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A genetic predisposition Malene Revsbech Christiansen WHR and genetic predispositions, Tuomas Presispositions. Kilpeläinen Circadian rhythm definition, Jeanne M. McCaffery; Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss. Diabetes 1 October ; 72 10 : — Although many individuals are able to achieve weight loss, maintaining this loss over time is challenging.