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Creatine and cognitive function

Creatine and cognitive function

Article Digestive aid drops PubMed Google Scholar Lind A, Creatin CJ, Petersen ET, Paulson OB, Siebner HR, Marsman A. Crewtine ME, Gusnard DA. Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway. Bayes factor that indicates how likely a null hypothesis is compared to an alternative hypothesis given the data. van DoornJ. Med Sci Sports Exerc.

Creatine and cognitive function -

Benton, D. The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. British Journal of Nutrition, 7 , — McMorris, T. Creatine supplementation and cognitive performance in elderly individuals. Aging, Neuropsychology, and Cognition, 14 5 , — Alves, C.

Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study. PLoS ONE, 8 10 , 1— Wilkinson, I. Effects of creatine supplementation on cerebral white matter in competitive sportsmen.

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In contrast, higher dietary creatine intake has been associated with better short-term memory. Creatine supplementation can increase brain CP content. In terms of available measurable performance effects on brain function, research is still in the early stages. So far there is some promising evidence that creatine supplementation may be a useful adjunct therapy for treating depression and PTSD.

Animal studies have found that creatine supplementation may be protective against traumatic brain injury. Creatine has been exhaustively studied for over thirty years.

Remember, creatine is synthesized in your body and you obtain some creatine naturally in foods you eat even trace amounts from plant sources. Creatine dietary supplements come in a variety of formulae creatine monohydrate, creatine citrate, and creatine alkaline , with creatine monohydrate being the original, and most-studied version.

Competing versions of creatine are marketed to provide greater absorption than their competitors, though no evidence supports the superiority of one form of creatine over another. If you choose to supplement creatine, a daily dose of 3g per day has been found to increase muscle creatine content within 4 weeks of supplementation.

Of course, it is always best to consult your medical provider before starting any new supplements. Ask Foodguides AI Articles Foodguides Products Contributors Mission. Ask Foodguides AI Articles Foodguides Products Contributors Mission Instagram Facebook Youtube Twitter. Neurobiol Dis. Mazzini L, Balzarini C, Colombo R, Mora G, Pastore I, De Ambrogio R, et al.

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Creatine monohydrate in myotonic dystrophy: a double-blind, placebo-controlled clinical study. J Neurol. Schneider-Gold C, Beck M, Wessig C, George A, Kele H, Reiners K, et al. Proximal myotonic myopathy. Tarnopolsky M. Clinical use of creatine in neuromuscular and neurometabolic disorders. Kley R, Tarnopolsky M, Vorgerd M.

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Creatine monohydrate does not increase strength in patients with hereditary neuropathy. Chetlin RD, Gutmann L, Tarnopolsky MA, Ullrich IH, Yeater RA. Resistance training exercise and creatine in patients with Charcot-Marie-Tooth disease.

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Am J Psychiatry. Li BSY, Wang H, Gonen O. Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy.

Magn Reson Imaging. Chang L, Mehringer CM, Ernst T, Melchor R, Myers H, Forney D, et al. Neurochemical alterations in asymptomatic abstinent cocaine users: a proton magnetic resonance spectroscopy study. Faulkner P, Lucini Paioni S, Kozhuharova P, Orlov N, Lythgoe DJ, Daniju Y, et al.

Daily and intermittent smoking are associated with low prefrontal volume and low concentrations of prefrontal glutamate, creatine, myo-inositol, and N -acetylaspartate. Addict Biol.

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J Child Neurol. Faulkner P, Paioni SL, Kozhuharova P, Orlov N, Lythgoe DJ, Daniju Y, et al. Relationship between depression, prefrontal creatine and grey matter volume.

J Psychopharmacol. Yue Q, Liu M, Nie X, Wu Q, Li J, Zhang W, et al. Quantitative 3. Lyoo IK, Yoon S, Kim TS, Hwang J, Kim JE, Won W, et al. A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.

Nemets B, Levine J. Int Clin Psychopharmacol. Braissant O. Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers. van de Kamp JM, Pouwels PJW, Aarsen FK, ten Hoopen LW, Knol DL, de Klerk JB, et al.

Long-term follow-up and treatment in nine boys with X-linked creatine transporter defect. Pazini FL, Cunha MP, Rosa JM, Colla ARS, Lieberknecht V, Oliveira Á, et al. Mol Neurobiol. Assis LC, Rezin GT, Comim CM, Valvassori SS, Jeremias IC, Zugno AI, et al.

Effect of acute administration of ketamine and imipramine on creatine kinase activity in the brain of rats. Rev Bras Psiquiatr. Kious BM, Kondo DG, Renshaw PF. Creatine for the treatment of depression. Mirowsky J, Ross CE. Age and depression. J Health Soc Behav.

Lind A, Boraxbekk CJ, Petersen ET, Paulson OB, Siebner HR, Marsman A. Regional myo-inositol, creatine, and choline levels are higher at older age and scale negatively with visuospatial working memory: a cross-sectional proton MR spectroscopy study at 7 Tesla on normal cognitive ageing.

Brown MS, Singel D, Hepburn S, Rojas DC. Increased glutamate concentration in the auditory cortex of persons with autism and first-degree relatives: a 1 H-MRS study. Autism Res. Nagae-Poetscher LM, Bonekamp D, Barker PB, Brant LJ, Kaufmann WE, Horská A. Asymmetry and gender effect in functionally lateralized cortical regions: a proton MRS imaging study.

J Magn Reson Imaging. Pouwels PJW, Frahm J. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn Reson Med. Tayoshi S, Sumitani S, Taniguchi K, Shibuya-Tayoshi S, Numata S, Iga J, et al.

Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy 1H-MRS.

Schizophr Res. Dunlop BW, Nemeroff CB. The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry. Download references. This supplement is supported by the Gatorade Sports Science Institute GSSI.

The supplement was guest edited by Dr. Lawrence L. Spriet, who convened a virtual meeting of the GSSI Expert Panel in October and received honoraria from the GSSI, a division of PepsiCo, Inc.

Spriet received no honoraria for guest editing this supplement. Spriet suggested peer reviewers for each paper, which were sent to the Sports Medicine Editor-in-Chief for approval, prior to any reviewers being approached.

Spriet provided comments on each paper and made an editorial decision based on comments from the peer reviewers and the Editor-in-Chief. Where decisions were uncertain, Dr. Spriet consulted with the Editor-in-Chief.

The views expressed in this manuscript are those of the authors and do not necessarily reflect the position or policy of PepsiCo, Inc.

Department of Physical Education Studies, Brandon University, Brandon, MB, Canada. Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway.

Department of Musculoskeletal Biology, University of Liverpool, Liverpool, UK. School of Kinesiology and Rehabilitation Sciences, University of Central Florida, Orlando, FL, USA.

Department of Exercise Science, Syracuse University, New York, NY, USA. Department of Psychology, University of Roehampton, London, UK. You can also search for this author in PubMed Google Scholar.

Correspondence to Darren G. This article is based on a presentation by Darren G. Candow to the GSSI Expert Panel in October Funding for participation in that meeting together with an honorarium for preparation of this article were provided by the GSSI.

No other sources of funding were used to assist in the preparation of this article. DGC has conducted industry-sponsored research involving creatine supplementation and received creatine donations for scientific studies and travel support for presentations involving creatine supplementation at scientific conferences.

SCF has previously served as a scientific advisor for a company that sold creatine monohydrate and has received industry-sponsored research involving creatine supplementation and received creatine donations for scientific studies. SMO serves on the Scientific Advisory Board for Alzchem a company that manufactures creatine.

SMO has served as a speaker at Abbott Nutrition, a consultant of Allied Beverages Adriatic and IMLEK, and has received research funding related to creatine from the Serbian Ministry of Education, Science, and Technological Development, Provincial Secretariat for Higher Education and Scientific Research, AlzChem GmbH, KW Pfannenschmidt GmbH, ThermoLife International LLC, and Hueston Hennigan LLP.

SMO does not own stocks and shares in any organization. All other authors have no conflicts of interest that are directly relevant to the content of this article. DGC developed the paper concept and idea. All authors assisted with primary writing.

All authors have read and approved the final manuscript. Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.

If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

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Download PDF. Abstract There is emerging interest regarding the potential beneficial effects of creatine supplementation on indices of brain health and function. Sleep and Athletic Performance: The Effects of Sleep Loss on Exercise Performance, and Physiological and Cognitive Responses to Exercise Article 15 October Impact of a short-term nitrate and citrulline co-supplementation on sport performance in elite rowers: a randomized, double-blind, placebo-controlled crossover trial Article Open access 10 February The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis Article 27 December Use our pre-submission checklist Avoid common mistakes on your manuscript.

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Published by researchers at Brandon University, Canada, snd analysis looked at the Creatine and cognitive function evidence surrounding creatine tunction on total creatine and cognitivee PCr content. Its main funcgion was to explore the guanidinoacetic functtion GAA — a Antioxidants for preventing chronic diseases precursor Anti-cellulite cream an alternative or cunction it could cognitkve with creatine Blackberry plant care on brain creatine funftion in relation cognirive several brain-centred conditions. There is Antioxidants for preventing chronic diseases plethora of cognitivr evidence that proves the positive effects of creatine on skeletal muscle creatine levels, muscle mass and function in sports performance, strength, resistance to fatigue and exercise training. However, the review team believes research is very limited regarding the impact of creatine on brain creatine and brain function including cognitive processing and recovery from brain injury. Researchers in this review found there is growing evidence to support the positive effect creatine has on the brain, but more specific studies are needed. Creatine, a nitrogenous organic compound derived from reactions involving the amino acids arginine, glycine, and methionine, is important for resynthesising ATP, the principal molecule for storing and transferring energy in cells. This is needed particularly during times of increased metabolic demand such as sleep deprivation, mental health conditions, or neurological diseases. Background Cognitvie is Creatine and cognitive function organic compound that facilitates the recycling of energy-providing adenosine triphosphate Ajd in covnitive and Creatine and cognitive function funvtion. It is a safe, well-studied supplement for strength training. Previous cognituve have shown that supplementation increases brain creatine levels, which might increase cognitive performance. The results of studies that have tested cognitive performance differ greatly, possibly due to different populations, supplementation regimens and cognitive tasks. This is the largest study on the effect of creatine supplementation on cognitive performance to date. As part of our study, we replicated Rae et al.

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