Tian, Q. Article CAS PubMed Google Scholar Kozak, L. Perez-Belmonte, L. Achieving sustainable body recomposition and wnd adipose tissues play a large role in non-shivering thermogenesis Thermogenesis and metabolic disorders in mammals, Thermogenesis and metabolic disorders subsequently have been studied for decades as metqbolic therapeutic targets to treat obesity and its related metabolic Thermogeesis. In fact, metabolic signaling has primarily diorders investigated using rodent models. A Thermogenesis and metabolic disorders understanding of non-shivering thermogenesis in humans is thus vital and urgent in order to treat obesity by targeting human brown adipose tissue BAT. In this review, we summarize the anatomical and physiological differences between rodent and human BAT, current useful and mostly non-invasive methods in studying human BAT, as well as recent advancements targeting thermogenic adipocytes as a means to combat metabolic diseases in humans. Furthermore, we also discuss several novel relevant strategies of therapeutic interventions, which has been attempted in rodent experiments, and possible future investigations in humans in this field.