Circadian rhythm aging -
Shift work and poor mental health: a meta-analysis of longitudinal studies. Am J Public Health. Bei B, Wiley JF, Trinder J, Manber R. Wittmann M, Dinich J, Merrow M, Roenneberg T. Social jetlag: misalignment of biological and social time.
Chronobiol Int. Duffy JF, Zitting KM, Chinoy ED. Aging and circadian rhythms. Sleep Med Clin. Burgess HJ, Wyatt JK, Park M, Fogg LF. Home circadian phase assessments with measures of compliance yield accurate dim light melatonin onsets.
Horne J, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. Kantermann T, Sung H, Burgess HJ.
Comparing the Morningness-Eveningness Questionnaire and Munich ChronoType Questionnaire to the dim light melatonin onset. Roenneberg T, Wirz-Justice A, Merrow M. Life between clocks: daily temporal patterns of human chronotypes.
Buysse DJ. Sleep health: can we define it? Does it matter? Emens J, Burgess HJ. Effect of light and melatonin and other melatonin receptor agonists on human circadian physiology. Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase.
Am J Physiol. Gabel K, Hoddy KK, Haggerty N, et al. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: a pilot study. Nutr Healthy Aging.
Haynes PL, Gengler D, Kelly M. Social rhythm therapies for mood disorders: an update. Positive Data on Oral Orexin Receptor 2 Agonist for Patients with Narcolepsy Type 1. Implementing Effective Insomnia Management: Important Issues in Evaluation and Treatment.
Get Cozy and Keep Sleeping. Wellness in Physician Colleagues. The Lunch Hour. Sleep Research Roundup: January 12, Around the Practice. Between the Lines. Expert Perspectives. Case-Based Psych Perspectives. Medical World News. Payer-Provider Perspective.
Psychiatric Times. All Publications. Partner Perspectives. Job Board. Clinical Scales. Conference Coverage. Conference Listing. Interactive Tools. Special Reports. Print Subscription. Expert Perspectives on the Unmet Needs in the Management of Major Depressive Disorder Novel Delivery Systems Utilized in the Treatment of Adult ADHD Expert Perspectives on the Clinical Management of Bipolar 1 Disorder Major Depressive Disorder.
Couch In Crisis Early Career Psychiatry History of Psychiatry Residents Corner. Cultural Corner. Film and Book Reviews Poetry Writers Contest.
Psychiatric Practice. Burnout Careers Coding Guidelines Risk Management Telepsychiatry. Climate Change Critical Conversations in Psychiatry Portraits Psychiatric Views on the Daily News Tales From the Clinic: The Art of Psychiatry Tales from the New Asylum.
Media Around the Practice. Publications Psychiatric Times. Resources Clinical Scales. Subscribe Print Subscription. Bipolar Disorder. Bipolar I Disorder. Case Discussions. Compulsive Disorders.
Cultural Psychiatry. Digital Psychiatry. Digital Therapeutics. Eating Disorders. Forensic Psychiatry. Impulse Control Disorder. Integrative Psychiatry. International Overdose Awareness. Major Depressive Disorder. Mental Health Systems. Mood Disorders. Personality Disorders. Psychiatric Emergencies.
Sleep Disorders. Special Populations. Transcranial Magnetic Stimulation. SPOTLIGHT - Expert Perspectives on the Unmet Needs in the Management of Major Depressive Disorder. Novel Delivery Systems Utilized in the Treatment of Adult ADHD. Expert Perspectives on the Clinical Management of Bipolar 1 Disorder.
Circadian Rhythms Across the Lifespan April 30, Helen J. Burgess, PhD Leslie M. Swanson, PhD. Related Videos. Related Content. Contact Us. Terms and Conditions.
Chronic jet-lag increases mortality in aged mice. Yu, E. Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging Albany NY 3 , — Morris, C.
Circadian misalignment increases cardiovascular disease risk factors in humans. USA , E—E Longo, V. Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Di Francesco, A. A time to fast. Article ADS PubMed CAS PubMed Central Google Scholar. Speakman, J.
Caloric restriction. Deepa, S. Necroptosis increases with age and is reduced by dietary restriction. Aging Cell 17 , e Mitchell, S. Daily fasting improves health and survival in male mice independent of diet composition and calories. The hallmarks of aging. Asher, G. SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Kenyon, C. elegans mutant that lives twice as long as wild type. Bonkowski, M. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction.
Singh, P. The genetics of aging: a vertebrate perspective. Schumacher, B. Age to survive: DNA damage and aging. Trends Genet. Zhang, R.
A circadian gene expression atlas in mammals: implications for biology and medicine. Crosby, P. Cell , — e Zheng, X. AKT and TOR signaling set the pace of the circadian pacemaker. Ramanathan, C. mTOR signaling regulates central and peripheral circadian clock function.
PLoS Genet. Cao, R. Mammalian target of rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock. Tulsian, R. Caloric restriction effects on liver mTOR signaling are time-of-day dependent.
Aging Albany NY 10 , — Acosta-Rodriguez, V. Mice under caloric restriction self-impose a temporal restriction of food intake as revealed by an automated feeder system. Wu, R. The circadian protein period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 Complex.
Sato, S. Circadian reprogramming in the liver identifies metabolic pathways of aging. Solanas, G. Aged stem cells reprogram their daily rhythmic functions to adapt to stress.
A role of the circadian system and circadian proteins in aging. Patel, S. Circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGFdependent mechanisms. FASEB J. Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms.
Chen, D. Tissue-specific regulation of SIRT1 by calorie restriction. Satoh, A. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.
Herranz, D. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Article ADS PubMed CAS Google Scholar. The critical role of metabolic pathways in aging. Diabetes 61 , — Hahn, O. A nutritional memory effect counteracts benefits of dietary restriction in old mice.
Mattison, J. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Colman, R. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.
Caloric restriction improves health and survival of rhesus monkeys. Nelson, W. Meal-timing, circadian rhythms and life span of mice. Mistlberger, R. Neurobiology of food anticipatory circadian rhythms.
Izumo, M. Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant. elife 3 , e Article PubMed Central Google Scholar.
Stokkan, K. Entrainment of the circadian clock in the liver by feeding. Damiola, F. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus.
Vollmers, C. Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression. Mendoza, J. Food-reward signalling in the suprachiasmatic clock.
Hatori, M. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Sherman, H. Timed high-fat diet resets circadian metabolism and prevents obesity.
Chaix, A. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Eckel-Mahan, K.
Reprogramming of the circadian clock by nutritional challenge. Kohsaka, A. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Arble, D. Circadian timing of food intake contributes to weight gain.
Obesity Silver Spring 17 , — Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock.
Mattson, M. Impact of intermittent fasting on health and disease processes. Martinez-Lopez, N. System-wide benefits of intermeal fasting by autophagy. Talan, M. Varady, K. Impact of intermittent fasting on glucose homeostasis.
Care 19 , — Anson, R. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Goodrick, C.
Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age. Ageing Dev. Arum, O. The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet.
Aging Cell 8 , — Hirao, A. Combination of starvation interval and food volume determines the phase of liver circadian rhythm in PerLuc knock-in mice under two meals per day feeding. Liver Physiol. Brandhorst, S. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan.
Wei, M. Cheng, C. Fasting-mimicking diet promotes Ngn3-driven beta-cell regeneration to reverse diabetes. Roberts, M.
A ketogenic diet extends longevity and healthspan in adult mice. Newman, J. Ketogenic diet reduces midlife mortality and improves memory in aging mice. Tognini, P. Distinct circadian signatures in liver and gut clocks revealed by ketogenic diet.
Solon-Biet, S. Dietary protein to carbohydrate ratio and caloric restriction: comparing metabolic outcomes in mice. Cell Rep. Laeger, T. FGF21 is an endocrine signal of protein restriction. The starvation hormone, fibroblast growth factor, extends lifespan in mice. elife 1 , e Bookout, A.
FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Miller, R. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4 , — Barcena, C.
Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism. Glycine supplementation extends lifespan of male and female mice. Aging Cell 18 , e Kawai, N. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.
Neuropsychopharmacology 40 , — Mordel, J. Activation of glycine receptor phase-shifts the circadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus. Willcox, D.
Caloric restriction and human longevity: what can we learn from the Okinawans? Biogerontology 7 , — Fontana, L.
Promoting health and longevity through diet: from model organisms to humans. Redman, L. Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.
Diaz-Ruiz, A. Benefits of caloric restriction in longevity and chemical-induced tumorigenesis are transmitted independent of NQO1. Mercken, E. Aging Cell 12 , — Martin, C. Effect of calorie restriction on mood, quality of life, sleep, and sexual function in healthy nonobese adults: the CALERIE 2 randomized clinical trial.
JAMA Intern. Das, S. Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy CALERIE -2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.
Harvie, M. Potential benefits and harms of intermittent energy restriction and intermittent fasting amongst obese, overweight and normal weight subjects—a narrative review of human and animal evidence. Basel 7 , 4 Schubel, R.
Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: a randomized controlled trial. Sundfor, T. Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: a randomized 1-year trial.
Effects of intermittent versus continuous energy restriction for weight loss on diet quality and eating behavior. A randomized trial. Safdie, F. Fasting and cancer treatment in humans: a case series report.
Aging Albany NY 1 , — Lee, C. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Dorff, T. Safety and feasibility of fasting in combination with platinum-based chemotherapy.
BMC Cancer 16 , de Groot, S. The effects of short-term fasting on tolerance to neo adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study. BMC Cancer 15 , Zuccoli, G. Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report.
Willi, S. The effects of a high-protein, low-fat, ketogenic diet on adolescents with morbid obesity: body composition, blood chemistries, and sleep abnormalities.
Pediatrics , 61—67 Hallbook, T. Ketogenic diet improves sleep quality in children with therapy-resistant epilepsy. Epilepsia 48 , 59—65 Article PubMed CAS Google Scholar.
Husain, A. Diet therapy for narcolepsy. Neurology 62 , — Afaghi, A. Acute effects of the very low carbohydrate diet on sleep indices. Castano-Martinez, T. Methionine restriction prevents onset of type 2 diabetes in NZO mice. Gill, S. A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits.
Gupta, N. A camera-phone based study reveals erratic eating pattern and disrupted daily eating-fasting cycle among adults in India. PLoS ONE 12 , e McHill, A. Later circadian timing of food intake is associated with increased body fat.
CAS PubMed PubMed Central Google Scholar. Garaulet, M. Timing of food intake predicts weight loss effectiveness. Stote, K. A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults.
Moro, T. Tinsley, G. Time-restricted feeding in young men performing resistance training: a randomized controlled trial. Sport Sci. Sutton, E. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes.
Bandin, C. Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: a randomized, crossover trial.
Lopez-Minguez, J. Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: a randomized, cross-over study. Wehrens, S. Meal timing regulates the human circadian system.
Jakubowicz, D. Influences of breakfast on clock gene expression and postprandial glycemia in healthy individuals and individuals with diabetes: a randomized clinical trial. Diabetes Care 40 , — Richter, J. Twice as high diet-induced thermogenesis after breakfast vs dinner on high-calorie as well as low-calorie meals.
Wittmann, M. Social jetlag: misalignment of biological and social time. Nimitphong, H. More evening preference is positively associated with systemic inflammation in prediabetes and type 2 diabetes patients. Knutsson, A. Health disorders of shift workers.
Vetter, C. Night shift work, genetic risk, and type 2 diabetes in the UK Biobank. Diabetes Care 41 , — Straif, K. Carcinogenicity of shift-work, painting, and fire-fighting.
Lancet Oncol. High-energy breakfast with low-energy dinner decreases overall daily hyperglycaemia in type 2 diabetic patients: a randomised clinical trial.
Diabetologia 58 , — Scheer, F. Adverse metabolic and cardiovascular consequences of circadian misalignment. Wefers, J. Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans.
Hirshkowitz, M. Health 1 , — Spiegel, K. Effects of poor and short sleep on glucose metabolism and obesity risk. Brandenberger, G. Effect of sleep deprivation on overall 24 h growth-hormone secretion.
Lancet , Knutson, K. Associations between sleep loss and increased risk of obesity and diabetes. Y Acad. Article ADS PubMed PubMed Central Google Scholar.
Taheri, S. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite.
Al Khatib, H. The effects of partial sleep deprivation on energy balance: a systematic review and meta-analysis. Dashti, H. Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications.
An aging interventions testing program: study design and interim report. Aging Cell 6 , — Mannick, J. mTOR inhibition improves immune function in the elderly. Johnson, S. mTOR is a key modulator of ageing and age-related disease.
Metformin as a tool to target aging. Martin-Montalvo, A. Metformin improves healthspan and lifespan in mice. Madeo, F. Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential. Ruben, M.
A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine. Article PubMed CAS PubMed Central Google Scholar.
Refinetti, R. Social stimuli fail to act as entraining agents of circadian rhythms in the golden hamster. A , — Zwighaft, Z. Circadian clock control by polyamine levels through a mechanism that declines with age.
Levi, F. Hrushesky, W. Circadian timing of cancer chemotherapy. Science , 73—75 Hori, K. Timing of cancer chemotherapy based on circadian variations in tumor tissue blood flow.
Cancer 65 , — Ferrannini, E. Sodium-glucose transporter-2 inhibition as an antidiabetic therapy. Hermida, R. Chronotherapy with nifedipine GITS in hypertensive patients: improved efficacy and safety with bedtime dosing.
Strong, R. Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7 , — Patrono, C. Role of aspirin in primary prevention of cardiovascular disease.
Tofler, G. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. Ohdo, S. Chronopharmacological study of acetylsalicylic acid in mice.
Cohen, M. Prospective comparison of patient characteristics and outcome of non-prior aspirin users versus aspirin users with unstable angina or non-Q-wave myocardial infarction treated with combination antithrombotic therapy.
Thrombolysis 4 , — Bonten, T. Time-dependent effects of aspirin on blood pressure and morning platelet reactivity: a randomized cross-over trial. Hypertension 65 , — McNeil, J. Effect of aspirin on all-cause mortality in the healthy elderly. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly.
Minois, N. Polyamines in aging and disease. Chen, Z. Development and therapeutic potential of small-molecule modulators of circadian systems. Small molecule modifiers of circadian clocks. Cell Mol. Life Sci. Nohara, K. Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.
Ueda, H. Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles. Kasukawa, T. Human blood metabolite timetable indicates internal body time. Hughey, J. ZeitZeiger: supervised learning for high-dimensional data from an oscillatory system.
Nucleic Acids Res. Agostinelli, F. What time is it? Deep learning approaches for circadian rhythms. Bioinformatics 32 , Laing, E. Blood transcriptome based biomarkers for human circadian phase. elife 6 , e Anafi, R. CYCLOPS reveals human transcriptional rhythms in health and disease.
Wittenbrink, N. High-accuracy determination of internal circadian time from a single blood sample. Braun, R. Universal method for robust detection of circadian state from gene expression. Harrison, D. Acarbose, alpha-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.
Aging Cell 13 , — Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an alpha-glucosidase inhibitor or a Nrf2-inducer. Aging Cell 15 , — Garratt, M. Sex differences in lifespan extension with acarbose and alpha estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling.
Aging Cell 16 , — Villanueva, J. Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. Mair, W. Aging and survival: the genetics of life span extension by dietary restriction. Terzibasi, E. Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri.
Aging Cell 8 , 88—99 Catterson, J. Short-term, intermittent fasting induces long-lasting gut health and TOR-independent lifespan extension. Download references. We thank Dr.
Kimberly Cox for helpful manuscript editing and Fernando Augusto for the art production of figures. We apologize for the omission of relevant work owing to space constraints.
This work was supported by the Howard Hughes Medical Institute, NIH grant R01 AG J. and C. is an Investigator and F. is an Associate in the Howard Hughes Medical Institute. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. Victoria A. Acosta-Rodríguez, Filipa Rijo-Ferreira, Carla B.
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. You can also search for this author in PubMed Google Scholar. Correspondence to Joseph S. Peer review information Nature Communications thanks Roman Kondratov, Frank Scheer and the other, anonymous, reviewer s for their contribution to the peer review of this work.
Open Access This article is licensed under a Creative Commons Attribution 4. Reprints and permissions. Acosta-Rodríguez, V. Importance of circadian timing for aging and longevity. Nat Commun 12 , Download citation. Received : 07 August Accepted : 29 March Published : 17 May Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. Skip to main content Thank you for visiting nature.
nature nature communications review articles article. Download PDF. Subjects Ageing Circadian rhythms and sleep Feeding behaviour Metabolism. Abstract Dietary restriction DR decreases body weight, improves health, and extends lifespan. Introduction Aging is a major risk factor for chronic diseases, including obesity, diabetes, cancer, cardiovascular disease, and neurodegenerative disorders 1.
Full size image. Feeding paradigms in animal models In the last two decades we have come to appreciate that, in addition to caloric content, timing of feeding and fasting periods between meals influence wellbeing 45 , Implications for human health Caloric restriction and fasting-mimicking diets in humans Long-term CR also improves several markers of health in humans, both in obese and non-obese individuals , Consequences of misalignment of the circadian system Genetic polymorphisms make some people more likely to behave as an early bird early chronotype or a night owl late chronotype.
Circadian medicine: optimizing when to treat The National Institute of Aging Intervention Testing Program ITP is a multicenter initiative assessing treatments with the potential to extend lifespan and delay disease onset and dysfunction in mice Final remarks As the human population ages, the increased risk of chronic diseases has become a public health burden worldwide.
References Lopez-Otin, C. Article CAS PubMed Google Scholar Richardson, A. Article PubMed Google Scholar Bellantuono, I. Article CAS PubMed PubMed Central Google Scholar Deelen, J.
Article ADS PubMed PubMed Central CAS Google Scholar Barzilai, N. Article PubMed Google Scholar Nakahata, Y. Article CAS PubMed PubMed Central Google Scholar Ramsey, K. Article ADS CAS PubMed PubMed Central Google Scholar Chang, H. Article CAS PubMed PubMed Central Google Scholar Chaudhari, A.
Article CAS PubMed PubMed Central Google Scholar Khapre, R. Article CAS Google Scholar Green, C. Article CAS PubMed PubMed Central Google Scholar Rijo-Ferreira, F.
Article PubMed PubMed Central CAS Google Scholar Mohawk, J. Article CAS PubMed PubMed Central Google Scholar Takahashi, J. Article CAS PubMed Google Scholar Bass, J.
Article ADS CAS PubMed PubMed Central Google Scholar Koike, N. Article ADS CAS PubMed PubMed Central Google Scholar Gamble, K. Article PubMed PubMed Central Google Scholar Challet, E. Article PubMed Google Scholar Cincotta, A.
Article CAS PubMed Google Scholar Lamia, K. Article ADS CAS PubMed PubMed Central Google Scholar Gatfield, D. Article ADS CAS PubMed PubMed Central Google Scholar Conboy, I. Article ADS CAS PubMed Google Scholar Froy, O.
Article PubMed Google Scholar Hood, S. Article PubMed PubMed Central Google Scholar Dubrovsky, Y. Article CAS Google Scholar He, B. Article CAS PubMed PubMed Central Google Scholar Katewa, S. Article CAS PubMed Google Scholar Yamazaki, S.
Article ADS CAS PubMed PubMed Central Google Scholar Valentinuzzi, V. Article CAS PubMed Google Scholar Zhang, Y.
Article CAS PubMed Google Scholar Sellix, M. Article CAS PubMed PubMed Central Google Scholar Libert, S. Article CAS PubMed Google Scholar Park, N. Article Google Scholar Kondratov, R. Article CAS PubMed PubMed Central Google Scholar Hurd, M. Article CAS PubMed Google Scholar Hurd, M.
CAS PubMed Google Scholar Li, H. Article CAS PubMed Google Scholar Rudic, R. Article PubMed PubMed Central CAS Google Scholar Turek, F. Article ADS CAS PubMed PubMed Central Google Scholar Marcheva, B. Article ADS CAS PubMed PubMed Central Google Scholar Paschos, G.
Article CAS PubMed PubMed Central Google Scholar Davidson, A. Article CAS PubMed PubMed Central Google Scholar Yu, E. Article CAS Google Scholar Morris, C. Article ADS CAS PubMed PubMed Central Google Scholar Longo, V.
Article CAS PubMed PubMed Central Google Scholar Di Francesco, A. Article ADS PubMed CAS PubMed Central Google Scholar Speakman, J. Article CAS Google Scholar Deepa, S. Article PubMed PubMed Central CAS Google Scholar Mitchell, S.
Article CAS PubMed Google Scholar Lopez-Otin, C. Article CAS PubMed PubMed Central Google Scholar Asher, G. Article ADS CAS PubMed PubMed Central Google Scholar Kenyon, C. Article ADS CAS PubMed Google Scholar Bonkowski, M. Article ADS CAS PubMed PubMed Central Google Scholar Singh, P.
Article CAS PubMed PubMed Central Google Scholar Schumacher, B. Article CAS PubMed Google Scholar Zhang, R. Article ADS CAS PubMed PubMed Central Google Scholar Crosby, P. Article CAS PubMed PubMed Central Google Scholar Zheng, X. Article CAS PubMed PubMed Central Google Scholar Ramanathan, C.
Article PubMed PubMed Central CAS Google Scholar Cao, R. Article CAS PubMed PubMed Central Google Scholar Tulsian, R. Article CAS Google Scholar Acosta-Rodriguez, V. Article CAS PubMed PubMed Central Google Scholar Wu, R. Article CAS PubMed Google Scholar Sato, S.
Article CAS PubMed PubMed Central Google Scholar Solanas, G. Article CAS PubMed Google Scholar Kondratov, R. Article CAS PubMed Google Scholar Patel, S.
Article ADS CAS PubMed PubMed Central Google Scholar Chen, D. Article CAS PubMed PubMed Central Google Scholar Satoh, A. Article CAS PubMed PubMed Central Google Scholar Herranz, D. Article ADS PubMed CAS Google Scholar Barzilai, N.
Article CAS PubMed PubMed Central Google Scholar Hahn, O. Article CAS PubMed PubMed Central Google Scholar Mattison, J. Article ADS CAS PubMed Google Scholar Colman, R. Article ADS PubMed CAS Google Scholar Mattison, J. Article ADS CAS PubMed PubMed Central Google Scholar Nelson, W.
Article CAS PubMed Google Scholar Mistlberger, R. Article CAS PubMed Google Scholar Izumo, M.
Research Circaddian Aging Dermatology Open Aginv Circadian rhythm aging correspondence to: Jennifer Y. Zhang, Duke BoxDurham, North CarolinaUSA. Email: Jennifer. Zhang duke. Find articles by Kirchner, S.Video
How optimizing circadian rhythms can increase healthy years - Satchin Panda - TEDxBoston Germaine RhyrhmKuniaki Otsuka; Chronobiology of Aging: A Mini-Review. Gerontology 15 February ; Circdaian 2 Agin — Aging Antibacterial detergent pods generally associated with weakening of the Circdian system. Circadian rhythm aging circadian amplitude is reduced and the circadian acrophase becomes more labile, tending to occur earlier with advancing age. As originally noted by Franz Halberg, similar features are observed in the experimental laboratory after bilateral lesioning of the suprachiasmatic nuclei, suggesting the involvement of clock genes in the aging process as they are in various disease conditions.
0 thoughts on “Circadian rhythm aging”