Category: Diet

Ribose sugar and immune response

Ribose sugar and immune response

bibtex BibTex. Advance article alerts. It is mainly supplied Extra Virgin Coconut Oil food Ribosee widely recommended as a supplement sygar metabolic therapy for chronic fatigue syndrome and coronary artery disease Perlmutter et al. After periods of intense exercise, D-ribose supplements may help recover stores of ATP in muscle cells. Tanji, N. Purine receptor modulators. Front Genet 9 ,

Ribose sugar and immune response -

Unlike DNA, however, RNA is most often single-stranded. An RNA molecule has a backbone made of alternating phosphate groups and the sugar ribose, rather than the deoxyribose found in DNA. Attached to each sugar is one of four bases: adenine A , uracil U , cytosine C or guanine G.

Different types of RNA exist in cells: messenger RNA mRNA , ribosomal RNA rRNA and transfer RNA tRNA. In addition, some RNAs are involved in regulating gene expression.

Certain viruses use RNA as their genomic material. Ribonucleic acid, or RNA. Addis P, Shecterle LM, St Cyr JA Cellular protection during oxidative stress: a potential role for D-ribose and antioxidants.

J Diet Suppl 9 3 — Faller KM, Medway DJ, Aksentijevic D, Sebag-Montefiore L, Schneider JE, Lygate CA, Neubauer S Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart. PLoS ONE 8 6 :e Del-Corso A, Cappiello M, Moschini R, Balestri F, Mura U, Ipata PL The furanosidic scaffold of d-ribose: a milestone for cell life.

Biochem Soc Trans 47 6 — Perrone A, Giovino A, Benny J, Martinelli F Advanced glycation end products AGEs : biochemistry, signaling, analytical methods, and epigenetic effects. Oxid Med Cell Longev Nowotny K, Jung T, Höhn A, Weber D, Grune T Advanced glycation end products and oxidative stress in type 2 diabetes mellitus.

Biomolecules 5 1 — Mou L, Hu P, Cao X, Chen Y, Xu Y, He T, Wei Y, He R Comparison of bovine serum albumin glycation by ribose and fructose in vitro and in vivo.

Biochim Biophys Acta Mol Basis Dis 1 Khanam A, Alouffi S, Rehman S, Ansari IA, Shahab U, Ahmad S An in vitro approach to unveil the structural alterations in d-ribose induced glycated fibrinogen. J Biomol Struct Dyn 39 14 — Liu JJ, You Y, Gao SQ, Tang S, Chen L, Wen GB, Lin YW Identification of the protein glycation sites in human myoglobin as rapidly induced by d-ribose.

Molecules 26 19 Mou L, Cao X, He T, He R The potential role of albumin glycation by ribose in diabetes mellitus. Sci China Life Sci 65 12 — Syrový I Glycation of albumin: reaction with glucose, fructose, galactose, ribose or glyceraldehyde measured using four methods.

J Biochem Biophys Methods 28 2 — Chen Y, Yu L, Wang Y, Wei Y, Xu Y, He T, He R d-Ribose contributes to the glycation of serum protein. Biochim Biophys Acta Mol Basis Dis — Zhang Z, Tai Y, Liu Z, Pu Y, An L, Li X, Li L, Wang Y, Yang Z, Duan C, Hou K, Zhang Q, Ren F, Ma Q, Su Y Effects of d-ribose on human erythrocytes: non-enzymatic glycation of hemoglobin, eryptosis, oxidative stress and energy metabolism.

Blood Cells Mol Dis Ishtikhar M, Siddiqui Z, Ahmad A, Ashraf JM, Arshad M, Doctor N, Al-Kheraif AA, Zamzami MA, Al-Thawadi SM, Kim J, Khan RH Phytochemical thymoquinone prevents hemoglobin glycoxidation and protofibrils formation: a biophysical aspect.

Siddiqui Z, Faisal M, Alatar AA, Ahmad S Glycation of hemoglobin leads to the immunogenicity as a result of neo-epitope generation. Zhang N, Tu Z, Wang H, Liu G, Wang Z, Huang T, Qin X, Xie X, Wang A Liquid chromatography high-resolution mass spectrometry identifies the glycation sites of bovine serum albumin induced by d-ribose with ultrasonic treatment.

J Agric Food Chem 66 3 — Alouffi S, Khanam A, Husain A, Akasha R, Rabbani G, Ahmad S d-ribose-mediated glycation of fibrinogen: role in the induction of adaptive immune response.

Chem Biol Interact Farzadfard A, König A, Petersen SV, Nielsen J, Vasili E, Dominguez-Meijide A, Buell AK, Outeiro TF, Otzen DE. Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition. Ahmad S, Al-Shaghdali K, Rehman S, Khan MY, Rafi Z, Faisal M, Alatar AA, Tahir IK, Khan S, Ahmad S, Shahab U Nonenzymatic glycosylation of isolated human immunoglobulin-G by D-ribose.

Cell Biochem Funct 40 5 — Siddiqui Z, Ishtikhar M, Moinuddin Ahmad S d-Ribose induced glycoxidative insult to hemoglobin protein: an approach to spot its structural perturbations.

Alvi SS, Nabi R, Khan MS, Akhter F, Ahmad S, Khan MS Glycyrrhizic acid scavenges reactive carbonyl species and attenuates glycation-induced multiple protein modification: an in vitro and in silico study. Arch Biochem Biophys Rodriguez-Capote K, Tovell K, Holmes D, Dayton J, Higgins TN Analytical evaluation of the Diazyme glycated serum protein assay on the siemens ADVIA comparison of results against HbA1c for diagnosis and management of diabetes.

J Diabetes Sci Technol 9 2 — Peng F, Xia X, He F, Li Z, Huang F, Yu X The effect of glycated hemoglobin and albumin-corrected glycated serum protein on mortality in diabetic patients receiving continuous peritoneal dialysis.

Perit Dial Int 35 5 — Akhter F, Khan MS, Alatar AA, Faisal M, Ahmad S Antigenic role of the adaptive immune response to d-ribose glycated LDL in diabetes, atherosclerosis and diabetes atherosclerotic patients. Life Sci — Akhter F, Khan MS, Singh S, Ahmad S An immunohistochemical analysis to validate the rationale behind the enhanced immunogenicity of D-ribosylated low density lipo-protein.

PLoS ONE 9 11 :e Akhter F, Khan MS, Ahmad S Acquired immunogenicity of calf thymus DNA and LDL modified by D-ribose: a comparative study. Hong J, Wang X, Zhang N, Fu H, Li W D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation.

Arch Pharm Res 41 8 — Zhang N, Zhao S, Hong J, Li W, Wang X Protective effects of kaempferol on D-ribose-induced mesangial cell injury. Khalid M, Petroianu G, Adem A Advanced glycation end products and diabetes mellitus: mechanisms and perspectives.

Biomolecules 12 4 Free Radic Biol Med — Mol Biol Rep 47 3 — Rowan S, Bejarano E, Taylor A Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochim Biophys Acta Mol Basis Dis 12 — De Bruyne S, van Schie L, Himpe J, De Somer F, Everaert I, Derave W, Van den Broecke C, Huizing M, Bostan N, Speeckaert M, Callewaert N, Van Aken E, Delanghe JR A potential role for fructosaminekinase in cataract treatment.

Int J Mol Sci 22 8 Wu B, Yu L, Hu P, Lu Y, Li J, Wei Y, He R GRP78 protects CHO cells from ribosylation. Biochim Biophys Acta Mol Cell Res 4 — Goyal R, Jialal I Type 2 Diabetes. StatPearls Publishing, Treasure Island. Google Scholar. Su T, He R D-ribose, an overlooked player in type 2 diabetes mellitus?

Sci China Life Sci 57 3 Yu L, Chen Y, Xu Y, He T, Wei Y, He R D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging Albany NY 11 14 — Wang Y, Yang P, Yan Z, Liu Z, Ma Q, Zhang Z, Wang Y, Su Y The relationship between erythrocytes and diabetes mellitus.

J Diabetes Res Yoo S, Bae JY, Moon J, Koh G System χc- overexpression prevents 2-deoxy-d-ribose-induced β-cell damage. Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M Complications of diabetes Iannuzzi C, Borriello M, Carafa V, Altucci L, Vitiello M, Balestrieri ML, Ricci G, Irace G, Sirangelo I D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts.

Biochim Biophys Acta — Thipsawat S Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: a review of the literature. Diab Vasc Dis Res 18 6 Guo J, Zheng HJ, Zhang W, Lou W, Xia C, Han XT, Huang WJ, Zhang F, Wang Y, Liu WJ Accelerated kidney aging in diabetes mellitus.

Oxid Med Cell Longev 27 Front Cell Dev Biol Biol Res 51 1 Miles WR, Root HF Psychologic tests applied in diabetic patients. Arch Intern Med — Article Google Scholar. Cheng LZ, Li W, Chen YX, Lin YJ, Miao Y Autophagy and diabetic encephalopathy: mechanistic insights and potential therapeutic implications.

Aging Dis 13 2 — Liu Y, Li M, Zhang Z, Ye Y, Zhou J Role of microglia-neuron interactions in diabetic encephalopathy. Ageing Res Rev — J Neurochem 6 — Int J Mol Sci 21 9 Rorbach-Dolata A, Piwowar A Neurometabolic evidence supporting the hypothesis of increased incidence of type 3 diabetes mellitus in the 21st century.

Biomed Res Int Lyu J, Yu LX, He YG, Wei Y, Dong, LL, Zhang SZ, Ma Y, Rong-Qiao He. Am J Urol Res 4 1 — Lu Y, Jiang H, Zhang H, Li R, Zhang Q, Luo D, Cai X, Li M Serum oxidized low density lipoprotein serves as a mediator for the inverse relationship between serum d-ribose and cognitive performance in type 2 diabetic patients.

Han C, Lu Y, Wei Y, Wu B, Liu Y, He R D-ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell Death Dis 5 3 :e Transl Psychiatry 11 1 Song Y, Du Y, An Y, Zheng J, Lu Y A systematic review and meta-analysis of cognitive and behavioral tests in rodents treated with different doses of D-ribose.

Front Aging Neurosci Xi M, Zhang L, Wei Y, Li T, Qu M, Hua Q, He R, Liu Y Effect of ribose-glycated BSA on histone demethylation.

Front Genet Wang Y, Shi C, Chen Y, Yu L, Li Y, Wei Y, Li W, He R Formaldehyde produced from d-ribose under neutral and alkaline conditions. Toxicol Rep — Aging Cell 14 5 — Wu B, Wang Y, Shi C, Chen Y, Yu L, Li J, Li W, Wei Y, He R Ribosylation-derived advanced glycation end products induce Tau hyperphosphorylation through brain-derived neurotrophic factor reduction.

J Alzheimers Dis 71 1 — Moschini R, Balestri F, Cappiello M, Signore G, Mura U, Del-Corso A Ribose intake as food integrator: is it a really convenient practice? Biomolecules 12 12 Castells CB, Arias VC, Castells RC Precolumn derivatization of reducing carbohydrates with 4- 3-Methyloxopyrazolinyl benzoic acid study of reaction, high-performance liquid chromatographic separation and quantitative performance of method.

Zemerov SD, Roose BW, Farenhem KL, Zhao Z, Stringer MA, Goldman AR, Speicher DW, Dmochowski IJ Xe NMR-protein sensor reveals cellular ribose concentration. Anal Chem 92 19 — Gao XD, Hu Y, Wang WF, Zhao XB, Du XZ, Shi YP Rapid and selective 19F NMR-based sensors for fingerprint identification of ribose.

Anal Chem 94 33 — Download references. The authors are grateful for the funding supports for this study: National Natural Science Foundation of China [Grant Number , ]; Natural Science Foundation of Inner Mongolia [Grant Number MS]; Postgraduate Education Innovation Program of Inner Mongolia [Grant Number SZ]; Health Science and Technology Project of Inner Mongolia [Grant Number ]; Grassland Talents Project of Inner Mongolia Institute of Biochemistry and Molecular Biology, Baotou Medical College, Baotou, Inner Mongolia, China.

Department of Clinical Laboratory, the Fourth Hospital of Baotou, Baotou, Inner Mongolia, China. You can also search for this author in PubMed Google Scholar. All authors contributed to the manuscript preparation. Reference collection were performed by ZW and ZY; Reference analysis were performed by YS, ZL, QM, XL, and LA; The first draft of the manuscript was written by YT and ZZ; all authors commented on previous versions of the manuscript.

All authors read and approved the final manuscript. Correspondence to Yan Su. This review does not contain any studies with human participants or animals performed by the authors.

To validate the harm caused by D -ribose in cognitive impairment and comprehensively study the underlying mechanisms, more precise and rigorous experiments with high sample sizes are warranted.

We summarized the effects of D -ribose intervention with different doses based on cognitive and behavioral tests and found that D -ribose was related to learning and memory functions. Our findings indicate that D -ribose intervention causes cognitive impairment, and cognition deteriorated with increasing dose.

Furthermore, the increase in AGEs in the blood and brain confirmed that D -ribose may be involved in cognitive impairment through glycosylation, resulting in the generation of AGEs.

These provide a new research direction for unveiling basic mechanisms and prospective therapeutic targets for the prevention and treatment of cognitive impairment in these patients. The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

YS and YD completed the data analysis and wrote the manuscript. JZ contributed to the data analysis. YL and YA supervised the project. All authors reviewed and approved the submitted version.

This research was supported by grants from National Natural Science Foundation of China and the Fundamental Research Funds for the Central Universities.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Abramov, A. The role of an astrocytic NADPH oxidas e in the neurotoxicity of amyloid beta peptides. B Biol. doi: PubMed Abstract CrossRef Full Text Google Scholar.

Akhter, F. Antigenic role of the adaptive immune response to d-ribose glycated LDL in diabetes, atherosclerosis and diabetes atherosclerotic patients.

Life Sci. Acquired immunogenicity of calf thymus DNA and LDL modified by D-ribose: a comparative study. An immunohistochemical analysis to validate the rationale behind the enhanced immunogenicity of D-ribosylated low density lipo-protein.

PLoS One 9:e Bio-physical characterization of ribose induced glycation: a mechanistic study on DNA perturbations. Alzheimers Dementia, Alzheimers Dement. Ashraf, G. An overview on global trends in nanotechnological approaches for Alzheimer therapy.

Drug Metab. Ashraf, J. Inhibiting effect of zinc oxide nanoparticles on advanced glycation products and oxidative modifications: A potential tool to counteract oxidative stress in neurodegenerative diseases. Au, B. Sex differences in the prevalence and incidence of mild cognitive impairment: A meta-analysis.

Ageing Res. Google Scholar. Batkulwar, K. ACS Chem. Borenstein, M. A basic introduction to fixed-effect and random-effects models for meta-analysis.

Methods 1, 97— Broom, A. Purine nucleosides. Further methylation studies of naturally occurring purine nucleosides. Biochemistry 3, — C Silva, T. Alzheimers Res. Cai, Y. Determination of several sugars in serum by high-performance anion-exchange chromatography with pulsed amperometric detection.

A , 98— Chen, L. D-Ribosylated Tau forms globular aggregates with high cytotoxicity. Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products. PLoS One 5:e Chen, X. d-Ribose as a Contributor to Glycated Haemoglobin.

EBioMedicine 25, — Chen, Y. D-ribose increases triglyceride via upregulation of DGAT in the liver. China Life Sci.

d-Ribose contributes to the glycation of serum protein. Acta Mol. Basis Dis. Dartigues, J. Lancet Neurol. Devadhasan, J. Dhanoa, T. Ribose: more than a simple sugar? Sports Med. Drevon, D. Intercoder reliability and validity of webplotdigitizer in extracting graphed data.

Dukic-Stefanovic, S. AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? Biogerontology 2, 19— Festing, M.

On determining sample size in experiments involving laboratory animals. Garcia-Alamino, J. Impact of heterogeneity and effect size on the estimation of the optimal information size: analysis of recently published meta-analyses. BMJ Open 7:e García-Bonilla, L. Evidence for the efficacy of statins in animal stroke models: A meta-analysis.

Han, C. D-ribose induces cellular protein glycation and impairs mouse spatial cognition. PLoS One 6:e D-ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation.

Cell Death Dis. Jia, J. Keller, P. Biosynthesis of riboflavin: mechanism of formation of the ribitylamino linkage. Biochemistry 27, — Lee, D. Li, S. D-ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications Review.

Lu, Y. Serum oxidized low density lipoprotein serves as a mediator for the inverse relationship between serum D-ribose and cognitive performance in type 2 diabetic patients.

D-ribose Ribose sugar and immune response can offer health benefits for those with certain conditions like heart Improving immune function, fibromyalgia, or myoadenylate deaminase Ribose sugar and immune response Anx. More research rsponse needed, but emerging Rkbose look promising. Though your body naturally produces ribose, some believe that D-ribose supplements can improve health or exercise performance. For this reason, research has examined whether ATP supplements can help improve energy stores in muscle cells. One study had participants complete an intense exercise program consisting of 15 all-out cycling sprints twice per day for one week. Ribose sugar and immune response

Video

What are your thoughts on D-Ribose? - Ask Dr. Gundry

Author: Musida

3 thoughts on “Ribose sugar and immune response

Leave a comment

Yours email will be published. Important fields a marked *

Design by ThemesDNA.com