World Cancer Research Fund Abd Institute for Cancer Research. Although becoming Lycopene and cancer prevention uncommon in most amd developed countries, stomach or gastric cancer remains one of the major causes of cancer death in the world. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids, pp

Lycopene and cancer prevention -

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How well do you score on brain health? Shining light on night blindness. Can watching sports be bad for your health? Beyond the usual suspects for healthy resolutions. April 3, By Harvard Prostate Knowledge Men who have been adding lycopene, a nutrient found in tomatoes, and other carotenoids to their diet in the hopes of staving off prostate cancer might want to reconsider.

Originally published April ; last reviewed February 24, About the Author. Harvard Prostate Knowledge See Full Bio. Share This Page Share this page to Facebook Share this page to Twitter Share this page via Email. Print This Page Click to Print. Related Content. Helzlsouer KJ, Comstock GW, Morris JS Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer.

Hung RJ, Zhang ZF, Rao JY, Pantuck A, Reuter VE, Heber D, Lu QY Protective effects of plasma carotenoids on the risk of bladder cancer. J Urol — Bruemmer B, White E, Vaughan TL, Cheney CL Nutrient intake in relation to bladder cancer among middle-aged men and women.

Riboli E, Gonzalez CA, Lopez-Abente G, Errezola M, Izarzugaza I, Escolar A, Nebot M, Hémon B, Agudo A Diet and bladder cancer in Spain: a multi-centre case-control study. Nomura AM, Kolonel LN, Hankin JH, Yoshizawa CN Dietary factors in cancer of the lower urinary tract. Okajima E, Ozono S, Endo T, Majima T, Tsutsumi M, Fukuda T, Akai H, Denda A, Hirao Y, Okajima E, Nishino H, Nir Z, Konishi Y Chemopreventive efficacy of piroxicam administered alone or in combination with lycopene and ß-carotene on the development of rat urinary bladder carcinoma after N -butyl- N - 4-hydroxybutyl nitrosamine treatment.

Giovannucci E Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. Mayne ST, Cartmel B, Lin H, Zheng T, Goodwin WJ Jr Low plasma lycopene concentration is associated with increased mortality in a cohort of patients with prior oral, pharynx or larynx cancers.

J Am Coll Nutr — Livny O, Kaplan I, Reifen R, Polak-Charcon S, Madar Z, Schwartz B Lycopene inhibits proliferation and enhances gap-junction communication of KB—1 human oral tumor cells.

Negri E, Franceschi S, Bosetti C, Levi F, Conti E, Parpinel M, La Vecchia C Selected micronutrients and oral and pharyngeal cancer. Zheng W, Blot WJ, Shu XO, Gao YT, Ji BT, Ziegler RG, Fraumeni JF Jr Diet and other risk factors for laryngeal cancer in Shangai, China.

Franceschi S, Bidoli E, Baron AE, Barra S, Talamini R, Serraino D, La Vecchia C Nutrition and cancer of the oral cavity and pharynx in north-east Italy. Associations with nutrient intakes, foods and food groups. Eur J Cancer B Oral Oncol — Bhuvaneswari V, Velmurugan B, Balasenthil S, Ramachandran CR, Nagini S Chemopreventive efficacy of lycopene on 7,dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.

Zakrzewska JM Oral lycopene—an efficacious treatment for oral leukoplakia? Evid Based Dent — El-Rouby DH Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline—1-oxide. Arch Oral Biol — Cheng HC, Chien H, Liao CH, Yang YY, Huang SY Carotenoids suppress proliferating cell nuclear antigen and cyclin D1 expression in oral carcinogenic models.

De Stefani E, Oreggia F, Boffetta P, Deneo-Pellegrini H, Ronco A, Mendilaharsu M Tomatoes, tomato-rich foods, lycopene and cancer of the upper aerodigestive tract: a case-control in Uruguay.

Oral Oncol — Giovannucci E, Clinton SK Tomatoes, lycopene, and prostate cancer. Proc Soc Exp Biol Med — Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH, Stampfer MJ Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis.

Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC Intake of carotenoids and retinol in relation to risk of prostate cancer.

Kelloff GJ, Lieberman R, Steele VE, Boone CW, Lubet RA, Kopelovitch L, Malone WA, Crowell JA, Sigman CC Chemoprevention of prostate cancer: concepts and strategies. Eur Urol — Ozten-Kandaş N, Bosland MC Chemoprevention of prostate cancer: natural compounds, antiandrogens, and antioxidants — in vivo evidence.

J Carcinog Etminan M, Takkouche B, Caamano-Isorna F The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies. Cancer Epidemiol Biomark Prev — Wei MY, Giovannucci EL Lycopene, tomato products, and prostate cancer incidence: a review and reassessment in the PSA screening era.

J Oncol Ilic D, Misso M Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review. Maturitas — Jian L, Lee AH, Binns CW Tea and lycopene protect against prostate cancer. Asia Pac J Clin Nutr — Jain MG, Hislop GT, Howe GR, Ghadirian P Plant foods, antioxidants, and prostate cancer risk: findings from case, control studies in Canada.

Beilby J, Ambrosini GL, Rossi E, De Klerk NH, Musk AW Serum levels of folate, lycopene, β-carotene, retinol and vitamin e and prostate cancer risk.

Kristal AR, Till C, Platz EA, Song X, King IB, Neuhouser ML, Ambrosone CB, Thompson IM Serum lycopene concentration and prostate cancer risk: results from the prostate cancer prevention trial. Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, Erdman JW Jr Cis-trans lycopene isomers, carotenoids and retinol in human prostate.

Van Gils CH, Bostick RM, Stern MC, Taylor JA Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene. Kristal AR, Schenk MJ Directions for future epidemiological research in lycopene and prostate cancer risk.

Ivanov NI, Cowell SP, Brown P, Rennie PS, Guns ES, Cox ME Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.

Clin Nutr — Clinton SK Tomatoes or lycopene: a role in prostate carcinogenesis? Siler U, Herzog A, Spitzer V, Seifert N, Denelavas A, Hunziker P, Barella L, Hunziker W, Lein M, Goralczyk R, Wertz K Lycopene effects on rat normal prostate and prostate tumor tissue.

Limpens J, Schroder FH, de Ridder CM, Bolder CA, Wildhagen MF, Obermuller-Jevic UC, Kramer K, van Weerden WM Combined lycopene and vitamin E treatment suppresses the growth of PC—C human prostate cancer cells in nude mice. Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman JW, Clinton SK Prostate carcinogenesis in N -methyl- N -nitrosurea NMU -testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.

Kucuk O, Sarkar F, Sakr W, Djuric Z, Khachik F, Pollak M, Bertram J, Grignon D, Banerjee M, Crissman J, Pontes E, Wood DP Jr Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy.

Chen L, Stazewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, vanBreemen R, Ashton D, Bowen PE Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.

Ansari MS, Gupta NP A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int — Mohanty NK, Saxena S, Singh UP, Goyal NK, Arora RP Lycopene as a chemopreventive agent in the treatment of high grade prostatic intraepithelial neoplasia.

Urol Oncol — Edinger MS, Koff WJ Effect of the consumption of tomato paste on plasma prostate specific antigen levels in patients with benign prostate hyperplasia. Braz J Med Biol Res — Urology — Chang S, Erdman JW, Clinton SK, Vadiveloo M, Strom SS, Yamamura Y, Duphorne CM, Spitz MR, Amos CI, Contois JH, Gu X, Babaian RJ, Scardino PT, Hursting SD Relationship between plasma carotenoids and prostate cancer.

Vogt TM, Mayne ST, Graubard BI, Swanson CA, Sowell AL, Schoenberg JB, Swanson GM, Greenberg RS, Hoover RN, Hayes RB, Ziegler RG Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites.

Van Breemen RB, Sharifi R, Viana M, Pajkovic N, Zhu D, Yuan L, Yang Y, Bowen PE, Stacewicz-Sapuntzakis M Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: a randomized, controlled trial. Cancer Prev Res Phila — Jemal A, Siegel R, Xu J, Ward E Cancer statistics.

Faramawi MF, Johnson E, Fry MW, Sall M, Zhou Y Consumption of different types of meat and the risk of renal cancer: meta-analysis of case-control studies. Maclure M, Willet W A case—control study of diet and risk of renal adenocarcinoma.

Epidemiology — Lindblad P, Wolk A, Bergstrom R, Adami HO Diet and risk of renal cell cancer: a population-based case—control study.

Mellemgaard A, McLaughlin JK, Overvad K, Olsen JH Dietary risk factors for renal cell carcinoma in Demark. Talamini R, Baron AE, Barra S, Bidoli E, La Vecchia C, Negri E, Serraino D, Franceschi S A case—control study of risk factors for renal cell cancer in northern Italy.

Cross B, Sahin K, Sahin N, Ciccone K, Osunkoya A, Master V, Harris W, Carthon B, Mohammad R, Bilir B, Canter D, Wertz K, Wu DQ, Moreno C, Walker C, Kucuk O Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model.

Zhao SZ, Wong JM, Arguelles LM Hospitalization costs associated with leiomyoma. Clin Ther — Terry KL, Missmer SA, Hankinson SE, Willett WC, De Vivo I Lycopene and other carotenoid intake in relation to risk of uterine leiomyomata.

Am J Obstet Gynecol Stewart EA Uterine fibroids. Lancet — Moore AB, Castro L, Yu L, Zheng X, Di X, Sifre MI, Kissling GE, Newbold RR, Bortner CD, Dixon D Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration.

Hum Reprod — Sahin K, Ozercan R, Onderci M, Sahin N, Gursu MF, Khachik F, Sarkar FH, Munkarah A, Ali-Fehmi R, Kmak D, Kucuk O Lycopene supplementation prevents the development of spontaneous smooth muscle tumors of the oviduct in Japanese quail.

Sahin N, Cross B, Sahin K, Ciccone K, Osunkoya A, Master V, Haris W, Carthon B, Mohammad R, Moreno C, Walker C, Kucuk O Preventıon of uterine leiomyoma by lycopene in the TSC2 mutant eker rat model. In: Fourth international congress on nutrition and cancer, Antalya, 19—23 Oct Conklin KA Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects.

Sahin K, Sahin N, Kucuk O Lycopene and chemotherapy toxicity. Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? Erhola M, Kellokumpu-Lehtinen P, Metsa-Ketela T, Alanko K, Nieminen MM Effects of anthracyclin-based chemotherapy on total plasma antioxidant capacity in small cell lung cancer patients.

Free Radic Biol Med — Block KI, Koch AC, Mead MN, Tothy PK, Newman RA, Gyllenhaal C Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials.

D'Incalci M, Steward WP, Gescher AJ Modulation of response to cancer chemotherapeutic agents by diet constituents: is the available evidence sufficiently robust for rational advice for patients? Cancer Treat Rev — Dogukan A, Tuzcu M, Agca CA, Gencoglu H, Sahin N, Onderci M, Ozercan IH, Ilhan N, Kucuk O, Sahin K A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl—2, and HSPs expression.

Rios AO, Antunes LMG, Bianchi MLP Bixin and lycopene modulation of free radical generation induced by cisplatin—DNA interaction. Food Chem — Zhou C, Han W, Zhang P, Cai M, Wei D, Zhang C Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats.

Nutr Res — Ferreira AL, Salvadori DM, Nascimento MC, Rocha NS, Correa CR, Pereira EJ, Matsubara LS, Matsubara BB, Ladeira MS Tomato-oleoresin supplement prevents doxorubicin-induced cardiac myocyte oxidative DNA damage in rats.

Mutat Res — Sendão MC, Behling EB, dos Santos RA, Antunes LM, de Lourdes Pires Bianchi M Comparative effects of acute and subacute lycopene administration on chromosomal aberrations induced by cisplatin in male rats.

Karimi G, Ramezani M, Abdi A Protective effects of lycopene and tomato extract against doxorubicin-induced cardiotoxicity. Phytother Res — Puri T, Goyal S, Julka PK, Nair O, Sharma DN, Rath GK Lycopene in treatment of high-grade gliomas: a pilot study.

Neurol India — Andic F, Garipagaoglu M, Yurdakonar E, Tuncel N, Kucuk O Lycopene in the prevention of gastrointestinal toxicity of radiotherapy. Download references. The authors would like to thank Prof. Nurhan Sahin, Dr. Mehmet Tuzcu, and Dr. Cemal Orhan for much valuable collaboration.

Department of Animal Nutrition, Firat University, Elazig, , Turkey. Kazim Sahin DVM, Ph. Faculty of Veterinary Medicine. Emory University, Winship Cancer Institute, Atlanta, GA, USA. You can also search for this author in PubMed Google Scholar.

Correspondence to Kazim Sahin DVM, Ph. Botany Department, M. Sukhadia University, Durga Nursery Road, Udaipur, , Rajasthan, India. Institute of Vine and Wine Sciences, Biological-Active Plant Substances Study, University of Bordeaux, Chemin de Leysotte CS , Villenave d'Ornon, , France.

Reprints and permissions. Sahin, K. Lycopene in Cancer Prevention. In: Ramawat, K. eds Natural Products. Springer, Berlin, Heidelberg. Published : 15 May Publisher Name : Springer, Berlin, Heidelberg.

Print ISBN : Online ISBN : eBook Packages : Chemistry and Materials Science Reference Module Physical and Materials Science Reference Module Chemistry, Materials and Physics. Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics. Skip to main content. Abstract Lycopene, a red-colored carotenoid, present in many fruits and vegetables, including tomatoes and their processed products, watermelon, guava, carrots, pink grapefruit, and sweet potatoes, is inversely associated with the risk of many cancers.

Keywords Cancer lycopene molecular mechanism nutrition prevention. Buying options Chapter EUR eBook EUR 2, Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions.

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Lycopene, a red-colored Lycopene and cancer prevention, present in many prevengion and vegetables, Alpha-lipoic acid antioxidant tomatoes and their processed products, watermelon, guava, carrots, pink dancer, and sweet Canncer, is inversely associated with the risk Lycopnee many preventkon. Unlike beta-carotene, Caancer lacks a beta-ionone Real-time glucose monitoring and therefore has no provitamin A activity. However, the 11 conjugated and two nonconjugated double bonds in lycopene make it highly reactive toward oxygen and free radicals. Lycopene has been proposed to protect against cancer through various properties including decreased lipid oxidation, inhibition of cancer cell proliferation, and most notably potent antioxidant properties, apoptosis, increased gap-junctional communication, interferences in insulin-like growth factor 1 receptor signaling pathways, and cell cycle progression. Preclinical studies and clinical trials show that lycopene has potent in vitro and in vivo antitumor effects, suggesting potential preventive and therapeutic roles for lycopene. Further mechanistic studies and randomized controlled clinical intervention trials with lycopene in cancer patients are warranted. Lycopene and cancer prevention Enhanced Brain Function and Awareness literature in the English language regarding prdvention of tomatoes and tomato-based Lycopene and cancer prevention and blood lycopene a compound derived predominantly from prevehtion level in relation to the risk yLcopene various cancers was reviewed. Nutrition for athletes 72 canxer Lycopene and cancer prevention, 57 prevsntion inverse associations between tomato intake or blood lycopene level and the risk of cancer at a defined anatomic site; 35 of these inverse associations were statistically significant. No study indicated that higher tomato consumption or blood lycopene level statistically significantly increased the risk of cancer at any of the investigated sites. About half of the relative risks for comparisons of high with low intakes or levels for tomatoes or lycopene were approximately 0. The evidence for a benefit was strongest for cancers of the prostate, lung, and stomach.

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Processed Tomatoes Reduce Animal Prostate Cancer