The medicament can be more localized with microspheres, and the ribose can incorporated with or into microspheres. The use of certain sugars as carriers of other substances has a long history.
Samuel Hahnemann who founded the healing science, homeopathy, found that lactose could be used as a carrier of substances rendered homeopatbic. Ethanol and even DMSO, being liquid, are more convenient to use as topical carriers, but D-ribose dissolved in water is also effective with a multiple action as disclosed in this application.
When solids are involved, as is the case with antibiotic topical preparations, D-ribose can again be a very effective carrier as is homeopathic-used lactose as a solid.
When D-ribose is used in a topical preparation, the ribose acts in several different ways, including like the carrier sugar of homeopathic lactose, as a soothing part of a topical vehicle, and as its own unique use as a hard-to-get-by-food precursor of key elements in the healing process.
When D-ribose is used in place of lactose for homeopathic medicaments, the medicaments remain the same as in standard homeopathic preparations, however, when microcurrent electromedical electrodes are used also, the energy of the electrical current is additive to the energy of the homeopathic-type preparation with the D-ribose.
When D-ribose is used solely as a topical vehicle for carrier and vehicle purposes, many ingredients such as anti-itch creams, gels, ointments, or lotions, including commonly used ones such as diphenhydramine and calamine lotion, can be combined with it to facilitate absorption and increase the effectiveness.
Since D-ribose is an immediate precursor to important coenzymes and energy molecules, it has both a therapeutic use of itself and a carrier use to facilitate the absorption of the accompanying ingredients, whatever they are.
Lower concentrations can be used also with considerable effectiveness, especially if the non-ribose ingredients are inexpensive and low cost is vital. On the other hand, when the non-ribose ingredients are much more expensive than the ribose, a greater proportion of ribose used can be more cost effective, because it can carry a larger proportion of expensive ingredients by its abundance.
Ribose has a soothing quality to it and it imparts this soothing ability to ingredients that accompany it, even if they are soothing also. Of special interest with respect to using D-ribose with energy therapy devices is the use of infrared coagulation, which like the laser provides therapeutic light, which quickly becomes heat Of the two, the infrared coagulators provide more injury per application than the lasers.
This is because the laser is much more precise in the amount of injury it inflicts as part of its surgical removal of a lesion or hair or its knife-like use in the radial keratotomy procedure.
D-ribose in any form of delivery can aid the healing of these uses. With the laser there is less tissue destruction than with the infrared coagulator per individual application with the transducer.
Therefore, although D-ribose can be beneficial for both, it is even more beneficial for iatrogenic burns using the infrared coagulator in the obliteration of tattoos as an example. Since the infrared coagulator is a much less expensive instrument, treatments can cost less, while the use of D-ribose can make patients less prone to poor healing of the burned area.
While the Redfield IRC is the best infrared coagulator on the market at the time of this disclosure, other brands can be helped therapeutically in the recovery of the tissue by concomitant use of D-ribose, either topically or internally.
Patent application No. In the case of burns from lasers or infrared coagulators, the combination of a topical mixture of antibiotic ointments, and D-ribose can work very well to promote faster healing and decrease infection even without taking it by mouth or by other routes concomitantly, although combining parenteral and topical means works best.
Many different amounts of D-ribose compared to antibiotics can be used effectively, but the use of 5 grams of D-ribose mixed with 15 grams of antibiotic ointments is a good mixture. When preferred, gels can be substituted for ointments with 5 grams of D-ribose used per 15 grams of antibiotic gel.
Substances like Silvadene are used in the same way. While more ribose can be used, this ratio keeps the texture of the ointment or gel more similar to its texture before adding ribose.
The commonest antibiotics used this way are bacitracin, polymixin, and neomycin either together or separately. D-ribose can be added to such topical material and any antibiotic recommended for topical use in the Physicians Desk Reference can be used also.
If D-ribose makes an expensive topical antibiotic work better, it is very cost-effective. Of course, being inexpensive for topical use, D-ribose makes any topical preparation it can aid, more cost effective, including the routine combined triple antibiotic ointments and their preparations as solitary antibiotics also.
Once the infection is under control, the minimizing of scarring is desirable. At the present time cortisone preparations, including new ones such as clocortolone pivalate, are the treatment of choice.
Nevertheless, D-ribose as described above can be combined with cortisone in a gel, cream or ointment. Once again, although lower concentrations can be used, to go above one gram of ribose per three grams of cortisone ointment, cream or gel, interferes with the uniformity of the product, and greater amounts of D-ribose than these are not needed.
Molecular Medicine volume 20ni — Cite this article. Metrics details. Rigose ADP-ribosyl ation PARylation is a protein ni reaction regulating various diverse Pure essential oils functions ranging from metabolism, Body composition and weight loss repair and transcription to cell death. We set out to investigate the role of PARylation in wound healing, a highly complex process involving various cellular and humoral factors. We found that topically applied poly ADP-ribose polymerase PARP inhibitors 3-aminobenzamide and PJ accelerated wound closure in a mouse model of excision wounding. Moreover, wounds also closed faster in PARP-1 knockout mice as compared with wild-type littermates.
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