Effects Mental fitness programs inhaled nitric oxide oxidw regional Nitric oxide and sleep quality flow are consistent with intravascular nitric oixde delivery. Nitric oxide and sleep quality PG, Chatkin JM, Qian W, HaightJSJ. Division of Hospital Medicine, Virginia Commonwealth University, Richmond, Virginia, USA. Brooks D, HornerRL, Kozar LF, et al. Provided by the Springer Nature SharedIt content-sharing initiative.

Nitric oxide and sleep quality -

Redline S et al Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med 2 — Wolff B et al Relation of self-reported sleep duration with carotid intima-media thickness in a general population sample.

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Sleep 37 3 — Greene RW Role for neuronal nitric oxide synthase in sleep homeostasis and arousal. Proc Natl Acad Sci U S A 50 — Download references. Division of Hospital Medicine, Virginia Commonwealth University, Richmond, Virginia, USA. Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

You can also search for this author in PubMed Google Scholar. Correspondence to Jensen H. Informed consent was obtained from all individual participants included in the study. There is no identifying information included in this article.

Reprints and permissions. Hyde, J. The effect of sleep duration on exhaled nitric oxide levels in U. Sleep Breath 21 , — Download citation. Received : 15 November Revised : 11 April Accepted : 23 May Published : 06 June Issue Date : December Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Purpose Poor sleep quality and duration are associated with systemic endothelial dysfunction.

Methods We used three National Health and Nutrition Examination Survey NHANES cycles — Results Of 13, participants Conclusion Sleeping less or more than 7 h is associated with pulmonary endothelial dysfunction as measured by FeNO.

Access this article Log in via an institution. References Benito-Leon J et al Author response. Circ Res 87 10 — Article CAS PubMed Google Scholar Calvin AD et al Experimental sleep restriction causes endothelial dysfunction in healthy humans.

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x Article PubMed Google Scholar Ikehara S et al Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: the JACC study. Sleep 32 3 — Article PubMed PubMed Central Google Scholar Redline S et al Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study.

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e0 Article CAS PubMed Google Scholar Nagai M et al Sleep duration and insomnia in the elderly: associations with blood pressure variability and carotid artery remodeling. Author information Authors and Affiliations Division of Hospital Medicine, Virginia Commonwealth University, Richmond, Virginia, USA Jensen H.

Hyde View author publications. View author publications. Ethics declarations Funding No funding was received for this research. Ana Cristina Ribeiro , Fordham University. Nitric oxide is a free radical neurotransmitter that is involved in a number of physiological and pathological processes.

Preliminary evidence suggests that nitric oxide could play a role in regulating vigilance. The experiments described in this thesis sought to characterize the involvement of nitric oxide in the homeostatic and circadian process of sleep regulation.

To examine the role of nitric oxide in the circadian component of sleep regulation, nitric oxide donors and a nitric oxide synthase inhibitor were microinjected directly to the suprachiasmatic nucleus, a major output of the suprachiasmatic nucleus, the sub-paraventricular zone, or the area surrounding the circadian pacemaker diencephalic region and sleep responses were recorded.

Anterior diencephalic microinjection of a nitric oxide synthase inhibitor greatly increased rapid-eye-movement sleep, and these effects were also seen after sub-paraventricular zone microinjection of the nitric oxide synthase inhibitor.

On the other hand, when the microinjections were aimed at the suprachiasmatic nucleus, nitric oxide donor suppressed rapid-eye-movement sleep.

Systemic injection of a nitric oxide synthase inhibitor at dark-onset greatly increased rapid-eye-movement sleep. These findings are consistent with the hypothesis that nitric oxide may have arousal-promoting effects, mediated in part by the suprachiasmatic nucleus.

In terms of the homeostatic process of sleep regulation, systemic injection of a nitric oxide synthase inhibitor shortened in length and decreased in amplitude the sleep rebound to sleep deprivation.

Also, in response to sleep deprivation, nitric oxide synthase enzyme activity was decreased in brain nuclei involved in sleep-wake cycle regulation.

On the other hand, nitric oxide synthase protein amounts were increased following extended wakefulness, especially inducible nitric oxide synthase in the basal forebrain.

Systemic injection of a nitric oxide synthase inhibitor at a time when homeostatic sleep pressure is spontaneously highest, at light onset, also decreased sleep amounts, suggesting that and intact nitric oxide-ergic signaling cascade is necessary for proper sleep responses to be mounted after both spontaneous and forced wakefulness.

For more Nitric oxide and sleep quality about PLOS Subject Areas, qnd here. Sleep loss can induce or aggravate the development of cardiovascular and cerebrovascular diseases. However, quwlity molecular Nitric oxide and sleep quality underlying this phenomenon is poorly understood. The present study was designed to investigate the effects of REM sleep deprivation on blood pressure in rats and the underlying mechanisms of these effects. After Sprague-Dawley rats were subjected to REM sleep deprivation for 5 days, their blood pressures and endothelial function were measured. Nitric oxide Qua,ity is a qquality messenger synthesized qyality three main isoforms Qualoty NO synthase NOS : neuronal nNOS, constitutive calcium dependentendothelial eNOS, constitutive, Nitric oxide and sleep quality dependent and inducible iNOS, calcium independent. Sports bars and carbohydrate content is Nitric oxide and sleep quality in the aand either in circumscribed neuronal Nitrci or in sparse Nirtic. Within qualify laterodorsal tegmentum LDTpedunculopontine tegmentum and dorsal raphe nucleus, NOS-containing neurons overlap neurons grouped according to their contribution to sleep mechanisms. The main target for NO is the soluble guanylate cyclase that triggers an overproduction of cyclic guanosine monophosphate. NO in neurons of the pontine tegmentum facilitates sleep particularly rapid-eye-movement sleepand NO contained within the LDT intervenes in modulating the discharge of the neurons through an auto-inhibitory process involving the co-synthesized neurotransmitters. Moreover, NO synthesized within cholinergic neurons of the basal forebrain, while under control of the LDT, may modulate the spectral components of the EEG instead of the amounts of different sleep states.