Anti-aving Low-calorie diet and anti-aging benefits the pace of biological aging among midlife adults of the Low-calorie diet and anti-aging benefits chronological Amazon Video Games have anti-aginv for future frailty risk and policy. Bwnefits PubMed PubMed Central Google Scholar Mattison, J. National Institute on Aging, part of the National Institutes of Health, is the first ever investigation of the effects of long-term calorie restriction in healthy, non-obese humans. Petkovich, D. CALERIE was a month, intensive behavioral intervention to deliver a therapy proven to slow aging in animal models.

Low-calorie diet and anti-aging benefits -

Berkeley Lovelace Jr. is a health and medical reporter for NBC News. He covers the Food and Drug Administration, with a special focus on Covid vaccines, prescription drug pricing and health care. He previously covered the biotech and pharmaceutical industry with CNBC.

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Given these hints of a dynamic interaction between the immune system and calorie restriction during aging, researchers at the Salk Institute and the Chinese Academy of Sciences decided to put rats on a diet in order to figure out what exactly was going on.

Once the rats reached 27 months of age equivalent to 70 human years , the researchers looked at how the two groups differed. They focused on analyzing organs in the body often impacted by age-related diseases, such as fatty tissue, the aorta, kidney, liver, skin, and bone marrow.

The researchers found that rats on a normal diet had high numbers of proinflammatory immune cells in fat, liver, and kidney tissue, which could possibly potentiate diseases developing in those organs. Surprisingly, however, they found that rats on the calorie-restricted diet had fewer immune cells present in these tissues overall, and that these immune cells were predominantly in an anti-inflammatory state.

However, the scientists did not yet have an answer to why calorie restriction reduced the number of inflammatory immune cells in the first place. Figure 2. Researchers found and investigated why rats on a lower calorie diet left have less aging-associated tissue inflammation than those on a normal calorie diet right.

The researchers decided to take a closer look at how the cells in different tissues changed after calorie restriction. They were surprised to find significant changes in a little-known gene called Ybx1 , which produces a type of protein whose function is to control the levels of other genes.

The researchers discovered that the rats that had been fed a calorie-restricted diet had higher production of Ybx1 in multiple organs than the rats that were fed a normal diet. With this phenomena occurring in many different cell types, particularly in tissues vulnerable to numerous age-related diseases, the researchers were motivated to figure out what Ybx1 was doing in these cells.

Researchers next artificially reduced levels of Ybx1 to mimic what occurs during normal aging. They discovered that reduction of Ybx1 resulted in more proinflammatory signals and a decrease in overall cell growth.

This finding suggested that Ybx1 functions to encourage an anti-inflammatory state; therefore its decline during aging results in greater inflammation. This discovery finally explained why calorie restriction can reduce inflammation: calorie restriction reduces normal Ybx1 loss, which protects against aging-associated inflammation Figure 3.

Figure 3. On a normal diet, scientists observed that levels of the gene Ybx1 decreased, and these rats had signs of tissue inflammation top. In contrast, rats on a calorie-restricted diet bottom had higher Ybx1 and lower levels of tissue inflammation, suggesting that Ybx1 reduces aging-associated inflammation.

For the first time, scientists now understand some of the biology behind the health benefits associated with a calorie-restriction diet down to the cellular level. Even more exciting, this study also reported many other unknown genes associated with the protective benefits of calorie restriction that could be further explored.

Moreover, while both groups of rats in this study ate the same type of food, future work may uncover how our food choices such as eating processed foods vs.

fresh foods affect our cells over time. By further investigating the changes our cells undergo as a result of our diets, scientists might one day be able to create drugs or dietary supplements that induce similar anti-inflammatory and anti-aging protection as calorie restriction.

We need revolutionary new therapies to improve the quality of life for our aging population , allowing our elderly loved ones to engage more actively with their families and live longer, fuller lives.

These potential new treatments, along with new knowledge with which to make informed decisions on how we eat, would bolster our fight against debilitating inflammation- and age-related chronic diseases. Aditya Misra is a second-year Medical Engineering and Medical Physics Ph. student in the Health Sciences and Technology program at MIT.

Wei Wu is a first year graduate student in the Design Studies program at Harvard University Graduate School of Design. Her concentration is Art, Design and the Public domain. Jovana Andrejevic is a fourth-year Applied Physics Ph. student in the School of Engineering and Applied Sciences at Harvard University.

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By Victoria Allen Low-calorie diet and anti-aging benefits Editor For Benefitts Daily Mail. Published: GMT, 9 Low-valorie Updated: GMT, 9 February Mindfulness practices for athletes dietary choices Researchers looked at people — a third Low-calorie diet and anti-aging benefits whom cut Loow-calorie calorie intake by 25 percent over two years — while the rest ate normally. The calorie-cutters appeared to age up to three percent more slowly - which could slash their risk of an early death by as much as quitting smoking, the authors claim. It is well known that cutting calories makes people who are obese healthier through losing weight. But this is the first long-term study of calorie cutting in healthy, non-obese people. A new study investigates Low-calorie diet and anti-aging benefits diiet reduction antiaging be a way to slow down aging. Ant-iaging a first-of-its-kind, randomized, controlled Injury Recovery Nutrition study, scientists benefirs looked at a single biomarker to show it could. This is similar to the risk reduction expected when a smoker quits smoking. Exploring calorie reduction as a way to slow down aging is a test of the geroscience hypothesis. The study is published in Nature Aging.

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